Exercise training and substrate utilisation in obesity

International Journal of Obesity

Volumn 23, Issue , 1999, Pages S11-S17

  van Baak, Marleen A ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Exercise training; Fat oxidation; Lipolysis; Obesity

Indexed keywords

FATTY ACID;

CONFERENCE PAPER; CONTROLLED STUDY; DIET; ENERGY BALANCE; EXERCISE; FATTY ACID TRANSPORT; GLUCOSE METABOLISM; HUMAN; LIPID METABOLISM; LUNG GAS EXCHANGE; OBESITY; OXIDATION; PRIORITY JOURNAL; WEIGHT REDUCTION;

ADIPOSE TISSUE; ENERGY METABOLISM; EXERCISE; FATTY ACIDS; FEMALE; GLUCOSE; HUMANS; LIPID METABOLISM; LIPOLYSIS; MALE; OBESITY; OXIDATION-REDUCTION; OXYGEN CONSUMPTION;

EID: 0032950947     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800879     Document Type: Article

References (87)

1. Council on Scientific Affairs of the American Medical Association. Treatment of obesity in adults. JAMA 1988; 260: 2547-2551.
2. Wilmore JH. Variations in physical activity habits and body composition. Int J Obes 1995; 19 (Suppl 4): S107-S112.
3. Garrow JS, Summerbell CD. Meta-analysis: effect of exercise, with or without dieting, on the body composition of overweight subjects. Eur J Clin Nutr 1995; 49: 1-10.
4. Ballor DL, Keesey RE. A meta-analysis of the factors affecting exercise-induced changes in body mass, fat mass and fat-free mass in males and females. Int J Obes 1991; 15: 717-726.
5. van Dale D, Saris WHM, ten Hoor F. Weight maintenance and resting metabolic rate 18-40 months after a diet-exercise treatment. Int J Obes 1990; 14: 347-359.
6. Kayman S, Bruvold W, Stern JS. Maintenance and relapse after weight loss in women: behavioral aspects. Am J Clin Nutr1990; 52: 800-807.
7. Hensrud DD, Weinsier RL, Darnell BE, Hunter GR. Relationship of co-morbidities of obesity to weight loss and four-year weight maintenance/rebound. Obes Res 1995; 3 (Suppl 2): S217-S222.
8. Pavlou KN, Krey S, Steffee W. Exercise as an adjunct to weight loss and maintenance in moderately obese subjects. Am J Clin Nutr 1989; 49: 1115-1123.
9. Kempen KPG. Metabolic effects weight cycling in obesity. Thesis Maastricht University, 1996.
10. Pasman WJ. Obesity treatment and weight maintenance. Thesis Maastricht University, 1998.
11. Bogardus C, Ravussin E, Robbins DC, Wolfe RR, Horton ES, Sims EAH. Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin dependent diabetes. Diabetes 1984; 33: 311-318.
12. Krotkiewski M, Lonnroth P, Mandroukas K, Wroblewski Z, Rebuffe-Scrive M, Holm G, Smith U, Bjorntorp P. The effects of physical training on insulin secretion and effectiveness and on glucose metabolism in obesity and type 2 (non-insulin dependent) diabetes mellitus. Diabetologia 1985; 28: 881-890.
13. Lamarche B, Despres JP, Pouliot MC, Moorjani S, Lupien PJ, Theriault G, Tremblay A, Nadeau A, Bouchard C. Is body fat loss a determinant factor in the improvement of carbohydrate and lipid metabolism following aerobic exercise training in obese women? Metabolism 1992; 41: 1249-1256.
14. Fagard RH. Prescription and results of physical activity. J Cardiovasc Pharmacol 1995; 25 (Suppl 1): S20-S27.
15. Williams PT, Krauss RM, Vranizan KM, Wood PD. Changes in lipoprotein subfractions during diet-induced and exercise-induced weight loss in moderately overweight men. Circulation 1990; 81: 1293-1304.
16. Wood PD, Stefanick ML, Dreon DM, Frey-Hewitt B, Garay SC, Williams PT, Superko HR, Fortmann SP, Albers JJ, Vranizan KM, Ellsworth NM, Terry RB, Haskell WL. Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise. New Engl J Med 1988; 319: 1173-1179.
17. Brownell KD. Exercise and obesity treatment: Psychological aspects. Int JObes 1995; 19 (Suppl 4): S122-S125.
18. Blair SN, Kampert JB, Kohl HW, Barlow CE, Macera CA, Paffenbarger RS, Gibbons LW. Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and allcause mortality in men and women. J Am Med Assoc 1996; 276: 205-210.
19. Fletcher GF, Balady G, Froelicher V, Hartley LH, Haskell WL, Pollock ML. Exercise standards. A statement for healthcare professionals from the American Heart Association. Circulation 1995; 91: 580-615.
