Acquired von Willebrand disease in patients with high platelet counts

Seminars in Thrombosis and Hemostasis

Volumn 23, Issue 5, 1997, Pages 425-431

  Budde, Ulrich ^a,c   Van Genderen, Perry J J ^b  

^a Laboratory Keeser/Arndt and Partners   (Germany)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c Lab Association Kesser and Arndt   (Germany)

Author keywords

Myeloproliferative disorders; Platelets; Thrombocythemia; Thrombocytosis; von Willebrand disease; von Willebrand factor

Indexed keywords

VON WILLEBRAND FACTOR;

ADULT; ANAMNESIS; ARTICLE; CASE REPORT; HEMOSTASIS; HUMAN; MALE; MYELOPROLIFERATIVE DISORDER; PATHOGENESIS; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOCYTOSIS; VON WILLEBRAND DISEASE;

EID: 0030827387     PISSN: 00946176     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-996119     Document Type: Article

References (46)

1. Vischer UM, DD Wagner: Von Willebrand factor proteolytic processing and multimerization precede the formation of Weihel-Palade bodies. Blood 83:3536-3544, 1994.
2. Ruggeri ZM, J Ware: The structure and function of von Willebrand factor. Thromb Haemostas 67:594-599, 1992.
3. Willebrand von EA: Hereditär pseudohemofili. Fin Laekaresaellsk Handl 68:87-112, 1926.
4. Simone JV, JA Cornet, CF Abildgaard: Acquired von Willebrand's syndrome in systemic lupus erythematosus. Blood 31: 806-812, 1968.
5. Handin RI, V Martin, WC Moloney: Antibody-induced von Willebrand's disease: A newly defined inhibitor syndrome. Blood 48:393-405, 1976.
6. Jakway JL: Acquired von Willebrand's disease. Hematol Oncol Clin North Am 6:1409-1419, 1992.
7. Rosen PJ: Bleeding problems in the cancer patient: Hematol Oncol Clin North Am 6:1315-1339, 1992.
8. Ruggeri ZM: Acquired abnormalities of von Willebrand factor - Facts to consider in patients with unexpected bleeding: J Lab Clin Med 121:377-379, 1993.
9. Bick RL, JF Strauss, EP Frenkel: Thrombosis and hemorrhage in oncology patients. Hematol Oncol Clin North Am 10:875-907, 1996.
10. Goad KE, HR Gralnick: Coagulation disorders in cancer. Hematol Oncol Clin North Am 10:457-470, 1996.
11. Hamidou M, C Agard, F Fressinaud, et al: Acquired von Willebrand's syndrome associated with lymphoproliferative disorders. Presse Med 26:12-14, 1997.
12. Rinder MR, RE Richard, HM Rinder: Acquired von Willebrand's disease: A concise review. Am J Hematol 54:139-145, 1997.
13. Inbal A, I Bank, A Zivelin, et al: Acquired von Willebrand disease in a patient with angiodysplasia resulting from immune-mediated clearance of von Willebrand factor. Br J Haematol 96:179-182, 1997.
14. Moake JL, PD Mcpherson: Abnormalities of von Willebrand factor multimers in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. Am J Med 87:N9-N15, 1989.
15. Schäfer G, U Budde, HH Hansen, et al: Severe hemostatic disturbances in a patient with polycythemia vera - Successful management with F VIII-substitution, cytopheresis, and cytostatic drugs. Haemostasis 12(suppl):78(Abstr), 1982.
16. Budde U, G Schäfer, N Müller, et al: Acquired von Willebrand's disease in the myeloproliferative syndrome. Blood 64:981-985, 1984.
17. Leupin L, EA Beck, M Furlan, et al: Hämostasestörung mit verminderter Aktivität des von Willebrand Faktors bei myeloproliferativen Syndromen. Schweiz Med Wochenschr 113:713-716, 1983.
18. Casonato A, F Fabris, L Zancan, et al: Acquired type I von Willebrand's disease in a patient with essential thrombocytosis. Acta Haematol 75:188-189, 1986.
19. Fabris F, A Casonato, MG Del Ben, et al: Abnormalities of von Willebrand factor in myeloproliferative disease: A relationship with bleeding diathesis. Br J Haematol 63:75-83, 1986.
20. Lopez-Fernandez MF, C Lopez-Berges, R Martin, et al: Abnormal structure of von Willebrand factor in myeloproliferative syndrome is associated with either thrombotic or bleeding diathesis. Thromb Haemostas 58:753-757, 1987.
21. Mohri H: Acquired von Willebrand's disease in patients with polycythemia rubra vera. Am J Hematol 26:135-146, 1987.
22. Raman BKS, M Sawdyk, SM Saeed: Essential thrombocythemia with acquired von Willebrand's disease. Am J Clin Pathol 88: 102-106, 1987.
