The transferrin receptor: Its role in iron metabolism and its diagnosis utility;Le recepteur de la transferrine: Role dans le metabolisme du fer et interet en biologie clinique

Annales de Biologie Clinique

Volumn 57, Issue 1, 1999, Pages 9-17

  Vernet, M ^a  

^a CROIX ROUSSE HOSPITAL   (France)

Author keywords

Anemia of chronic diseases; Endocytosis; Erythropoiesis; Iron deficiency; Iron status; Transferrin receptor

Indexed keywords

CELL RECEPTOR; FERRITIN; MESSENGER RNA; MONOMER; RECOMBINANT ERYTHROPOIETIN; TRANSFERRIN; TRANSFERRIN RECEPTOR; IRON;

ANEMIA; BLOOD LEVEL; BONE MARROW CELL; CANCER; CHRONIC KIDNEY FAILURE; CYTOLYSIS; DIAGNOSTIC TEST; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROBLAST; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; HEMOGLOBIN SYNTHESIS; HUMAN; INFECTION; INFLAMMATORY DISEASE; IRON DEFICIENCY ANEMIA; IRON STORAGE; METABOLISM; REVIEW; STANDARDIZATION; AGE; BLOOD; CHEMISTRY; CHRONIC DISEASE; PHYSIOLOGY; REFERENCE VALUE;

AGE FACTORS; ANEMIA, IRON-DEFICIENCY; CHRONIC DISEASE; ERYTHROID PROGENITOR CELLS; ERYTHROPOIESIS; HUMANS; IRON; RECEPTORS, TRANSFERRIN; REFERENCE VALUES; TRANSFERRIN;

EID: 0032970614     PISSN: 00033898     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (49)

