Cytomegalovirus replication in human retinal pigment epithelial cells: Altered expression of viral early proteins

Investigative Ophthalmology and Visual Science

Volumn 37, Issue 5, 1996, Pages 814-825

  Detrick, Barbara ^a   Rhame, Jean ^a   Wang, Yun ^b   Nagineni, Chandrasekharam N ^b   Hooks, John J ^b  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

Author keywords

cytomegalovirus; flow cytometry; immediate early genes; retinal pigment epithelium

Indexed keywords

IMMEDIATE EARLY PROTEIN; VIRUS ANTIGEN; VIRUS PROTEIN;

AMNION CELL; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; CYTOPATHOGENIC EFFECT; EPITHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; VIRUS DETECTION; VIRUS INFECTION; VIRUS REPLICATION;

BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; CYTOMEGALOVIRUS; CYTOPATHOGENIC EFFECT, VIRAL; EPITHELIUM; FIBROBLASTS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMEDIATE-EARLY PROTEINS; PIGMENT EPITHELIUM OF EYE; VIRUS REPLICATION;

EID: 0029876303     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Huang ES, Kowalik TF. The Pathogenicity of Human Cytomegalovirus: An Overview in Molecular Aspects of Human Cytomegalovirus Diseases. Becker Y, Darai G, Huang ES, eds. Heidelberg: Springer-Verlag; 1993:3-45.
2. Hirsch MS. Cytomegalovirus and its role in the pathogenesis of acquired immunodeficiency syndrome. Transplant Proc. 23;1991:118-121.
3. Maclean H, Dillon B. Cytomegalovirus retinitis: Diagnosis and treatment. Int J STD AIDS. 4;1993:322-325.
4. Mocarski ES. Cytomegalovirus biology and replication. In: Roizman B, Whitley RJ, Lopez C, eds. The Human Herpesviruses. New York: Raven Press; 1993:173-226.
5. McDonough SH, Spector DH. Transcription in human fibroblasts permissively infected by human Cytomegalovirus strain AD 169. Virology. 1983:125:31-46.
6. Wathen MW, Stinski MF. Temporal patterns of human cytomegalovirus transcription: Mapping the viral RNAs synthesized at immediate-early, early, and late times after infection. J Virol. 1982;41:462-477.
7. Minton EJ, Tysoe C, Sinclair JH, Sissons JGP. Human cytomegalovirus infection of the monocyte/macrophage lineage in hone marrow. J Virol. 1994;68:4017-4021.
8. Sambucetti LC, Cherrington JM, Wilkinson GWG, Mocarski ES. NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral trans-activator and by T cell stimulation. EMBO J. 1989;8:4251-4258.
9. Thomsen DR, Stenberg RM, Goins WF, Stinski MF. Promoter regulatory region of the major immediate early gene of human cytomegalovirus. Proc Natl Acad Sci USA. 1984;81:665-663.
10. Lukac DM, Manuppello JR, Alwine JC. Transcriptional activation by the human cytomegalovirus immediate-early proteins: Requirements for simple promoter structures and interactions with multiple components of the transcription complex. J Virol. 1994;68:5184-5193.
11. Kerry JA, Priddy MA, Stenberg RM. Identification of sequence elements in the human cytomegalovirus DNA polymerase gene promoter required for activation by viral gene products. J Virol. 1994;68:4167-4176.
12. Mocarski ES, Abenes GB, Manning WC, Sambucetti LC, Cherrington JM. Molecular genetic analysis of cytomegalovirus gene regulation in growth, persistence and latency. Curr Top Microbiol Immunol. 1990;154:47-74.
13. Myerson D, Hackman RC, Nelson JA, Ward DC, McDougall JK. Widespread presence of histologically occult cytomegalovirus. Hum Pathol. 1984;15:1645-1658.
