Adverse effects and toxicity of inhaled nitric oxide

Respiratory Care

Volumn 44, Issue 3, 1999, Pages 315-330

  Hess, Dean R ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Adverse effects; Methemoglobin; Nitric oxide; Nitrogen dioxide; NO; Peroxynitrite; Toxicity

Indexed keywords

LUNG SURFACTANT; METHEMOGLOBIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROGEN DIOXIDE; PEROXYNITRITE;

ADULT RESPIRATORY DISTRESS SYNDROME; CLINICAL TRIAL; CONFERENCE PAPER; DRUG SAFETY; HEART LEFT VENTRICLE FILLING PRESSURE; HUMAN; HYPOXEMIA; INHALATIONAL DRUG ADMINISTRATION; LIPID PEROXIDATION; METHEMOGLOBINEMIA; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PULMONARY HYPERTENSION; REBOUND; RISK ASSESSMENT; THROMBOCYTE AGGREGATION INHIBITION;

EID: 0032940479     PISSN: 00201324     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (165)

1. Clutton-Brock J Two cases of poisoning by contamination of nitrous oxide with higher oxides of nitrogen during anaesthesia. Brit J Anaesth 1967;39(5):388-392.
2. Rosenberg AA, Kennaugh JM, Moreland SG, Fasha LM, Hale KA, Torielli FM, et al. Longitudinal follow-up of a cohort of newborn infants treated with inhaled nitric oxide for persistent pulmonary hypertension. J Pediatr 1997;131(1 Pt 1):70-75.
3. Luhr O, Aardal S, Nathorst-Westfelt U, Berggren L, Johansson LA, Wahlin L, Frostell C. Pulmonary function in adult survivors of severe acute lung injury treated with inhaled nitric oxide. Acta Anaesthesiol Scand 1998;42(4):391-398.
4. McIntyre RC. Jr, Moore FA, Moore EE, Piedalue F, Haenel JS, Fullerton DA. Inhaled nitric oxide variably improves oxygenation and pulmonary hypertension in patients with acute respiratory distress syndrome. J Trauma 1995,39(3):418-425.
5. Rossaint R, Gerlach H, Schmidt-Ruhnke H, Pappert D, Lewandowski K, Steudel W, Falke K. Efficacy of inhaled nitric oxide in patients with severe ARDS. Chest 1995;107(4).1107-1115.
6. Manktelow C, Bigatello LM, Hess D, Hurford WE. Physiologic determinants ot the response to inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology 1997;87(2):297-307.
7. Michael JR, Barton RG, Saffle JR, Mone M, Markewitz BA, Hillier K, et al. Inhaled nitric oxide versus conventional therapy: effect on oxygenation in ARDS. Am J Respir Crit Care Med 1998;157(5 Pt 1):1372-1380
8. Troncy E, Collet JP, Shapiro S, Guimond JG, Blair L, Ducruet T, et al. Inhaled nitric oxide in acute respiratory distress syndrome: a pilot randomized controlled study Am J Respir Crit Care Med 1998,157(5 Pt 1) 1483-1488.
9. Dellinger RP, Zunmerman JL, Taylor RW, Straube RC, Hauser DL, Criner GJ, et al Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group. Crit Care Med 1998; 26(1). 15-23
10. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. The Neonatal Inhaled Nitric Oxide Study Group. N Engl J Med 1997,336(9):597-604. Published erratum appears in N Engl J Med 1997;337(6):434.
11. Kinsella JP, Truog WE, Walsh WF, Goldberg RN, Ban Calan E, Mayock DE. Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn J Pediatr 1997,131(1 Pt 1):55-62.
12. Davidson D, Barefield ES, Kattwinkel J, Dudell G, Damask M, Straube R, et al. Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response, multicenter study. Pediatrics 1998;101(3 Pt 1):325-334.
13. Roberts JD Jr, Fineman JR, Morin FCr, Shaul PW, Rimar S, Schreiber MD, et al. Inhaled mine oxide and persistent pulmonary hypertension of the newborn The Inhaled Nitric Oxide Study Group. N Engl J Med 1997;336(9).605-610.
14. Oriot D, Boussemart T, Berthier M, Bonneau D, Coisne D. Paradoxical effect of inhaled nitric oxide in a newborn with pulmonary hypertension (letter). Lancet 1993;342(8867):364-365.
