Comparison of finasteride versus spironolactone in the treatment of idiopathic hirsutism

Fertility and Sterility

Volumn 68, Issue 6, 1997, Pages 1000-1003

  Erenus, Mithat ^a,b   Yücelten, Deniz ^a   Durmuşoǧlu, Fatih ^a   Gürbüz, Oya ^a  

^a MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b NONE   (Turkey)

Author keywords

Finasteride; Idiopathic hirsutism; Spironolactone

Indexed keywords

FINASTERIDE; FOLLITROPIN; LUTEINIZING HORMONE; PRASTERONE SULFATE; SPIRONOLACTONE; TESTOSTERONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLLITROPIN BLOOD LEVEL; HIRSUTISM; HUMAN; IDIOPATHIC DISEASE; LUTEINIZING HORMONE BLOOD LEVEL; ORAL DRUG ADMINISTRATION; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SINGLE BLIND PROCEDURE; STATISTICAL ANALYSIS; TESTOSTERONE BLOOD LEVEL; TREATMENT OUTCOME; TREATMENT PLANNING;

ADULT; ALDOSTERONE ANTAGONISTS; DRUG ADMINISTRATION SCHEDULE; ENZYME INHIBITORS; FEMALE; FINASTERIDE; GONADAL STEROID HORMONES; HIRSUTISM; HUMANS; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; SPIRONOLACTONE; TREATMENT OUTCOME;

EID: 0031466911     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(97)00371-3     Document Type: Article

References (22)

1. 1. Cumming DC, Yang JC, Rebar RW, Yen S. Treatment of hirsutism with spironolactone. J Am Med Assoc 1982;247: 1295-8.
2. 2. Schapiro G, Evron S. A novel use of spironolactone treatment of hirsutism. J Clin Endocrinol Metab 1988;51:429-32.
3. 3. Tremblay RR. Treatment of hirsutism with spironolactone. J Clin Endocrinol Metab 1980;15:363-71.
4. 4. Dewhurst CJ, Underhill R, Goldman S, Mansfield M. The treatment of hirsutism with cyproterone acetate (antiandrogen). Br J Obstet Gynaecol 1977;84:119-23.
5. 5. O'Brien RC, Cooper ME, Murray RML, Seeman E, Thomas AK, Jerums G. Comparison of sequential cyproterone acetate/ estrogen versus spironolactone/oral contraceptive in the treatment of hirsutism. J Clin Endocrinol Metab 1991;72: 1008-13.
6. 6. Erenus M, Yücelten D, Gürbüz O, Durmuşoǧlu F, Pekin S. Comparison of spironolactone-oral contraceptive versus cyproterone acetate-estrogen regimens in the treatment of hirsutism. Fertil Steril 1996;66:216-9.
7. 7. Erenus M, Gürbüz O, Durmuşoǧlu F, Demirçay Z, Pekin S. Comparison of the efficacy of spironolactone versus flutamide in the treatment of hirsutism. Fertil Steril 1994;61:613-6.
8. 8. Cusan L, Dupont A, Gomez JL, Tembley RR, Labrie F. Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial. Fertil Steril 1994; 61:281-7.
9. 9. Marcondes JAM, Minnani SL, Luthold WW, Wachenberg BL, Samojlik E, Kirschner MA. Treatment of hirsutism in women with flutamide. Fertil Steril 1992;57:543-7.
10. 10. Kutten F, Mowszowicz I, Schaison G, Mauvais-Jarvis P. Androgen production and skin metabolism in hirsutism. J Endocrinol 1977;75:83-91.
11. 11. Serafini P, Lobo RA. Increased 5-alpha reductase activity in idiopathic hirsutism. Fertil Steril 1985;43:74-8.
12. 12. Castello R, Tosi F, Perrone F, Negri C, Muggeo M, Moghetti P. Outcome of long-term treatment with the 5-alpha reductase inhibitor finasteride in idiopathic hirsutism. Clinical and hormonal effect during a 1 year course of therapy and 1 year follow up. Fertil Steril 1996;66:734-40.
13. 13. Fruzetti F, de Lorenzo D, Parrini D, Ricci C. Effects of finasteride, a 5-alpha reductase inhibitor, on circulating androgens and gonadotropin secretion in hirsute women. J Clin Endocrinol Metab 1994;79:831-5.
14. 14. Moghetti P, Castello R, Magnani CM, Tosi F, Negri C, Armanini D, et al. Clinical and hormonal effects of the 5-alpha reductase inhibitor finasteride in idiopathic hirsutism. J Clin Endocrinol Metab 1994;79:1115-21.
15. 15. Wong IL, Morris RS, Chang L, Spahn M, Stanczyk FZ, Lobo R. A prospective randomized trial comparing finasteride to spironolactone in the treatment of hirsute women. J Clin Endocrinol Metab 1995;80:233-8.
16. 16. Ciotta L, Cianci A, Calogero AE, Palumbo MA, Marletta E, Sciuto A, et al. Clinical and endocrine effects of finasteride, a 5-alpha reductase inhibitor, in women with idiopathic hirsutism. Fertil Steril 1995;64:299-306.
17. 17. Tolino A, Petrone A, Sarnacchiaro F, Cirillo D, Ronsini S, Lombardi G, et al. Finasteride in the treatment of hirsutism: new therapeutic perspectives. Fertil Steril 1996;66:61-5.
18. 18. Ferriman D, Gallwey CD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961;21:1440-7.
19. 19. Rittmaster RS. Finasteride. N Engl J Med 1994;330:120-5.
20. 20. Jenkins EP, Andersson S, Imperoto McGinley J, Wilson JD, Rusell DW. Genetic and pharmacological evidence of more than one human steroid 5-alpha reductase. J Clin Invest 1992;89:293-300.
21. 21. Menard RH, Stripp B, Gillette JR. Spironolactone and testicular cytochrome P 450 decreased testosterone formation in several species and changes in hepatic drug metabolism. Endocrinology 1974;94:1628-36.
22. 22. Lobo RA, Shoupe D, Serafini P, Brinton D, Horton R. The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women. Fertil Steril 1985;43:429-32.