Nitric oxide synthase gene transfer to the vessel wall

Current Opinion in Nephrology and Hypertension

Volumn 8, Issue 1, 1999, Pages 75-81

  Kibbe, Melina ^a   Billiar, Timothy ^a   Tzeng, Edith ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE SYNTHASE; VIRUS VECTOR;

ARTERY INJURY; BRAIN ARTERY; CAROTID ARTERY; CELL PROLIFERATION; CORONARY ARTERY; ENZYME ACTIVITY; GENE THERAPY; GENE TRANSFER; GRAFT FAILURE; PRIORITY JOURNAL; PULMONARY ARTERY; REVIEW; SMOOTH MUSCLE FIBER; SYSTEMIC CIRCULATION; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE; VASOMOTOR REFLEX; VEIN GRAFT;

ANIMALS; BLOOD VESSELS; GENE TRANSFER TECHNIQUES; HUMANS; NITRIC OXIDE SYNTHASE;

EID: 0032941332     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199901000-00012     Document Type: Review

References (45)

1. 1 Radomski MW, Palmer RM, Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet 1987; 2;1057-1058.
2. 2 Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A 1991; 88:4651-4655.
3. 3 Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989; 83:1774-1777.
4. 4 Ziche M, Morbidelli L, Masini E, Amerini S, Granger HJ.. Maggi CA, et al. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vivo promoted by substance P. J Clin Invest 1994; 94:2036-2044.
5. 5 Tzeng E, Kim YM, Pitt BR, Lizonova A, Kovesdi I, Billiar TR. Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis. Surgery 1997; 122:255-263.
6. 6 Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327:524-526.
7. 7 Rees DD, Palmer RM, Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci U S A 1989; 86:3375-3378.
8. 8 Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 1989; 2:997-1000.
9. 9 Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery arid vein is nitric oxide. Proc Natl Acad Sci U S A 1987; 84:9265-9269.
10. 10 Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 1995; 377:239-242.
11. 11 Cohen RA. The role of nitric oxide arid other endothelium-derived vasoactive substances in vascular disease. Prog Cardiovasc Disord 1995; 38:105-128.
12. 12 Janssens SP, Bloch KD, Nong Z, Gerard RD, Zoldhelyi P, Collen D. Adenoviral-mediated transfer of the human endothelial nitric oxide synthase gene reduces acute hypoxic pulmonary vasoconstriction in rats. J Clin Invest 1996; 98:317-324.
13. 13 Lin KF, Chao L, Chao J. Prolonged reduction of high blood pressure with human nitric oxide synthase gene delivery. Hypertension 1997; 30:307-313.
14. 14 Chen AF, O'Brien T, Tsutsui M, Kinoshita H, Pompili VJ, Crotty TB, et al. Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery. Circ Res 1997; 80:327-335.
15. 15 Cable DG, O'Brien T, Kullo IJ, Schwanz RS, Schaff HV, Pompili VJ. Expression and function of a recombinant endothelial nitric oxide synthase gene in porcine coronary arteries. Cardiovasc Res 1997; 35:553-559.
16. 16 Ooboshi H, Chu Y, Rios CD, Faraci FM, Davidson BL, Heistad DD. Altered vascular function after adenovirus-mediated overexpression ot endotholial nitric oxide synthase. Am J Physiol 1997; 273:H265-270.
17. 17 Kullo U, Mozes G, Schwartz RS, Gloviczki P, Tsutsui M, Katusic ZS, O'Brien T. Enhanced endothelium-dependent relaxations after gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries. Hypertension 1997; 30:314-320.
18. 18 Kullo IJ, Mozes G, Schwartz RS, Gloviczki P, Crotty TB, Barber DA, et al. Adventitial gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries alters vascular reactivity. Circulation 1997; 96:225-226.
19. 19 Tsutsui M, Chen AF, O'Brien T, Crotty TB, Katusic ZS. Adventitial expression of recombinant eNOS gene restores NO production in arteries without endothelium. Arterioscler Thromb Vasc Biol 1998; 18:1231-1241. This article definitively demonstrates that the adventitial delivery of the eNOS gene to the vasculature could regulate vasomotor function.
20. 20 Onoue H, Tsutsui M, Smith L, Stelter A, O'Brien T, Katusic ZS. Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery after experimental subarachnoid hemorrhage. Stroke 1998; 29:1959-1965. This article demonstrates that eNOS gene transfer to the vasculature could reverse arterial vasospasm associated with vascular pathology.
21. 21 Chen AY, Jiang SW, Crotty TB, Tsutsui M, Smith LA, O'Brien T, Katusic ZS. Effects of in vivo adventitial expression of recombinant endothelial nitric oxide synthase gene in cerebral arteries. Proc Natl Acad Sci USA 1997; 94:12568-12573.
22. 22 Katusic ZS, Milde JH, Cosentino F, Mitrovic BS. Subarachnoid hemorrhage and endothelial L-arginine pathway in small brain stem arteries in dogs. Stroke 1993; 24:392-399.
23. 23 Johns RA, Linden JM, Peach MJ. Endothelium-dependent relaxation and cyclic GMP accumulation in rabbit pulmonary artery are selectively impaired by moderate hypoxia. Circ Res 1989; 65:1508-1515.