1. Kohgo Y, Nishisato T, Kondo H, Tsushima N, Niitsu Y, Urushizaki I. Circulating transferrin receptor in human serum. Br J Haematol 1986 ; 64 : 277-81.
2. Huebers HA, Finch CA. The physiology of transferrin and transferrin receptors. Physiol Rev 1987 ; 67 : 520-82.
3. Iacopetta BJ, Morgan EH, Yeah GCT. Transferrin receptors and iron uptake during erythroid cell development. Bioch Biophys Acta 1982 ; 687 : 204-10.
4. Lombard M, Chua E, O'Toole P. Regulation of intestinal non-haem iron absorption. Gut 1997 ; 40 : 435-9.
5. Trowbridge IS, Newman RA, Domingo DL, Sauvage C. Transferrin receptors : structure and function. Biochem Pharmacol 1984 ; 33 : 925-32.
6. Baynes ED, Skikne BS, Cook JD. Circulating transferrin receptor and assessment of iron status. J Nutr Biochem 1994 ; 5 : 322-30.
7. May WS, Cuatrecasas P. Transferrin receptor : its biological significance. J Membrane Biol 1985 ; 88 : 205-15.
8. Testa U, Pelosi E, Peschle C. The transferrin receptor. Crit Rev Oncol 1993 ; 4: 241-76.
9. Hentze MW, Kuhn LC. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci USA 1996 ; 93 : 8175-82.
10. Addess KJ, Basilion JP, Klausner RD, Rouault TA, Pardi A. Structure and dynamics of the iron responsive element RNA : implications for binding of the RNA by iron regulatory binding proteins. J Mol Biol 1997 ; 274 : 72-83.
11. Shih YJ, Baynes RD, Hudson BG, Cook JD. Characterization and quantitation of the circulating forms of serum transferrin receptor using domain-specific antibodies. Blood 1993 ; 82 : 234-8.
12. Beguin Y, Loo M, Fillet G. Le dosage du récepteur circulant de la transferrine : une nouveauté pour quantifier l'érythropoïèse. Med Hyg 1991 ; 49 : 2041-5
13. Rutledge EA, Enns CA. Cleavage of the transferrin receptor is influenced by the composition of the O-linked carbohydrate at position 104. J Cell Biol 1996 ; 168 : 284-93.
14. Rutledge EA, Gaston I, Root BJ, McGraw TE, Enns CA. The transferrin receptor cytoplasmic domain determines its rate of transport through the biosynthetic pathway and its susceptibility to cleavage early in the pathway. J Biol Chem 1998 ; 273 : 11269-75.
15. Ponka P, Beaumont C, Richardson DR. Function and regulation of transferrin and ferritin. Sem Hematol 1998 ; 35 : 35-54.
16. Thorstensen K, Romslo I. The role of transferrin in the mechanism of cellular iron uptake. Biochem J 1990 ; 271 : 1-10.
17. Feder JN, Penny DM, Irrinki A, et al. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA 1998 ; 95 : 1472-7.
18. Lebron JA, Bennett MJ, Vaughn DE, et al. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell 1998 ; 93 : 111-23.
19. Pietrangelo A, Camaschella C. Molecular genetics and control of iron metabolism in hemochromatosis. Haematologica 1998 ; 83 : 456-61.
20. Cooper MJ, Zlotkin SH. Day-to-day variation of transferrin receptor and ferritin in healthy men and women. Am J Clin Nutr 1996 ; 64 : 738-42.
21. Allen J, Backstrom KR, Cooper JA, et al. Measurement of soluble transferrin receptor in serum of healthy adults. Clin Chem 1998 ; 44 : 35-9.
22. Hikawa A, Nomata Y, Suzuki T, Ozasa H, Yamada O. Soluble transferrin receptor-transferrin complex in serum : measurement by latex agglutination nephelometric immunoassay. Clin Chim Acta 1996 ; 254 : 159-72.
23. Kuiper-Kramer EPA, Huisman CMS, Van Raan J, Van Eijk HG. Analytical and clinical implications of soluble transferrin receptors in serum. Eur J Clin Chem Clin Biochem 1996 ; 34 : 645-9.
24. Suominen P, Punnonen K, Rajamaki A, Irjala K. Evaluation of new immunoenzymometric assay for measuring soluble transferrin receptor to detect iron deficiency in anemic patients. Clin Chem 1997 ; 43 : 1641-6.
25. Kuiper-Kramer EPA, Van Raan J, Van Eijk HG. A new assay for soluble transferrin receptors in serum : time for standardisation. Eur J Clin Chem Clin Biochem 1997 ; 35 : 793.
26. Kuiper-Kramer EPA, Baerts W, Bakker R, Van Eyck J, Van Raan J, Van Eijk HG. Evaluation of the iron status of the newborn by soluble transferrin receptors in serum. Clin Chem Lab Med 1998 ; 36 : 17-21.
27. Kohgo Y, Niitsu Y, Nishisato J, Kato J, Kondo H, Sasaki K, Urushizaki I. Quantitation and characterization of serum transferrin receptor in patients with anemias and polycythemias. Jpn J Med 1988 ; 27 : 64-70.
28. Flowers CH, Skikne BS, Covell AM, Cook JD. The clinical measurement of serum transferrin receptor. J Lab Clin Med 1989 ; 114 : 368-77.
29. Ahluwalia N. Diagnostic utility of serum transferrin receptors measurement in assessing iron status. Nutr Rev 1998 ; 56 : 133-41.
30. Maes M, Bosmans E, Scharpé S, et al. Components of biological variation in serum soluble transferrin receptor : relationships to serum iron, transferrin and ferritin concentrations, and immune and haematological variables. Scand J Clin Lab Invest 1997 ; 57 : 31-41.
31. Mast AE, Blinder MA, Gronowski AM, Chumley C, Scott MG. Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Clin Chem 1998 ; 44 : 45-51.
32. Huebers HA, Beguin Y, Pootrakul P, Einspahr D, Finch CA. Intact transferrin receptors in human plasma and their relation to erythropoïesis. Blood 1990 ; 75 : 102-7.
33. Baynes RD. Assessment of iron status. Clin Biochem 1996 ; 29 : 209-15.
34. Cook JD, Lynch SR. The liabilities of iron deficiency. Blood 1986 ; 68 : 803-9.
35. Skikne BS, Flowers CH, Cook JD. Serum transferrin receptor : a quantitative measure of tissue iron deficiency. Blood 1990 ; 75 : 1870-6.
36. Cook JD, Skikne BS, Baynes RD. Serum transferrin receptor. Annu Rev Med 1993 ; 44 : 63-74.
37. Rusia U, Flowers C, Madan N. Serum transferrin receptor levels in the evaluation of iron deficiency in the neonate. Acta Paediatr Jpn 1995 ; 38 : 455-9.
38. Zhu YI, Haas JD. Response of serum transferrin receptor to iron supplementation in iron-depleted, nonanemic women. Am J Clin Nutr 1998 ; 67 : 271-5.
39. Ferguson BJ, Skikne BS, Simpson KM, Baynes RD, Cook JD. Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J Lab Clin Med 1992 ; 119 : 385-90.
40. Punnonen K, Irjala K, Rajamaki A. Iron-deficiency anemia is associated with high concentrations of transferrin receptor in serum. Clin Chem 1994 ; 40 : 774-6.
41. Punnonen K, Irjala K, Rajamaki A. Serum transferrin receptor and its ratio to serum ferrilin in the diagnosis of iron deficiency. Blood 1997 ; 89 : 1052-7.
42. Petterson T, Kivivuori SM, Siimes MA. Is serum transferrin receptor useful for detecting iron-deficiency in anaemic patients with chronic inflammatory diseases ? Br J Rheumatol 1994 ; 33 : 740-4.
43. Kuiper-Kramer EPA, Coenen JLLM, Huisman CMS, Abbes A, Van Raan J, Van Eijk HG. Relationship between soluble transferrin receptors in serum and membrane-bound transferrin receptors. Acta Haematol 1998 ; 99 : 8-11.
44. Beguin Y, Loo M, R'Zik S, Sautois B, Lejeune F, Rorive G, Fillet G. Early prediction of response to recombinant human erythropoietin in patients with the anemia of renal failure by serum transferrin receptor and fibrinogen. Blood 1993 ; 82 : 2010-6.
45. Ahluwalia N, Skikne BS, Savin V, Chonko A. Markers of masked iron deficiency and effectiveness of EPO therapy in chronic renal failure. Am J Kidney Dis 1997 ; 30 : 532-41.
46. Carmel R, Skikne BS. Serum transferrin receptor in the megaloblastic anemia of cobalamin deficiency. Eur J Haematol 1992 ; 49 : 246-50.
47. Gareau R, Gagnon MG, Thellend C. et al. Transferrin soluble receptor : a possible probe for detection of erythropoietin abuse by athletes. Horm Met Res 1994 ; 26 : 311-2.
48. Beguin Y, Clemons GK, Pootrakul P, Fillet G. Quantitative assessment of erythropoiesis and functional classification of anemia based on measurement of serum transferrin receptor and erythropoietin. Blood 1993 ; 81 : 1067-76.
49. Fellman V, Rapola J, Pihko H, Varilo T, Raivio KO. Iron-overloaded disease in infants involving fetal growth retardation, lactic acidosis, liver haemosiderosis, and aminoaciduria. Lancet 1998 ; 351 : 490-3.