Expression and function of recombinant endothelial NO synthase in coronary artery smooth muscle cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 11, 1997, Pages 2405-2412

  Kullo, Iftikhar J ^a   Schwartz, Robert S ^a   Pompili, Vincent J ^a   Tsutsui, Masato ^a   Milstien, Sheldon ^b   Fitzpatrick, Lorraine A ^a   Katusic, Zvonimir S ^a   O'Brien, Timothy ^a  

^a MAYO CLINIC   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Adenovirus; Gene transfer; Nitric oxide; Nitric oxide synthase; Vascular smooth muscle cells

Indexed keywords

NITRIC OXIDE SYNTHASE; VIRUS VECTOR;

ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROGENESIS; CELL PROLIFERATION; CORONARY ARTERY ATHEROSCLEROSIS; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; GENE TARGETING; NONHUMAN; PRIORITY JOURNAL; SWINE; VASCULAR SMOOTH MUSCLE;

EID: 0031443418     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.11.2405     Document Type: Article

References (13)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
2. Schwartz RS, Srivatsa SS, Simari RD, Holmes DR Jr. Coronary restenosis: insights from animal models. In: Vetrovec GW, Carabello, BA, eds. Invasive Cardiology: Current Diagnostic and Therapeutic Issues. Armonk, NY: Futura Publishing Co Inc; 1996: 67-76.
3. Schwartz RS, Holmes DR Jr, Topol E. The restenosis paradigm revisited: an alternative proposal for cellular mechanisms. J Am Coll Cardiol. 1992;20:1284-1293.
4. Wilcox JN. Thrombin and other potential mechanisms underlying restenosis. Circulation. 1991;84:432-435.
5. Lafont A, Guerot C, Lemarchand P. Which gene for restenosis? Lancet. 1995;346:1442-1443.
6. Garg UC, Hassid A. Nitric oxide generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 1989;83:1774-1776.
7. Sarkar R, Meinberg EG, Stanley JC, Gordon D, Webb RC. Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells. Circ Res. 1996;78:225-230.
8. Trachtman JH, Futterweit S, Singhal P. Nitric oxide modulates the synthesis of extracellular matrix proteins in cultured rat mesangial cells. Biochem Biophys Res Commun. 1995;207:120-125.
9. Kolpakov V, Gordon D, Kulik TJ. Nitric oxide-generating compounds inhibit total protein and collagen synthesis in cultured vascular smooth muscle cells. Circ Res. 1995;76:305-309.
10. Mellion BT, Ignarro LJ, Ohlstein EGH, Pontecarvo EG, Hyman AI, Kadowitz PJ. Evidence for the inhibitory role of guanosine 3′:5′-monophosphate in ADP induced human platelet aggregation in the presence of nitric oxide and related vasodilators. Blood. 1981;57:946-955.
11. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A. 1991; 88:4651-4655.
12. Gibbons GH, Dzau VJ. Molecular therapies for vascular diseases. Science. 1996;272:689-693.
13. Maragos CM, Morley D, Wink DA, Dunams TM, Saavedra JE, Hoffman A, Bove AA, Isaac L, Hrabie JA, Reefer LK. Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide: vasorelaxant effects. J Med Chem. 1991;34: 3242-3247.