Differential sensitivity of transcription factors to mustard-damaged DNA

Chemico-Biological Interactions

Volumn 118, Issue 1, 1999, Pages 51-67

  Chen, Xin Ming ^a   Gray, Peter J ^b   Cullinane, Carleen ^a   Phillips, Don R ^a  

^a LA TROBE UNIVERSITY   (Australia)

^b AERO AND MAR RESEARCH LABORATORY   (Australia)

Author keywords

Alkylating agents; CEES, 2 Chloroethyl ethyl sulphide; DNA damage; Electrophoretic mobility shift assay; EMSA, Electrophoretic mobility shift assay; Transcription factors

Indexed keywords

CHLORMETHINE; MUSTARD GAS; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR SP1;

ARTICLE; CONSENSUS SEQUENCE; DNA ALKYLATION; DNA BINDING; DNA DAMAGE; DRUG COMPARISON; IN VITRO STUDY;

BASE SEQUENCE; BINDING SITES; CONSENSUS SEQUENCE; DNA ADDUCTS; DNA DAMAGE; DNA-BINDING PROTEINS; DNA-DIRECTED RNA POLYMERASES; ESCHERICHIA COLI; KINETICS; MECHLORETHAMINE; OLIGODEOXYRIBONUCLEOTIDES; SP1 TRANSCRIPTION FACTOR; TATA BOX; TATA-BOX BINDING PROTEIN; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTOR TFIIB; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0033022802     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(98)00117-3     Document Type: Article

References (46)