24. 24 McQuillan LP, Leung GK, Marsden PA, Kostyk SK, Kourembanas S. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms [published errata appear in Am J Physiol 1995; 268: section H following table of contents and 1995; 268(6 Part 3);section H following table of contents]. Am J Physiol 1994; 267:H1921-1927.
25. 25 Giaid A, Saleh D. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 1995; 333:214-221.
26. 26 Rudic RD, Shesely EQ, Maeda N, Smithies O, Segal SS, Sessa WC. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodelling. J Clin Invest 1998; 101:731-736.
27. 27 von der Leyen HE, Gibbons GH, Morishita R, Lewis NP, Zhang L, Nakajima M, et al. Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci USA 1995; 92:1137-1141.
28. 28 Varenne O, Pislaru S, Gillijns H, Van Pelt N, Gerard RD, Zoldhelyi P, et al. Local adenovirus-mediated transfer of human endothelial nitric oxide synthase reduces luminal narrowing after coronary angioplasty in pigs. Circulation 1993; 98:919-926.
29. 29 Janssens S, Flaherty D, Nong Z, Varenne O, Van Pelt N, Haustermans C, et al. Human endothelial nitric oxide synthase gene transfer inhibits vascular smooth muscle cell proliferation and neointima formation after balloon injury in rats. Circulation 1998; 97:1274-1281.
30. 30 Chen L, Daum G, Forough R, Clowes M, Walter U, Clowes AW. Overexpression of human endothelial nitric oxide synthase in rat vascular smooth muscle cells and in balloon-injured carotid artery. Circ Res 1998; 82:862-870.
31. 31 Shears LL, Kibbe MR, Murdock AD, Billiar TR, Lizonova A, Kovesdi I, et al. Efficient inhibition of intimai hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo. J Am Coll Surg 1998; 187:295-306. This article demonstrates that very low titres of AdiNOS gene transfer can inhibit neointimal formation effectively in both the rat and pig models of arterial injury.
32. 32 Kullo U, Schwartz RS, Pompili VJ, Tsutsui M, Milstien S, Fitzpatrick LA, et al. Expression and function of recombinant endothelial NO synthase in coronary artery smooth muscle cells. Arterioscler Thromb Vasc Biol 1997; 17:2405-2412.
33. 33 Tzeng E, Shears LL, Robbins PD, Pitt BR, Geller DA, Watkins SC, et al. Vascular gene transfer of the human inducible nitric oxide synthase; characterization of activity and effects on myointimal hyperplasia. Mol Med 1996; 2:211-225.
34. 34 Tzeng E, Billiar TR, Robbing PD, Loftus M, Stuehr DJ. Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer. Proc Natl Acad Sci U S A 1995; 92:11771-11775.
35. 35 Tzeng E, Yoneyama T, Hatakeyama K, Shears LL, Billiar TR. Vascular inducible nitric oxide synthase gene therapy: requirement for guanosine triphosphate cyclohydrolase I. Surgery 1996; 120:315-321.
36. 36 Channon KM, Blazing MA, Shetty GA, Potts KE, George SE. Adenoviral gene transfer of nitric oxide synthase: high level expression in human vascular cells. Cardiovasc Res 1996; 32:962-972.
37. 37 Karayannacos PE, Hostetler JR, Bond MG, Kakos GS, Williams RA, Kilman JW, Vasko JS. Late failure in vein grafts: mediating factors in subendothelial fibromuscular hyperplasia. Ann Surg 1978; 187:183-188.
38. 38 Matsumoto T, Komori K, Yonemitsu Y, Morishita R, Sueishi K, Kaneda Y, Sugimachi K. Hemagglutinating virus of Japan-liposome-mediated gene transfer of endothelial cell nitric oxide synthase inhibits intimal hyperplasia of canine vein grafts under conditions of poor runoff. J Vasc Surg 1998; 27:135-144. This is the first article to demonstrate the efficacy of NOS gene transfer in preventing intimal hyperplasia in autologous vein grafts.
39. 39 Kerber S, Rahmel A, Heinemann-Vechtel O, Budde T, Deng M, Scheld HH, Breithardt G. Angiographic, intravascular ultrasound and functional findings early after orthotopic heart transplantation. Int J Cardiol 1995; 49:119-129.
40. 40 Mehra MR, Ventura HO, Smart FW, Stapleton DD, Collins TJ, Ramee SR, et al. New developments in the diagnosis and management of cardiac allograft vasculopathy. Tex Heart Inst J 1995; 22:138-144.
41. 41 Suzuki J, Isobe M, Morishita R, Aoki M, Horie S, Okubo Y, et al. Prevention of graft coronary arteriosclerosis by antisense cdk2 kinase oligonucleotide [see comments]. Nat Med 1997; 3:900-903.
42. 42 Shears LL, Kawaharada N, Tzeng E, Billiar TR, Watkins SC, Kovesdi I, et al. Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis. J Clin Invest 1997; 100:2035-2042. This is the only paper demonstrating the efficacy of NOS gene transfer in preventing transplant vasculopathy.
43. 43 Dusting GJ, Macdonald PS. Endogenous nitric oxide in cardiovascular disease and translation. Ann Med 1995; 27: 395-406.
44. 44 Tanaka S, Kamiite W, Ito T, Nozaki S, Uchikoshi F, Miyata M, Nakata S, et al. Evaluation of nitric oxide during acute rejection after heart transplantation in rats. Transplant Proc 1995; 27: 576-577
45. 45 Devlin J, Palmer RM, Gonde CE, O'Grady J, Heaton N, Tan KC, et al. Nitric oxide generation. A predictive parameter of acute allograft rejection. Transplantation 1994; 58: 592-595.