Receptor inhibition of pheromone signaling is mediated by the Ste4p G(β) subunit

Molecular and Cellular Biology

Volumn 19, Issue 1, 1999, Pages 441-449

  Kim, Jinah ^a   Couve, Andrés ^a,b   Hirsch, Jeanne P ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; HORMONE RECEPTOR; MATING HORMONE ALPHA FACTOR; PHEROMONE;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; BINDING COMPETITION; CONFORMATIONAL TRANSITION; GENE DELETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR AFFINITY; RECEPTOR BINDING; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE;

SACCHAROMYCES CEREVISIAE;

EID: 0032962538     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.19.1.441     Document Type: Article

References (38)

1. Bender, A., and G. F. Sprague, Jr. 1989. Pheromones and pheromone receptors are the primary determinants of mating specificity in the yeast Saccharomyces cerevisiae. Genetics 121:463-476.
2. Caplan, A. J., D. M. Cyr, and M. G. Douglas. 1992. YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism. Cell 71:1143-1155.
3. Chang, F., and I. Herskowitz. 1990. Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2. Cell 63:999-1011.
4. Clapham, D. E., and E. J. Neer. 1997. G protein βγ subunits. Annu. Rev. Pharmacol. Toxicol. 37:167-203.
5. Clark, K. L., D. Dignard, D. Y. Thomas, and M. Whiteway. 1993. Interactions among the subunits of the G protein involved in Saccharomyces cerevisiae mating. Mol. Cell. Biol. 13:1-8.
6. 1 arrest response in cells expressing an inappropriate pheromone receptor. Mol. Cell. Biol. 16:4478-4485.
7. Cross, F. R. 1990. The DAF2-2 mutation, a dominant inhibitor of the STE4 step in the α-factor signalling pathway of Saccharomyces cerevisiae MATa cells. Genetics 126:301-308.
8. Cross, F. R. 1997. 'Marker swap' plasmids: convenient tools for budding yeast molecular genetics. Yeast 13:647-653.
9. Cross, F. R., and A. H. Tinkelenberg. 1991. A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle. Cell 65:875-883.
10. Dietzel, C., and J. Kurjan. 1987. The yeast SCG1 gene: a Gα-like protein implicated in the a- and α-factor response pathway. Cell 50:1001-1010.
11. Gietz, R. D., and A. Sugino. 1988. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74:527-534.
12. Heithier, H., M. Fröhlich, C. Dees, M. Baumann, M. Häring, P. Gierschik, E. Schiltz, W. L. C. Vaz, M. Hekman, and E. J. M. Helmreich. 1992. Subunit interactions of GTP-binding proteins. Eur. J. Biochem. 204:1169-1181.
13. Herskowitz, I. 1995. MAP kinase pathways in yeast: for mating and more. Cell 80:187-197.
14. Hirsch, J. P., and F. R. Cross. 1993. The pheromone receptors inhibit the pheromone response pathway in Saccharomyces cerevisiae by a process that is independent of their associated Gα protein. Genetics 135:943-953.
15. Inouye, C., N. Dhillon, and J. Thorner. 1997. Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling. Science 278: 103-106.
16. Ito, H., Y. Fukuda, K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells with alkali cations. J. Bacteriol. 153:163-168.
17. Kim, J., A. Couve, and J. P. Hirsch. Unpublished data.
18. Kim, J., H. Zhong, A. Vershon, and J. P. Hirsch. Unpublished data.
19. Lambright, D. G., J. Sondek, A. Bohm, N. P. Skiba, H. E. Hamm, and P. B. Sigler. 1996. The 2.0 Å crystal structure of a heterotrimeric G protein. Nature 379:311-319.
20. Leberer, E., D. Y. Thomas, and M. Whiteway. 1997. Pheromone signalling and polarized morphogenesis in yeast. Curr. Opin. Genet. Dev. 7:59-66.
21. Leeuw, T., C. Wu, J. D. Schrag, M. Whiteway, D. Y. Thomas, and E. Leberer. 1998. Interaction of a G-protein β-subunit with a conserved sequence in Ste20/PAK family protein kinases. Nature 391:191-195.
22. Lehrach, H., D. Diamond, J. M. Wozney, and H. Boedtker. 1977. RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. Biochemistry 16:4743-4751.
23. β protein of Saccharomyces cerevisiae confer a defect in recovery from pheromone treatment. Genetics 148:947-961.
24. Ma, H., S. Kunes, P. J. Schatz, and D. Botstein. 1987. Plasmid construction by homologous recombination in yeast. Gene 58:201-216.
25. 1 arrest. Mol. Cell. Biol. 11:1030-1039.
26. McCaffrey, G., F. J. Clay, K. Kelsay, and G. F. Sprague, Jr. 1987. Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 7:2680-2690.
27. Peter, M., A. Gartner, J. Horecka, G. Ammerer, and I. Herskowitz. 1993. FAR1 links the signal transduction pathway to the cell cycle machinery in yeast. Cell 73:747-760.
28. Peter, M., and I. Herskowitz. 1994. Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Farl. Science 265:1228-1231.
29. Phillips, W. J., and R. A. Cerione. 1992. Rhodopsin/transducin interactions. I. Characterization of the binding of the transducin-βγ subunit complex to rhodopsin using fluorescence spectroscopy. J. Biol. Chem. 267:17032-17039.
30. Sherman, F., G. R. Fink, and J. B. Hicks. 1989. Laboratory course manual for methods in yeast genetics. Cold Spring Harbor Laboratory. Plainview. N.Y.
31. A protein βγ dimer at 2.1 Å resolution. Nature 379:369-374.
32. Sprague, G. F., Jr. 1990. Combinatorial associations of regulatory proteins and the control of cell type in yeast. Adv. Genet. 27:33-63.
33. Sprague, G. F., Jr., and J. W. Thorner. 1992. Pheromone response and signal transduction during the mating process of Saccharomyces cerevisiae, p. 657-744. In E. W. Jones, J. R. Pringle, and J. R. Broach (ed.), The molecular and cellular biology of the yeast Saccharomyces: gene expression. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
34. Taylor, J. M., G. G. Jacob-Mosier, R. G. Lawton, M. VanDort, and R. R. Nenbig. 1996. Receptor and membrane interaction sites on Gβ. J. Biol. Chem. 271:3336-3339.
35. 1γ2. Cell 83:1047-1058.
36. Whiteway, M., K. L. Clark, E. Leberer, D. Dignard, and D. Y. Thomas. 1994. Genetic identification of residues involved in association of α and β G-protein subunits. Mol. Cell. Biol. 14:3223-3229.
37. Whiteway, M. S., C. Wu, T. Leeuw, K. Clark, A. Fourest-Lieuvin, D. Y. Thomas, and E. Leberer. 1995. Association of the yeast pheromone response G protein βγ subunits with the MAP kinase scaffold Ste5p. Science 269: 1572-1575.
38. Yashar, B., K. Irie, J. A. Printen, B. J. Stevenson, G. F. Sprague, Jr., K. Matsumoto, and B. Errede. 1995. Yeast MEK-dependent signal transduction: response thresholds and parameters affecting fidelity. Mol. Cell. Biol. 15:6545-6553.