New concepts in the aetiology and management of neonatal thrombocytopenia

Seminars in Neonatology

Volumn 4, Issue 1, 1999, Pages 27-40

  Murray, N A ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Haemopoietic progenitor; Megakaryocytopoiesis; Newborn; Platelet; Thrombocytopenia; Thrombopoiesis; Thrombopoietin

Indexed keywords

RECOMBINANT THROMBOPOIETIN;

ARTICLE; CLINICAL TRIAL; DISEASE CLASSIFICATION; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG EFFECT; HUMAN; IMMUNE MEDIATED INJURY; LABORATORY DIAGNOSIS; MEGAKARYOPOIESIS; NEWBORN; NEWBORN DISEASE; PRACTICE GUIDELINE; PREMATURITY; SEPSIS; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS;

EID: 0032963218     PISSN: 10842756     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1084-2756(99)80005-0     Document Type: Article

References (80)

1. Vainchenker W Bouguet J Guichard J Megakaryocyte colony formation from human bone marrow precursors Blood 54 1979 940 945
2. Briddell RA Brandt JE Straneva JE Characterisation of the human burst-forming unit-megakaryocyte Blood 74 1989 145 151
3. Mazur EM Hoffman R Chasis J Immunofluorescent identification of human megakaryocyte colonies using an antiplatelet glycoprotein antiserum Blood 57 1981 277 286
4. Bellucci S Han ZC Pidard D Identification of a normal human bone marrow cell population co-expressing megakaryocytic and erythroid markers in culture Eur J Haematol 48 1992 259 265
5. Chatelain C De Bast M Symann M Identification of a light density murine megakaryocyte progenitor (LD-CFU-MK) Blood 72 1988 1187 1192
6. Gewirtz AM Poncz M Megakaryocytopoiesis and platelet production Hoffman R Benz EJ Shattil SJ Furie B Cohen HJ Hematology Basic Principles and Practice 1st edn. 1991 Churchill Livingstone 1149
7. Radley JM Haller CJ The mechanism of platelet release Blood 56 1980 996 999
8. Shaklai M Tavassoli M Demarcation membrane system in rat megakaryocytes and the mechanism of platelet formation: a membrane reorganisation process J Ultrastruct Res 62 1978 270 285
9. Zauli G Valvassori L Capitani S Presence and characteristics of circulating megakaryocyte progenitor cells in human fetal blood Blood 81 1993 385 390
10. Murray NA Roberts IAG Circulating megakaryocytes and their progenitors (BFU-MK and CFU-MK) in term and pre-term neonates Br J Haematol 89 1995 41 46
11. Nishihira H Toyoda Y Miyazaki H Growth of macroscopic human megakaryocyte colonies from cord blood with recombinant human thrombopoietin (c-mpl ligand) and the effects of gestational age on frequency of colonies Br J Haematol 92 1996 23 28
12. Murray NA Roberts IAG Circulating megakaryocytes and their progenitors in early thrombocytopenia in preterm neonates Pediatr Res 40 1996 112 119
13. Hann IM Development of blood in the fetus Hann IM Gibson BES Letsky Fetal and Neonatal Haematology 1st edn. 1991 Bailliere Tindall 1 28
14. Forester F Daffos F Catherine N Developmental hematopoiesis in normal human fetal blood Blood 77 1991 2360 2363
15. Holmberg L Gustavii B Jonsson A A prenatal study of fetal platelet count and size with application to the fetus at risk of Wiskott Aldrich syndrome J Pediatr 102 1983 773 781
16. Forester F Daffos F Galacteros F Haematological values of 163 normal fetuses between 18 and 30 weeks of gestation Pediatr Res 20 1986 342 346
17. Allen Graeve JL De Alarcon PA Megakaryocytopoiesis in the human fetus Arch Dis Child 64 1989 481 484
18. Trowbridge EA Pulmonary platelet production: a physical analogue of mitosis Blood Cells 13 1988 451 458
19. Martin JF Salter DN Trowbridge EA Abnormal intrapulmonary platelet production: a possible cause of vascular and lung disease Lancet i 1983 793 796
20. Kaufman RM Airo R Plooack S Circulating megakaryocytes and platelet release in the lung Blood 26 1965 720 731
21. Ellis MH Avraham H Groopman JE The regulation of megakaryocytopoiesis Blood Rev 9 1995 1 6
22. Han ZC Bellucci S Caen JP Regulation of human megakaryocytopoiesis Nouv Rev Fr Hematol 32 1990 395 396
