Conversion of the Kunitz-type module of collagen VI into a highly active trypsin inhibitor by site-directed mutagenesis

European Journal of Biochemistry

Volumn 238, Issue 2, 1996, Pages 333-340

  Kohfeldt, Eddie ^a   Göhring, Walter ^a   Mayer, Ulrike ^a   Zweckstetter, Markus ^a   Holak, Tad A ^a   Chu, Mon Li ^b   Timpl, Rupert ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

collagen VI; elastase; Kunitz module; protein modeling; trypsin

Indexed keywords

COLLAGEN TYPE 6; TRYPSIN INHIBITOR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING KINETICS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; HYDROGEN BOND; MODEL; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0029893254     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0333z.x     Document Type: Article

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