15. Barbera JA, Roger N, Roca J, Rovira I, Higenbottam TW, Rodriguez-Roison R. Worsening of pulmonary gas exchange with nitric oxide inhalation in chronic obstructive pulmonary disease. Lancet 1996;347(8999):436-440.
16. Katayama Y, Higenbottam TW, de Atauri MJ, Cremona G, Akamine S, Barbera JA, Rodriguez-Roison R. Inhaled nitric oxide and arterial oxygen tension in patients with chronic obstructive pulmonary disease and severe pulmonary hypertension. Thorax 1997; 52(2):120-124.
17. Roger N, Barbera JA, Roca J, Rovira I, Gomez FP, Rodriguez-Roison R. Nitric oxide inhalation during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1997; 156(3 Pt 1):800-806.
18. Yoshida M, Taguchi O, Gabazza EC, Kobayashi T, Yamakami T, Kobayashi H, et al. Combined inhalation of nitric oxide and oxygen in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1997,155(2):526-529.
19. Hopkins SR, Johnson EC, Richardson RS, Wagner H, De Rosa M, Wagner PD. Effects of inhaled nitric oxide on gas exchange in lungs with shunt or poorly ventilated areas. Am J Respir Crit Care Med 1997;156(2 Pt 1):484-491.
20. Mellion BT, Ignarro LJ, Ohlstein EH, Pontecorvo EG, Hyman AL, Kadowitz PJ. Evidence for the inhibitory role of guanosine 3′, 5′-monophosphate in adp-induced human platelet aggregation in the prevence of nitric oxide and related vasodilators. Blood 1981; 57(5) 946-955.
21. Radomoski MW, Palmer RM, Moncada S. Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide, and prostacyclin in platelets. Br J Pharmacol 1987;92(1):181-187.
22. Bassenge E, Antiplatelet effects of endothelium-derived relaxing factor and nitric-oxide donors. Eur Heart J 1991;12(Suppl E):12-15
23. Weber AA, Strobach H, Schror K. Direct inhibition of platelet function by organic nitrates via nitric oxide formation. Eur J Pharmacol 1993;247(1):29-37.
24. Loscalzo J, Antiplatelet and antithrombic effects of organic nitrates. Am J Cardiol 1992;70(8):18B-22B.
25. Radomski MW, Moncada S. Regulation of vascular homeostasis by nitric oxide. Thromb Haemost 1993;70(1):36-41.
26. Adric C, Bloch KD, Moreno PR, Hurford WE, Guerro JL, Holt R, et al. Inhaled nitric oxide increases coronary artery patency after thrombolysis. Circulation 1996;94(8):1919-1926.
27. Nong Z, Hoylaerts M, Van Pelt N, Collen D, Janssens S. Nitric oxide inhalation inhibits platelet aggregation and platelet-mediated pulmonary thrombosis in rats. Circ Res 1997;81(5):865-869.
28. Gries A, Bode C, Peter K, Herr A, Bohrer H, Motsch J, Martin E. Inhaled nitric oxide inhibits human platelet aggregation, P-selectin expression, and fibrinogen binding in vitro and in vivo. Circulation 1998;97(15):1481-1487.
29. Hogman M, Frostell C, Amberg H, et al. Bleeding time prolongation and NO inhalation (letter). Lancet 1993;341(8861):1664-1665.
30. Hogman M, Frostell C, Arnberg H, Sandhagen B, Hedenstierna G. Prolonged bleeding time during nitric oxide inhalation in the rabbit. Acta Physiol Scand 1994;151(1):125-129.
31. Gries A, Bottiger BW, Dorsam J, Bauer H, Weirnann J, Bode C, et al. Inhaled nitric oxide inhibits platelet aggregation after pulmonary embolism in pigs. Anesthesiology 1997;86(2):387-393.
32. Samama CM, Diaby M, Fellahi JL, Mdhafar A, Eyraud D, Arock M, et al. Inhibition of platelet aggregation by inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology 1995;83(1):56-65.
33. George TN, Johnson KJ, Bates JN, Segar JL. The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates. J Pediatr 1998;132(4):731-734.
34. Loh E, Stamler JS, Hare JM, Loscalzo J, Colucci WS Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction. Circulation 1994;90(6):2780-2785.