20. Fletcher GF, Balady G, Blair SN, Blumenthal J, Caspersen C, Chaitman B, Epstein S, Sivarajan-Froelicher ES, Froelicher VF, Pina IL, Pollock ML. Statement on exercise: benefits and recommendations for physical activity programs for all Americans. Circulation 1996; 94: 857-862.
21. Flatt J-P. Glycogen levels and obesity. Int J Obes 1996; 20 (Suppl 2): S1-S11.
22. Tremblay A, Buemann B. Exercise-training, macronutrient balance and body weight control. Int J Obes 1995; 19: 79-86.
23. Zurlo F, Lillioja S, Esposito-Del Puente A, Nyomba BL, Raz I, Saad MF, Swinburn BA, Knowler WC, Bogardus C, Ravussin E. Low ratio of fat to carbohydrate oxidation as predictor of weight gain: a study of 24-h RQ. Am J Physiol1990; 259: E650-E657.
24. Lean MEJ, James WPT. Metabolic effects of isoenergetic nutrient exchange over 24 hours in relation to obesity in women. Int J Obes 1988; 12: 15-27.
25. Buemann B, Astrup A, Christensen NJ, Madsen J. Effect of moderate cold exposure on 24-h energy expenditure: similar response in postobese and nonobese women. Am J Physiol1992; 263: E1040-E1045.
26. Buemann B, Astrup A, Madsen J, Christensen NJ. A 24-h energy expenditure study on reduced-obese and nonobese women: effect of b-blockade Am J Clin Nutr 1992; 56: 662-670.
27. Ranneries C, Bülow J, Buemann B, Christensen NJ, Madsen J, Astrup A. Fat metabolism in formerly obese women. Am J Physiol 1998; 274: E155-E161.
28. Ballor DL, Harvey-Berino JR, Ades PA, Cryan J, Calles-Escanden J. Decrease in fat oxidation following a meal in weight-reduced individuals: a possible mechanism for weight recidivism. Metabolism 1996; 45: 174-178.
29. Schutz Y, Tremblay A, Weinsier RL, Nelson KM. Role of fat oxidation in the long-term stabilization of body weight in obese women. Am J Clin Nutr 1992; 55: 670-674.
30. Wolfe RR. Metabolic interactions between glucose and fatty acids in human. Am J Clin Nutr 1998; 67 (Suppl): S519-S526.
31. Hellström L, Langin D, Reynisdottir S, Dauzats M, Arner P. Adipocyte lipolysis in normal weight subjects with obesity among first-degree relatives. Diabetologia 1996; 39: 921-928.
32. Reynisdottir S, Wahrenberg H, Carlstrom K, Rossner S, Arner P. Catecholamine resistance in fat cells of women with upper-body obesity due to decreased expression of beta2-adrenocep-tors. Diabetologia 1994; 37: 428-435.
33. Reynisdottir S, Langin D, Carlstrom K, Holm C, Rossner S, Arner P. Effects of weight reduction on the regulation of lipolysis in adipocytes of women with upper-body obesity. Clin Sci 1995; 89: 421-429.
34. Blaak EE, van Baak MA, Kemerink GJ, Pakbiers MTW, Heidendal GAK, Saris WHM. b-Adrenergic stimulation of energy expenditure and forearm skeletal muscle metabolism in lean and obese men. Am J Physiol 1994; 267: E306-E315.
35. Schiffelers SLH, van Baak MA, Saris WHM. bj-Adrenoceptor mediated thermogenesis in lean and obese men. Int J Obes1997; 21 (Suppl 2): S59 (abstract no. S283).
36. Schiffelers SLH, Saris wHm, van Baak MA. b2-Adrenoceptor mediated lipolysis and fat oxidation are reduced in obese men. Int J Obes 1998; 22 (Suppl) S75 (abstract no. S283).
37. Blaak EE, van Baak MA, Kemerink GJ, Pakbiers MTW, Heidendal GAK, Saris WHM. b-Adrenergic stimulation of skeletal muscle metabolism in relation to weight reduction in obese men. Am J Physiol 1994; 267: E316-E322.
38. Lillioja S, Foley J, Bogardus C, Mott D, Howard BV. Free fatty acid metabolism and obesity in man: in vivo in vitro comparisons. Metabolism 1986; 35: 508-514.
39. Macdonald IA. Advances in our understanding of the role of the sympathetic nervous system in obesity. Int J Obes 1995; 19 (Suppl 2): S2-S7.
40. Kaartinen JM, Hreniuk SP, Martin LF, Ranta S, LaNoue KF, Ohisalo JJ. Attenuated adenosine-sensitivity and decreased adenosine-receptor number in adipocyte plasma membranes in human obesity. Biochem J 1991; 279: 17-22.
41. Blaak EE, van Baak MA, Kemerink GJ, Pakbiers MTW, Heidendal GAK, Saris WHM. b-Adrenergic stimulation and abdominal subcutaneous fat flow in lean, obese and reduced-obese subjects. Metabolism 1995; 44: 183-187.
