TIMP expression in toxic and cholestatic liver injury in rat

Journal of Hepatology

Volumn 27, Issue 3, 1997, Pages 535-544

  Roeb, Elke ^a   Purucker, Edmund ^a   Breuer, Bettina ^a   Nguyen, Huan ^a   Heinrich, Peter C ^a   Rose John, Stefan ^b   Matern, Siegfried ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Cholestasis; Fibrosis; Haptoglobin; Liver; Matrix homeostasis; Rat; TIMP

Indexed keywords

COLLAGENASE; HAPTOGLOBIN; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INVASION; CHOLESTASIS; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; GLYCOSYLATION; HOMEOSTASIS; LIVER FIBROSIS; LIVER INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

EID: 0030815132     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(97)80359-5     Document Type: Article

References (47)

1. Birkedal-Hansen H, Werb Z, Welgus Z, Van Wart H. Matrix Metalloproteinases and Inhibitors. 1992;Gustav Fischer Verlag, New York.
2. Denhardt DT, Feng B, Edwards DR, Cocuzzi ET, Malyankar UM. Tissue inhibitor of metalloproteinases (TIMP, aka TPA): structure, control of expression and biological functions. Pharmacol Ther. 59:1993;329-341.
3. Roeb E, Rose-John S, Erren A, Edwards DR, Matern S, Graeve L, et al. Tissue inhibitor of metalloproteinases-2 (TIMP-2) in rat liver cells is increased by lipopolysaccharide and prostaglandin E2. FEBS Lett. 357:1995;33-36.
4. Ray JM, Stetler-Stevenson WG. TIMP-2 expression modulates human melanoma cell adhesion and motility. Inhibition of Matrix Metalloproteinases. 732:1994;233-247 Ann NY Acad Sci.
5. Staskus PW, Masiarz FR, Pallanck LJ, Hawkes SP. The 21-kDa protein is a transformation-sensitive metalloproteinase inhibitor of chicken fibroblasts. J Biol Chem. 264:1991;17374-17378.
6. Greene J, Wang M, Liu YE, Raymond LA, Rosen C, Shi YE. Molecular cloning and characterization of human tissue inhibitor of metalloproteinases, 4. J Biol Chem. 271:1996;30375-30380.
7. Carome MA, Striker LJ, Peten EP, Moore J, Yang CW, Stetler-Stevenson WG, et al. Human glomeruli express TIMP-1 mRNA and TIMP-2 protein and mRNA. Am J Physiol. 264:1993;923-929.
8. Kossakowska AE, Urbanski SJ, Huchcroft SA, Edwards DR. Relationship between the clinical aggressiveness of large cell immunoblastic lymphomas and expression of 92 kDa gelatinase (type IV collagenase) and tissue inhibitor of metalloproteinases-1 (TIMP-1) RNAs. Oncol Res. 4:1992;233.
9. Kossakowska AE, Urbanski SJ, Huchcroft SA, Edwards DR. Relationship between the clinical aggressiveness of large cell immunoblastic lymphomas and expression of 92 kDa gelatinase (type IV collagenase) and tissue inhibitor of metalloproteinases-1 (TMP-1) RNAs. Oncol Res. 233:1992;233-240.
10. Ponton A, Coulombe B, Skup D. Decreased expression of tissue inhibitor of metalloproteinases in metastatic tumor cells leading to increased levels of collagenase activity. Cancer Res. 51:1991;2138-2143.
11. Brophy CM, Marks WH, Reilly JM, Tilson MD. Tissue inhibitor of metalloproteinases (TIMP) is matrix associated in aortic tissue: report of a radioimmunoassay. Biochem Biophys Res Commun. 167:1990;898-903.
12. Stetler-Stevenson WG, Aznavoorian GS, Liotta LA. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Ann Rev Cell Biol. 9:1993;541-573.
13. Kirk TZ, Mark ME, Chua CC, Chua BH, Mayes MD. Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloproteinase (TIMP-1) with two forms of TIMP-1. J Biol Chem. 270:1995;3423-3428.
14. Arthur MJ. Collagenases and liver fibrosis. J Hepatol. 22:1995;43-48.
15. Murawaki Y, Kawasaki H, Burkhardt H. Serum collagenase activity in chronic liver diseases. Pathol Res Pract. 190:1994;929-933.
16. Roeb E, Graeve L, Hoffmann R, Decker K, Ewards DR, Heinrich PC. Regulation of tissue inhibitor of metalloproteinase-1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures. Hepatology. 18:1993;1437-1442.
17. Kordula T, Gütgemann I, Rose-John S, Roeb E, Osthues A, Tschesche H, et al. Synthesis of tissue inhibitor of metalloproteinases-1 (TIMP-1) in human hepatoma cells (HepG2): upregulation by interleukin-6 and transforming growth factor β FEBS Lett. 313:1992;143-147.
18. Edwards DR, Waterhouse P, Holman ML, Denhardt DT. A growth-responsive gene (16C8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity: evidence for inducible and constitutive transcripts. Nucleic Acids Res. 14:1986;8863-8878.
19. Leco KJ, Hayden LJ, Sharma RR, Rocheleau H, Greenberg AH, Edwards DR. Differential regulation of TIMP-1 and TIMP-2 mRNA expression in normal Ha-ras transformed murine fibroblasts. Gene. 117:1992;209-217.
20. Leco KJ, Khokha R, Pavloff N, Hawkes SP, Edwards DR. Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. J Biol Chem. 269:1994;9352-9360.