35. Bocchi EA, Bacal F, Auler Jr JO, Carmone MJ, Bellotti G, Pileggi F. Inhaled nitric oxide leading to pulmonary edema in stable severe heart failure. Am J Cardiol 1994;74(1):70-72.
36. Semigran MJ, Cockrill BA, Kacmarek R, Thompson BT, Zapol WM, Dec GW, Fifer MA Hemodynamic effects of inhaled nitric oxide in heart failure. J Am Coll Cardiol 1994;24(4):982-988
37. Hare JM, Shernan SK, Body SC, Graydon E, Colucci WS, Louper GS. Influence of inhaled nitric oxide on systemic flow and ventricular filling pressure in patients receiving mechanical circulatory assistance. Circulation 1997;95(9):2250-2253. Published erratum appears in Circulation 1997;96(3):1065.
38. Hayward CS, Kalnins WV, Rogers P, Feneley MP, MacDonald PS, Kelly RP, Effect of inhaled nitric oxide on normal human left ventricular function. J Am Coll Cardiol 1997;30(1):49-56.
39. Goldstein DJ, Dean DA, Smerling A, Oz MC, Burkoff D, Dickstein ML, et al. Inhaled nitric oxide is not a negative motropic agent in a porcine model of pulmonary hypertension. J Thorac Cardiovasc Surg 1997;114(3):461-466.
40. Gerlach H, Pappert D, Lewandowski K, Rossaint R, Falke KJ. Long-term inhalation with evaluated low doses of nitric oxide for selective improvement of oxygenation in patients with adult respiratory distress syndrome. Intensive Care Med 1993;19(8):443-449.
41. Bigatello LM, Hurford WE, Kacmarek RM, Roberts JD Jr, Zapol WM. Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Effects on pulmonary hemodynamics and oxygenation Anesthesiology 1994; 80(4):761-770.
42. Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 1993;328(6):399-405.
43. Miller OI, Tang SF, Keech A, Celermajer DS. Rebound pulmonary hypertension on withdrawal from inhaled nitric oxide (letter). Lancet 1995;346(8966):51-52.
44. Lavoie A, Hall JB, Olson DM, Wylam ME. Life-threatening effects of discontinuing inhaled nitric oxide in severe respiratory failure. Am J Respir Crit Care Med 1996;153(6 Pt 1):1985-1987.
45. Atz AM, Adatia I, Wessel DL. Rebound pulmonary hypertension after inhalation of nitric oxide. Ann Thorac Surg 1996;62(6):1759-1764
46. Cueto E, Lopez-Herce J, Sanchez A, Carrillo A. Life-threatening effects of discontinuing inhaled nitric oxide in children. Acta Paediatr 1997;86(12):1337-1339.
47. Packer M, Meller J, Medina N, Gorlin R, Herman MV. Rebound hemodynamic events after the abrupt withdrawal of nitroprusside in patients with severe chronic heart failure. N Engl J Med 1979;301(22):1193-1197.
48. Kiff RJ, Moss DW, Moncada S. Effect of nitric oxide gas on generation of nitric oxide by isolated blood vessels: implications for inhalation therapy. Br J Pharmacol 1994:113(2):496-498.
49. Assreuy J, Cunha FQ, Liew FY, Moncada S. Feedback inhibition of nitric oxide synthase activity by nitric oxide. Br J Pharmacol 1993;108(3):833-837.
50. Ravichandran LV, Johns RA, Rengasamy A. Direct and reversible inhibition of endothelial nitric oxide synthase by nitric oxide. Am J Physiol 1995;268(6 Pt 2):H2216-H2223.
51. Sheehy AM, Burson MA, Black SM. Nitric oxide exposure inhibits endothelial NOS activity but not gene expression: a role for superoxide. Am J Physiol 1998;274(5 Pt 1):L833-L841.
52. Aly H, Sahni R, Wung JT. Weaning strategy with inhaled nitric oxide treatment in persistent pulmonary hypertension of the newborn. Arch Dis Child Fetal Neonatal Ed 1997;76(2):F118-F122.
53. al-Alaiyan S, al-Omran A, Dyer D. The use of phosphodiesterase inhibitor (dipyridamole) to wean from inhaled nitric oxide. Intensive Care Med 1996;22(10):1093-1095.
54. Ivy DD, Kinsella JP, Ziegler JW, Abman SH. Dipyridamole attenuates rebound pulmonary hypertension after inhaled nitric oxide withdrawal in postoperative congenital heart disease. J Thorac Cardiovasc Surg 1998,115(4):875-882.