14. Pepose JS, Newman C, Bach MC, et al. Pathologic features of cytomegalovirus retinopathy after treatment with antiviral agent ganciclovir. Ophthalmology. 1987;94:414-424.
15. Egbert PR, Polland RB, Gallagher JG, Merigan TC. Cytomegalovirus retinitis in immunosuppressed hosts: II: Ocular manifestations. Ann Int Med. 1980;93:664-670.
16. Bok D. Retinal photoreceptor-pigment epithelium interactions. Invest Ophthalmol Vis Sci. 1985;26:1659-1694.
17. Detrick B, Hooks JJ. Autoimmune aspects of ocular disease. In: Rose N, MacKay I, eds. The Autoimmune Diseases. Vol. II. New York: Academic Press; 1992;345-361.
18. Miceli MV, Newsome DA, Novak LC, Beuerman RW. Cytomegalovirus replication in culture human retinal pigment epithelial cells. Curr Eye Res. 1989;8:835-839.
19. Pepose JS, Hilborne LH, Cancilla PA, Foos RY. Concurrent herpes simplex and cytomegalovirus retinitis and encephalitis in the acquired immune deficiency syndrome (AIDS). Ophthalmology. 1984;91:1669-1677.
20. Wang Y, Detrick B, Hooks JJ. Coronavirus (JHM) replication within the retina: Analysis of cell tropism in mouse retinal cell cultures. Virology. 1993;193:124-137.
21. Detrick B, Newsome D, Percopo C, Hooks JJ. Class II antigen expression and gamma interferon modulation of monocytes and retinal pigment epithelial cells from patients with retinitis pigmentosa. Clin Immunol Immunopathol. 1985;36:201-211.
22. Hooks JJ, Chan CC, Detrick G. Identification of the lymphokines, interferon-gamma and interleukin-2, in inflammatory eye diseases. Invest Ophthalmol Vis Sci. 1988;29:1444-1451.
23. Percopo C, Hooks JJ, Shinohara T, Caspi R, Detrick B. Cytokine-mediated activation of a neuronal retinal resident cell provokes antigen presentation. J Immunol. 1990;145:4101-4107.
24. Liversidge HFS, Thomson AW, Forrester JV. Lymphokine-induced MHC class II antigen expression of cultured retinal pigment epithelial cells and the influence of cyclosporine A. Immunology. 1988;63:313-317.
25. Baudouin C, Fred-Reygrobellet D, Jambou P, Gastaud P, Lapalus P. HLA-DR and DQ expression on human retinal pigment epithelial cells in vitro. Graefe's Arch Clin Exp Ophthalmol. 1989;228:86-88.
26. Nagineni CN, Detrick B, Hooks JJ. Synergistic effects of gamma interferon on inflammatory mediators that induce interleukin-6 gene expression and secretion by human retinal pigment epithelial cells. Clin Diag Lab Immunol. 1994;1:569-577.
27. Elner SG, Elner VM, Pavilack MA, et al. Modulation and function of intercellular adhesion molecule-1 (CD54) on human retinal pigment epithelial cells. Lab Invest. 1992;66:200-211.
28. Einer VM, Scales S, Einer SG, Danforth J, Kunkel SL, Strieter RM. Interleukin-6 gene expression and secretion by cytokine stimulated human retinal pigment epithelial cells. Exp Eye Res. 1992;54:361-368.
29. Fish KM, Depto BS, Moses AV, Britt W, Nelson JA. Growth kinetics of human cytomegalovirus are altered in monocyte-derived macrophages. J Virol. 1995;69:3737-3743.
30. Dutko FJ, Oldstone MBA. Cytomegalovirus causes a latent infection in undifferentiated cells and is activated by induction of cell differentiation. J Exp Med. 1981;154:1636-1651.
31. Gonczol E, Andrews PW, Plotkin SA. Cytomegalovirus replicates in differentiated but not in undifferentiated human embryonal carcinoma cells. Science. 1984;224:159-161.