21. Ramadori G, Neubauer K, Odenthal M, Nakamura T, Knittel T, Schwogler S, et al. The gene of hepatocyte growth factor is expressed in fat-storing cells of rat liver and is downregulated during cell growth and by transforming growth factor-beta. Biochem Biophys Res Commun. 183:1992;739-742.
22. Bolt MJ, Sitrin MD, Favus MJ, Rosenberg JH. Hepatic vitamin D 25-hydroxylase: inhibition by bile duct ligation or bile salt. Hepatology. 1:1981;436-440.
23. Scherrer K, Darnell JE. Sedimentation characteristics of rapidly labelled RNA from HeLa cells. Biochem Biophys Res Commun. 7:1962;486-490.
24. Rose-John S, Dietrich A, Marks F. Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts. Gene. 74:1988;465-471.
25. Feinberg AP, Vogelstein B. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem. 132:1983;6-13.
26. Wilkinson DG. In situ Hybridization. A Practical Approach. 1992;Oxford University Press, Oxford.
27. Arthur MJ. Degradation of matrix proteins in liver fibrosis. Pathol Res Pract. 190:1994;825-833.
28. Baumann H, Prowse KR, Marinkovic S, Vonn K-A, Jahreis GP. Stimulation of hepatic acute-phase response by cytokines and glucocorticoids. Ann NY Acad Sci. 557:1989;280-295.
29. Roeb E, Graeve L, Müllberg J, Matern S, Rose-John S. TIMP-1 protein expression is stimulated by IL-1β and IL-6 in primary rat hepatocytes. FEBS Lett. 349:1994;45-49.
30. Iredale JP, Murphy G, Hembry RM, Friedman SL, Arthur MJP. Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinase-1: implications for regulation of matrix degradation in liver. J Clin Invest. 90:1992;282-287.
31. Kurschat P, Graeve L, Erren A, Gatsios P, Rose-John S, Roeb E, et al. Expression of a biologically active murine tissue inhibitor of metalloproteinases-1 (TIMP-1) in baculovirus-infected insect cells. Purification and tissue distribution in the rat. Eur J Biochem. 254:1995;1096-1102.
32. Iredale JP, Benyon RC, Arthur MJP, Ferris WF, Alcolado R, Winwood PJ, et al. Tissue inhibitor of metalloproteinases-1 mRNA expression is enhanced relative to interstitial collagenase mRNA in experimental liver injury and fibrosis. Hepatology. 24:1996;176-184.
33. Burt AD. Cellular and molecular aspects of hepatic fibrosis. J Pathol. 170:1993;105-114.
34. Murawaki Y, Yamamoto H, Kawasaki H, Shima H. Serum tissue inhibitor of metalloproteinases in patients with chronic liver disease and with hepatocellular carcinoma. Clin Chim Acta. 218:1993;47-58.
35. Muzzillo DA, Imoto M, Fukuda Y, Koyama Y, Saga S, Nagai Y, et al. Clinical evaluation of serum tissue inhibitor of metalloproteinases-1 levels in patients with liver diseases. J Gastroenterol Hepatol. 8:1993;437-441.
36. Eddy AA, Giachelli CM. Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria. Kidney Int. 47:1995;1546-1557.
37. Sharma AK, Mauer SM, Kim Y, Michael AFSO. Altered expression of matrix metalloproteinase-2, TIMP, and TIMP-2 in obstructive nephropathy. J Lab Clin Med. 125:1995;754-761.
38. Bou-Gharios G, Osman J, Black C, Olsen I. Excess matrix accumulation in scleroderma is caused partly by differential regulation of stromelysin and TIMP-1 synthesis. Clin Chim Acta. 231:1991;69-78.
39. Gress TM, Muller-Pillasch F, Lerch MM, Friess H, Buchler M, Beger HG, et al. Balance of expression of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in chronic pancreatitis. Z Gastroenterol. 32:1994;221-225.
40. Fukuda Y, Imoto M, Koyama Y, Miyazawa Y, Nakano I, Hattori M, et al. Immunohistochemical study on tissue inhibitors of metalloproteinases in normal and pathological human livers. Gastroenterol Jpn. 26:1991;37-41.
41. Lindsay CK, Thorgeirsson UP. Localization of messenger RNA for tissue inhibitor of metalloproteinases-1 and type IV collagenases/gelatinases in monkey hepatocellular carcinomas. Clin Exp Metastasis. 13:1995;381-388.
42. Böker KHW, Albrecht K, Karbäkhsh-Ravari B, Büttner J, Manns MP, Lichtinghagen R. Expression of metalloproteinase-inhibitors TIMP-1, -2, and -3 in normal and fibrotic human liver. Hepatology. 22:1995;370A.
43. Friedman SL. The cellular basis of hepatic fibrosis: Mechanisms and treatment strategies. N Engl J Med. 328:1993;1828-1835.
44. Milani S, Herbst H, Schuppan D, Grappone C, Pellegrini G, Pinzani M, et al. Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am J Pathol. 144:1994;528-537.
45. Phillips B, Lee SS, Zhang Y, Kossakowska AE, Urbanski SJ. Expression of metalloproteinases and their inhibitors (TIMPs) in bile duct-ligated rates. Hepatology. 22:1995;370A.
46. Apte SS, Hayashi K, Seldin MF, Mattei MG, Hayashi M, Olsen BR. Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10. Dev Dyn. 200:1994;177-197.
47. Uria JA, Ferrando AA, Velasco G, Freije JM, Lopez-Otin C. Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family. Cancer Res. 54:1994;2091-2094.