55. Curry S. Methemoglobinemia. Ann Emerg Med 1982;11(4):214-221
56. Wennmalm A, Benthin G, Petersson AS. Dependence of the metabolism of nitric oxide (NO) in healthy human whole blood on the oxygenation of its red cell hemoglobin. Br J Pharmacol 1992;106(3): 507-508.
57. Wennmalm A, Benthin G, Edlund A, Jungersten L, Kieler-Jensen N, Lundin S, et al. Metabolism and excretion of nitric oxide in humans An experimental and clinical study. Circ Res 1993;73(6):1121-1127.
58. Kuma F, Properties of methemoglobin reductase and kinetic study of methemoglobin reduction. J Biol Chem 1981;256(11):5518-5523.
59. Scott EM, Hoskins, DD. Heriditary methemoglobinemia in Alaskan Eskimos and Indians. Blood 1958;13:795-802.
60. Eng LL, Loo M, Fah FK. Diaphorase activity and variants in normal adults and newborns Br J Haematol 1972;23(4):419-425.
61. Ross JD. Deficient activity of DPNH-dependent methemoglobin diaphorase in cord blood erythrocytes. Blood 1963;21:51-62.
62. Zijlstra WG, Buursma A, Meeuwsen-van der Roest WP. Absorption spectra of human fetal and adult oxyhemoglobin, de-oxyhemoglobin, carboxyhemoglobin, and methemoglobin. Clin Chem 1991;37(9):1633-1638.
63. Zwart A, Buursma A, Oeseburg B, Zijlstra WG. Determination of hemoglobin derivatives with the IL 282 CO-Oximeter as compared with a manual spectrophotometric five-wavelength method. Clin Chem 1981;27(11):1903-1907.
64. Severinghaus JW, Kelleher JF Recent developments in pulse oximetry (review). Anesthesiology 1992;76(6):1018-1038.
65. Spurzem JR, Bonekat HW, Shigeoka JW. Factitious methemoglobinemia caused by hyperlipemia. Chest 1984;86(1):84-86.
66. Iwamoto J, Krasney JA, Monn FC 3rd. Methemoglobin production by nitric oxide in fresh sheep blood. Respir Physiol 1994;96(2-3):273-283.
67. Toothill C. The chemistry of the in-vivo reaction between hemoglobin and various oxides of nitrogen. Br J Anaesth 1967;39(5):405-412.
68. Azoulay E, Soler P, Blayo MC, Basset F. Nitric oxide effects on lung structure and blood oxygen in rats. Bull Eur Physiopath Respir 1977;13(5):629-644.
69. Azoulay E, Lachia L, Blayo MC, Pocidalo JJ. Methemoglobinemia induced by nitric oxide in whole blood. Quantitative relationship. Toxicol Eur Res 1978;1(1):7-12.
70. Doyle MP, Pickering RA, DeWeert TM, Hoekstra JW, Pater D. Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites. J Biol Chem 1981;256(23):12393-12398.
71. Kon K, Maeda N, Shiga T. Effect of nitric oxide on the oxygen transport of human erythrocytes. J Toxicol Environ Health 1977; 2(5):1109-1113.
72. Maeda N, Imaizumi K, Kon K, Shiga T. A kinetic study on functional impairment of nitric oxide-exposed rat erythrocytes Environ Health Perspect 1987;73:171-177.
73. Wennmalm A, Benthin G, Edlund A, Jungersten L, Kieler-Jensen N, Lundin S, et al. Metabolism and excretion of nitric oxide in humans. An experimental and clinical study Circ Res 1993;73(6):1121-1127.
74. Chien JC. Reactions of nitric oxide with methemoglobin. J Am Chem Soc 1969;91(8):2166-2168.
75. Young JD, Dyar O, Xiong L, Howell S. Methaemoglobin production in normal adults inhaling low concentrations of nitric oxide. Intensive Care Med 1994;20(8):581-584.
76. Young JD, Sear JW, Valvini EM. Kinetics of methaemoglobin and serum nitrogen oxide production during inhalation of nitric oxide in volunteers. Br J Anaesth 1996;76(5):652-656.
77. Gibson QH, Roughton FJW. The kinetics of equilibria of the reactions of nitric oxide with sheep hemoglobin. J Physiology (Lond) 1957;136:5-7-526.
