Antiandrogen treatment of polycystic ovary syndrome

Endocrinology and Metabolism Clinics of North America

Volumn 28, Issue 2, 1999, Pages 409-421

  Rittmaster, R S ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; CYPROTERONE ACETATE; FINASTERIDE; FLUTAMIDE; SPIRONOLACTONE;

CLINICAL FEATURE; DRUG EFFECT; FEMALE; HIRSUTISM; HORMONAL THERAPY; HUMAN; MALE TYPE ALOPECIA; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; REVIEW; TESTOSTERONE SYNTHESIS; TREATMENT PLANNING;

EID: 0033013807     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8529(05)70077-3     Document Type: Article

References (46)

1. J.H. Barth How hairy are hirsute women? Clin Endocrinol (Oxford) 47 1997 255
2. J.H. Barth C.A. Cherry F. Wojnarowska Cyproterone acetate for severe hirsutism: Results of a double-blind dose-ranging study Clin Endocrinol 35 1991 5
3. S. Belisle E.J. Love Clinical efficacy and safety of cyproterone acetate in severe hirsutism: Results of multicentered Canadian study Fertil Steril 46 1986 1015
4. E. Carmina R.A. Lobo Gonadotrophin-releasing hormone agonist therapy for hirsutism is as effective as high dose cyproterone acetate but results in a longer remission Hum Reprod 12 1997 663
5. M. Castello F. Tosi F. Perrone Outcome of long-term treatment with the 5α-reductase inhibitor finasteride in idiopathic hirsutism: Clinical and hormonal effects during a 1-year course of therapy and 1-year follow-up Fertil Steril 66 1996 734
6. P.D.A. Crosby R.S. Rittmaster Predictors of clinical response in hirsute women treated with spironolactone Fertil Steril 55 1991 1076
7. L. Cusan A. Dupont Gomez J.-L. Comparison of flutamide and spironolactone in the treatment of hirsutism: A randomized controlled trial Fertil Steril 61 1994 281
8. De Leo V. D. Lanzetta D. D'Antona Hormonal effects of flutamide in young women with polycystic ovary syndrome J Clin Endocrinol Metab 83 1998 99
9. C. Eil S.K. Edelson The use of human skin fibroblasts to obtain potency estimates of drug binding to androgen receptors J Clin Endocrinol Metabol 59 1984 51
10. M. Erenus O. Gurbuz F. Durmusoglu Comparison of the efficacy of spironolactone versus flutamide in the treatment of hirsutism Fertil Steril 61 1994 613
11. M. Erenus D. Yücelten F. Durmusoglu Comparison of finasteride versus spironolactone in the treatment of idiopathic hirsutism Fertil Steril 68 1997 1000
12. M. Erenus D. Yucelten O. Gurbuz Comparison of spironolactone–oral contraceptive versus cyproterone acetate–estrogen regimens in the treatment of hirsutism Fertil Steril 66 1996 216
13. S. Evron G. Shapiro Y.Z. Diamant Induction of ovulation with spironolactone (Aldactone) in anovulatory oligomenorrheic and hyperandrogenic women Fertil Steril 36 1981 468
14. Falsetti L. De Fusco D. G. Eleftheriou Treatment of hirsutism by finasteride and flutamide in women with polycystic ovary syndrome Gynecol Endocrinol 11 1997 251
15. L. Falsetti E. Pasinetti Effects of long-term administration of an oral contraceptive containing ethinylestradiol and cyproterone acetate on lipid metabolism in women with polycystic ovary syndrome Acta Obstet Gynecol Scand 74 1995 56
16. D. Ferriman J.D. Gallwey Clinical assessment of body hair growth in women J Clin Endocrinol Metab 21 1961 1440
17. G.J. Gormley E. Stoner R.S. Rittmaster Effects of finasteride (MK-906), a 5α-reductase inhibitor, on circulating androgens in male volunteers J Clin Endocrinol Metab 70 1990 1136
18. O. Grigoriou C. Papadias S. Konidaris Comparison of flutamide and cyproterone acetate in the treatment of hirsutism: A randomized controlled trial Gynecol Endocrinol 10 1996 119
19. T.D. Groves B. Corenblum Spironolactone therapy during human pregnancy Am J Obstet Gynecol 172 1995 1655
