Acquired von Willebrand disease due to increasing platelet count can readily explain the paradox of thrombosis and bleeding in thrombocythemia

Clinical and Applied Thrombosis/Hemostasis

Volumn 5, Issue 3, 1999, Pages 147-151

  Michiels, Jan Jacques ^a  

^a Goodheart Institute   (Netherlands)

Author keywords

Acquired von Willebrand syndrome; Aspirin; Bleeding; Essential thrombocythemia; Myeloproliferative disorders; Platelet thrombi; Polycythemia vera; Thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; VON WILLEBRAND FACTOR;

ARTICLE; BLEEDING TENDENCY; GASTROINTESTINAL HEMORRHAGE; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOCYTHEMIA; TRANSIENT ISCHEMIC ATTACK; VON WILLEBRAND DISEASE;

EID: 0032975906     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/107602969900500301     Document Type: Article

References (35)

1. Michiels JJ. Erythromelalgia and thrombocythemia (thesis). Rotterdam: 1981.
2. van Genderen PJJ, Michiels JJ. Erythromelalgic, thrombotic and hemorrhagic thrombocythemia. Presse Med 1994;23:73.
3. Michiels JJ, Abels J, Steketee J, et al. Erythromelalgia caused by platelet-mediated arteriolar inflammation and thrombosis in thrombocythemia. Ann Intern Med 1985;102:466.
4. Michiels JJ, van Genderen PJJ, Lindemans J, van Vliet HHDM Erythromelalgic, thrombotic and hemorrhagic thrombocythemia Leuk Lymphoma 1996;22(suppl 1):47.
5. Michiels JJ, Koudstaal PJ, Mulder AH, van Vliet HHDM. Transient neurologic and ocular manifestations in primary thrombocythemia. Neurology 1993;43:1107.
6. Scheffer MG, Michiels JJ, Simoons ML, Roelandt JRTC. Thrombocythemia and coronary artery disease. Am Heart J 1991;122 573.
7. Michiels JJ, van Genderen PJJ, Jansen PHP, Koudstaal PJ. Atyphcal transient ischemic attacks in thrombocythemia of various im eloproliferative disorders. Leuk Lymphoma 1996;22(suppl 1):65.
8. Michiels JJ. Platelet dependent and aspirin responsive arterial thrombophilia in essential thrombocythemia. Thorax J 1996;8:1.
9. van Genderen PJJ, Michiels JJ. Erythromelalgia: a pathognomomo microvascular thrombotic complication in essential thrombocythe mia and polycythemia vera. Semin Thromb Hemost 1997;23:357.
10. Koudstaal PJ, Koudstaal A. Neurologic and visual symptoms its essential thrombocythemia. Semin Thromb Hemost 1997;23:365.
11. Griesshammer M, Bangerter M, van Vliet HHDM, Michiels JJ. Aspirin in essential thrombocythemia: Status Quo and Quo Vadis Semin Thromb Hemost 1997;23:371.
12. Michiels JJ. Erythromelalgia and vascular complications in polycythemia vera. Semin Thromb Hemost 1997;23:441.
13. Ravandi-Kashani F, Schafer AI. Microvascular disturbances thrombosis and bleeding in thrombocythemia: current concepts and perspectives. Semin Thromb Hemost 1997;23:479.
14. Gunz FW. Hemorrhagic thrombocythemia. A critical review. Blood 1960;15:706.
15. Michiels JJ. Erythromelalgia and thrombocythemia. A disease of platelet prostaglandin metabolism. Semin Thromb Hemost 1995; 23:335.
16. Mason JE, DeVita VT, Canellos GP. Thrombocytosis in chrome granulocytic leukemia: incidence and clinical significance. Blood 1974;44:483.
17. Epstein E, Goedel A. Hämorrhagische Thrombozythämie. Vicchows Arch 1934;293:233.
18. van Genderen PJJ, Mulder PGH, Waleboer M, et al. Prevention from treatment of thrombotic complications in essential thrombocythemia: efficacy and safety of aspirin. Br J Haematol 1997;97: 179.
19. Fabris F, Casonato A. Del Ben MG, et al. Abnormalities of Willebrand factor in myeloproliferative disease: a relationship w bleeding diathesis. Br J Haematol 1986;63:75.
20. Mohri H. Acquired von Willebrand disease in patients with polycythemia vera. Am J Hematol 1987;26:135.
21. Lopez-Fernandez MF, Lopez-Berges C, Martin R. et al. Abnormal structure of von Willebrand factor in myeloproliferative syndrome is associated to either thrombotic or bleeding diathesis. Thromb. Haemost 1987;58:753.
22. Tatewaki W, Takahashi H, Shibata A. Multimeric composition of plasma von Willebrand factor in chronic myeloproliferative disorders. Clin Lab Haematol 1988;10:417.
23. Castaman G, Lattuada A, Ruggeri M, et al. Platelet von Willebrand factor abnormalities in myeloproliferative syndromes. Am J Hematol 1995;49:289.
24. van Genderen PJJ, Budde U, Michiels JJ, et al. The reduction of large von Willebrand factor multimers in plasma in essential thrombocythemia is related to the platelet count. Br J Haematol 1996;93:962.
25. Budde U, Scharf RE, Franke P, et al. Elevated platelet count as a cause of abnormal von Willebrand factor multimer distribution in plasma. Blood 1993;82:1749.
26. Budde U, Dent JA, Berkowitz SD, et al. Subunit composition of plasma von Willebrand factor in patients with the myeloproliferative syndrome. Blood 1986;68:1213.
27. Leupin L, Beck EA, Furlan M, Bucher U. Hämostasestörung mit verminderter Aktivität des von Willebrand-Faktors bei myeloproliferativen Syndromen. Schweiz Med Wochenschr 1993;113:713.
28. Budde U, Schaefer G, Mueller N, et al. Acquired von Willebrand's disease in the myeloproliferative syndrome. Blood 1984;64:981.
29. Raman BKS, Sawdyk M, Saeed AM. Essential thrombocythemia with acquired von Willebrand's disease. Am J Clin Pathol 1987; 88:102.
30. Murakawa M, Okamura T, Tsutsumi K, et al. Acquired von Willebrand's disease in association with essential thrombocythemia: regression following treatment. Acta Haematol 1992;87:83.
31. van Genderen PJJ, Michiels JJ, van der Poel-van de Luitgaarde SCPAM, van Vliet HHDM. Acquired von Willebrand disease as a cause of recurrent mucocutaneous bleeding in primary thrombocythemia with platelet count. Ann Hematol 1994;69:81.
32. Budde U, van Genderen PJJ. Acquired von Willebrand disease in patients with high platelet counts. Semin Thromb Hemost 1997;23: 425.
33. van Genderen PJJ, Leenknegt H, Michiels JJ. The paradox of bleeding and thrombosis in thrombocythemia: is von Willebrand factor the link? Semin Thromb Hemost 1997;23:385.
34. van Genderen PJJ, Prins FJ, Lucas IS, et al. Decreased half-life time of plasma von Willebrand factor collagen binding activity in essential thrombocythemia: normalization after cytoreduction of the increased platelet count. Br J Haematol 1997;99:832.
35. van Genderen PJJ, van Vliet HHDM, Prins FJ, et al. The excessive prolongation of the bleeding time by aspirin in essential thrombocythemia is related to a decrease of large von Willebrand factor multimers in plasma. Ann Hematol 1997;75:215.