78. Channick RN, Newhart JW, Johnson FW, Moser KM. Inhaled nitric oxide reverses hypoxic pulmonary vasoconstriction in dogs. A practical nitric oxide delivery and monitoring system. Chest 1994; 105(6):1842-1847.
79. Abman SH, Gnebel JL, Parker DK, Schmidt JM, Swanton D, Kinsella JP. Acute effects of inhaled nitric oxide in children with severe hypoxemic respiratory failure. J Pediatrics 1994;124(6):881-888.
80. Levy B, Bollaert PE, Bauer P, Nace L, Audibert G, Larean A. Therapeutic optimization including inhaled nitric oxide in adult respiratory distress syndrome in a polyvalent intensive care unit. J Trauma 1995;38(3):370-374.
81. Puybasset L, Stewart T, Rouby JJ, Cluzel P, Mourgeon E, Belin MF, et al. Inhaled nitric oxide reverses the increase in pulmonary vascular resistance induced by permissive hypercapnia in patients with acute respiratory distress syndrome. Anesthesiology 1994; 80(6):1254-1267.
82. Kinsella JP, Abman SH. Methaemoglobin during nitric oxide therapy with high-frequency ventilation (letter). Lancet 1993;342(8871):615.
83. Lowson SM, Rich GF, McArdle PA, Jaidev J, Morris GN. The response to varying concentrations of inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesth Analg 1996;82(3):574-581
84. Beghetti M, Habre W, Friedli B, Berner M. Continuous low dose inhaled nitric oxide for treatment of severe pulmonary hypertension after cardiac surgery in paediatric patients. Br Heart J 1995;73(1): 65-68.
85. Wessel DL, Adatia I, Thompson JE, Hickey PR. Delivery and monitoring of inhaled nitric oxide in patients with pulmonary hypertension Cric Care Med 1994;22(6):930-938.
86. Hovenga S, Koenders ME. van der Werf TS, Moshage H, Zijlstra JG. Methaemoglobinaemia after inhalation of nitric oxide for treatment of hydrochlorothiazide-induced pulmonary oedema (letter). Lancet 1996;348(9033):1035-1036.
87. Macdonald P, Mundy J, Rogers P, Harrison G, Branch J, Glanville A, et al. Successful treatment of life-threatening acute reperfusion injury after lung transplantation with inhaled nitric oxide. J Thorac Cardiovasc Surg 1995,110(3):861-863.
88. Jacob TD, Nakayama DK, Seki I, Exler R, Lancaster JR Jr, Sweetland MA, et al. Hemodynamic effects and metabolic fate of inhaled nitric oxide in hypoxic piglets. J Appl Physiol 1994;76(4).1794-1801.
89. Martin W, Villani GM, Jothianandan D, Furchgott RF. Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. J Pharmacol Exp Ther 1985;232(3):708-716.
90. Keaney JF Jr, Puyana J-C, Francis S, Loscalzo JF, Stamler JS, Loscalzo J. Methylene blue reverses endotoxin-induced hypotension. Circ Res 1994;74(6):1121-1125.
91. Young JD, Dyar OJ, Xiong L, Zhang J, Gavaghan D. Effect of methylene blue on the vasodilator action of inhaled nitric oxide in hypoxic sheep. Brit J Anaesth 1994;73(4):511-516.
92. Mayer B, Brunner F, Schmidt K. Inhibition of nitric oxide synthasis by methylene blue. Biochem Pharmacol 1993;45(2):367-374.
93. Greenbaum R, Bay J, Hargreaves MD, Kain ML, Kelman GR, Nunn JF, et al. Effects of higher oxides of nitrogen on the anaesthetized dog. Br J Anaesth 1967;39(5):393-403.
94. Shtel FO. Morbid anatomical changes in the lungs of dogs after inhalation of higher oxides of nitrogen during anaesthesia. Br J Anaesth 1967;39(5):413-424.
95. Douglas WW, Hepper NG, Colby TV. Silo-fitler's disease. Mayo Clin Proc 1989;64(3):291-304.
96. Zwemer FL, Pratt DS, May JJ. Silo filler's disease in New York State. Am Rev Respir Dis 1992;146(3):650-653.
97. Dupuy PM, Lancon JP, Francoise M, Frostell CG. Inhaled cigarette smoke selectively reverses human hypoxic vasoconstriction. Intensive Care Med 1995;21(11):941-944.
