Effect of isosorbide mononitrate on the human optic nerve and choroidal circulations

British Journal of Ophthalmology

Volumn 83, Issue 2, 1999, Pages 162-167

  Grunwald, Juan E ^a   Iannaccone, Alessandro ^a,b,c   DuPont, Joan ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOSORBIDE MONONITRATE; NITRIC OXIDE DONOR; PLACEBO;

ADULT; ARTICLE; BLOOD FLOW; CHOROID VASCULARIZATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; HEART RATE; HUMAN; HUMAN EXPERIMENT; INTRAOCULAR PRESSURE; LASER DOPPLER FLOWMETRY; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; OPTIC NERVE; ORAL DRUG ADMINISTRATION; PERFUSION PRESSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINA FOVEA; STATISTICAL ANALYSIS;

EID: 0032967245     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.83.2.162     Document Type: Article

References (38)

1. Zurakowski D, Vorwerk CK, Gorla M, et al. Nitrate therapy may retard glaucomatous optic neuropathy perhaps through modulation of glutamate receptors. Vision Res (in press).
2. Afshari NA, Zurakowski D, Dreyer EB. The effect of long acting nitrate preparations on glaucomatous optic neuropathy. (ARVO abstracts) Invest Ophthalmol Vis Sci 1997;38(Suppl):S277.
3. Grunwald JE, DuPont J, Dreyer EB. Effect of chronic nitrate treatment on retinal vessel caliber in open-angle glaucoma. Am J Ophthalmol 1997;123:753-8.
4. Abrams J. Long-acting nitrates in cardiovascular disease. In: Giles TD, Garbus SB, eds. Use of longer-acting agents in cardiac therapy. Recent advances. USA: Health Care Communications, Inc, 1989;107-28.
5. Abshagen UWP. Pharmacokinetics of isosorbide mononitrate. Am J Cardiol 1992;70:61G-6G.
6. Hutt V, Theodor R, Pabst G, et al. Evaluation of bioavailability and pharmacokinetics of two isosorbide-5-mononitrate preparations in healthy volunteers. J Clin Pharmacol 1992;32:553-7.
7. Schaumann N. Pharmacokinetics of isosorbide dinitrate and isosorbide-5-mononitrate. Int J Clin Pharmacol Ther Tox 1989;27:445-53.
8. Thadani U, Maranda CR, Amsterdam E, et al. Lack of pharmacological tolerance and rebound angina pectoris during twice-daily therapy with isusorbide-5-mononitrate. Ann Intern Med 1994;120:353-9.
9. Riva CE, Cranstoun SD, Grunwald JE, et al. Choroidal blood flow in the foveal region of the human ocular fundus. Invest Ophthalmol Vis Sci 1994;35:4273-81.
10. Riva CE, Harino S, Petrig BL, et al. Laser-Doppler flowmetry in the optic nerve. Exp Eye Res 1992;55:499-506.
11. Petrig BL, Riva CE. Optic nerve head laser Doppler flowmetry: principles and computer analysis. In: Kaiser, HJ, Flammer J, Hendrickson P, eds. Ocular blood flow. Basle: Karger, 1996:120-7.
12. Frayser R, Hickam JB. Effect of vasodilator drugs on the retinal blood flow in man. Arch Ophthalmol 1965;73:640-2.
13. Hickam JB, Frayser R. Studies of the retinal circulation in man. Observations on vessel diameter, arteriovenous oxygen difference, and mean circulation time. Circulation 1966;33:302-16.
14. Sinclair A-M, Hughes AD, Sever PS. Effect of nifedipine and glyceryl trinitrate on retinal blood flow in normal subjects. J Hum Hypertens 1993;7:399-401.
15. Wizemann A, Maier T, Wizemann V. Wirksamkeit unterschiedlicher Therapieprinzipien bei experimentellen Netzhautgefäβ-verschlüssen. Fortschr Ophthalmol 1983;80:176-8.
16. Kuritzky S. Nitroglycerin to treat acute loss of vision. [Letter] N EngI J Med 1990;323:1428.
17. Charness ME, Liu GT. Central retinal artery occlusion in giant cell arteritis: treatment with nitroglycerin. Neurology 1991;41:1698-9.
