Disruption of transcription in vitro and gene expression in vivo by DNA adducts derived from a benzo[a]pyrene diol epoxide located in heterologous sequences

Carcinogenesis

Volumn 18, Issue 2, 1997, Pages 239-244

  Butler, Andrew P ^a   Johnson, David G ^a   Kumar, A Pratap ^a   Narayan, Satya ^b   Wilson, Samuel H ^b,c   MacLeod, Michael C ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROXYBENZO[A]PYRENE OXIDE; PLASMID DNA; PROTEIN P53; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CARCINOGENESIS; CONTROLLED STUDY; DNA ADDUCT; EXPRESSION VECTOR; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; REPORTER GENE; TRANSCRIPTION REGULATION;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ANIMALS; CELL LINE; DNA ADDUCTS; GENE EXPRESSION REGULATION; GENES, REPORTER; GENETIC VECTORS; HELA CELLS; HUMANS; INSECTS; LUCIFERASES; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031416755     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.2.239     Document Type: Article

References (54)

1. Beland, F.A. and Poirier, M.C. (1989) DNA adducts and carcinogenesis. In Sirica, A.E. (ed.) The Pathobiology of Neoplasia. Plenum Press, NY, pp. 57-78.
2. Jeffrey, A.M. (1987) DNA modification by chemical carcinogens. In Huberman, E. and Goff, S. (eds.) Mechanism of Cellular Transformation by Carcinogenic Agents. Pergamon Press, Elmsford, NY, pp. 33-71.
3. Brookes, P. and Osborne, M.R. (1982) Mutation in mammalian cells by stereoisomers of anti-benzo[a]pyrene diol epoxide in relation to the extent and nature of the DNA reaction products. Carcinogenesis, 3, 1223-1226.
4. Yang, J.-L., Maher, V.M. and McCormick, J.J. (1987) Kinds of mutation formed when a shuttle vector containing adducts of (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene replicates in human cells. Proc. Natl Acad. Sci. USA, 84, 3787-3791.
5. MacLeod, M.C., Adair, G. and Humphrey, R.M. (1988) Differential efficiency of mutagenesis at three genetic loci in CHO cells by a benzo[a]pyrene diol epoxide. Mut. Res., 199, 243-254.
6. Barbacid, M. (1987) Ras genes. Annu. Rev. Biochem., 56, 779-827.
7. Hollstein, M., Sidransky, D., Vogelstein, B. and Harris, C.C. (1991) P53 mutations in human cancers. Science, 253, 49-53.
8. Marshall, C.J., Vousden, K.H. and Phillips, D.H. (1984) Activation of c-Haras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo[a]pyrene diol epoxide. Nature, 310, 586-589.
9. Barrett, J.C. and T'so, P.O.P. (1978) Relationship between somatic mutation and neoplastic transformation. Proc. Natl Acad. Sci. USA, 75, 3297-3301.
10. Kennedy, A.R. (1991) Is there a critical target gene for the first step in carcinogenesis? Environ. Health Perspect., 93, 199-203.
11. Kamiya, K., Yasukawa-Barnes, J., Mitchen, J.M., Gould, M.N. and Clifton, K.H. (1995) Evidence that carcinogenesis involves an imbalance between epigenetic high-frequency initiation and suppression of promotion. Proc. Natl Acad. Sci. USA, 92, 1332-1336.
12. Hsu, W., Lin, E.J.S., Harvey, R.G. and Weiss, S.B. (1977) Mechanism of phage phiX174 DNA inactivation by benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide. Proc. Natl Acad. Sci. USA, 74, 3335-3339.
13. Moore, P. and Strauss, B.S. (1979) Sites of inhibition of in vitro DNA synthesis in carcinogen- and UV-treated φX174 DNA. Nature, 278, 664-666.
14. Leffler, S., Pulkrabek, P., Grunberger, D. and Weinstein, I.B. (1977) Template activity of calf thymus DNA modified by a dihydrodiol epoxide derivative of benzo[a]pyrene. Biochemistry, 16, 3133-3136.