23. Sato K: Plasma von Willebrand factor abnormalities in patients with essential thrombocythemia. Keio J Med 37:54-71, 1988.
24. Tatewaki W, H Takahashi, A Shibata: Multimeric composition of plasma von Willebrand factor in chronic myeloproliferative disorders. Clin Lab Haematol 10:417-425, 1988.
25. Tatewaki W, H Takahashi, M Hanano, et al: Multimeric composition of plasma von Willebrand factor in chronic myelocytic leukemia. Thromb Res 52:23-32, 1988.
26. Murakawa M, T Okamura, T Tsutsumi, et al: Acquired von Willebrand's disease in association with essential thrombocythemia - Regression following treatment. Acta Haematol 87: 83-87, 1992.
27. van Genderen PJJ, JJ Michiels, SCPAM van der Poel van de Luytgaarde, et al: Acquired von Willebrand disease as a cause of recurrent mucocutaneous bleeding in primary thrombocythemia: Relationship with platelet count. Ann Hematol 69: 81-84, 1994.
28. van Genderen PJJ, U Budde, JJ Michiels, et al: The reduction of large von Willebrand factor multimers in plasma in essential thrombocythaemia is related to the platelet count. Br J Haematol 93:962-965, 1996.
29. Carter C, BJ Boughton: Acquired von Willebrand's disease in myeloproliferative syndrome - Spontaneous remission during pregnancy. Thromb Haemostas 67:387-388, 1992.
30. Tatewaki W, H Takahashi, E Takakuwa, et al: Plasma von Willebrand factor proteolysis in patients with chronic myeloproliferative disorders - No possibility of ex vivo degradation by calcium-dependent proteases. Thromb Res 56:191-199, 1989.
31. Zimmerman TS, JA Dent, ZM Ruggeri, et al: Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of oligomer type IIC, IID and IIE. J Clin Invest 77:947-951, 1986.
32. Budde U, JA Dent, SD Berkowitz, et al: Subunit composition of plasma von Willebrand factor in patients with the myeloproliferative syndrome. Blood 68:1213-1217, 1986.
33. Budde U, RE Scharf, P Franke, et al: Elevated platelet count as a cause of abnormal von Willebrand factor multimer distribution in plasma. Blood 82:1749-1757, 1993.
34. Menschengieser S, A Blanco, A Woods, et al: Intraplatelet levels of vWf:Ag and fibrinogen in myeloproliferative disorders. Thromb Res 48:311-319, 1987.
35. Castaman G, A Lattuada, M Ruggeri, et al: Platelet von Willebrand factor abnormalities in myeloproliferative syndromes. Am J Hematol 49:289-293, 1995.
36. Rodeghiero F, GC Castaman, A Tosetto, et al: Platelet von Willebrand factor assay - Results using 2 methods for platelet lysis. Thromb Res 59:259-267, 1990.
37. Van Genderen PJJ, JJ Michaels: Erythromelalgic, thrombotic and haemorrhagic manifestations of thrombocythaemia. Presse Med 23:73-77, 1994.
38. Casonato A, F Fabris, M Boscaro, et al: Increased factor VIII/vWf levels in patients with reduced platelet number. Blut 54:281-288, 1987.
39. Bellucci S, M Janvier, G Tobelem, et al: Essential thrombocythemias: Clinical, evolutionary and biological data. Cancer 58:2440-2447, 1986.
40. Fenaux P, M Simon, MT Caulier, et al: Clinical course of essential thrombocythemia in 147 cases. Cancer 66:549-556, 1990.
41. Mohri H, T Ohkubo: Acquired von Willebrand's syndrome due to an inhibitor of IgG specific for von Willebrand's factor in polycythemia rubra vera. Acta Haematol 78:258-264, 1987.
42. Rock G, RK Smiley, P Tittley, et al: An antibody to platelet membrane antigen associated with thrombotic events in essential thrombocythemia. Am J Hematol 28:85-89, 1988.
43. Furlan M, R Robles, B Lämmle: Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis. Blood 87:4223-4234, 1996.
44. Tsai HM: Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion. Blood 87:4235-4244, 1996.
45. van Genderen PJJ, FJ Prins, IS Lucas, et al: Decreased half-life time of plasma von Willebrand factor collagen binding activity in essential thrombocythemia: Normalization after cytoreduction of the increased platelet count. In press Br J Haematol 1997.
46. Berkowitz SD, H Nozaki, K Titani, et al: Evidence that calpains and elastase do not produce the von Willebrand factor fragments present in normal plasma and IIA von Willebrand disease. Blood 72:721-727, 1988.