32. Weinshenker BG, Wilton S, Rice GPA. Phorbol ester-induced differentiation permits productive human cytomegalovirus infection in a monocytic cell line. J Immunol. 1988;140:1625-1631.
33. Tanaka J, Sadanari H, Sato H, Fukuda S. Sodium butyrate-inducible replication of human cytomegalovirus in a human epithelial cell line. Virology. 1991;185:271-280.
34. Maciejenski JP, Bruening EE, Donahue RE, Mocarski ES, Young NS, St. Jeor SC. Infection of hematopoietic cells by human cytomegalovirus. Blood. 1992;80:170-178.
35. Sinclair JH, Baillie J, Bryant LA, Taylor-Wiedeman JA, Sissons JG. Repression of human cytomegalovirus major immediate early gene expression in a monocytic cell line. J Gen Virol. 1992;73:433-435.
36. Detrick B, Rodrigues M, Chan CC, Tso MOM, Hooks JJ. Expression of HLA-DR antigen on retinal pigment epithelial cells in retinitis pigmentosa. Am J Ophthalmol. 1986;101:584-590.
37. Nelson JA, Fish K, Ibanez C, et al. Dependence of cytomegalovirus replication on monocyte differentiation. In: Michelson S, Plotkin SA, eds. Multidisciplinary Approach to Understanding CMV Disease. Amsterdam: Elsevier; 1993:77-86.
38. Shelbourn SL, Kothari SK, Sissons JPG, Sinclair JH. Repression of human cytomegalovirus gene expression associated with a novel immediate-early regulatory region binding factor. Nucl Acids Res. 1989;17:9165-9171.
39. Ghazal P, DeMattei C, Giulietti E, Kliewer SA, Umesono K, Evans RM. Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonic cells. PNAS USA. 1992;89:7630-7634.
40. Wolff D, Sinzger C, Drescher P, Jahn G, Plachter B. Reduced levels of IE2 gene expression and shutdown of early and late viral genes during latent infection of the glioblastoma cell line U138-MG with selectable recombinants of human cytomegalovirus. Virology. 1994;204:101-113.
41. Arlt H, Lang D, Gebert S, Stamminger T. Identification of binding sites for the 86-kilodalton IE2 protein of human cytomegalovirus within an IE2-responsive viral early promoter. J Virol. 1994;68:4117-4125.
42. Oldstone MBA. Molecular anatomy of viral persistence. J Virol. 1991;65:6381-6386.
43. Koszinski UH, Del Val M, Reddehase MJ. Cellular and molecular basis of the protective immune response to cytomegalovirus infection. Curr Top Microbiol Immunol. 1990;154:189-220.
44. Reddehase MJ, Mutter W, Munch K, Buhring HJ, Koszinowski UH. CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity. J Virol. 1987;61:3102-3108.
45. Koszinski UH, Reddehase MJ, Keil GM, et al. Molecular analysis of herpesviral gene products recognized by protective cytolytic T lymphocytes. Immunol Lett. 1987;16:185-192.
46. Jonjic S, Del Val M, Keil GM, Reddehase MJ, Koszinowski UH. A nonstructural viral protein expressed by a recombinant vaccinia virus protects against lethal cytomegalovirus infection. J Virol. 1988;62:1653-1658.
47. Rodgers B, Borysiewicz L, Mundin J, Graham S, Sissons P. Immunoaffinity purification of a 72K early antigen of human cytomegalovirus: analysis of humoral and cell-mediated immunity to the purified polypeptide. J Gen Virol. 1987;68:2371-2378.
48. Borysiewicz LK, Hickling JK, Graham S, et al. Human cytomegalovirus specific cytotoxic T cells. J Exp Med. 1988;168:919-931.
49. Reusser P, Riddell SR, Meyers JD, Greenberg PD. Cytotoxic T lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: Pattern of recovery and correlation with cytomegalovirus infection and disease. Blood. 1991;78:1373-1380.