The genetics of common diseases: The implications of population variability

CIBA Foundation Symposia

Volumn , Issue 197, 1996, Pages 300-311

  Weatherall, D J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; CHRONIC DISEASE; ERYTHROCYTE; GENERAL ASPECTS OF DISEASE; GENETIC PREDISPOSITION; GENETIC SELECTION; GENETIC VARIABILITY; GENETICS; HUMAN; MALARIA; POPULATION; REVIEW;

ANIMALS; CHRONIC DISEASE; DISEASE; ERYTHROCYTES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALARIA; POPULATION; SELECTION (GENETICS); VARIATION (GENETICS);

EID: 0029680322     PISSN: 03005208     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Ames BN, Shigenaya MK, Hagen TM 1993 Oxidants, antioxidants and the degenerative disease of ageing. Proc Natl Acad Sci USA 90:7915-7922
2. Bennett ST, Lucassen AM, Gough SCL et al 1995 Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat Genet 9:284-292
3. Davies JL, Kawaguchi Y, Bennett ST et al 1994 A genome-wide search for human type 1 diabetes susceptibility gene. Nature 371:130-136
4. Flint J, Harding RM, Boyce AJ, Clegg JB 1993 The population genetics of the haemoglobinopathies. Clin Haematol 6:215-262
5. Garrod AE 1931 The inborn factors in disease: an essay. Oxford University Press, Oxford
6. Gibbon A 1990 Gerontology research comes of age. Science 250:622-625
7. Haldane JBS 1948 The rate of mutation of human genes. Proceedings of the Eighth International Congress of Genetics and Heredity. Hereditas (suppl) 35:267-273
8. Hill AVS, Allsopp CEM, Kwiatkowski D et al 1991 Common West African HLA antigens are associated with protection from severe malaria. Nature 352:595-600
9. Hill AVS, Elvin J, Willis AC et al 1992 Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 360:434-439
10. Jarolim P, Palek J, Amato D et al 1991 Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis. Proc Natl Acad Sci USA 88:11022-11026
11. Kwiatkowski D 1995 Malarial toxins and the regulation of parasite density. Parasitol Today 11:206-212
12. Kwiatkowski D, Hill AVS, Sambou I et al 1990 TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet 336:1201-1204
13. McGuire W, Hill AVS, Allsopp CEM, Greenwood BM, Kwiatkowski D 1994 Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria. Nature 371:508-511
14. Miller LH 1994 Impact of malaria on genetic polymorphism and genetic diseases in Africans and African Americans. Proc Natl Acad Sci USA 91:2415-2419
15. Mourant AE, Kopec AC, Domaniewska-Sobezak K 1978 Blood groups and disease. Oxford University Press, Oxford
16. Murphy PM 1993 Molecular mimicry and the generation of host defense protein diversity. Cell 72:823-826
17. Neel JV 1962 'Thrifty' genotype rendered detrimental by progress? Am J Hum Genet 14:353-361
18. O'Brien SJ 1991 Ghetto legacy. Curr Biol 1:209-211
19. Ruwende C, Khoo SC, Snow RW et al 1995 Natural selection of hemizygotes and heterozygotes for glucose-6-phosphate dehydrogenase deficiency in Africa by resistance to severe malaria. Nature 376:246-249
20. Vaxillaire M, Boccio V, Philippi A et al 1995 A gene for early-onset non-insulin-dependent diabetes mellitus (Maturity Onset Diabetes of the Young) maps to chromosome 12q. Nat Genet 9:418-423
21. Weatherall DJ, Bell JI, Clegg JB et al 1988 Genetic factors as determinants of infectious disease transmission in human communities. Philos Trans R Soc Lond B Biol Sci 321:327-348
22. Weatherall DJ, Clegg JB 1981 The thalassaemia syndromes, 3rd edn. Blackwell Scientific, Oxford
23. Weiss KM, Ferrell RE, Harris CL 1984 A New World syndrome of metabolic diseases with a genetic and evolutionary basis. Yearb Phys Anthropol 27:153-178
24. + thalassaemia to severe malaria: imprecations for the time depth of malarial selection. Proc Brit Soc Parasitol 5th Malaria Meeting, p 13-14
25. Zhang YY, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
26. Zimmet P, Dowse G, Finch C, Serjeantson S, King H 1990 The epidemiology and natural history of NIDDM: lessons from the South Pacific. Diabetes Metab Rev 6:91-124