23. Hoffman R Regulation of megakaryocytopoiesis Blood 74 1989 1196 1212
24. Burrows RF Kelton JG Incidentally detected thrombocytopenia in healthy mothers and their infants N Engl J Med 319 1988 142 145
25. Burrows RF Kelton JG Thrombocytopenia at delivery: A prospective survey of 6715 deliveries Am J Obstet Gynecol 162 1990 731 734
26. Castle V Andrew M Kelton J Frequency and mechanism of neonatal thrombocytopenia J Pediatr 108 1986 749 755
27. Metha P Rohitkumar V Neumann L Thrombocytopenia in the high risk infant J Pediatr 97 1980 791 794
28. Blanchette VS Rand ML Platelet disorders in newborn infants: diagnosis and management Semin Perinatol 21 1997 53 62
29. Homans A Thrombocytopenia in the neonate Pediatric Clin North Am 43 1996 737 756
30. Andrew M The hemostatic system of the infant Nathan D Oski F Hematology of Infancy and Childhood 4th edn 1992 WB Saunders Philadelphia 115 154
31. 111In-oxine platelet survivals in thrombocytopenic infants Blood 70 1987 652 656
32. Amato M Fauchere JC Herman U Jr Coagulation abnormalities in low birth weight infants with peri-intraventricular hemorrhage Neuropediatrics 19 1988 154 157
33. Andrew M Castle V Saigal S Clinical impact of neonatal thrombocytopenia J Pediatr 110 1987 457 464
34. Van De Bor M Briet E Van Bel F Hemostasis and periventricular-intraventricular hemorrhage of the newborn Am J Dis Child 140 1986 1131 1134
35. Setzer ES Webb IB Wassenaar JW Platelet dysfunction and coagulopathy in intraventricular hemorrhage in the premature infant J Pediatr 100 1982 599 605
36. Muellar-Eckhardt C Kiefel V Grubert A 348 cases of suspected neonatal alloimmune thrombocytopenia Lancet i 1989 363 366
37. Beardsley DS Immune thrombocytopenia in the perinatal period Semin Perinatol 14 1990 368 373
38. Burrows RF Kelton JG Fetal thrombocytopenia and its relation to maternal thrombocytopenia N Engl J Med 329 1993 1463 1466
39. Bussel JB Berkowitz RL Mcfarland JG Antenatal treatment of neonatal alloimmune thrombocytopenia N Engl J Med 319 1988 1374 1378
40. Muller JY Alloimmune thrombocytopenia in the newborn Curr Stud Hematol Blood Transfus 55 1988 94 103
41. Blanchette VS Peters MA Pegg-Feige K Alloimmune thrombocytopenia. Review from a neonatal intensive care unit Curr Stud Hematol Blood Transfus 52 1986 87 96
42. Stoll BJ Gordon T Korones SB Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network J Pediatr 129 1996 63 71
43. Zipursky A Palko J Milner R The hematology of bacterial infections in premature infants Pediatrics 57 1976 839 853
44. Tate DY Carlton GT Johnson D Immune thrombocytopenia in severe neonatal infections J Pediatr 98 1981 449 453
45. Gross SJ Filston HC Anderson JC Controlled study of treatment for disseminated intravascular coagulation in the neonate J Pediatr 100 1982 445 448
46. Andrew M Caco VC Kirpalani H A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants J Pediatr 123 1993 285 291
47. Blanchette VS Kuhne T Hume H Platelet transfusion therapy in newborn infants Transfusion Med Rev 9 1995 215 230
48. American Association of Blood Banks Pediatric Hematology Therapy Committee: Pediatric transfusion audits 3rd edition 1992
49. de Sauvage FJ Hass PE Spencer SD Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand Nature 369 1994 533 538
50. Lok S Kaushansky K Holly RD Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo Nature 369 1994 565 568
51. Kaushansky K Lok S Holly RD Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin Nature 369 1994 568 571
52. Wendling F Maraskovsky E Debill N C-mpl ligand is a humoral regulator of megakaryocytopoiesis Nature 369 1994 571 574
53. Mazur EM South K Human megakaryocyte colony-stimulating factor in sera from aplastic dogs: partial purification, characterisation, and determination of hematopoietic cell lineage specificity Exp Hematol 13 1985 1164 1172
54. Mazur EM de Alarcon P South K Human serum megakaryocyte colony stimulating activity increases in response to intensive cytotoxic chemotherapy Exp Hematol 12 1984 624 628
