Human munc13 is a diacylglycerol receptor that induces apoptosis and may contribute to renal cell injury in hyperglycemia

Molecular Biology of the Cell

Volumn 10, Issue 5, 1999, Pages 1609-1619

  Song, Yong ^a   Ailenberg, Menachem ^a   Silverman, Mel ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DIACYLGLYCEROL; DNA; MESSENGER RNA; PHORBOL ESTER; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CELL DIFFERENTIATION; DIABETES MELLITUS; DIABETIC NEPHROPATHY; ENZYME ACTIVATION; GENE OVEREXPRESSION; HUMAN; HYPERGLYCEMIA; KIDNEY CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES;

ANIMALIA; DIDELPHIDAE;

EID: 0032948523     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.10.5.1609     Document Type: Article

References (31)

1. Advani, R.J., Bae, H., Bock, J.B., Chao, D.S., Doung, Y., Prekeris, R., Yoo, J., and Scheller R.H. (1998). Seven novel mammalian SNARE proteins localize to distinct membrane compartments. J. Biol. Chem. 273, 10371-10324.
2. Areces, L.B., Kazanietz, M.G., and Blumberg, P.M. (1994). Close similarity of baculovirus-expressed n-chimaerin and protein kinase Cα as phorbol ester receptors. J. Biol. Chem. 269, 19553-19558.
3. Balch, W.E., Bunphy, W.G., Braell, W.A., and Rothman, J.E. (1994). Reconstitution of the transport of protein between successive compartments of the Golgi measured by the coupled incorporation of N-acetylglucosamine. Cell 39, 405-416.
4. Banfield, D.K., Lewis, M.U., Rabouille, C., Warren, G., and Pelham, H.R.B. (1994). Localization of Sed5, a putative vesicle targeting molecule, to the cis-Golgi network involves both its transmembrane and cytoplasmic domains. J. Cell Biol. 127, 357-371.
5. Betz, A., Ashery, U., Rickmann, M., Augustin, I., Neher, E., Sudhof, T.C., Rettig, J., and Brose, N. (1998). Munc13 is a presynaptic phorbol ester receptor that enhances neurotransmitter release. Neuron 21, 123-136.
6. Betz, A., Okamoto, M., Benseler, F., and Brose, N. (1997). Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. J. Biol. Chem. 272, 2520-2526.
7. Blobe, G.C., Stribling, S., Obeid, L.M., and Hannum, Y.A. (1998). Protein kinase C isoenzymes: regulation and function. Cancer Surv 27, 213-248.
8. Bock, J.B., Klumperman, J., Davanger, S., and Scheller, R.H. (1997). Syntaxin 6 functions in trans-Golgi network vesicle trafficking. Mol. Biol. Cell 8, 1261-1271.
9. Brose, N., Hofmann, K., Hata, Y., and Sudhof, C. (1995). Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins. J. Biol. Chem. 270, 25273-25280.
10. Chinen, K., Takahashi, E., and Nakamura, Y. (1996). Isolation and mapping of a human gene (SEC14L), partially homologous to yeast SEC14, that contains a variable number of tandem repeat (VNTR) sites in its 3′ untranslated region. Cytogenet. Cell Genet. 73, 218-223.
11. Deacon, E.M., Pongracz, J., Griffiths, G., and Lord, J.M. (1997). Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis. Mol. Pathol. 50, 124-131.
12. Derubertis, F.R., and Craven, P.A. (1994). Activation of protein kinase C in glomerular cells in diabetes: mechanisms and potential links to the pathogenesis of diabetic glomerulopathy. Diabetes 43, 1-8.
13. 2+ associated with apoptosis. In: Cell Death, Methods in Cell Biology, Vol. 46, ed. L.M. Schwartz and B.A. Osborne, San Diego: Academic Press, 41-55.
14. Hise, M.K., and Mehta, P.S. (1988). Characterization and localization of calcium/phospholipid-dependent protein kinase-C during diabetic renal growth. Endocrinology 123, 1553-1558.
15. Ishii, H., et al. (1996). Amelioration of vascular dysfunctions in diabetic rats by an oral PKC β inhibitor. Science 272, 728-731.
16. Ishii, N., Ogawa, Z., Suzuki, K., Numakami, K., Saruta, T., and Itoh, H. (1996). Glucose loading induces DNA fragmentation in rat proximal tubular cells. Metabolism 45, 1348-1353.
17. Kearns, B.G., McGee, T.P., Mayinger, P., Gedvilaite, A., Phillips, S.E., Kagiwada, S., and Bankaitis, V.A. (1997). Essential role for diacylglycerol in protein transport from the yeast Golgi complex. Nature 387, 101-105.
18. King, G.L., Ishii, H., and Koya, D. (1997). Diabetic vascular dysfunction: a model of excessive activation of protein kinase C. Kidney Int. 52(suppl 60), S-77-S-85.
19. Lavin, M.F., Watters, D., and Song, Q. (1996). Role of protein kinase activity in apoptosis. Experientia 52, 979-994.
20. Leszczynski, D. (1996). The role of protein kinase C in regulation of apoptosis: a brief overview of the controversy. Cancer J. 9, 308-313.
21. Martin, T.F.J. (1997). Greasing the Golgi budding machine. Nature 387, 21-22.
22. Maruyama, I.N., Brenner, S. (1991). A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 88, 5729-5733.
23. Mochly-Rosen, D., and Kauvar, L.M. (1998). Modulating protein kinase C signal transduction. Adv. Pharmacol. 44, 91-145.
24. Morris, S.M., and Yu-Lee, L. (1998). Expression of RNUDC, a potential nuclear movement protein in mammalian cells: localization to the Golgi apparatus. Exp. Cell Res. 238, 23-32.
25. 2+-dependent exocytotic machinery. J. Biol. Chem. 272, 1681-1684.
26. Ortiz, A., Ziyadeh, F.N., and Neilson, E.G. (1997). Expression of apoptosis-regulatory genes in renal proximal tubular epithelia cells exposed to high ambient glucose and in diabetic kidneys. J. Invest. Med. 45, 50-56.
27. Schleicher, E., and Nerlich, A. (1996). The role of hyperglycemia in the development of diabetic complications. Horm. Metab. Res. 28, 367-373.
28. Song, Y., Ailenberg, M., Silverman, M. (1998). Cloning of a novel gene in the human kidney homologous to rat munc13s: its potential role in diabetic nephropathy. Kidney Int. 53, 1689-1695.
29. Tellam, J.T., Jams, D.E., Stevens, T.H., and Piper R.C. (1997). Identification of a mammalian Golgi Sec1P-like protein, mVps45. J. Biol. Chem. 272, 6187-6193.
30. Whitman, S.P., Civoli, F., and Daniel, L.W. (1997). Protein kinase CβII activation by 1-(-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and bcl-2α down-regulation. J. Biol. Chem. 272, 23481-23484.
31. Xia, P., Inoguchi, T., Kern, T.S., Engerman, R.L., Oates, P.J., and King, G.L. (1994). Characterization of the mechanism for the chronic activation of diacyglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes 43, 1122-1129.