18. Hessemer V, Schmidt KG. Einfluss des Vasodilatators Isosorbiddinitrat auf den okularen Kreislauf. Klin Monatsbl Augenheilkd 1996;208:1880-195.
19. Hessemer V, Schmidt KG. Influence of the vasodilator drug isosorbide dinitrate on ocular circulation. Arch Ophthalmol 1997;115:324-7.
20. Harino S, Riva CE, Petrig BL. Intravenous nicardipine in cats increases optic nerve but not retinal blood flow. Invest Ophthalmol Vis Sci 1992;33:2885-90.
21. Yao K, Tschudi M, Flammer J, et al. Endothelium-dependent regulation of vascular tone of the porcine ophthalmic artery. Invest Ophthalmol Vis Sci 1991;32:1791-8.
22. Haefliger IO, Flammer J, Luscher TF. Nitric oxide and endothelin-1 are important regulators of human ophthalmic artery. Invest Ophthalmol Vis Sci 1992;33:2340-3.
23. Haefliger IO, Zschauer A, Anderson DR. Relaxation of retinal pericyte contractile tone through the nitric oxide-cyclic guanosine monophosphate pathway. Invest Ophthalmol Vis Sci 1994;35:991-7.
24. Meyer P, Flammer J, Luscher TF. Endothelium-dependent regulation of the ophthalmic microcirculation in the perfused porcine eye: role of nitric oxide and endothelins. Invest Ophthalmol Vis Sci 1993;34:3614-21.
25. Kitamura Y, Okamura T, Kani K, et al. Nitric oxide-mediated retinal arteriolar and arterial dilatation induced by substance P. Invest Ophthalmol Vis Sci 1993;34:2859-65.
26. Goldstein IM, Ostwald P, Roth S. Nitric oxide: a review of its role in retinal function and disease. Vision Res 1996;36:2979.
27. 2+ concentration and on force in the bovine ophthalmic artery. Invest Ophthalmol Vis Sci 1996;37:2612-23.
28. Nishimura K, Riva CE, Harino S, et al. Effects of endothelin-1 on optic nerve head blood flow in cats. J Ocul Pharmacol Ther 1996;12:75-83.
29. Buerk DG, Riva CE, Cranstoun SD. Nitric oxide has a vasodilatory role in cat optic nerve head during flicker stimuli. Microvasc Res 1996;52:13-26.
30. Kondo M, Wang L, Bill A. Vascular reponses in retina and optic nerve to L-NAME, a nitric oxide blocker, and flickering light in monkeys. ARVO Abstracts. Invest Ophthalmol Vis Sci 1995; 36(Suppl):477.
31. Kondo M, Wang L, Bill A. The role of nitric oxide in hyperaemic response to flicker in the retina and optic nerve in cats. Acta Ophthalmol Scand 1997;75:232-5.
32. Qi X, Guy J. Localization of NADPH diaphorase/nitric oxide synthase in the optic nerve of the normal guinea pig: a light and electron microscopic study. J Comp Neurol 1996;370:396-404.
33. Neufeld AH, Hernandez MR, Gonzalez M. Nitric oxide synthase in the human glaucomatous optic nerve head. Arch Ophthalmol 1997;115:497-503.
34. Vorwerk CK, Hyman BT, Miller JW, et al. The role of neuronal and endothelial nitric oxide synthase in retinal excitotoxicity. Invest Ophthalmol Vis Sci 1997;38:2038-2044.
35. Mann RM, Riva CE, Stone RA, et al. Nitric oxide and choroidal blood flow regulation. Invest Ophthalmol Vis Sci 1995;36:925-30.
36. Zagvazdin YS, Fitzgerald MEC, Sancesario G, et al. Neural nitric oxide mediates Edinger-Westphal nucleus evoked increase in choroidal blood flow in the pigeon. Invest Ophthalmol Vis Sci 1996;37:666-72.
37. Riva CE, Titze P, Hero M, et al. Effect of acute decreases of perfusion pressure on choroidal blood flow in humans. Invest Ophthalmol Vis Sci 1997;38:1752-60.
38. Flügel C, Tamm ER, Mayer B, et al. Species differences in choroidal vasodilative innervation: evidence for specific intrinsic nitrergic and VIP-positive neurons in the human eye. Invest Ophthalmol Vis Sci 1994;35:592-9.