55. Kawakita M Ogawa M Goldwasser Characterisation of human megakaryocyte colony stimulating factor in the urinary extracts from patients with aplastic anemia and idiopathic thrombocytopenic purpura Blood 61 1983 556 560
56. Hoffman R Mazur E Bruno E Assay of an activity in the serum of patients with disorders of thrombopoiesis that stimulates formation of megakaryocytic colonies N Engl J Med 305 1981 533 538
57. Hill RJ Levin J Levin FC Correlation of in vitro and in vivo biological activities during the partial purification of thrombopoietin Exp Hematol 20 1992 354 360
58. Dessypris EN Chuncharunee S Frierson KE Thrombopoiesis-stimulating factor: its effects on megakaryocyte colony formation in vitro and its relation to human granulocyte-macrophage colony-stimulating factor Exp Hematol 18 1990 754 757
59. McDonald TP Clift RE Cottrell MB A four-step procedure for the purification of thrombopoietin Exp Hematol 17 1989 865 871
60. Zeigler FC de Sauvage F Widmer HR In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells Blood 84 1994 4045 4052
61. Debili N Wendling F Katz A The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiation factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors Blood 86 1995 2516 2525
62. Gurney AL Carver-Moore K de Sauvage FJ Thrombocytopenia in c-mpl-deficient mice Science 265 1994 1445 1447
63. Solar GP Kerr WG Zeigler FC Role of c-mpl in early hematopoiesis Blood 92 1998 4 10
64. Emmons RV Reid DM Cohen RL Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction Blood 87 1996 4068 4071
65. Tahara T Usuki K Sato H A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders Br J Haematol 93 1996 783 788
66. Nagata Y Shozaki Y Nagahisa H Serum thrombopoietin level is not regulated by transcription but by the total counts of both megakaryocytes and platelets during thrombocytopenia and thrombocytosis Thromb Haemost 77 1997 808 814
67. Fielder PJ Gurney AL Stenfanich E Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets Blood 87 1996 2154 2161
68. Sato T Fuse A Nhmi H Binding and regulation of thrombopoietin to human platelets Br J Haematol 100 1998 704 711
69. Takeshita A Shinjo K Naito K Amount of mpl on bone marrow haemopoietic precursor cells from healthy volunteers and patients with refractory anaemia Br J Haematol 99 1997 746 755
70. Broudy VC Lin NL Sabath DF Human platelets display high-affinity receptors for thrombopoietin Blood 89 1997 1896 1904
71. Murray NA Watts TL Roberts IAG Endogenous thrombopoietin levels and effect of recombinant human thrombopoietin on megakaryocyte precursors in term and preterm babies Pediatr Res 43 1998 148 151
72. Watts TL, Murray NA, Roberts IAG. Evidence for impaired thrombpoietin production in preterm babies with early thrombocytopenia. (in press).
73. Grossmann A Lenox J Ren H-P Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice Exp Hematol 24 1996 1238 1246
74. Akahori H Shibuya K Obuchi M Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia Br J Haematol 94 1996 722 728
75. Harker LA Marzec UM Kelly AB Prevention of thrombocytopenia and neutropenia in a nonhuman primate model of marrow suppressive chemotherapy by combined pegylated recombinant human megakaryocyte growth and development factor and recombinant human granulocyte colony-stimulating factor Blood 89 1997 155 165
76. Neelis KJ Qingliang L Thomas GR Prevention of thrombocytopenia by thrombopoietin in myelosuppressed rhesus monkeys accompanied by prominent erythropoietic stimulation and iron depletion Blood 90 1997 58 63
77. Basser RL Rasko JE Clarke K Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer Lancet 348 1996 1279 1281
78. Vadhan-Raj S Murray LJ Bueso-Ramos C Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer Ann Intern Med 126 1997 673 681
79. O'Malley CJ Rasko JE Basser RL Administration of pegylated human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation Blood 88 1996 3288 3298
80. Fanucchi M Glaspy J Crawford J Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer N Engl J Med 336 1997 404 409