메뉴 건너뛰기




Volumn 54, Issue 3, 1997, Pages 161-174

Metabolic flux distributions in recombinant Saccharomyces cerevisiae during foreign protein production

Author keywords

Flux analysis; Metabolic engineering; Promoter GAL10; Recombinant yeast culture; Stoichiometric flux balancing analysis

Indexed keywords

ADENOSINETRIPHOSPHATE; AMINO ACIDS; BATCH CELL CULTURE; BIOSYNTHESIS; ETHANOL; METABOLISM; NUCLEIC ACIDS; PROTEINS; SUGARS; YEAST;

EID: 0031560764     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(97)01694-5     Document Type: Article
Times cited : (28)

References (24)
  • 2
    • 0014287250 scopus 로고
    • Galactose transport in Saccharomyces cerevisiae: nonmetabolizable sugars as substrates and inducers of the galactose transport system
    • Cirillo, P. (1968) Galactose transport in Saccharomyces cerevisiae: nonmetabolizable sugars as substrates and inducers of the galactose transport system. J. Bacteriol. 95, 1727-1731.
    • (1968) J. Bacteriol. , vol.95 , pp. 1727-1731
    • Cirillo, P.1
  • 3
    • 0025792931 scopus 로고
    • Identifying rate-controlling enzymes in metabolic pathways without kinetic parameters
    • Delgado, J.P. and Liao, J.C. (1991) Identifying rate-controlling enzymes in metabolic pathways without kinetic parameters. Biotechnol. Prog. 7, 15-20.
    • (1991) Biotechnol. Prog. , vol.7 , pp. 15-20
    • Delgado, J.P.1    Liao, J.C.2
  • 4
    • 0025488467 scopus 로고
    • Comparative studies of glucose catabolism by Escherichia coli grown in a complex medium under aerobic and anaerobic conditions
    • Diaz-Ricci, J.C., Hitzmann, B., Rinas, U. and Bailey, J.E. (1990) Comparative studies of glucose catabolism by Escherichia coli grown in a complex medium under aerobic and anaerobic conditions. Biotechnol. Prog. 6, 326-332.
    • (1990) Biotechnol. Prog. , vol.6 , pp. 326-332
    • Diaz-Ricci, J.C.1    Hitzmann, B.2    Rinas, U.3    Bailey, J.E.4
  • 5
    • 0027111930 scopus 로고
    • Influence of expression of the pet operon on intracellular metabolic fluxes of Escherichia coli
    • Diaz-Ricci, J.C., Tsu, M. and Bailey, J.E. (1992) Influence of expression of the pet operon on intracellular metabolic fluxes of Escherichia coli. Biotechnol. Bioeng. 39, 59-65.
    • (1992) Biotechnol. Bioeng. , vol.39 , pp. 59-65
    • Diaz-Ricci, J.C.1    Tsu, M.2    Bailey, J.E.3
  • 6
    • 0027909873 scopus 로고
    • Utilization of glucose and amino acids in insect cell cultures: Quantifying the metabolic flows within the primary pathways and medium development
    • Ferrance, J.P., Giel, A. and Ataai, M. M. (1993) Utilization of glucose and amino acids in insect cell cultures: Quantifying the metabolic flows within the primary pathways and medium development. Biotechnol. Bioeng. 42, 697-707.
    • (1993) Biotechnol. Bioeng. , vol.42 , pp. 697-707
    • Ferrance, J.P.1    Giel, A.2    Ataai, M.M.3
  • 7
    • 0027909872 scopus 로고
    • Analysis of metabolic fluxes in batch and continuous cultures of Bacillus subtilis
    • Goel, A., Ferrance, J., Jeong, J. and Ataai, M.M. (1993) Analysis of metabolic fluxes in batch and continuous cultures of Bacillus subtilis. Biotechnol. Bioeng. 42,686-696.
    • (1993) Biotechnol. Bioeng. , vol.42 , pp. 686-696
    • Goel, A.1    Ferrance, J.2    Jeong, J.3    Ataai, M.M.4
  • 8
    • 0029328462 scopus 로고
    • Suppressed acid formation by cofeeding of glucose and citrate in Bacillus cultures: Emergence of pyruvate kinase as a potential metabolic engineering site
    • Goel, A., Lee, J., Domach, M.M. and Ataai, M.M. (1995) Suppressed acid formation by cofeeding of glucose and citrate in Bacillus cultures: Emergence of pyruvate kinase as a potential metabolic engineering site. Biotechnol. Prog. 11, 380-385.
    • (1995) Biotechnol. Prog. , vol.11 , pp. 380-385
    • Goel, A.1    Lee, J.2    Domach, M.M.3    Ataai, M.M.4
  • 9
    • 0015989446 scopus 로고
    • A linear steady-state treatment of enzymatic chains. General properties, control and effector strength
    • Heinrich, R. and Rapoport, T.A. (1974) A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur. J. Biochem. 42, 89-95.
    • (1974) Eur. J. Biochem. , vol.42 , pp. 89-95
    • Heinrich, R.1    Rapoport, T.A.2
  • 10
    • 0022985811 scopus 로고
    • The central metabolic pathways of Escherichia coli: Relationship between flux and control at a branch point, efficiency of conversion to biomass, and excretion of acetate