98. Alving K, Fornhem C, Lundberg JM. Pulmonary effects of endogenous and exogenous nitric oxide in the pig: relation to cigarette smoke inhalation. Br J Pharmacol 1993;110(2):739-746.
99. Oilman MJ, Sylvester JT, Kennedy TP, Menkes HA, Traystman RJ. Vascular effects of cigarette smoke in isolated pig lungs. Am Rev Respir Dis 1981;124(5):549-553.
100. Maron MB, Crowe TD, Braughler JM. Cigarette smoke causes acute fluctuations in the cyclic GMP content of the isolated intact lung. Respiration 1984;45(1):39-44.
101. Norman V, Keith CH. Nitrogen oxides in tobacco smoke. Durham: Liggett & Myers Tobacco Co. 1965.
102. Groll-Knapp E, Haider M, Kienzl K, Handler A, Trimmel M. Changes in discrimination learning and brain activity (ERPS) due to combined exposure to NO and CO in rats. Toxicology 1988;49(2-3):441-447.
103. Hugod C. Ultrastractural changes of the rabbit lung after 5 ppm nitric oxide exposure. Arch Environ Health 1979;34(1):12-17.
104. Mercer RR, Costa DL, Costa JD. Alveolar septal injury from low level exposures to nitric oxide (abstract). Am Rev Respir Dis 1993;147(4 Pt 2):A385.
105. Henry Y, Ducrocq C, Drapier JC, Servent D, Pellat C, Guissani A. Nitric oxide, a biological effector: electron paramagnetic resonance detection of nitrosyl-iron-protein complexes in whole cells (review). Eur Biophys J 1991;20(1):1-15.
106. von Nieding G, Wagner JM, Krekeler H. Investigation of the acute effects of nitrogen monoxide on lung function in man. Proceedings. Third International Clean Air Congress, Dusseldorf, 1973. Verlag des Vereins Deutcher Ingenieure.
107. Kagawa J. Respiratory effects of 2-hr exposure to 1.0 ppm nitric oxide in normal subjects Envir Res 1982,22:485-490.
108. Frostell C, Hogman M, Hedenstrom H, Hedenstiema G. Is nitric oxide inhalation beneficial for the asthmatic patient? (abstract) Am Rev Respir Dis 1993;147(4 Pt 2):A515.
109. Roger N, Barbera JA, Farre R, Cobos A, Roca J, Rodriguez-Roisin R. Effect of nitric oxide inhalation on respiratory system resistance in chronic obstructive pulmonary disease. Eur Respir J 1996;9(2):190-195.
110. Rayhrer CS, Edmisten TD, Cephas GA, Tribble CG, Kron IL, Young JS. Nitric oxide potentiates acute lung injury in an isolated rabbit lung model. Ann Thorac Surg 1998;65(4):935-938.
111. Narula P, Xu J, Kazzaz JA, Robbins CG, Davis JM, Horowitz S. Synergistic cytotoxicity from nitric oxide and hyperoxia in cultured lung cells. Am J Physiol 1998;274(3 Pt 1):L411-L416.
112. Garat C, Jayr C, Eddahibi S, Laffon M, Meignan M, Adnot S. Effects of inhaled nitric oxide or inhibition of endogenous nitric oxide formation on hyperoxic lung injury. Am J Respir Crit Care Med 1997:155(6):1957-1964.
113. Kinsella JP, Parker TA, Galan H, Sheridan BC, Halbower AC, Abman SH. Effects of inhaled nitric oxide on pulmonary edema and lung neutrophil accumulation in severe experimental hyaline membrane disease. Pediatr Res 1997;41(4 Pt 1):457-463.
114. Chollet-Martin S, Gatecel C, Kermarrec N, Gougerot-Pocidalo MA, Payen DM. Alveolar neutrophil functions and cytokine levels in patients with the adult respiratory distress syndrome during nitric oxide inhalation. Am J Respir Crit Care Med 1996;153(3):985-990.
115. Kavanagh BP, Mouchawar A, Goldsmith J, Pearl RG. Effects of inhaled NO and inhibition of endogenous NO synthesis in oxidant-induced acute lung injury. J Appl Physiol 1994;76(3):1324-1329.
