α-Adrenergic activity and cardiovascular effects of besipirdine HCI (HP 749) and metabolite P7480 in vitro and in the conscious rat and dog

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 1, 1997, Pages 337-346

  Hubbard, John W ^a   Nordstrom, Scott T ^a   Smith, Craig P ^a   Brooks, Karen M ^a   Laws Ricker, Lynn ^a   Zhou, Lily ^a   Vargas, Hugo M ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; BESIPIRDINE; DEPROPYLBESIPIRDINE; DRUG METABOLITE; IDAZOXAN; NORADRENALIN; PHENYLEPHRINE; PRAZOSIN; UNCLASSIFIED DRUG;

ADRENERGIC ACTIVITY; ADRENERGIC RECEPTOR BLOCKING; ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CHRONOTROPISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; GUINEA PIG; HEART ATRIUM CONTRACTION; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; NORADRENALIN RELEASE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ADRENERGIC AGENTS; ANIMALS; AORTA; BLOOD PRESSURE; DOGS; FEMALE; GUINEA PIGS; HEART RATE; INDOLES; MALE; MYOCARDIAL CONTRACTION; NOREPINEPHRINE; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA; VASOCONSTRICTION;

EID: 0030946884     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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