The immunolocalization of bcl-2 at the maternal-fetal interface in healthy and failing pregnancies

Human Reproduction

Volumn 12, Issue 1, 1997, Pages 153-158

  Lea, R G ^a,c   Al Sharekh, N ^a   Tulppala, M ^b   Critchley, H O D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Apoptosis; bcl 2; CD56; Miscarriage; Pregnancy

Indexed keywords

CD56 ANTIGEN; PROTEIN BCL 2;

ADULT; ARTICLE; CELL AGGREGATION; CHORION VILLUS; CLINICAL ARTICLE; COMPUTER ANALYSIS; CONTROLLED STUDY; DECIDUA; EPITHELIUM; FEMALE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LARGE GRANULAR LYMPHOCYTE; PLACENTA; RECURRENT ABORTION; SPONTANEOUS ABORTION; STROMA; SYNCYTIOTROPHOBLAST; TISSUE DISTRIBUTION; TROPHOBLAST;

EID: 0031039849     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/12.1.153     Document Type: Article

References (21)

1. Akcali, K.C., Khan, S.A. and Morton, B.C. (1996) Effect of decidualization on the expression of bax and bcl-2 in the rat uterine endometrium Endocrinology, 137, 3123-3130.
2. Brach, M.A., de Vos, S., Gruss, H.J. et al. (1992) Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death. Blood, 80, 2920-2924.
3. King, A., Wellings, V., Gardner, L. et al. (1989) Immunocytochemical characterisation of the unusual large granular lymphocytes in human endometrium throughout the menstrual cycle. Hum. Immunol., 24, 195-205.
4. Knudson, C.M., Tung, K.S.K., Tourtellotte, W.G. et al. (1995) Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science, 270, 96-99.
5. Koh, E.A.T., Illingworth, P.J., Duncan, W.C. et al. (1995) Immunolocalisation of bcl-2 protein in human endometrium in the menstrual cycle and simulated early pregnancy. Hum. Reprod., 10, 1557-1562.
6. Lea, R.G., Underwood, J., Flanders, K. et al. (1995) A subset of patients with recurrent spontaneous abortion is deficient in transforming growth factor b2-producing 'suppressor cells' in uterine tissue near the placental attachment site. Am. J. Reprod. Immunol., 34, 52-64.
7. Loke, Y.W. and King, A. (1995) Uterine mucosal leucocytes. In Loke, Y.W. and King, A. (eds), Human Implantation: Cell Biology and Immunology. Cambridge University Press, Cambridge, UK, p. 102.
8. Lowrey, J.A., Williams, A.R.W., Howie, S.E.M. et al. (1995) A novel image analysis based technique for a quantitation of lymphoid cells in endometrial stroma. J. Pathol., 176, 23A.
9. Miller, J.F., Williamson, E., Glue, J. et al. (1980) Fetal loss after implantation: a prospective study. Lancet, 2, 554-556.
10. Mills, J.L., Simpson, J.L., Driscoll, S.G. et al. (1988) Incidence of spontaneous abortion among normal women and insulin-dependent diabetic women whose pregnancies were identified within 21 days of conception. N. Engl. J. Med., 319, 1617-1623.
11. Oltavi, Z.N., Milliman, C.L. and Korsmeyer, S.J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell, 74, 609-619.
12. Parr, E.L., Tung, H.N. and Parr, M.B. (1987) Apoptosis as the mode of uterine cell death during embryo implantation in mice and rats. Biol. Reprod., 36, 211-225.
13. Piacentini, M.L. and Autori, F. (1994) Immunohistochemical localisation of tissue transglutaminase and Bcl-2 in rat uterine tissues during embryo implantation and post-partum involution. Differentiation, 57, 51-61.
14. Ratts, V.S., Flaws, J.A., Kolp, R. et al. (1995) Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad. Endocrinology, 136, 3665-3668.
15. Sakuragi, N., Matsuo, H., Coukos, G. et al. (1994) Differentiation-dependent expression of the BCL-2 proto-oncogene in the human trophoblast lineage. J. Soc. Gynecol. Invest., 1, 164-172.
16. Stern, J.J., Dorfmann, A.D., Gutierrez-Najar, A.J. et al. (1996) Frequency of abnormal karyotypes among abortuses from women with and without a history of recurrent spontaneous abortion. Fertil. Steril., 65, 250-253.
17. Tabibzadeh, S., Zupi, E., Babaknia, A. et al. (1995) Site and menstrual cycle-dependent expression of proteins of the tumour necrosis factor (TNF) receptor family, and BCL-2 oncoprotein and phase-specific production of TNFa in human endometrium. Hum. Reprod., 10, 277-286.
18. Thompson, E.B. (1994) Apoptosis and steroid hormones. Mol. Endocrinol., 8, 665-673.
19. Tulppala, M., Ramsay, T., Salonen, R. et al. (1993) A prospective study on 63 couples with a history of recurrent spontaneous abortion: contributing factors and the outcome of subsequent pregnancies. Hum. Reprod., 8, 764-770.
20. Wyllie, A.H. (1994) Death gets a break. Nature, 369, 272-273.
21. Wyllie, A.H., Kerr, J.F.R. and Currie, A.R. (1980) Cell death: the significance of apoptosis. Int. Rev. Cytol., 68, 251-306.