Amphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 3, 1999, Pages 702-704

  Helmerhorst, Eva J ^a   Reijnders, Ingrid M ^a   Van 'T Hof, Wim ^a   Simoons Smit, Ina ^b   Veerman, Enno C I ^a   Amerongen, Arie V Nieuw ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; FLUCONAZOLE; HISTATIN; HISTATIN 5; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; CONTROLLED STUDY; CROSS RESISTANCE; DRUG MECHANISM; DRUG SCREENING; FROG; FUNGICIDAL ACTIVITY; MYCOSIS; NONHUMAN; PRIORITY JOURNAL;

EID: 0032979798     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.3.702     Document Type: Article

References (21)

1. Conly, J., R. Rennie, J. Johnson, S. Farah, and L. Hellman. 1992. Disseminated candidiasis due to amphotericin B-resistant Candida albicans. J. Infect. Dis. 165:761-764.
2. Fan-Havard, P., D. Capano, S. M. Smith, A. Mangia, and R. H. K. Eng. 1991. Development of resistance in Candida isolates from patients receiving prolonged antifungal therapy. Antimicrob. Agents Chemother. 35:2302-2305.
3. Hancock, R. E. W. 1997. Peptide antibiotics. Lancet 349:418-422.
4. Hazen, K. C. 1995. New and emerging yeast pathogens. Clin. Microbiol. Rev. 8:462-478.
5. Helmerhorst, E. J., W. Van 't Hof, E. C. I. Veerman, I. Simoons-Smit, and A. V. Nieuw Amerongen. 1997. Synthetic histatin analogs with broad-spectrum antimicrobial activity. Biochem. J. 326:39-45.
6. Kelly, S. L., D. C. Lamb, D. E. Kelly, J. Loeffler, and H. Einsele. 1996. Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients. Lancet 348:1523-1524.
7. 5,6-desaturation. FEBS Lett. 400:80-82.
8. Knoke, M., K. Schulz, and H. Bernhardt. 1997. Dynamics of Candida isolations from humans from 1992-1995 in Greifswald, Germany. Mycoses 40: 105-110.
9. Landman, D., G. Saurina, and J. M. Quale. 1998. Failure of all antifungal therapy for infection due to Candida albicans: a new AIDS-related problem? Clin. Infect. Dis. 26:183-184.
10. Law, D., C. B. Moore, and D. W. Denning. 1997. Amphotericin B resistance testing of Candida spp.: a comparison of methods. J. Antimicrob. Chemother. 40:109-112.
11. Manavathu, E. K., G. J. Alangaden, and S. A. Lerner. 1996. A comparative study on the broth micro- and macro-dilution techniques for the determination of the in vitro susceptibility of Aspergillus fumigatus. Can. J. Microbiol. 42:960-964.
12. Marichal, P., H. Vanden Bossche, F. C. Odds, G. Nobels, D. W. Warnock, V. Timmerman, C. Van Broeckhoven, S. Fay, and P. Mose-Larsen. 1997. Molecular biological characterization of an azole-resistant Candida glabrata isolate. Antimicrob. Agents Chemother. 41:2229-2237.
13. Nolte, F. S., T. Parkinson, D. J. Falconer, S. Dix, J. Williams, C. Gilmore, R. Geller, and J. R. Wingard. 1997. Isolation and characterization of fluconazole- and amphotericin B-resistant Candida albicans from blood of two patients with leukemia. Antimicrob. Agents Chemother. 44:196-199.
14. Sokol-Anderson, M., J. E. Sligh, Jr., S. Elberg, J. Brajtburg, G. S. Kobayashi, and G. Medoff. 1988. Role of cell defense against oxidative damage in the resistance of Candida albicans to the killing effect of amphotericin B. Antimicrob. Agents Chemother. 32:702-705.
15. Soravia, E., G. Martini, and M. Zasloff. 1988. Antimicrobial properties of peptides from Xenopus granular gland secretions. FEBS Lett. 228:337-340.
16. Sterling, T. R., and W. C. Merz. 1998. Resistance to amphotericin B - emerging clinical and microbiological patterns. Drug Res. Updates 1:161-165.
17. Tsai, H., and L. A. Bobek. 1997. Human salivary histatin-5 exerts potent fungicidal activity against Cryptococcus neoformans. Biochim. Biophys. Acta 1336:367-369.
18. Tsai, H., and L. A. Bobek. 1997. Studies of the mechanism of human salivary histatin-5 candidacidal activity with histatin-5 variants and azole-sensitive and -resistant Candida species. Antimicrob. Agents Chemother. 41:2224-2228.
19. Vanden Bossche, H., P. Marichal, and F. C. Odds. 1994. Molecular mechanisms of drug resistance in fungi. Trends Microbiol. 2:393-400.
20. Van 't Hof, W., P. C. Driedijk, M. Van den Berg, A. G. Beck-Sickinger, G. Jung, and R. C. Aalberse. 1991. Epitope mapping of the Dermatophagoides pteronyssinus house dust mite major allergen Der p II using overlapping synthetic peptides. Mol. Immunol. 28:1225-1232.
21. White, T. C., K. A. Marr, and R. A. Bowden. 1998. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin. Microbiol. Rev. 11:382-402.