Finasteride in the treatment of hirsutism: New therapeutic perspectives

Fertility and Sterility

Volumn 66, Issue 1, 1996, Pages 61-65

  Tolino, A ^a   Petrone, A ^a   Sarnacchiaro, F ^a   Cirillo, D ^a   Ronsini, S ^a   Lombardi, G ^a   Nappi, C ^a  

^a NONE   (Italy)

Author keywords

5 reductase; finasteride; hyperandrogenism; Idiopathic hirsutism; polycystic ovary syndrome

Indexed keywords

FINASTERIDE; STEROID 5ALPHA REDUCTASE INHIBITOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HIRSUTISM; HUMAN; ORAL DRUG ADMINISTRATION; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0029895071     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0015-0282(16)58388-5     Document Type: Article

References (25)

1. F. Sciarra V. Toscano Sindromi iperandrogeniche G. Benagiano M. Negri Endocrinologia della riproduzione umana 1993 Unione-Tipografico-Editrice-Torinese Torino 505 515
2. P. Serafini R.A. Lobo Increased 5 α -reductase activity in idiopathic hirsutism Fertil Steril 43 1985 74 78
3. F. Kutten I. Mowszowicz G. Schaison P. Mauvais-Jarvis Androgen production and skin metabolism in hirsutism J Endocrinol 75 1977 83 89
4. P.M. Stewart C.H.L. Shackleton G.H. Beastall C.R.W. Edwards 5 α -reductase activity in polycystic ovary syndrome Lancet 335 1990 431 433
5. R.A. Lobo U. Goebelsmann R. Horton Evidence for the importance of peripheral tissue events in the development of hirsutism in polycystic ovary syndrome J Clin Endocrinol Metab 57 1983 393 397
6. A. Boisselle R.R. Tremblay New therapeutic approach to the hirsute patient Fertil Steril 32 1979 276 279
7. R. Underhill C.J. Dewhurst Further clinical experience in the treatment of hirsutism with cyproterone acetate Br J Obstet Gynaecol 86 1979 139 141
8. M.G. Chapman M. Dowsett C.J. Dewhurst S.L. Jeffcoate Spironolactone in combination with an oral contraceptive: an alternative treatment for hirsutism Br J Obstet Gynaecol 92 1985 983 985
9. R.A. Vigersky I. Mehlman A.R. Glass C.E. Smith Treatment of hirsute women with cimetidine N Engl J Med 303 1980 1042 1045
10. M. Marugo D. Bernasconi M. Meozzi A. Cuva L. Fazzuoli Efficacy of flutamide in the treatment of hirsute women J Endocrinol Invest 14 1991 168
11. A.L. Dallob N.S. Sadick W. Unger S. Lipert L.A. Geissler S.L. Gregoire The effect of finasteride, a 5 α -reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness J Clin Endocrinol Metab 79 1994 703 706
12. D. Ferriman J.D. Gallwey Clinical assessment of body hair growth in women J Clin Endocrinol Metab 21 1961 1440 1447
13. I. Morimoto A. Edmiston D. Hawks R. Horton Studies on the origin of androstanediol and androstanediol glucuronide in young and elderly men J Clin Endocrinol Metab 52 1981 772 778
14. R. Horton D. Endres M. Galmarini Ideal conditions for hydrolysis of androstanediol 3 α ,17 β -diol glucuronide in plasma J Clin Endocrinol Metab 59 1984 1027
15. I.H. Thorneycroft W.O. Ribeiro S. Stone S.A. Tillson Radioimmunoassay of androstenedione Steroids 21 1973 111
16. T. Ito R. Horton DHT in human peripheral plasma J Clin Endocrinol Metab 31 1970 362
17. J. Barberia L. Pages R. Horton Measurement of androstanediol in plasma in a radioimmunoassay using celite column chromatography Fertil Steril 27 1976 1101 1104
18. T. Kinouchi L. Pages R. Horton A specific RIA for testosterone in peripheral plasma J Lab Clin Med 82 1973 309
19. R.J. Paulson P.C. Serafini J.A. Catalino R.A. Lobo Measurements of 3 α ,17 β -glucuronide in serum and urine and the correlation with skin 5 α -reductase activity Fertil Steril 46 1986 222 226
20. M.A. Kirschner E. Samojlik E. Szmal Clinical usefulness of plasma androstanediol glucuronide measurements in women with idiopathic hirsutism J Clin Endocrinol Metab 65 1987 597 601
21. V. Toscano Hirsutism: pilosebaceous unit dysregulation role of peripheral and glandular factors J Endocrinol Invest 14 1991 153 170
22. E. Stoner The clinical development of a 5 α -reductase inhibitor, finasteride J Steroid Biochem Mol Biol 37 1990 375 378
23. G.J. Gormley E. Stoner R.S. Rittmaster H. Gregg D.L. Thompson K.C. Lasseter Effects of finasteride (MK-906), a 5 α -reductase inhibitor, on circulating androgens in male volunteers J Clin Endocrinol Metab 70 1990 1136 1141
24. A.E. Thigpen R.I. Silver J.M. Guileyardo M.L. Casey J.D. McConnell D.W. Russel Tissue distribution and ontogeny of steroid 5 α -reductase isoenzyme expression J Clin Invest 92 1993 903 910
25. E.P. Jenkins S. Andersson J. Imperato-McGinley J.D. Wilson D.W. Russell Genetic and pharmacological evidence for more than one human steroid 5 α -reductase J Clin Invest 89 1992 293 300