42. Wolfe RR, Peters EJ, Klein S, Holland OB, Rosenblatt J, Howard G Jr. Effect of short-term fasting on lipolytic responsiveness in normal and obese human subjects. Am J Physiol1987; 252: E189-E196.
43. Webber J, Taylor J, Greathead H, Dawson J, Buttery PJ, Macdonald IA. A comparison of the thermogenic, metabolic and haemodynamic responses to infused adrenaline in lean and obese subjects. Int J Obes 1994; 18: 717-724.
44. van der Vusse GJ, Glatz JFC, Stam HCG, Reneman RS. Fatty acid homeostasis in the normoxic and ischemic heart. Physiol Rev 1992; 72: 881-940.
45. Hagenfeldt L. Metabolism of free fatty acids and ketone bodies during exercise in normal and diabetic man. Diabetes1979; 28 (Suppl 1): S66-S70.
46. Turcotte LP, Richter RA, Kiens B. Increased plasma FFA uptake and oxidation in trained vs. untrained humans. Am J Physiol 1992; 262: E791-E799.
47. Brouns F, van der Vusse GJ. Utilization of lipids during exercise in human subjects: metabolic and dietary constraints. Br J Nutr 1998; 79: 117-128.
48. Winder WW. Malonyl-CoA-Regulator of fatty acid oxidation in muscle during exercise. Exerc Sport Sci Rev 1998; 26: 117-132.
49. Kern PA. Potential role of TNFa and lipoprotein lipase as candidate genes for obesity. JNutr 1997; 127: (Suppl) S1917-S1922.
50. Eckel RH, Yost TJ, Jensen DR. Sustained weight reduction in moderately obese women results in decreased activity of skeletal muscle lipoprotein lipase. Eur J Clin Invest 1995; 25: 396-402.
51. Astrup A, Buemann B, Toubro S, Raben A. Defects in substrate oxidation involved in the predisposition to obesity. ProcNutrSoc 1996; 55: 817-828.
52. Wade AJ, Marbut MM, Round JM. Muscle fiber type and aetiology of obesity. Lancet 1990; 335: 805-808.
53. Simoneau J-A, Bouchard C. Skeletal muscle metabolism and body fat content in men and women. Obes Res 1995; 3: 23-29.
54. Kriketos AD, Baur LA, O’Connor J, Carey D, King S, Caterson ID, Storlien LH. Muscle fiber type composition in infant and adult populations and relationships with obesity. Int J Obes 1997; 21: 796-801.
55. Hickey MS, Carey JO, Azevedo JL, Houmard JA, Pories WJ, Israel RG, Dohm GL. Skeletal muscle fiber composition is related to adiposity and in vitro glucose transport rate in humans. Am J Physiol 1995; 268: E453-E457.
56. Mandarino LJ, Consoli A, Jain A, Lelley DE. Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM. Am J Physiol 1996; 270: E463-E470.
57. Flatt J-P. The difference in the storage capacities for carbohydrate and for fat, and its implications in the regulation of body weight. Ann NY Acad Sci 1987; 499: 104-123.
58. Schrauwen P, van Marken Lichtenbelt WD, Saris WHM, Westerterp KR. Role of glycogen-lowering exercise in the change of fat oxidation in response to a high-fat diet. Am J Physiol 1997; 273: E623-E629.
59. Muller C, Assimacopoulos-Jeannet F, Mosimann F, Schneiter Ph, Riou JP, Pachiaudi C, Felber JP, Jequier E, Jeanrenaud B, Tappy L. Endogenous glucose production, gluconeogenesis and liver glycogen concentration in obese non-diabetic patients. Diabetologia 1997; 40: 463-468.
60. Martin WH III, Dalsky GP, Hurley BF, Matthews DE, Bier DM, Hagberg JM, Rogers MA, King DS, Holloszy JO. Effect of endurance training on plasma FFA turnover and oxidation during exercise. Am J Physiol 1993; 265: E708-E714.
61. Coggan AR, Kohrt WM, Spina RJ, Bier DM, Holloszy JO. Endurance training decreases plasma glucose turnover and oxidation during moderate intensity exercise in man. J Appl Physiol 1990; 68: 990-996.
62. Kiens B, Essen-Gustavsson B, Christensen NJ, Saltin B. Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training. J Physiol 1993; 469: 459-478.
63. Hurley BF, Nemeth PM, Martin WH III, Hagberg JM, Dalsky GP, Holloszy JO. Muscle triglyceride utilization during exercise: effect of training. J Appl Physiol 1986; 60: 562-567.
64. Phillips SM, Green HJ, Tarnopolsky MA, Heigenhauser GJF, Hill RE, Grant SM. Effects of training duration on substrate turnover and oxidation during exercise. J Appl Physiol 1996; 81: 2182-2191.
