Mediators of alkalosis-induced relaxation in pulmonary arteries from normoxic and chronically hypoxic piglets

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 276, Issue 1 20-1, 1999, Pages

  Gordon, John B ^a,b   Halla, Ted R ^a   Fike, Candice D ^a   Madden, Jane A ^a  

^a CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Children's Hospital of Wisconsin   (United States)

Author keywords

Endothelium derived relaxing factors; Newborn; Potassium channels; Pulmonary hypertension

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 4 AMINOPYRIDINE; CYCLIC GMP; GUANYLATE CYCLASE INHIBITOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ALKALOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; SWINE; VASCULAR SMOOTH MUSCLE;

EID: 0032942290     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1999.276.1.l155     Document Type: Article

References (44)

1. + channels in canine pulmonary arterial smooth muscle cells. Pflügers Arch. 433: 758-765, 1997.
2. Aschner, J. L., and T. K. Smith. Role of nitric oxide (NO) in pH-dependent modulation of vasoactive responses in newborn pulmonary arteries (PA) (Abstract). Pediatr. Res. 39: 325A, 1996.
3. Baffa, J. M., and J. B. Gordon. Pathophysiology, diagnosis, and management of pulmonary hypertension in infants and children. J. Intensive Care Med. 11: 90-107, 1996.
4. Barnard, J. W., P. S. Wilson, T. M. Moore, W. J. Thompson, and A. E. Taylor. Effect of nitric oxide and cyclooxygenase products on vascular resistance in dog and rat lungs. J. Appl. Physiol. 74: 2940-2948, 1993.
5. Ca channel antagonists reduce NO donor-mediated relaxation of vascular and tracheal smooth muscle. Am. J. Physiol. 268 (Lung Cell. Mol. Physiol. 12): L152-L159, 1995.
6. Brunner, F., K. Schmidt, E. B. Nielsen, and B. Mayer. Novel guanylyl cyclase inhibitor potently inhibits cyclic GMP accumulation in endothelial cells and relaxation of bovine pulmonary artery. J. Pharmacol. Exp. Ther. 277: 48-53, 1996.
7. + channels mediate vasodilation produced by lemakalim in rabbit pulmonary artery. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H1907-H1915, 1993.
8. Duara, S., M. H. Gewitz, and W. W. Fox. Use of mechanical ventilation for clinical management of persistent pulmonary hypertension of the newborn. Clin. Perinatal. 11: 641-652, 1984.
9. Fike, C. D., and T. N. Hansen. The effect of alkalosis on hypoxia-induced pulmonary vasoconstriction in lungs of newborn rabbits. Pediatr. Res. 25: 383-388, 1989.
10. Fike, C. D., and M. R. Kaplowitz. Effect of chronic hypoxia on pulmonary vascular pressures in isolated lungs of newborn pigs. J. Appl. Physiol. 77: 2853-2862, 1994.
11. Fike, C. D., and M. R. Kaplowitz. Chronic hypoxia alters nitric oxide-dependent pulmonary vascular responses in lungs of newborn piglets. J. Appl. Physiol. 81: 2078-2087, 1996.
12. Fineman, J. R., J. Wong, and S. J. Soifer. Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs. Pediatr. Res. 33: 341-346, 1993.
13. Gao, Y., H. Zhou, and J. U. Raj. Heterogeneity in role of endothelium-derived NO in pulmonary arteries and veins of full-term fetal lambs. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H1586-H1592, 1995.
14. Garthwaite, J., E. Southam, C. L. Boulton, E. B. Nielsen, K. Schmidt, and B. Mayer. Potent and selective inhibition of nitric oxide-sensitiveguanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol. Pharmacol. 48: 184-188, 1995.
15. Gerboth, G. D., R. M. Effros, R. J. Roman, and E. R. Jacobs. pH-induced calcium transients in type II alveolar epithelial cells. Am. J. Physiol. 264 (Lung Cell. Mol. Physiol. 8): L448-L457, 1993.
16. Gordon, J. B., J. Hortop, and T. S. Hakim. Developmental effects of hypoxia and indomethacin on distribution of vascular resistances in lamb lungs. Pediatr. Res. 26: 325-329, 1989.
17. Gordon, J. B., F. R. Martinez, P. A. Keller, M. L. Tod, and J. A. Madden. Differing effects of acute and prolonged alkalosis on hypoxic pulmonary vasoconstriction. Am. Rev. Respir. Dis. 148: 1651-1656, 1993.
18. Hammerman, C., and M. J. Aramburo. Effects of hyperventilation on prostacyclin formation and on pulmonary vasodilation after group B β-hemolytic streptococci-induced pulmonary hypertension. Pediatr. Res. 29: 282-287, 1991.
19. Ishida, Y., and H. Honda. Inhibitory action of 4-ammopyridine on Ca-ATPase of the mammalian sarcoplasmic reticulum. J. Biol. Chem. 268: 4021-4024, 1993.
