ETV6-AML1 translocation breakpoints cluster near a purine/pyrimidine repeat region in the ETV6 gene

Blood

Volumn 93, Issue 1, 1999, Pages 293-299

  Thandla, Srinivas P ^b   Ploski, Jonathan E ^b   Raza Egilmez, Samina Z ^b   Chhalliyil, Pradheepkumar P ^b   Block, AnneMarie W ^b   De Jong, Pieter J ^b   Aplan, Peter D ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; PURINE; PYRIMIDINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CHILD; CHROMOSOME 12; CHROMOSOME 13; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA RECOMBINATION; EXON; GENE CLUSTER; GENE FUSION; GENE INSERTION; GENE MAPPING; GENE REARRANGEMENT; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

EID: 0032960839     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.1.293     Document Type: Article

References (39)

1. Rabbitts TH: Chromosomal translocations in human cancer. Nature 372:143, 1994
2. Cline MJ: The molecular basis of leukemia. N Engl J Med 330:328, 1994
3. Thandla S, Apian PD: Molecular biology of acute lymphocytic leukemia. Semin Oncol 24:45, 1997
4. Campana D, Pui C-H: Detection of minimal residual disease in acute leukemia. Methodologic advances and clinical significance. Blood 85:1416, 1995
5. Rubnitz JE, Downing JR, Pui C, Shurtleff SA, Raimondi SC, Evans WE, Head DR, Crist WM, Rivera GK, Hancock ML, Boyett JM, Buijs A, Grosveld G, Behm FG: TEL gene rearrangement in acute lymphoblastic leukemia: A new genetic marker with prognostic significance. J Clin Oncol 15:1150, 1997
6. Rubnitz JE, Shuster JJ, Land VJ, Link MP, Pullen DJ, Camitta BM, Pui C, Downing JR, Behm FG: Case-control study suggests a favorable impact of TEL rearrangement in patients treated with antimetabolite-based therapy: A Pediatric Oncology Group study. Blood 89:1143, 1997
7. Golub TR, Barker GF, Lovett M, Gilliland DG: Fusion of PDGFR receptor beta to a novel ets-like gene. TEL, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307, 1994
8. Raynaud SD, Baens M, Grosgeorge J, Rodgers K, Reid CDL, Dainton M, Dyer M, Fuzibet JG, Gratecos N, Taillan B, Ayraud N, Marynen P: Fluorescence in situ hybridization analysis of t(3;12)(q26; p13): A recurring chromosomal abnormality involving the TEL gene (ETV6) in myelodysplastic syndromes. Blood 88:682, 1996
9. Peeters P, Wlodarska I, Baens M, Criel A, Selleslag D, Hagemeijer A, Van der Berghe H, Marynen P: Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders. Cancer Res 57:564, 1997
10. Papadopoulos P, Ridge SA, Boucher CA, Stocking C, Wiedemann LM: The novel activation of ABL by fusion to an ets-related gene, TEL. Cancer Res 55:34, 1995
11. Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, van Kessel AG, Riegman P, Deprez RL, Zwarthoft E, Hagemeijer A, Grosveld G: Translocation (12;22)(p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. Oncogene 10:1511, 1995
12. Golub TR, Barker FG, Bohlander SK, Heibert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 92:4917, 1995
13. Romana SP, Le Coniat M, Berger R: t(12;21): A new recurrent translocation in acute lymphoblastic leukemia. Genes Chromosomes Cancer 9:186, 1994
14. Romana SP, Mauchauffe M, Le Coniat M, Chumakov I, Le Paslier D, Berger R, Bernard OA: The t(12;21) of acute lymphoblastic leukemia results in a TEL-AML1 gene fusion. Blood 85:3662, 1995
15. Raimondi SC, Shurtleff SA, Downing JR, Rubnitz J, Mathew S, Hancock M, Pui C-H, Rivera GK, Grosveld GC, Behm FG: 12 p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia. Blood 90:4559, 1997
16. Kobayashi H, Satake N, Maseki N, Sakashita A, Kaneko Y: The der(21)t(12;21) chromosome is always formed in a 12;21 translocation associated with childhood acute lymphoblastic leukemia. Br J Haematol 94:105, 1996
17. Miyoshi H, Ohira M, Shimizu K, Mitani K, Hirai H, Imai T, Yokoyama K, Soeda E, Ohki M: Alternative splicing and genomic structure of the AMLI gene involved in acute myeloid leukemia. Nucleic Acids Res 23:2762, 1995
