Alternative oxidase inhibitors potentiate the activity of atovaquone against Plasmodium falciparum

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 3, 1999, Pages 651-654

  Murphy, Anina D ^a   Lang Unnasch, Naomi ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOVAQUONE; OXIDOREDUCTASE INHIBITOR; PROGUANIL; SALICYLHYDROXAMIC ACID;

ANTIMALARIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; ENZYME INHIBITION; GROWTH INHIBITION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OXYGEN CONSUMPTION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RESPIRATORY CHAIN;

EID: 0033017821     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.3.651     Document Type: Article

References (29)

1. Abdo, K. M., J. E. Huff, J. K. Haseman, and C. J. Alden. 1986. No evidence of carcinogenicity of D-mannitol and propyl gallate in F344 rats or B6C3F1 mice. Food Chem. Toxicol. 24:1091-1097.
2. Basco, L, K., O. Ramiliarisoa, and J. L. Bras. 1995. In vitro activity of atovaquone against the African isolates and clones of Plasmodium falciparum. Am. J. Trop. Med. Hyg. 53:388-391.
3. Berenbaum, M. C. 1978. A method for testing synergy with any number of agents. J. Infect. Dis. 137:122-120.
4. Canfield, C. J., M. Pudney, and W. E. Gutteridge. 1995. Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro. Exp. Parasitol. 80:373-381.
5. Chiodini, P. L., C. P. Conlon, D. B. Hutchinson, J. A. Farquhar, A. P. Hall, T. E. Peto, H. Birley, and D. A. Warrell. 1995. Evaluation of atovaquone in the treatment of patients with uncomplicated Plasmodium falciparum malaria. J. Antimicrob. Chemother. 36:1073-1078.
6. Clarkson, A. B., E. J. Bienen, G. Pollakis, and R. W. Grady. 1989. Trypanocidal CoQ analogues: their effect on other mitochondrial systems. Comp. Biochem. Physiol. B 94:245-251.
7. Dacre, J. C. 1974. Long-term toxicity study of n-propyl gallate in mice. Food Cosmet. Toxicol. 12:125-129.
8. Desjardins, R. E., C. J. Canfield, J. D. Haynes, and J. D. Chulay. 1979. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob. Agents Chemother. 16:710-718.
9. Fidock, D. A., and T. E. Wellems. 1997. Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc. Natl. Acad. Sci. USA 94:10931-10936.
10. Fry, M., and M. Pudney. 1992. Site of action of the antimalarial hydroxynapthoquinone, 2-[trans-4-(4′-chlorphenyl) cyclohexyl]-3-hydroxy-1.4-napthoquinone (566C80). Biochem. Pharmacol. 43:1545-1553.
11. Gutteridge, W. E. 1991. 566C80, an antimalarial hydroxynapthoquinone with broad spectrum: experimental activity against opportunistic parasitic infections of AIDS patients. J. Protozool. 38:141S-143S.
12. Gutteridge, W. E., D. Dave, and W. H. Richards. 1979. Conversion of dihydroorotate to orotate in parasitic protozoa. Biochim. Biophys. Acta 582:390-401.
13. Hudson, A. T., M. Dickins, C. D. Ginger, W. E. Gutteridge, T. Holdich, D. S. A. Hutchinson, M. Pudney, A. W. Randall, and V. S. Latter. 1991. 566C80: a potent broad spectrum anti-infective agent with activity against malaria and opportunistic infection in AIDS patients. Drugs Exp. Clin. Res. 17:427-435.
14. Ittarat, I., W. Asawamahasakda, and S. R. Meshnick. 1994. The effects of antimalarials on the Plasmodium falciparum dihydroorotate dehydrogenase. Exp. Parasitol. 79:50-56.
15. Ittarat, I., H. K. Webster, and Y. Yuthavong. 1992. High-performance liquid Chromatographic determination of dihydroorotate dehydrogenase of Plasmodium falciparum and effects of antimalarials on enzyme activity. J. Chromatogr. 582:57-64.
16. Lang-Unnasch, N. 1992. Purification and properties of Plasmodium falciparum malate dehydrogenase. Mol. Biochem. Parasitol. 50:17-26.
17. LeBlanc, S. B. 1995. Studies on pyrimidine biosynthesis and linkage with mitochondrial respiration in Plasmodium falciparum. Ph.D. thesis. University of Alabama at Birmingham.
18. Looareesuwan, S., C. Viravan, H. K. Webster, D. E. Kyle, D. B. Hutchinson, and C. J. Canfield. 1916. Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for the treatment of acute uncomplicated malaria in Thailand. Am. J. Trop. Med. Hyg. 54:62-66.
19. McIntosh, L. 1994. Molecular biology of the alternative oxidase. Plant Physiol. 105:781-786.
20. Moore, A. L., and J. N. Siedow. 1991. The regulation and nature of the cyanide-resistant alternative oxidase of plant mitochondria. Biochim. Biophys. Acta 1059:121-140.
21. Murphy, A. D., J. Doeller, B. Hearn, and N. Lang-Unnasch. 1997. Plasmodium falciparum: cyanide-resistant oxygen consumption. Exp. Parasitol. 87: 112-120.
22. Scheitel, L. W. 1988. Plasmodium metabolism and related organellar functions during various stages of the life-cycle: carbohydrates, p. 171-217. In W. H. Wernsdorfer and S. I. McGregor (ed.). Malaria principles and practice of malariology. Churchill Livingstone, New York, N.Y.
23. Tallarida, R. J., and L. S. Jacob. 1979. The dose-response relation in pharmacology. Springer-Verlag, New York, N.Y.
24. van der Heijden, C. A., P. J. Janssen, and J. J. Strik. 1986. Toxicology of gallates: a review and evaluation. Food Chem. Toxicol. 24:1067-1070.
25. Vanlerberghe, G. C., A. E. Vanlerberghe, and L. McIntosh. 1994. Molecular genetic alteration of plant respiration: silencing and overexpression of alternative oxidase in transgenic tobacco. Plant Physiol. 106:1503-1510.
26. Watkins, W. M., D. G. Sixsmith, and J. D. Chulay. 1984. The activity of proguanil and its metabolites, cycloguanil and p-chlorophenylbiguanide, against Plasmodium falciparum in vitro. Ann. Trop. Med. Parasitol. 78:273-278.
27. Wooden, J. M., L. H. Harwell, B. Vasquez, and C. H. Sibley. 1997. Analysis in yeast of antimalarial drugs that target the dihydrofolate reductase of Plasmodium falciparum. Mol. Biochem. Parasitol. 85:25-40.
28. Yeo, A. E., M. D. Edstein, and K. H. Rieckmann. 1997. Antimalarial activity of the triple combination of proguanil, atovaquone and dapsone. Acta Trop. 67:207-214.
29. Yeo, A. E. T., M. D. Edstein, G. D. Shanks, and K. H. Rieckmann. 1997. Potentiation of the antimalarial activity of atovaquone by doxycycline against Plasmodium falciparum in vitro. Parasitol. Res. 83:489-491.