65. Phillips SM, Green HJ, Tarnopolsky MA, Heigenhauser GJF, Hill RE, Grant SM. Progressive effect of endurance training on metabolic adaptations in working skeletal muscle. Am J Physiol 1996; 270: E265-E272.
66. Klein S, Coyle EF, Wolfe RR. Fat metabolism during low-intensity exercise in endurance-trained and untrained men. Am J Physiol 1994; 267: E934-E940.
67. Coyle EF. Substrate utilization during exercise in active people. Am J Clin Nutr1995; 61 (Suppl): S968-S979.
68. Bielinski R, Schutz Y, Jéquier E. Energy metabolism during postexercise recovery. Am J Clin Nutr 1985; 42: 69-82.
69. Bahr R, Hansson P, Sejersted OM. Triglyceride/fatty acid cycling is increased after exercise. Metabolism 1990; 39: 993-999.
70. Poehlman ET, Gardner AW, Arciero PJ, Goran MI, Calles-Escandon J. Effects of endurance training on total fat oxidation in elderly persons. J Appl Physiol 1994; 76: 2281-2287.
71. Calles-Escandon J, Goran MI, O’Connell M, Nair KS, Dan-forth E Jr. Exercise increases fat oxidation at rest unrelated to changes in energy balance or lipolysis. Am J Physiol 1996; 270: E1009-E1014.
72. Henriksson J. Muscle fuel selection: effect of exercise and training. Proc Nutr Soc 1995; 54: 125-138.
73. Simoneau J-A. Adaptation of human skeletal muscle to exercise-training. Int J Obes 1995; 19 (Suppl 4): S9-S13.
74. Crampes F, Beauville M, Rivière D, Garrigues M. Effect of physical training in humans on the response of isolated fat cells to epinephrine. J Appl Physiol 1986; 61: 25-29.
75. Crampes F, Rivière D, Beauville M, Marceron M, Garrigues M. Lipolytic response of adipocytes to epinehrine in sedentary and exercise-trained subjects: sex-related differences. Eur J Appl Physiol 1989; 59: 249-255.
76. Després JP, Bouchard C, Savard R, Tremblay A, Marcotte M, Theriault G. Effects of exercise-training and detraining on fat cell lipolysis in men and women. Eur J Appl Physiol 1984; 53:25-30
77. Després JP, Bouchard C, Savard R, Tremblay A, Marcotte M, Theriault G. Level of physical fitness and adipocyte lipolysis in humans. J Appl Physiol 1984; 56: 1157-1161.
78. Després JP, Bouchard C, Savard R, Tremblay A, Marcotte M, Theriault G. The effect of a 20-week endurance training program on adipose-tissue morphology and lipolysis in men and women. Metabolism 1984; 33: 235-239.
79. Mauriège P, Prud’homme D, Marcotte M, Yoshioka M, Tremblay A, Despres JP. Regional differences in adipose tissue metabolism between sedentary and endurance-trained women. Am J Physiol 1997; 273: E497-E506.
80. Nicklas BJ. Effects of endurance exercise on adipose tissue metabolism. Exerc Sport Sci Rev 1997; 25: 77103.
81. Stallknecht B, Simonsen L, Billow J, Vinten J, Galbo H. Effect of training on epinephrine-stimulated lipolysis determined by microdialysis in human adipose tissue. Am J Physiol 1995; 269: E1059-E1066.
82. Svendsen OL, Krotkiewski M, Hassager C, Christiansen C. Effects on muscles of dieting with or without exercise in overweight postmenopausal women. J Appl Physiol 1996; 80: 1365-1370.
83. Nicklas BJ, Rogus EM, Goldberg AP. Exercise blunts declines in lipolysis and fat oxidation after dietary-induced weight loss in obese older women. Am J Physiol 1997; 273: E149-E155.
84. Kempen KPG, Saris WHM, Westerterp KR. Energy balance during an 8-wk energy-restricted diet with and without exercise in obese women. Am J Clin Nutr 1995; 62: 722-729.
85. Buemann B, Astrup A, Christensen NJ. Three months aerobic training fails to affect 24-hour energy expenditure in weight-stable, post-obese women. Int J Obes 1992; 16: 809-816.
86. Treuth MS, Hunter GR, Weinsier RL, Kell SH. Energy expenditure and substrate utilization in older women after strength training: 24-h calorimeter results. J Appl Physiol1995; 78: 2140-2146.
87. van Aggel-Leijssen DPC, Saris WHM, van Baak MA. The effect of exercise training at different intensities on respiratory exchange ratio (RER) of obese men. Int J Obes 1998; 22 (Suppl) S283 (abstract).