15. Nath, S.T., Lee, M.-S. and Romano, L.J. (1987) Effect of carcinogenic adducts on transcription by T7 RNA polymerase. Nucleic Acids Res., 15, 4257-4279.
16. Ramet, M., Castren, K., Jarvinen, K., Pekkala, K., Turpeenniemi-Hujanen, T., Soini, Y., Paakko, P. and Vahakangas, K. (1995) p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines. Carcinogenesis, 16, 2117-2124.
17. El-Deiry, W.S. Harper, J.W., O'Connor, P.M., Velculescu, V.E., Canman, C.E., Jackman, J., Pietenpol, J.A., Burrell, M., Hill, D.E., Wang, Y., Wiman, K.G., Mercer, W.E., Kastan, M.B., Kohn, K.W., Elledge, S.J., Kinzler, K.W. and Vogelstein, B. (1994) WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res., 54, 1169-1174.
18. MacLeod, M.C., Powell, K.L. and Tran, N. (1995) Binding of the transcription factor, Sp1, to non-target sites in DNA modified by benzo[a]pyrene diol epoxide. Carcinogenesis, 16, 975-983.
19. MacLeod, M.C., Powell, K.L., Kuzmin, V.A., Kolbanovskiy, A. and Geacintov, N.E. (1996) Interference of benzo[a]pyrene diol epoxidedeoxyguanosine adducts in a GC box with binding of the transcription factor Sp1. Mol. Carcinogenesis, 16, 44-52.
20. Treiber, D.K., Zhai, X., Jantzen, H.-M. and Essigmann, J.M. (1994) Cisplatin-DNA adducts are molecular decoys for the ribosomal transcription factor hUBF (human upstream binding factor). Proc. Natl Acad. Sci. USA, 91, 5672-5676.
21. Kadonaga, J.T., Jones, K.A. and Tjian, R. (1986) Promoter-specific activations of RNA polymerase II transcription by Sp1. TIBS, 11, 20-23.
22. Narayan, S., Widen, S.G., Beard, W.A. and Wilson, S.H. (1994) A high efficiency HeLa cell nuclear transcription extract. J. Biol. Chem., 269, 12755-12763.
23. van Steeg, H., van Oostrom, C.T.M., van Kranen, H.J. and van Kreijl, C.F. (1988) Nucleotide sequence of the rat ornithine decarboxylase gene. Nucleic Acids Res., 16, 8173-8174.
24. Kumar, A.P., Mar, P.K., Zhao, B., Montgomery, R.L., Kang, D.-C. and Butler, A.P. (1995) Regulation of rat ornithine decarboxylase promoter activity by binding of transcription factor Sp1. J. Biol. Chem., 270, 4341-4348.
25. Mar, P.K., Kumar, A.P., Anderson, L., Martinez, L.A., Zhao, B., Montgomery, R.L. and Butler, A.P. (1995) Characterization of novel phorbol ester- and serum-responsive sequences of the rat ornithine decarboxylase gene promoter. Mol. Carcinogenesis, 14, 240-250.
26. Courey, A.J. and Tjian, R. (1988) Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell, 55, 887-898.
27. Johnson, D.G., Ohtani, K. and Nevins, J.R. (1994) Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Develop., 8, 1514-1525.
28. Shapiro, D.J., Sharp, P.A., Wahli, W.W. and Keller, M.J. (1988) A high efficiency HeLa cell nuclear transcription extract. DNA, 7, 47-55.
29. Jackson, S.P. and Tjian, R. (1989) Purification and analysis of RNA polymerase II transcription factors by using wheat germ agglutinin affinity chromatography. Proc. Natl Acad. Sci. USA, 86, 1781-1785.
30. Schneider, I. (1972) Cell lines derived from late embryonic stages of Drosophila melanogaster. J. Embryol. Exp. Morphol., 27, 353-365.
31. Bradford, M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-252.
32. Ptashne, M. (1988) How eukaryotic transcriptional activators work. Nature, 335, 683-689.
33. Tam, S.W., Theodoras, A.M., Shay, J.W., Draetta, G.F. and Pagano, M. (1994) Differential expression and regulation of cyclin D1 protein in normal and tumor human cells: association with cdk4 is required for cyclin D1. Oncogene, 9, 2663-2667.
34. 1 cyclin-dependent kinases. Genes Develop., 9, 1149-1163.
