A child with localized vulval pemphigoid and IgG autoantibodies targeting the C-terminus of collagen XVII/BP180

British Journal of Dermatology

Volumn 140, Issue 6, 1999, Pages 1133-1138

  Schumann, H ^a   Amann, U ^a   Tasanen, K ^a,b   Muller S ^a   Zillikens, D ^c   Metze, D ^a   Luger, T ^a   Bruckner Tuderman, L ^a   Bonsmann, G ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Bullous pemphigoid antigen; Chronic bullous disease of childhood; Cicatricial pemphigoid; Epitope mapping; Localized vulval pemphigoid of childhood

Indexed keywords

AUTOANTIBODY; COLLAGEN; COMPLEMENT COMPONENT C3; HLA DQ ANTIGEN; IMMUNOGLOBULIN G ANTIBODY;

ARTICLE; CASE REPORT; FEMALE; HUMAN; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOGLOBULIN DEPOSITION; PEMPHIGOID; PRIORITY JOURNAL; SCHOOL CHILD; VULVA DISEASE;

AUTOANTIBODIES; BIOLOGICAL MARKERS; CHILD; COLLAGEN; COMPLEMENT C3; DIAGNOSIS, DIFFERENTIAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITOPE MAPPING; EPITOPES; FEMALE; HLA-DQ ANTIGENS; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULIN G; MICROSCOPY, FLUORESCENCE; PEMPHIGUS; SKIN; VULVAR DISEASES;

EID: 0032984377     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.1999.02891.x     Document Type: Article

References (25)

1. 1 DeCastro P, Jorizzo JL, Rajaraman S et al. Localized vulvar pemphigoid in a child. Pediatr Dermatol 1985; 2: 302-7.
2. 2 Oranje AP, Vuzevski VD, van Joost T et al. Bullous pemphigoid in children. Int J Dermatol 1991; 30: 339-42.
3. 3 Guenther LC, Shum D. Localized childhood vulvar pemphigoid. J Am Acad Dermatol 1990; 22: 762-4.
4. 4 Levine V, Sanchez M, Nestor M. Localized vulvar pemphigoid in a child misdiagnosed as sexual abuse. Arch Dermatol 1992; 128: 804-6.
5. 5 Saad RW, Domloge-Hultsch N, Yancey KB et al. Childhood localized vulvar pemphigoid is a true variant of bullous pemphigoid. Arch Dermatol 1992; 128: 807-10.
6. 6 Zone JJ, Taylor TB, Kadunce DP, Meyer LJ. Identification of the cutaneous basement membrane antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis. J Clin Invest 1990; 85: 812-20.
7. 7 Marinkovich MP, Taylor TB, Keene DR et al. LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120-kD anchoring filament protein synthesized by epidermal cells, J Invest Dermatol 1996; 106: 734-8.
8. 8 Pas HH, Kloosterhuis GJ, Heeres K et al. Bullous pemphigoid and linear IgA dermatosis sera recognize a similar 120-kD keratinocyte collagenous glycoprotein with antigenic cross-reactivity to BP180. J Invest Dermatol 1997; 108: 423-9.
9. 9 Balding SD. Prost C, Diaz LA et al. Cicatricial pemphigoid autoantibodies react with multiple sites on the BP180 extracellular domain. J Invest Dermatol 1996; 106: 141-6.
10. 10 Schäcke H, Schumann H, Hammami-Hauasli N et al. Two forms of collagen XVII in keratinocytes: a full length transmembrane protein and a soluble ectodomain. J Biol Chem 1998; 273: 25937-43.
11. 11 Zillikens D, Pose PA, Balding SD et al. Tight clustering of extracellular BP180 epitopes recognized by bullous pemphipoid autoantibodies. J Invest Dermatol 1997; 109: 573-9.
12. 12 Zillikens D, Mascaro JM, Rose PA et al. A highly sensitive enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoid. J Invest Dermatol 1997; 109; 679-83.
13. 13 Zone JJ, Taylor TB, Kadunce DP et al. IgA antibodies in chronic bullous disease of the childhood react with a 97 kD basement membrane zone protein. J Invest Dermatol 1996; 106: 1277-80.
14. 14 Bedane C, McMillan JR, Balding SD et al. Bullous pemphigoid and cicatricial pemphigoid autoantibodies react with ultrastructurally separable epitopes on the BP180 ectodomain: evidence that BP180 spans the lamina lucida. J Invest Dermatol 1997; 108: 901-7.
15. 15 Yunis H, Mobini N, Yunis EJ et al. Common major histocompatibility complex class II markers in clinical variants of cicatricial pemphigoid. Proc Natl Acad Sci USA 1994; 91: 7747-51.
16. 16 Chan LS, Hammerberg C, Cooper KD. Significantly increased occurrence of HLA-DQB1*0301 allele in patients with ocular cicatricial pemphigoid. J Invest Dermatol 1997; 108: 129-32.
17. 17 Bruckner-Tuderman L, Nilssen Ö, Zimmermann D et al. Immunohistochemical and mutation analysis demonstrate that procollagen VII is processed to collagen VII through removal of the NC-2 domain. J Cell Biol 1995; 131: 551-9.
18. 18 Giudice GJ, Emery D, Diaz LA. Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180. J Invest Dermatol 1992; 99: 243-50.
19. 19 Kohfeldt E, Göhring W, Mayer U et al. Conversion of the Kunitz-type module of collagen VI into a highly active trypsin inhibitor by site-directed mutagenesis. Eur J Biochem 1996; 238: 333-40.
20. 20 Schumann H, Hammami-Hauasli N, Pulkkinen L et al. Three novel homozygous point mutations and a new polymorphism in the COL17A1 gene: relations to biological and clinical phenotypes of junctional epidermolysis bullosa. Am J Hum Genet 1997; 60: 1344-53.
21. M NaCl split skin and immunoblotting. Br J Dermatol 1994; 130: 610-16.
22. 22 Rico MJ. Autoimmune blistering diseases in children. Semin Dermatol 1995; 14: 54-9.
23. 23 Bouloc A, Vignon-Pennamen M-D, Caux F et al. Lichen planus pemphigoides is a heterogeneous disease: a report of five cases studied by immunoelectron microscopy. Br J Dermatol 1998; 138; 972-80.
24. 24 Zone JJ, Taylor TB, Meyer LJ, Peterson MJ. The 97 kD linear IgA bullous disease antigen is identical to a portion of the extracellular domain of the 180 kD bullous pemphigoid antigen, BPAG2. J Invest Dermatol 1998; 110: 207-10.
25. 25 Rosenbaum MM, Sterly NB, Greenwald MJ, Gerson CR. Cicatricial pemphigoid in a 6-year-old girl: report of a case and review of the literature. Pediatr Dermatol 1984; 2: 13-22.