Effect of dissolved oxygen concentration on the intracellular flux distribution for pyruvate fermentation

Journal of Biotechnology

Volumn 68, Issue 2-3, 1999, Pages 135-147

  Hua, Qiang ^a   Shimizu, Kazuyuki ^a  

^a KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Dissolved oxygen concentration; Intracellular flux distribution; Pyruvate fermentation

Indexed keywords

BIOCONVERSION; METABOLISM; METABOLITES; OXYGEN; REDOX REACTIONS; SALTS;

DISSOLVED OXYGEN CONCENTRATION; PYRUVATE;

FERMENTATION;

PYRUVIC ACID;

ARTICLE; BIOMASS; FERMENTATION; GROWTH; METABOLISM; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; TECHNIQUE; TORULOPSIS GLABRATA;

TORULOPSIS GLABRATA;

EID: 0032990221     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(98)00196-5     Document Type: Article

References (19)

1. Bruinenberg F.M., van Dijken J.P., Scheffers W.A. A theoretical analysis of NADPH production and consumption in yeasts. J. Gen. Microbiol. 129:1983;953-964.
2. Bruinenberg F.M., van Dijken J.P., Scheffers W.A. An enzymic analysis of NADPH production and consumption in Candida utilis CBS621. J. Gen. Microbiol. 129:1983;965-971.
3. Cortassa S., Aon J., Aon M. Fluxes of carbon, phosphorylation, and redox intermediates during growth of S. cerevisiae on different carbon sources. Biotechnol. Bioeng. 47:1995;193-208.
4. Djavadi F.H.S., Moradi M., Djavadi-Ohaniance L. Direct oxidation of NADPH by submitochondrial particles from Saccharomyces cererisiae. Eur. J. Biochem. 107:1980;501-504.
5. Fell D.A. Metabolic control analysis: A survey of its theoretical and experimental development. Biochem. J. 286:1992;313-330.
6. van Gulik W.M., Heijnen J.J. A metabolic network stoichiometry analysis of microbial growth and product formation. Biotechnol. Bioeng. 48:1995;681-698.
7. Jin S., Ye K., Shimizu K. Metabolic flux distributions in recombinant Saccharomyces cerevisiae during foreign protein production. J. Biotechnol. 54:1997;161-174.
8. Jorgensen H., Nielsen J., Villadsen J. Metabolic flux distributions in Penicillium chrysogenum during fed-batch cultivations. Biotechnol. Bioeng. 46:1995;117-131.
9. Ko Y.F., Bentley W.E., Weigand W.A. An integrated metabolic modeling approach to describe the energy efficiency of Escherichia coli fermentations under oxygen-limited conditions: cellular energetics, carbon flux, and acetate production. Biotechnol. Bioeng. 42:1993;843-853.
10. Lagunas R. Energy metabolism of S. cerevisiae discrepancy between ATP balance and known metabolic functions. Biochim. Biophys. Acta. 440:1976;661-674.
11. Malmberg L.-H., Hu W.-S. Identification of rate-limiting steps in cephalosporic C biosynthesis in Cephalosporium acremonium: A theoretical analysis. Appl. Microbiol. Biotechnol. 38:1992;122-128.
12. Marx A., Striegel K., de Graaf A.A., Sahm H., Eggeling L. Response of the central metabolism of Corynebacterium glutamicum to different flux burdens. Biotechnol. Bioeng. 56:1997;168-180.
13. Nielsen J., Villadsen J. Bioreaction Engineering Principle. 1994;Plenum, New York.
14. Stouthamer A.H. A theoretical study on the amount of ATP required for synthesis of microbial cell material. Antonie van Leeuwenhoek. 39:1973;545-565.
15. Takao S., Yokota A., Tanida M. Enzymatic production of tryptophan coupled to pyruvic acid fermentation. J. Ferment. Technol. 62:1984;329-334.
16. Takiguchi N., Shimizu H., Shioya S. An on-line physiological state recognition system for the lysine fermentation process based on a metabolic reaction model. Biotechnol. Bioeng. 55:1997;170-181.
17. Vallino J.J., Stephanopoulos G. Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction. Biotechnol. Bioeng. 41:1993;633-646.
18. Walsh K., Koshland D.E. Jr Branch point control by phosphorylation state of isocitrate. J. Biol. Chem. 26:1985;8430-8437.
19. Yonehara T., Miyata R. Fermentation production of pyruvate from glucose by Torulopsis glabrata. J. Ferment. Bioeng. 78:1994;155-159.