DNA encoding individual mycobacterial antigens protects mice against tuberculosis

Brazilian Journal of Medical and Biological Research

Volumn 32, Issue 2, 1999, Pages 231-234

  Silva, C L ^a   Bonato, V L D ^a   Lima, V M F ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cytokines; DNA vaccination; Th1 Th2; Tuberculosis

Indexed keywords

GAMMA INTERFERON; MYCOBACTERIUM ANTIGEN; VIRUS VECTOR;

ANTIGEN PRESENTATION; BCG VACCINATION; CELL MEDIATED CYTOTOXICITY; CONFERENCE PAPER; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DNA TRANSFECTION; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNITY; LYMPHOCYTOPOIESIS; MOLECULAR CLONING; MOUSE; NONHUMAN; TREATMENT OUTCOME; TUBERCULOSIS; VACCINATION;

MYCOBACTERIUM; MYCOBACTERIUM BOVIS BCG;

EID: 0032982149     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X1999000200012     Document Type: Conference Paper

References (16)

1. Kochi A (1991). The global tuberculosis situation and the new control strategies of the World Health Organization. Tubercle, 72: 1-6.
2. Snyder DE (Editor) (1994). Tuberculosis: the world situation. History of the disease and efforts to combat it In: Tuberculosis. Back to the Future. Wiley, Chichester, 13-33.
3. Fine PEM (1989). The BCG story: lessons from the past and implications for the future. Review of Infectious Diseases, 11: S353-S359.
4. Fine PEM (1988). BCG vaccination against tuberculosis and leprosy. British Medical Bulletin, 44: 704-716.
5. Silva CL, Palacios A, Colston MJ & Lowrie DB (1992). Mycobacterium leprae 65hsp antigen expressed from a retroviral vector in a macrophage cell line is presented to T cells in association with MHC class II in addition to MHC class I. Microbial Pathogenesis, 12: 27-38.
6. Lowrie DB, Tascon RE, Colston MJ & Silva CL (1994). Towards a DNA vaccine against tuberculosis. Vaccine, 12: 1537-1540.
7. + T-lymphocytes of Mycobacterium leprae heat-shock protein 65 antigen by macrophages transfected with the mycobacterial gene. Immunology, 78: 35-42.
8. Silva CL & Lowrie DB (1994). A single mycobacterial protein (hsp65) expressed by a transgenic antigen-presenting cell vaccinates mice against tuberculosis. Immunology, 82: 244-248.
9. Silva CL, Silva MF, Pietro RCLR & Lowrie DB (1994). Protection against tuberculosis by passive transfer with T cell clones recognizing mycobacterial heat-shock protein 65. Immunology, 83: 341-346.
10. Silva CL, Pietro RCLR, Januário A, Bonato VDL, Lima VMF, Silva MF & Lowrie DB (1995). Protection against tuberculosis by bone marrow cells expressing mycobacterial hsp65. Immunology, 86: 519-524.
11. Lowrie DB, Tascon RE & Silva CL (1995). Vaccination against tuberculosis. International Archives of Allergy and Immunology, 108: 309-312.
12. Silva CL, Silva MF, Pietro RCLR & Lowrie DB (1996). Characterization of the T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65. Infection and Immunity, 64: 2400-2407.
13. Lowrie DB, Silva CL, Colston MJ, Ragno S & Tascon RE (1997). Protection against tuberculosis by plasmid DNA. Vaccine, 15: 834-838.
14. Lowrie DB, Silva CL & Tascon RE (1997). Genetic vaccination against tuberculosis. Springer Seminars in Immunopathology, 19: 161-173.
15. Lowrie DB, Silva CL & Tascon RE (1997). DNA vaccines agairst tuberculosis. Immunology and Cell Biology, 75: 591-594.
16. Bonato VLD, Lima VMF, Tascon RE, Lowrie DB & Silva CL (1998). Identification and characterization of protective T cells in hsp65 DNA vaccinated and Mycobacterium tuberculosis infected mice. Infection and Immunity, 66: 169-175.