Endothelial modulation of pH-dependent pressor response in isolated perfused rabbit lungs

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 270, Issue 1 39-1, 1996, Pages

  Yamaguchi, Kazuhiro ^a   Takasugi, Tomoaki ^a   Fujita, Hirohumi ^a   Mori, Masaaki ^a   Oyamada, Yoshitaka ^a   Suzuki, Kohichi ^a   Miyata, Atsushi ^a   Aoki, Takuya ^a   Suzuki, Yukio ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

endothelium derived relaxing factor; hemoglobin; hypercapnic acidosis; hypocapnic alkalosis; L argininosuccinic acid; methemoglobin; methylene blue; nitric oxide; papaverine

Indexed keywords

ARGININOSUCCINIC ACID; ENDOTHELIUM DERIVED RELAXING FACTOR; HEMOGLOBIN; METHEMOGLOBIN; METHYLENE BLUE; NITRIC OXIDE; PAPAVERINE;

ANIMAL TISSUE; ARTICLE; HYPERCAPNIA; HYPOCAPNIA; ISOLATED LUNG; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG VASOCONSTRICTION; MALE; NONHUMAN; PH; PRESSOR RESPONSE; PRIORITY JOURNAL; RABBIT; SHEAR STRESS; VASODILATATION;

EID: 0030042759     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.270.1.h252     Document Type: Article

References (27)

1. Adams, D. J., J. Barakeh, R. Laskey, and C. V. Breemen. Ion channels and regulation of intracellular calcium in vascular endothelial cells. FASEB J. 3, 2389-2400, 1989.
2. Austin, J. H., and D. L. Drabkin. Spectrophotometric studies. Methemoglobin. J. Biol. Chem. 112: 67-88, 1935.
3. Barer, G. R., and J. R. McCurrie. Pulmonary vasomotor responses in the cat; the effects and interrelationships of drugs, hypoxia and hypercapnia. Q. J. Exp. Physiol. 54: 156-172, 1969.
4. 3, and metabolic inhibitors. J. Gen. Physiol. 67: 91-112, 1976.
5. Drabkin, D. L., and J. H. Austin. Spectrophotometric studies. Preparations from washed blood cells; nitric oxide, hemoglobin and sulfhemoglobin J. Biol. Chem. 112: 51-65, 1935.
6. Emery, C. J., P. J. M. Sloan, F. H. Mohammed, and G. R. Barer. The action of hypercapnia during hypoxia on pulmonary vessels. Bull. Eur. Physiopathol. Respir. 13: 763-776, 1977.
7. Farrukh, I. S., G. H. Gurtner, P. B. Terry, W. Tohidi, J. Yang, F. Adkinson, and J. R. Michael. Effect of pH on pulmonary vascular tone, reactivity, and arachidonate metabolism. J. Appl. Physiol. 67: 445-452, 1989.
8. Furchgott, R. F. Roles of endothelium in responses of vascular smooth muscle. Circ. Res. 53: 557-573, 1983.
9. Gold, M. E., K. S. Wood, G. M. Buga, R. E. Byrns, and J. L. Ignarro. L-arginine causes whereas L-argininosuccinic acid inhibits endothelium-dependent vascular smooth muscle relaxation. Biochem. Biophys. Res. Commun. 161: 536-543, 1989.
10. 15N) nitrate in biological fluid. Anal. Biochem. 126: 131-138, 1982.
11. 2 on membrane electrical properties of rat cerebral arteries. Pfluegers Arch. 394: 182-185, 1982.
12. Ignarro, L. J., G. W. Buga, K. S. Wood, R. E. Byrns, and G. Chaudhuri. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA 84: 9265-9269, 1987.
13. Johns, R. A., J. M. Linden, and J. Peach. Endothelium-dependent relaxation and cyclic GMP accumulation in rabbit pulmonary artery are selectively impaired by moderate hypoxia. Circ. Res. 65: 1508-1515, 1989.
14. Kato, M., and N. C. Staub. Response of small pulmonary arteries to unilobar hypoxia and hypercapnia. Circ. Res. 19: 426-440, 1966.
15. Koyama, T., and M. Horimoto. Pulmonary microcirculatory response to localized hypercapnia. J. Appl. Physiol. 53: 1556-1564, 1982.
16. Liu, S., D. E. Crawley, P. J. Barnes, and T. W. Evans. Endothelium-derived relaxing factor inhibits hypoxic pulmonary vasoconstriction in rats. Am. Rev. Respir. Dis. 143: 32-37, 1991.
17. 2 concentrations on hypoxic pulmonary vasoconstriction. J. Appl. Physiol. 34: 318-323, 1973.
18. Marshall, C., L. Lindgren, and B. E. Marshall. Metabolic and respiratory hydrogen ion effects on hypoxic pulmonary vasoconstriction. J. Appl. Physiol. 57: 545-550, 1984.
19. Moncada, S., R. M. Palmer, and E. A. Higgs. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43: 109-142, 1991.
20. Orchard, C. H., and J. C. Kentish. Effects of changes of pH on the contractile function of cardiac muscle. Am. J. Physiol 258 (Cell Physiol. 27): C967-C981, 1990.
21. Palmer, R. M., A. G. Ferrige, and S. Moncada. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature Lond. 327: 524-526, 1987.
22. Raffestin, B., and I. F. McMurtry. Effects of intracellular pH on hypoxic vasoconstriction in rat lungs. J. Appl. Physiol 63: 2524-2531, 1987.
23. Sylvester, J. T., P. Rock, J. E. Gottlieb, and R. C. Wetzel. Acute hypoxic responses. In: Abnormal Pulmonary Circulation, edited by E. H. Bergofsky. New York: Churchill Livingstone, 1986, p. 127-165.
24. Viles, P. H., and J. T. Shepherd. Evidence for a dilator action of carbon dioxide on the pulmonary vessels of the cat. Circ. Res 22: 325-332, 1968.
25. Von Euler, U., and G. Lilijestrand. Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol. Scand. 12: 301-320, 1946
26. Woolson, R. F. Statistical Methods for the Analysis of Biomedical Data. New York: Wiley, 1987. p. 327-354.
27. Yamaguchi, K., M. Mori, A. Kawai, T. Takasugi, A. Umeda, T. Kawashiro, and T. Yokoyama. Regulation of blood flow in pulmonary microcirculation by vasoactive arachidonic acid metabolites: analysis in acute lung injury. Adv. Exp. Med. Biol. 345: 113-120, 1994.