35. Swick, A.G., Blake, M.C, Kahn, J.W. and Azizkhan, J.C. (1989) Functional analysis of GC element binding and transcription in the hamster dihydrofolate reductase gene promoter. Nucleic Acids Res., 17, 9291-9304.
36. Thomsen, D.R., Stenberg, R.M., Goins, W.F., and Stinski, M.F. (1984) Promoter-regulatory region of the major immediate early gene of human cytomegalovirus. Proc. Natl Acad. Sci. USA, 81, 659-663.
37. Xu, R., Mao, B., Xu, J., Li, B., Birke, S., Swenberg, C.E. and Geacintov, N.E. (1995) Stereochemistry-dependent bending in oligonucleotide duplexes induced by site-specific covalent benzo[a]pyrene diol epoxide-guanine lesions. Nucleic Acids Res., 23, 2314-2319.
38. Horikoshi, M., Bertuccioli, C., Takada, R., Wang, J., Yamamoto, T. and Roeder, R.G. (1992) Transcription factor TFIID induces DNA bending upon binding to the TATA element. Proc. Natl Acad. Sci. USA, 89, 1060-1064.
39. Omichinski, J.G., Clore, G.M., Schaad, O., Felsenfeld, G., Trainor, C., Appella, E., Stahl, S.J. and Gronenborn, A.M. (1993) NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1. Science, 261, 438-446.
40. Giese, K. Cox, J. and Grosschedl, R. (1992) The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures. Cell, 69, 185-195.
41. Huber, H.E., Goodhart, P.J. and Huang, P.S. (1994) Retinoblastoma protein reverses DNA bending by transcription factor E2F. J. Biol. Chem., 269, 6999-7005.
42. Cress, W.D. and Nevins, J.R. (1996) A role for a bent DNA structure in E2F-mediated transcription activation. Mol. Cell. Biol., 16, 2119-2127.
43. Cosman, M., de los Santos, C., Fiala, R., Singh, S.B., Hingerty, B.E., Ibanez, V., Margulis, L.A., Live, D., Geacintov, N.E., Broyde, S. and Patel, D.J. (1992) Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA. Proc. Natl Acad. Sci. USA, 89, 1914-1918.
44. Gidoni, D., Dynan, W.S. and Tjian, R. (1984) Multiple specific contacts between a mammalian transcription factor and its cognate promoters. Nature, 312, 409-413.
45. Dorn, A., Affolter, M., Müller, M., Gehring, W.J. and Leupin, W. (1992) Distamycin-induced inhibition of homeodomain-DNA complexes. EMBO J., 11, 279-286.
46. Ho, S.N., Boyer, S.H., Schreiber, S.L., Danishefsky, S.J. and Crabtree, G.R. (1994) Specific inhibition of formation of transcription complexes by a calicheamicin oligosaccharide: a paradigm for the development of transcriptional antagonists. Proc. Natl Acad. Sci. USA, 91, 9203-9207.
47. Sun, D. and Hurley, L.H. (1995) TBP binding to the TATA box induces a specific downstream unwinding site that is targeted by pluramycin. Chem. Biol., 2, 457-469.
48. Levine, A.J. (1993) The tumor suppressor genes. Annu. Rev. Biochem., 62, 623-651.
49. Mitchell, P.J., Wang, C. and Tjian, R. (1987) Positive and negative regulation of transcription in vitro: enhancer binding protein AP2 is inhibited by SV40 T antigen. Cell, 50, 847-861.
50. Pitot, H.C. and Heidelberger, C. (1963) Metabolic regulatory circuits and carcinogenesis. Cancer Res., 23, 1694-1700.
51. Keller, A.D. (1995) Model genetic circuits encoding autoregulatory transcription factors. J. Theor. Biol., 172, 169-185.
52. MacLeod, M.C. (1996) A possible role in chemical carcinogenesis for epigenetic, heritable changes in gene expression. Mol. Carcinogenesis, 15, 241-250.
53. Ohtani, K., DeGregori, J. and Nevins, J.R. (1995) Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl Acad. Sci. USA, 92, 12146-12150.
54. Geng, Y., Eaton, E.N., Picon, M., Roberts, J.M., Lundberg, A.S., Gifford, A., Sardet, C. and Weinberg, R.E. (1996) Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene, 12, 1173-1180.