18. Romana SP, Poirel H, Leconiat M, Flexor M-A, Mauchaffe M, Jonveaux P, Macintyre EA, Berger R, Bernard OA: High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia. Blood 86:4263, 1995
19. Raynaud S, Cave H, Baens M, Bastard C, Cacheux V, Grosgeorge J, Guidal-Giroux C, Guo C, Vilmer E, Marynen P, Grandchamp B: The 12:21 translocation involving TEL and deletion of the other TEL allele: Two frequently associated alterations found in childhood acute lymphoblastic leukemia. Blood 87:2891, 1996
20. Aplan PD, Lombardi DP, Ginsberg AM, Cossman J, Bertness VL Kirsch IR: Disruption of the human SCL locus by "illegitimate" V(D)J recombinase activity. Science 250:1426, 1990
21. Tycko B, Sklar J: Chromosomal translocations in lymphoid neoplasia: A reappraisal of the recombinase model. Cancer Cells 2:1, 1990
22. Strout MP, Marcucci G, Bloomfield CD, Caligiuri MA: The partial tandem duplication of ALL1(MLL) is consistently generated by Alu-mediated homologous recombination in acute myeloid leukemia. Proc Natl Acad Sci USA 95:2390, 1998
23. Maraschin J, Dutrillaux B, Aurias A: Chromosome aberrations induced by etoposide (VP-16) are not random. Int J Cancer 46:808, 1990
24. Boehm T, Mengle-Gaw L, Kees U.R, Spurr N, Lavenir I, Forster A, Rabbitts TH: Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumors. EMBO J 8:2621, 1989
25. Fitzgerald TJ, Neale GAM, Raimondi SC, Goorha RM: c-tal, a helix-loop-helix protein is juxtaposed to the T cell receptor-b chain gene by a reciprocal chromosomal translocation: t(1;7)(p32;q35). Blood 78:2686, 1991
26. Aplan PD, Raimondi SC, Kirsch IR: Disruption of the SCL gene by a 1(1;3) translocation in a patient with T cell acute lymphoblastic leukemia. J Exp Med 176:1303, 1992
27. Ford AM, Bennett CA, Price CM, Bruin MCA, Van Wering ER, Greaves M: Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia. Proc Natl Acad Sci USA 95:4584, 1998
28. Bernard OA, Romana SP, Poirel H, Berger R: Molecular cytogenetics of t(12;21)(p13;q22). Leuk Lymphoma 23:459, 1996
29. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215, 1988
30. Davis LG, Dibner MD, Battey JF: Basic Methods in Molecular Biology. New York, NY, Elsevier, 1986
31. Stanulla M, Wang J, Chervinsky DS, Thandla S, Aplan PD: DNA Cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher order chromatin fragmentation during the initial stages of apoptosis. Mol Cell Biol 17:4070, 1997
32. Ioannau PA, de Jong PJ: Preparation of PAC clones using pCYPAC vector, in Dracopoli NC, Haines JL, Korf BR, Moir DT, Morton CC, Seidman CE, Seidman JG, Smith DR, Boyle AL (eds): Current Protocols in Human Genetics, vol 1. New York, NY, Wiley, 1994, p 5.15.2
33. Ioannau PA, de Jong PJ: Modified alkaline lysis miniprep for recovery of DNA from PAC clones, in Dracopoli NC, Haines JL, Korf BR, Moir DT, Morton CC, Seidman CE, Seidman JG, Smith DR, Boyle AL (eds): Current Protocols in Human Genetics, vol 1. New York, NY, Wiley, 1994, p 5.15.15
34. Borkhardt A, Cazzaniga G, Viehmann S, Valsecchi MG, Ludwig WD, Burci L, Mangioni S, Schrappe M, Riehm H, Lampert F, Basso G, Masera G, Harbott J, Biondi A: Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Blood 90:571, 1997
35. Baens M, Peeters P, Guo C, Aerssens J, Marynen P: Genomic organisation of TEL: The human ETS-variant gene 6. Genome Res 6:404, 1996
36. Cullen M, Noble J, Erlich H, Thorpe K, Beck S, Klitz W, Trowsdale J, Carrington M: Characterization of recombination in the HLA Class II region. Am J Hum Genet 60:397, 1997
37. n repetitive tracts affect several stages of Rec A-promoted recombination. J Mol Biol 273:105, 1997
38. Hackman P, Gabbani G, Osterholm AM, Hellgren D, Lambert B: Spontaneous length variation in microsatellite DNA from human T-cell clones. Genes Chromosomes Cancer 14:215, 1995
39. Samadashwily GM, Raca G, Mirkin SM: Trinucleotide repeats affect DNA replication in vivo. Nat Genet 17:298, 1997