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Volumn 5, Issue 7, 1999, Pages 736-737

MEK wars, a new front in the battle against cancer

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSTATIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE;

EID: 0033021061     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/10457     Document Type: Short Survey
Times cited : (39)

References (14)
  • 1
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    • Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
    • Sebolt-Leopold, et al. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nature Med. 5, 810-816 (1999).
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    • Sebolt-Leopold1
  • 2
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    • Signal transduction through MAP kinase cascades
    • Lewis, T.S., Shapiro, P.S. & Ahn, N.G. Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74, 49-139 (1998).
    • (1998) Adv. Cancer Res. , vol.74 , pp. 49-139
    • Lewis, T.S.1    Shapiro, P.S.2    Ahn, N.G.3
  • 3
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
    • Cowley, S., Paterson, H., Kemp, P. & Marshall, C.J. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77, 841-852 (1994).
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 4
    • 0028141496 scopus 로고
    • Transformation of mammalian cells by constitutively active MAP kinase kinase
    • Mansour, S.J. et al. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265, 966-970 (1994).
    • (1994) Science , vol.265 , pp. 966-970
    • Mansour, S.J.1
  • 7
    • 0028901847 scopus 로고
    • MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos
    • Okazaki, K. & Sagata, N. MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos. Oncogene 10, 1149-1157 (1995).
    • (1995) Oncogene , vol.10 , pp. 1149-1157
    • Okazaki, K.1    Sagata, N.2
  • 8
    • 0033090990 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase anti-sense oligonucleotide inhibits the growth of human lung cancer cells
    • Nishio, K. et al. Mitogen-activated protein kinase anti-sense oligonucleotide inhibits the growth of human lung cancer cells. Int. J. Oncol. 14, 461-469 (1999).
    • (1999) Int. J. Oncol. , vol.14 , pp. 461-469
    • Nishio, K.1
  • 9
    • 85069256803 scopus 로고    scopus 로고
    • Anthrax lethal factor causes proteolytic inactivation of MAP-Kinase-Kinase
    • in the press
    • Duesbery, N. and Vande Woude, G.F. Anthrax lethal factor causes proteolytic inactivation of MAP-Kinase-Kinase. Lett. Appl. Microbiol. (in the press 1999).
    • (1999) Lett. Appl. Microbiol.
    • Duesbery, N.1    Vande Woude, G.F.2
  • 10
    • 0033590636 scopus 로고    scopus 로고
    • Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
    • Hoshino, R. et al. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene 18, 813-822 (1999).
    • (1999) Oncogene , vol.18 , pp. 813-822
    • Hoshino, R.1
  • 11
    • 0032945857 scopus 로고    scopus 로고
    • Differential cyclin-dependent kinase expression and activation in human colon cancer
    • Salh, B. et al. Differential cyclin-dependent kinase expression and activation in human colon cancer. Anticancer Res. 19, 741-748 (1999).
    • (1999) Anticancer Res. , vol.19 , pp. 741-748
    • Salh, B.1
  • 12
    • 0030946366 scopus 로고    scopus 로고
    • Hyperexpression of mitogen-activated protein kinase in human breast cancer
    • Sivaraman, V.S., Wang, H., Nuovo, G.J., & Malbon, C.C. Hyperexpression of mitogen-activated protein kinase in human breast cancer. J. Clin. Invest. 99, 1478-1483 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 1478-1483
    • Sivaraman, V.S.1    Wang, H.2    Nuovo, G.J.3    Malbon, C.C.4
  • 13
    • 0031769940 scopus 로고    scopus 로고
    • In situ visualization of intratumor growth factor signaling: Immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms
    • Mandell, J.W., Hussaini, I.M., Zecevic, M., Weber, M.J. & Vandenberg, S.R. In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms. Am. J. Pathol. 153, 1411-1423 (1998).
    • (1998) Am. J. Pathol. , vol.153 , pp. 1411-1423
    • Mandell, J.W.1    Hussaini, I.M.2    Zecevic, M.3    Weber, M.J.4    Vandenberg, S.R.5
  • 14
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    • Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
    • Duesbery, N.S. et al. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science 280, 734-737 (1998).
    • (1998) Science , vol.280 , pp. 734-737
    • Duesbery, N.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.