20. J. Hammerstein J. Meckies I. Leo-Rossberg Use of cyproterone acetate in the treatment of acne, hirsutism, and virilism J Steroid Biochem 6 1975 827
21. E.L. Helfer J.L. Miller L.I. Rose Side-effects of spironolactone therapy in the hirsute woman J Clin Endocrinol Metab 66 1988 208
22. J. Imperato-McGinley R.S. Sanchez J.R. Spencer Comparison of the effects of the 5α-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: Dose-response studies Endocrinology 131 1992 1149
23. F. Kelestimur Y. Sahin Comparison of Diane 35 and Diane 35 plus spironolactone in the treatment of hirsutism Fertil Steril 69 1998 66
24. R.A. Lobo D. Shoupe P. Serafini The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women Fertil Steril 43 1985 200
25. C. Longcope Adrenal and gonadal androgen secretion in normal females Clin Endocrinol Metab 15 1986 213
26. D.L. Loriaux R. Menard A. Taylor Spironolactone and endocrine dysfunction Ann Intern Med 85 1976 630
27. E. Ludwig Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex Br J Dermatol 97 1977 247
28. V. Luu-The Y. Sugimoto L. Puy Characterization, expression, and immunohistochemical localization of 5α-reductase in human skin J Invest Dermatol 102 1994 221
29. P. Mauvais-Jarvis Regulation of androgen receptor and 5α-reductase in the skin of normal and hirsute women Clin Endocrinol Metab 15 1986 307
30. J.A. Miller H.S. Jacobs Treatment of hirsutism and acne with cyproterone acetate Clin Endocrinol Metab 15 1986 373
31. P. Moghetti R. Castello C.M. Magnani Clinical and hormonal effects of the 5α-reductase inhibitor finasteride in idiopathic hirsutism J Clin Endocrinol Metab 79 1994 1115
32. I.I. Muderris F. Bayram Y. Sahin A comparison between two doses of flutamide (250 mg/d and 500 mg/d) in the treatment of hirsutism Fertil Steril 68 1997 644
33. R.C. O'Brien M.E. Cooper R.M.L. Murray Comparison of sequential cyproterone acetate/estrogen versus spironolactone/oral contraceptive in the treatment of hirsutism J Clin Endocrinol Metab 72 1991 1008
34. R.S. Rittmaster 5α-reductase inhibitors J Androl 18 1997 582
35. R.S. Rittmaster Gonadotropin-releasing hormone (GnRH) agonists and estrogen/progestin replacement for the treatment of hirsutism: Evaluating the results J Clin Endocrinol Metabol 80 1995 3403
36. R.S. Rittmaster D.L. Thompson Effect of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: The relative importance of the ovary and the adrenal in the pathogenesis of hirsutism J Clin Endocrinol Metab 70 1990 1096
37. Y. Sahin F. Bayram F. Kelestimur Comparison of cyproterone acetate plus ethinyl estradiol and finasteride in the treatment of hirsutism [in process citation] J Endocrinol Invest 21 1998 348
38. M.E. Sawaya Clinical updates in hair Dermatol Clin 15 1997 37
39. J. Shapiro V.H. Price Hair regrowth: Therapeutic agents Dermatol Clin 16 1998 341
40. T. Similowski B. Orcel J.P. Derenne CD8+ lymphocytic pneumonitis in a patient receiving cyproterone acetate South Med J 90 1997 1048
41. P. Spritzer L. Billaud J.C. Thalabard Cyproterone acetate versus hydrocortisone treatment in late-onset adrenal hyperplasia J Clin Endocrinol Metab 70 1990 642
42. A. Tolino A. Petrone F. Sarnacchiaro Finasteride in the treatment of hirsutism: New therapeutic perspectives Fertil Steril 66 1996 61
43. A. Tosti C. Misciali B.M. Piraccini Drug-induced hair loss and hair growth: Incidence, management and avoidance Drug Safety 10 1994 310
44. I.L. Wong R.S. Morris L. Chang A prospective randomized trial comparing finasteride to spironolactone in the treatment of hirsutism J Clin Endocrinol Metab 80 1995 233
45. V. Wynn I.F. Godsland M. Seed Paradoxical effects of the anti-androgen cyproterone acetate on lipid and lipoprotein metabolism Clin Endocrinol (Oxford) 24 1986 183
46. D.K. Wysowski J.L. Fourcroy Safety of flutamide? Fertil Steril 62 1994 1089