LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120-kDa anchoring filament protein synthesized by epidermal cells

Journal of Investigative Dermatology

Volumn 106, Issue 4, 1996, Pages 734-738

  Marinkovich, M Peter ^a   Taylor, Ted B ^b   Keene, Douglas R ^c   Burgeson, Robert E ^d   Zone, John J ^c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c SHRINERS HOSPITAL FOR CHILDREN   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Autoimmune; Basement membrane; Lamina lucida

Indexed keywords

AUTOANTIGEN;

ARTICLE; AUTOIMMUNITY; BULLOUS SKIN DISEASE; HUMAN; PRIORITY JOURNAL;

EID: 0029970497     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12345782     Document Type: Article

References (18)

1. Bhogal BF, Wojnaroska F, Marsden RA, Black MM, McKee PH: Linear IgA bullous dermatosis of adults and children: an immunoelectron microscopic study. Br J Dermatol 117:289-296, 1987
2. Burgeson RE: Basement membranes. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF (eds.). Dermatology in General Medicine, Fourth Edition. McGraw-Hill, New York, 1993
3. Chan LS, Wang XS, Lapiere JC, Marinkovich MP, Jones JCR, Woodley DT: A newly identified 105 kD lower lamina lucida autoantigen is an acidic protein distinct from the 105 kD γ2 chain of laminin-5. J Invest Dermatol 105:75-79, 1995
4. Chorzelski TP, Jablonska S, Beutner EH, Bean SF, Furey NL: Linear IgA bullous dermatosis. In: Beutner E, Chorzelski T, Bean S (eds.). Immunopathology of the Skin. John Wiley & Sons, New York, 1979
5. Fine JD, Horiguchi Y, Jester J, Couchman JR: Detection and partial characterization of a midlamina-lucida-hemidesmosome associated antigen (19-DEJ-1) present within human skin. J Invest Dermatol 92:825-830, 1989
6. Gammon WR, Fine JD, Forbes M, Briggaman RA: Immunofluorescence on salt split skin for the detection and differentiatinn of BMZ autoantibodies. J Am Acad Dermatol 27:79-87, 1992
7. Kirtschig G, Marinkovich MP, Burgeson RE, Yancey KB: Anti-basement membrane autoantibodies in patients with anti-epiligrin cicatricial pemphigoid bind the α subunit of lamini 5. J Invest Dermatol 105:543-548, 1995
8. Klatte DH, Kurkapus MA, Grelling KA, Jones JCR. Immunochemical characterization of three components of the hemidesmosome and their expression in cultured epithelial cells. J Cell Biol 109:3377-3390, 1989
9. Lunstrum GP, Sakai LY, Keene DR, Morris NP, Burgeson RE: Large complex globular domains of type VII procollagen contribute to the structure of anchoring fibrils. J Biol Chem 261:9042-9048, 1986
10. Maddox BK, Sakai LY, Keene DR, Glanville RW: Connective tissue microfibrils: isolation and characterization of three large pepsin resistant domains of fibrillin. J Biol Chem 264:21381-21389, 1989
11. Marinkovich MP: The molecular genetics of basement membrane diseases. Arch Dermatol 129:1557-1565, 1993
12. Marinkovich MP, Lunstrum GP, Burgeson RE: The anchoring filament protein kalinin is synthesized and secreted as a high molecular weight precursor. J Biol Chem 267:17900-17906, 1992a
13. Marinkovich MP, Lunstrum GP, Keene DR, Burgeson RE: The dermal-epidermal junction of human skin contains a novel laminin variant. J Cell Biol 119:695-703, 1992b
14. O'Farrell PH: High resolution two-dimensional electrophoresis of proteins. J Biol Chem 250:4007-4021, 1975
15. Rousselle P, Lunstrum GP, Keene DR, Burgeson RE: Kalinin: An epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J Cell Biol 114:567-576, 1991
16. Sakai LY, Keene DR, Morris NP, Burgeson RE: Type VII collagen is a major structural component of anchoring fibrils. J Cell Biol 103:1577-1586, 1986
17. Timpl R, Dziadek M: Structure, development and molecular pathology of basement membranes. Int Rev Exp Path 29:1-112, 1986
18. Zone JJ, Taylor TB, Kandunce DP, Meyer LJ: Identification of the cutaneous basement membrane antigen in linear IgA bullous dermatosis. J Clin Invest 85:812-820, 1990