    • Holms, W.H. (1986) The central metabolic pathways of Escherichia coli: Relationship between flux and control at a branch point, efficiency of conversion to biomass, and excretion of acetate. Curr. Top. Cell. Regul. 28, 69-105.
    • (1986) Curr. Top. Cell. Regul. , vol.28 , pp. 69-105
    • Holms, W.H.1
  • 11
    • 0029589978 scopus 로고
    • Metabolic pathway analysis of recombinant Sacharomyces cerevisiae with a galactose-inducible promoter based on a signal flow modeling approach
    • Jin, S., Ye, K. and Shimizu, K. (1995) Metabolic pathway analysis of recombinant Sacharomyces cerevisiae with a galactose-inducible promoter based on a signal flow modeling approach. J. Ferment. Bioeng. 80, 541-551.
    • (1995) J. Ferment. Bioeng. , vol.80 , pp. 541-551
    • Jin, S.1    Ye, K.2    Shimizu, K.3
  • 12
    • 0029905367 scopus 로고    scopus 로고
    • Application of artificial neural network and fuzzy control for fed-batch cultivation of recombinant Saccharomyces cerevisiae
    • Jin, S., Ye, K., and Shimizu, K. (1996) Application of artificial neural network and fuzzy control for fed-batch cultivation of recombinant Saccharomyces cerevisiae. J. Ferment. Bioeng. 81, 412-421.
    • (1996) J. Ferment. Bioeng. , vol.81 , pp. 412-421
    • Jin, S.1    Ye, K.2    Shimizu, K.3
  • 13
    • 0028953910 scopus 로고
    • Regulation of carbon metabolism in chemostat cultures of Saccharomyces cerevisiae grown on mixtures of glucose and ethanol
    • Jong-Gubbels, P.D., Vanrolleghem, P., Heijnen, S., van Dijken, J.P and Pronk, J.T. (1995) Regulation of carbon metabolism in chemostat cultures of Saccharomyces cerevisiae grown on mixtures of glucose and ethanol. Yeast, 11, 407-418.
    • (1995) Yeast , vol.11 , pp. 407-418
    • Jong-Gubbels, P.D.1    Vanrolleghem, P.2    Heijnen, S.3    Van Dijken, J.P.4    Pronk, J.T.5
  • 14
    • 0015824267 scopus 로고
    • The control of flux
    • In: Davies, D.D. (Ed.), Cambridge University Press, Cambridge
    • Kacser, H. and Burns, J.A. (1973) The control of flux. In: Davies, D.D. (Ed.), Rate Control of Biological Processes. Cambridge University Press, Cambridge, pp. 65-104.
    • (1973) Rate Control of Biological Processes , pp. 65-104
    • Kacser, H.1    Burns, J.A.2
  • 17
    • 0025866296 scopus 로고
    • Network rigidity and metabolic engineering in metabolite overproduction
    • Stephanopoulos, G. and Vallino, J.J. (1991) Network rigidity and metabolic engineering in metabolite overproduction. Science 252, 1675-1681.
    • (1991) Science , vol.252 , pp. 1675-1681
    • Stephanopoulos, G.1    Vallino, J.J.2
  • 18
    • 0030051960 scopus 로고    scopus 로고
    • Effect of Vitreoscilla Hemoglobin dosage on microaerobic Escherichia coli carbon and energy metabolism
    • Tsai, P.S., Hatzimanikatis, V. and Bailey, J.E. (1996) Effect of Vitreoscilla Hemoglobin dosage on microaerobic Escherichia coli carbon and energy metabolism. Biotechnol. Bioeng. 49, 139-150.
    • (1996) Biotechnol. Bioeng. , vol.49 , pp. 139-150
    • Tsai, P.S.1    Hatzimanikatis, V.2    Bailey, J.E.3
  • 20
    • 0028973161 scopus 로고
    • A metabolic network stoichiometry analysis of microbial growth and product formation
    • Van Gulik, W.M. and Heijnen, J.J. (1995) A metabolic network stoichiometry analysis of microbial growth and product formation. Biotechnol. Bioeng. 48, 681-698.
    • (1995) Biotechnol. Bioeng. , vol.48 , pp. 681-698
    • Van Gulik, W.M.1    Heijnen, J.J.2
  • 21
    • 0027723421 scopus 로고
    • Metabolic capabilities of Escherichia coli II. Optimal growth patterns
    • Varma, A. and Palsson, B.O. (1993) Metabolic capabilities of Escherichia coli II. Optimal growth patterns. J. Theor. Biol. 165, 503-522.
    • (1993) J. Theor. Biol. , vol.165 , pp. 503-522
    • Varma, A.1    Palsson, B.O.2
  • 22
    • 0029635981 scopus 로고
    • Parametric sensitivity of stoichiometric flux balance models applied to wild type Escherichia coli metabolism
    • Varma, A. and Palsson, B.O. (1995) Parametric sensitivity of stoichiometric flux balance models applied to wild type Escherichia coli metabolism. Biotechnol. Bioeng. 45, 69-79.
    • (1995) Biotechnol. Bioeng. , vol.45 , pp. 69-79
    • Varma, A.1    Palsson, B.O.2
  • 23
    • 0021801376 scopus 로고
    • Branch point control by the phosphorylation state of isocitrate dehydrogenase
    • Walsh, K. and Koshland, D.E., Jr. (1985) Branch point control by the phosphorylation state of isocitrate dehydrogenase. J. Biological. Chem. 260, 8430-8437.
    • (1985) J. Biological. Chem. , vol.260 , pp. 8430-8437
    • Walsh, K.1    Koshland D.E., Jr.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.