Endogenous glucose production, gluconeogenesis and liver glycogen concentration in obese non-diabetic patients

Diabetologia

Volumn 40, Issue 4, 1997, Pages 463-468

  Muller C ^a   Assimacopoulos Jeannet, F ^b   Mosimann, F ^c   Schneiter, Ph ^a   Riou, J P ^d   Pachiaudi, C ^d   Felber, J P ^a   Jequier E ^a   Jeanrenaud, B ^b   Tappy, L ^a,e  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d INSERM   (France)

^e UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

glycogenolysis; substrate oxidation

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; GLUCONEOGENESIS; GLYCOGEN LIVER LEVEL; HUMAN; ISOTOPE LABELING; LIVER BIOPSY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL;

EID: 2442741384     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050701     Document Type: Article

References (32)

1. DeFronzo RA (1988) The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37: 667-687
2. Consoli A, Nurjhan N, Capani F, Gerich J (1989) Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 38: 550-575
3. 13C nuclear magnetic resonance study. J Clin Invest 90: 1323-1327
4. Jenssen T, Nurjhan N, Consoli A, Gerich JE (1990) Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. J Clin Invest 86: 489-497
5. Winkler B, Rathgeb I, Bjerknes C, Steele R, Altszuler N (1973) Effect of norepinephrine on glycerol and glucose metabolism in the normal dog. Am J Physiol 225: 81-84
6. Winkler B, Rathgeb I, Steele R, Altszuler N (1970) Conversion of glycerol to glucose in the normal dog. Am J Physiol 219: 497-502
7. Jahoor F, Peters EJ, Wolfe RR (1990) The relationship between gluconeogenic substrate supply and glucose production in humans. Am J Physiol 258:E288-E296
8. Wolfe RR, Jahoor F, Shaw JHF (1987) Effect of alanine infusion on glucose and urea production in man. J Parenter Enter Nutr 11: 109-111
9. Clore JN, Glickman PS, Nestler JE, Blackard WG (1991) In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans. Am J Physiol 261:E425-E429
10. Tounian P, Schneiter P, Henry S, Jéquier E, Tappy L (1994) Effects of infused fructose on endogenous glucose production, gluconeogenesis and glycogen metabolism in healthy humans. Am J Physiol 267:E710-E717
11. Magnusson I, Rothman DL, Jucker B, Cline GW, Shulman RG (1994) Liver glycogen turnover in fed and fasted humans. Am J Physiol 266:E796-E803
12. Tappy L, Cayeux M-C, Schneiter P et al. (1995) Effects of lactate on glucose metabolism in healthy subjects and in severely injured hyperglycemic patients. Am J Physiol 268:E630-E635
13. Welle S, Barnard RR, Statt M, Amatruda JM (1992) Increased protein turnover in obese women. Metabolism 41: 1028-1034
14. Jahoor F, Klein S, Wolfe R (1992) Mechanism of regulation of glucose production by lipolysis in humans. Am J Physiol 262:E353-E358
15. Felig P, Wahren J, Hendler R, Brundin T (1974) Splanchnic glucose and amino acid metabolism in obesity. J Clin Invest 53: 582-590
16. Elia M, Fuller N, Murgatroyd PR (1988) The potential use of the labelled bicarbonate method for estimating energy expenditure in man. Proc Nutr Soc 47: 247-258
17. 13C labelled glucose at a very low level of enrichment in man. Diabetologia 33: 449-456
18. Hawk P (1947) The Kjeldahl method. In: Hawk PB, Oser BL, Simonson WH (eds) Practical physiological chemistry. Blakiston, Toronto, pp 814-822
19. Chan TM, Exton JH (1976) A rapid method for the determination of glycogen content and radioactivity in small quantities of tissues or isolated hepatocytes. Anal Biochem 71: 96-105
20. Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
21. 14C-glucose. Recent Prog Horm Res 19: 445-488
22. Kelley DE, Mokan M, Simoneau JA, Mandarino LJ (1993) Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 92: 91-98
23. 13C. Int J Obes 18: 591-595
24. Gay LJ, Schneiter P, Schulz Y, Di Vetta V, Jéquier E, Tappy L (1994) A non invasive assessment of hepatic glycogen kinetics and post-absorptive gluconeogenesis in man. Diabetologia 37: 517-523
25. Felig P, Wahren J, Hendler R (1978) Influence of maturity-onset diabetes on splanchnic glucose balance after oral glucose ingestion. Diabetes 27: 121-126
26. Chiasson JL, Liljenquist JE, Lacy WW, Jennings AS, Cherrington AD (1977) Gluconeogenesis: methodological approaches in vivo. Fed Proc 36: 229-235
27. Haesler E, Schneiter P, Temler E, Jéquier E, Tappy L (1995) Effects of lactate infusion on hepatic gluconeogenesis and glycogenolysis. Clin Physiol 15: 581-595
28. Landau BR, Wahren J, Chandramouli V, Schumann WC, Ekberg K, Kalhan SC (1996) Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest 98: 378-385
29. 13C] glucose. Am J Physiol 245:E476-E482
30. Tappy L, Acheson K, Curchod B et al. (1994) Overnight glucose metabolism in obese non insulin dependent diabetic patients and in healthy lean individuals. Clin Physiol 14: 251-265
31. Jansson P-A, Larsson A, Smith U Lönnroth P (1994) Lactate release from the subcutaneous tissue in lean and obese men. J Clin Invest 93: 240-246
32. Bozzetti F (1995) Nutrition support in patients with cancer. In: Payne-James J, Grimble G, Silk D (eds) Artificial nutrition support in clinical practice. Edward Arnold, London, pp 511-533