1. Ross W.C.J. Biological Alkylating Agents: Fundamental Chemistry and the Design of Compounds for Selective Toxicity. 1962;Butterworths and Company, London.
2. Hemminki K., Ludlum D.B. Covalent modification of DNA by antineoplasticagents. J: Natl. Cancer Inst. 73:1984;1021-1028.
3. Rink S.M., Solomon M.S., Taylor M.J., Rajur S.B., McLaughlin L.W., Hopkins P.B. Covalent structure of a nitrogen mustard-induced DNA interstrand crosslink: an N′-N′ linkage of deoxyguanine residues at the duplex sequence 5′-d(GNC). J. Am. Chem. Soc. 115:1993;2551-2557.
4. Osborne M.R., Wilman D.E.V., Lawley P.D. Alkylation of DNA by the nitrogenmustard bis(2-chloroethyl)methylamine. Chem. Res. Toxicol. 8:1995;316-320.
5. Fidder A., Moes G.W.H., Scheffer A.G., van der Schans G.P., Baan R.A., de Jong L.P.A., Benschop H.P. Synthesis, characterization, and quantitation of the major adducts between sulfur mustard and DNA of calf thymus and human blood. Chem. Res. Toxicol. 7:1994;199-204.
6. Ludlum D.B., Kent S., Mehta J.R. Formation of O6-ethythioethylguanine in DNAby reaction with the sulfur mustard, chloroethyl sulfide, and its apparent lack of repair by O6-alkylguanine-DNA alkyltransferase. Carcinogenesis. 7:1986;1203-1206.
7. Gray P.J., Cullinane C., Phillips D.R. In vitro transcription analysis of DNAalkylation by nitrogen mustard. Biochemistry. 30:1991;8036-8040.
8. Pieper R.O., Fustscher B.W., Erickson L.C. Transcription-terminating lesionsinduced by bifunctional alkylating agents in vitro. Carcinogenesis. 10:1989;1307-1314.
9. Pieper R.O., Erickson L.C. DNA adenine adducts induced by nitrogen mustard and their role in transcription termination in vitro. Carcinogenesis. 11:1990;1739-1746.
10. Masta A., Gray P.J., Phillips D.R. Effect of sulphur mustard on the initiation and elongation oftranscription. Carcinogenesisl. 7:1996;525-532.
11. Wassermann K., Damgaard J. Ongoing activity of RNA polymerase II confers preferential repair of nitrogen mustard-induced N-alkylpurines in the hamster dihydrofolate reductase gene. Cancer Res. 54:1994;175-181.
12. Roeder R.G. The role of general initiation factors in transcription by RNA polymerase II. Trends Biol. Sci. 21:1996;327-335.
13. Nikolov D.B., Burley S.K. RNA polymerase II transcription initiation: a structural view. Proc. Natl. Acad. Sci. U.S.A. 94:1997;15-22.
14. Nikolov D.B., Burley S.K. 2.1 A resolution refined structure of a TATA box binding protein (TBP). Nat. Struct. Biol. 1:1994;621-637.
15. Nikolov D.B., Hu S.-H., Lin J., Grasch A., Hoffmann A., Horikoshi M., Chua N.-H., Roeder R.G., Burley S.K. Crystal structure of TFIID TATA-box binding protein. Nature. 360:1992;40-46.
16. Orphanides G., Lagrange T., Reinberg D. The general transcription factors of RNA polymerase II. Genes Dev. 10:1996;2657-2683.
17. Latchman D.S. Transcription factors: an overview. Int. J. Exp. Pathol. 74:1993;417-422.
18. Bustin S.A., McKay I.A. Transcription factors: targets for new designer drugs. Br. J. Biomed. Sci. 51:1994;147-157.
19. Broggini M., D'Incalci M. Modulation of transcription factor-DNA interactions by anticancer drugs. Anti-Cancer Drug Des. 9:1994;373-387.
20. Welch J.J., 3rd Raucher F.J., Beerman T.A. Targeting DNA-binding drugs to sequence-specific transcription factor DNA complex. Differential effects of intercalating end minor groove birding drugs. J: Biol. Chem. 26931051:1994;31058.
21. Bellorini M., Moncollin V., D'Incalci M., Mongelli N., Mantovani R. Distamycin A and tallimustine inhibit TBP binding and basal in vitro transcription. Nucleic Acids Res. 23:1995;1657-1663.
22. Fabbri S., Prontera C., Broggini M., D'Incalci M. Differential inhibition of the DNA binding of transcription factors NF kappa B and OTF-1 by nitrogen mustard and quinacrine mustard transcriptional implication. Carcinogenesis. 14:1993;1963-1967.
23. Gray P.J. Sulphur mustards inhibit binding of transcription factor AP2 in vitro. Nucleic Acids Res. 23:1995;4378-4382.
24. Gray P.J., Phillips D.R. Effects of alkylating agents on initiation and elongation of the lac W5 promoter. Biochemistry. 32:1993;12471-12477.
25. Masta A., Gray P.J., Phillips D.R. Molecular basis of nitrogen mustard effects on transcription processes: role of depurination. Nucleic Acids Res. 22:1994;3880-3886.
26. Kudo S., Fukuda M. Transcriptional activation of human leukosialin (CD43) gene by Sp1 through binding to a GGGTGG motif. Eur. J. Biochem. 223:1994;319-327.
27. Kim J.L., Nikolov D.B., Burley S.K. Co-crystal structure of TBP recognizing the minor groove of a TATA element. Nature. 365:1993;520-527.
28. Kim Y., Geiger J.H., Hahn S., Sigler P.B. Crystal structure of a yeast TBP/TATA box complex. Nature. 365:1993;512-520.
29. Lee S., Hahn S. Model for binding of transcription factor TFIIB to the TBP-DNA complex. Nature. 376:1995;609-612.
30. Imbalzano A.N., Zaret K.S., Kingston R.E. Transcription factor (TF) IIB and TFIIA can independently increase the affinity of the TATA-binding protein for DNA. J: Biol. Chem. 269:1994;8280-8286.
31. Lawley P.D., Phillips D.H. DNA adducts from chemotherapeutic agents. Mutat. Res. 355:1996;13-40.
32. Kadonaga J.T., Courey A.J., Tjian R. Distinct regions of Sp1 modulate DNA binding and transcription activation. Science. 242:1988;1566-1570.
33. Williams T., Admon A., Luscher B., Tjian R. Cloning and expression of AP2, a cell-type-specific transcription factor that activates inducible enhancer element. Genes Dev. 2:1988;1557-1569.
34. Chiang S.-Y., Welch J.J., Rauscher F.J., Beerman T.A. Effect of DNA-binding drugs on early growth response factor-1 and TATA box-binding protein complex formation with the herps simplex virus latency promoter. J. Biol. Chem. 271:1996;23999-24004.
35. Tornmasi S., Swiderski P.M., Tu Y., Kaplan B.E., Pfeifer G.P. Inhibition of transcription factor binding ultraviolet-induced pyrimidine dimers. Biochemistry. 35:1996;15693-15703.
36. 32P postlabeling method for the detection of adducts in the DNA of human fibroblasts exposed to sulfur mustard. Chem. Biol. Interact. 100:1996;77-84.
37. Dabrowska M.I., Becks L.L., Lelli J.L., Levee M.G., Hinshaw D.B. Sulfur mustard induces apoptosis and necrosis in endothelial cells. Toxicol. Appl. Pharmacol. 141:1996;568-583.
38. Raffray M., Cohen G.M. Apoptosis and necrosis in toxicology: a continuum or distinct modes of cell death? Pharmacol. Ther. 75:1997;153-177.
39. Huang J.C., Zamble D.B., Reardon J.T., Lippard S.J., Sancar A. HMG-domain proteins specifically inhibit the repair of the major DNA adduct of anticancer drug cisplatin by human excision nuclease. Proc. Natl. Acad. Sci. U.S.A. 91:1994;10394-10398.
40. Dunham S.U., Lippard S.J. DNA sequence context and protein composition modulate HMG-domain protein recognition of cisplatin-modified DNA. Biochemistry. 36:1997;11428-11436.
41. Butler A.P., Johnson D.G., Kumar A.P., Narayan S., Wilson S.H., MacLeod M.C. Disruption of transcription in vitro and gene expression in vivo by DNA adducts derived from a benzo[a]pyrene diol epoxide located in heterologous sequence. Carcinogenesis. 18:1997;239-244.
42. Drapkin R., Reardon J.T., Ansari A., Huang J.C., Zawel L., Ahn K., Sancar A., Reinberg D. Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II. Nature. 368:1994;769-772.
43. Nocentini S., Coin F., Saijo M., Tanaka K., Egly J.M. DNA damage recognition by XPA protein promoters efficient recruitment of transcription factor II H. J: Biol. Chem. 272:1997;22991-22994.
44. You Z., Feaver W.J., Friedberg E.C. Yeast RNA polymerase II transcription in vitro is inhibited in the presence of nucleotide excision repair: complementation of inhibition by Holo-TFIIH and requirement for RAD26. Mol. Cell. Biol. 18:1998;2668-2676.
45. Vichi P., Coin F., Renaud J.P., Vermeulen W., Hoeijmakers J.H., Moras D., Egly J.M. Cisplatin- and UV-damaged DNA lure the basal transcription factor TFIID/TBP. EMBO J. 16:1997;7444-7456.
46. Tornaletti S., Pfeifer G.P. UV light as a footprinting agent modulation of UV-induced DNA damage by transcription factors bound at the promoters of three human genes. J. Mol. Biol. 249:1995;714-728.