20. + channels in arteriolar muscle cells. Am. J. Physiol. 274 (Heart Circ. Physiol. 43): H27-H34, 1998.
21. Le Cras, T. D., C. Xue, A. Rengasamy, and R. A. Johns. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am. J. Physiol. 270 (Lung Cell. Mol. Physiol. 14): L164-L170, 1996.
22. Levy, M., R. M. R. Tulloh, H. Komai, K. Stuart-Smith, and S. G. Haworth. Maturation of the contractile response and its endothelial modulation in newborn porcine intrapulmonary arteries. Pediatr. Res. 38: 25-29, 1995.
23. McDonald, L. J., and F. Murad. Nitric oxide and cyclic GMP signaling. Proc. Soc. Exp. Biol. Med. 211: 1-6, 1996.
24. Mitchell, J. A., G. De Nucci, T. D. Warner, and J. R. Vane. Alkaline buffers release EDRF from bovine cultured aortic endothelial cells. Br. J. Pharmacol. 103: 1295-1302, 1991.
25. Morin, F. C., III. Hyperventilation, alkalosis, prostaglandins, and pulmonary circulation of the newborn. J. Appl. Physiol. 61: 2088-2094, 1986.
26. Morin, F. C., III, and K. R. Stenmark. Persistent pulmonary hypertension of the newborn. Am. J. Respir. Crit. Care Med. 151: 2010-2032, 1995.
27. O'Donnell, D. C., M. L. Tod, and J. B. Gordon. Developmental changes in endothelium-dependent relaxation of pulmonary arteries: role of EDNO and prostanoids. J. Appl. Physiol. 81: 2013-2019, 1996.
28. + channels: regulation in human pulmonary vascular smooth muscle cells. Am. J. Physiol. 272 (Cell Physiol. 41): C1271-C1278, 1997.
29. Peng, W., S. V. Karwande, J. R. Hoidal, and I. S. Farrukh. Potassium currents in cultured human pulmonary arterial smooth muscle cells. J. Appl. Physiol. 80: 1187-1196, 1996.
30. Perreault, T., and J. De Marte. Maturational changes in endothelium-derived relaxations in newborn piglet pulmonary circulation. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H302-H309, 1993.
31. Pfister, S. L., N. Spitzbarth, W. Edgemond, and W. B. Campbell. Vasorelaxation by an endothelium-derived metabolite of arachidonic acid. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H1021-H1030, 1996.
32. ATP-channel activation causes marked vasodilation in the hypertensive neonatal pig lung. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H1532-H1536, 1992.
33. Reddy, V. M., J. Wong, J. R. Liddicoat, M. Johengen, R. Chang, and J. R. Fineman. Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H562-H570, 1996.
34. Rudolph, A. M., and S. Yuan. Response of the pulmonary vasculature to hypoxia and H+ ion concentration changes. J. Clin. Invest. 45: 399-411, 1966.
35. Schreiber, M. D., M. A. Heymann, and S. J. Soifer. Increased arterial pH, not decreased PaCO2, attenuates hypoxia induced pulmonary vasoconstriction in newborn lambs. Pediatr. Res. 20: 113-117, 1986.
36. Schreiber, M. D., and S. J. Soifer. Respiratory alkalosis attenuates thromboxane-induced pulmonary hypertension. Crit. Care Med. 16: 1225-1228, 1988.
37. + current in rat pulmonary artery muscle cells. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H365-H370, 1994.
38. Steinhorn, R. H., F. C. Morin III, S. F. Gugino, E. C. Giese, and J. A. Russell. Developmental differences in endothelium-dependent responses in isolated ovine pulmonary arteries and veins. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H2162-H2167, 1993.
39. 4Cl-induced changes in intracellular pH (Abstract). FASEB J. 10: A105, 1996.
40. West, G. A., D. C. Leppla, and J. M. Simard. Effects of external pH on ionic currents is smooth muscle cells from the basilar artery of the guinea pig. Circ. Res. 71: 201-209, 1992.
41. Yamaguchi, T., R. F. O'Brien, W. L. Hanson, W. W. Wagner, Jr., and I. F. McMurtry. Prostacyclin contributes to inhibition of hypoxic pulmonary vasoconstriction by alkalosis. Prostaglandins 38: 53-63, 1989.
42. Yamaguchi, K., T. Takasugi, H. Fujita, M. Mori, Y. Oyamada, K. Suzuki, A. Miyata, T. Aoki, and Y. Suzuki. Endothelial modulation of pH-dependent pressor response in isolated perfused rabbit lungs. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H252-H258, 1996.
43. Yuan, X. J., M. L. Tod, L. J. Rubin, and M. P. Blaustein. NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels. Proc. Natl. Acad. Sci. USA 93: 10489-10494, 1996.
44. Ca channels antagonizes NO-induced relaxation in pulmonary artery. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H904-H912, 1997.