Bcl-2 protein expression in breast cancer in relation to established prognostic factors and other clinicopathological variables

Annals of Oncology

Volumn 6, Issue 10, 1995, Pages 1005-1010

  Binder, C ^a   Marx, D ^a   Overhoff, R ^a   Binder, L ^b   Schauer, A ^a   Hiddemann, W ^a  

^a Department of Haematology/Oncology ^*  (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Bcl 2; Breast cancer; Immunohistochemistry; Prognostic factors

Indexed keywords

PROTEIN BCL 2;

ADULT; AGED; ARTICLE; BREAST CANCER; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS;

BREAST NEOPLASMS; FEMALE; HUMANS; NEOPLASM STAGING; PROGNOSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE;

EID: 0029582891     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.annonc.a059064     Document Type: Article

References (35)

1. Z.N. Oltvai C.L. Milliman S.J. Korsmeyer Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death Cell 74 1993 609 619
2. L.H. Boise M. Gonzalez-Garcia C.E. Postema Bcl-X, a bcl-2 -related gene that functions as a dominant regulator of apoptotic cell death Cell 74 1993 597 608
3. 1 and Bcl-2, displaces Bax and promotes cell death Cell 80 1995 285 291
4. K.M. Kozopas T. Yang H.L. Buchan mcl1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to bcl2 Proc Nad Acad Sci USA 90 1993 3516 3520
5. S. Takayama T. Sato S. Krajewski Cloning and functional analysis of Bag-1: A novel Bcl-2 binding protein with anti-cell-death activity Cell 80 1995 279 284
6. D.J. Kane ThA Sarafian R. Anton Bcl-2 inhibition of neural death: Decreased Generation of reactive oxygen species Science 262 1993 1274 1277
7. A. Benito D. Grillot G. Nunez Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells Am J Pathol 146 1995 481 490
8. B. Nathan R. Anbazhagan P. Clarkson Expression of Bcl-2 in the developing human featal and infant breast Histopathology 24 1994 73 76
9. X.H. Liang S. Mungal A. Ayscue Bcl-2 protooncogene expression in cervical carcinoma cell lines containing inactive p53 J Cell Biochem 5 1995 509 521
10. A. Sierra B. Lloveras X. Castellsagué Bcl-2 expression is associated with lymph node metastasis in human ductal breast carcinoma Int J Cancer 60 1995 54 60
11. R.D. Leek L. Kaklamanis F. Pezzella bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor-receptor-negative tumors and in situ cancer Br J Cancer 69 1994 135 139
12. S.R. Johnston K.A. MacLennan N.P. Sach Modulation of Bcl-2 and Ki-67 expression in oestrogen receptor-positive human breast cancer by tamoxifen Eur J Cancer 30A 1994 1663 1669
13. C. Doglioni A.P. DeiTos L. Laurino The prevalence of Bcl-2 immunoreactivity in breast carcinomas and its clinicopathological correlates, with particular reference to oestrogen receptor status Virchows Arch 424 1994 47 51
14. R. Silvestrini S. Veneroni M.G. Daidone The Bcl-2 protein: A prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients J Natl Cancer Inst 86 1994 499 504
15. B. Nathan B. Gusterson D. Jadayel Expression of Bcl-2 in primary breast cancer and its correlation with tumor phenotype Ann Oncol 5 1994 409 414
16. H. Joenssu L. Pylkkänen S. Toikkanen Bcl-2 protein expression and long-term survival in breast cancer Am J Pathol 145 1994 1191 1198
17. J. Gee J. Robertson I. Ellis Immunocytochemical localization of Bcl-2 protein in human breast cancers and its relationship to a series of prognsotic markers and response to endocrine therapy Int J Cancer 59 1994 619 628
18. H.J.G. Bloom W.W. Richardson Histologic grading and prognosis in breast cancer Br J Cancer 11 1957 359 377
19. H. Meden D. Marx T. Raab EGF-R and overexpression of the oncogene c-erbB-2 in ovarian cancer: Immunohistochemical findings and prognostic value J Obstet. Gynaecol 21 1995 167 178
20. D. Marx A. Schauer C. Reiche C-erbB-2-expression in correlation to other biological parameters of breast cancer J Cancer Res Clin Oncol 116 1990 15 20
21. S. Krajewski M. Krajewska A. Shabaik Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2 Am J Pathol 145 1994 1323 1336
22. S. Krajewski M. Krajewska A. Shabaik Immunohistochemical analysis of in vivo patterns of Bcl-X expression Cancer Res 54 1994 5501 5507
23. A. Fanidi E.A. Harrington G.I. Evan Co-operative interaction between c-myc and bcl-2 -protooncogenes Nature 359 1993 554 556
24. T. Miyashita M. Harigai M. Hanada Identification of a p53-dependent negative response element in the bcl-2 gene Cancer Res; 54 1994 3131 3135
25. T. Miyashita J. Reed Tumor suppressor p53 is a direct transcriptional activator of the human bax gene Cell 80 1995 293 299
26. D.M. Hockenbery Z.N. Oltvai X-M Yin Bcl-2 functions in an antioxidant pathway to prevent aopoptosis Cell 75 1993 241 251
27. G.A.C. Murrell M.J.O. Francis L. Bromley Modulation of fibroblast proliferation by oxygen free radicals Biochem J 265 1990 659 665
28. Y. Sun L.W. Oberley T.D. Oberley Lowered antioxidant enzymes in spontaneously transformed embryonic mouse liver cells in culture Carcinogenesis 14 1993 1457 1463
29. J.A. Pietenpol N. Papadopoulos S. Markowitz Paradoxical inhibition of solud id tumor cell growth by Bcl-2 Cancer Res 54 1994 3714 3717
30. T. Rajkumar W.J. Gullick A monoclonal antibody ofto the human c-erbB-3 protein stimulates the anchorage-independent growth of breast cancer cell lines Br J Cancer 70 1994 459 465
31. S.A. Prigent N.R. Lemoine C.M. Hughes Expression of the c-erbB-3 protein in normal ahuman adult and fetal tissues Oncogene 7 1992 1273 1278
32. N.R. Lemoine D.M. Barnes D.P. Hollywood Expression of the erbB-23 gene product in breast cancer Br J Cancer 66 1992 1116 1121
33. C.M. Quinn J.L. Ostrowski S.A. Lane c-erbB-3 protein expression in human breast cancer: comparison with other tumour variables and survival Histopathology 25 1994 247 252
34. B.J.B. Simpson J. Weatherill A.M. Lessells c-erbB-3 protein expression in ovarian tumours Br J Cancer 71 1995 758 762
35. D. Marx A. Schauer Expression of the c-erbB oncoproteins in breast cancer J Cancer Res Clin Oncol 120 1994 R2