116. Kam ML. Higher oxides of nitrogen in anesthetic gas circuits. Br J Anaesth 1967;39(5):382-387.
117. Austin AT. The chemistry of the higher oxides of nitrogen as related to the manufacture, storage and administration of nitrous oxide. Br J Anaesth 1967;39(5):345-350.
118. Glasson WA, Tuesday CS. The atmospheric thermal oxidation of nitric oxide. J Am Chem Soc 1963;85:2901-2904.
119. Bouchet M, Renaudin MH, Raveau C, Mercier JC, Dehan M, Zupan V. Safety requirement for use of inhaled nitric oxide in neonares (letter). Lancet 1993,341(8850):968-969.
120. Fourbert L, Fleming B, Latimer R, Jonas M, Oduro A, Borland C, et al. Safety guidelines for use of nitric oxide. Lancet 1992;339(8809):1615-1616.
121. Stephens RJ, Freeman G, Evans MJ. Early response of lungs to low levels of nitrogen dioxide: light and electron microscopy. Arch Environ Health 1972;24(3):160-179.
122. Nishimura M, Hess D, Kacmarek RM, Ritz R, Hurford WE Nitrogen dioxide production during mechanical ventilation with nitric oxide in adults: effects of ventilator internal volume, air versus nitrogen dilution, minute ventilation, and inspired oxygen fraction. Anesthesiology 1995;82(5):1246-1254.
123. Frampton MW, Morrow PE, Cox C, Gibb FR, Speers DM, Utell MJ. Effects of nitrogen dioxide exposure on pulmonary function and airway reactivity in normal humans. Am Rev Respir Dis 1991;143(3).522-527.
124. Miyamoto K, Aida A, Nishimura M, Nakano T, Kawakami Y, Ohmori Y, et al Effects of humidity and temperature on nitrogen dioxide formation from nitric oxide (letter). Lancet 1994;343(8905):1099-1100.
125. NIOSH recommendations for occupational safety and health standards 1988. MMWR Morb Mortal Wkly Rep 1988;37(Suppl 7):1-29.
126. Bauer MA, Utell MJ, Morrow PE, Speers DM, Gibb FR. Inhalation of 0.30 ppm nitrogen dioxide potentiates exercise-induced bronchospasm in asthmatics. Am Rev Respir Dis 1986;134(6):1203-1208.
127. 3. Am J Respir Crit Care Med 1994;150(3):642-647.
128. Orehek J, Massari JP, Gayard P, Grimaude C, Charpin J. Effects of short-term, low-level nitrogen dioxide exposure on bronchial sensitivity of asthmatic patients. J Clin Invest 1976;57(2):301-307.
129. Kleinman MT, Bailey RM, Linn WS, Anderson KR, Whynot JD, Shamoo DA, Hackney JD. Effect of 0.2 ppm nitrogen dioxide on pulmonary function and response to bronchoprovocation in asthmatics. J Toxicol Environ Health 1983;12(4-6):815-826.
130. Sandstrom T, Stjernberg N, Eklund A, Ledin MC, Bjermer L, Kolmodin-Hedman B, et al. Inflammatory cell response in bronchoalveolar lavage fluid after nitrogen dioxide exposure of healthy subjects: a dose-response study. Eur Respir J 1991;4(3):332-339.
131. Williams RA, Rhoades RA, Adams WS. The response of lung tissue and surfactant to nitrogen dioxide exposure. Arch Intern Med 1971;128(1):101-108.
132. Freeman G, Crane SC, Furiosi NJ, Stephens RJ, Evans MJ, Moore WD. Covert reduction in ventilatory surface area in rats during prolonged exposure to subacute nitrogen dioxide. Am Rev Respir Dis 1972;106(4):563-569.
133. McElroy MC, Pittet JF, Allen L, Wiener-Kronish JP, Dobbs LG. Biochemical detection of type I cell damage after nitrogen dioxide-induced lung injury in rats. Am J Physiol 1997;273(6 Pt 1):L1228-L1234.
134. Gupta D, Aggarwal AN, Jain S, Behera D, Jindal SK. Acute pulmonary effects of toxic nitrogen dioxide fume inhalation. Respir Care 1998;43(7):557-561.
135. 2. Arch Environ Health 1972;24(3):180-188.
136. 2 exposure on alveolar permeability and glutathione peroxidase in healthy humans. Am Rev Respir Dis 1992;146(3):654-659.
137. Bylin G, Hedenstierna G, Lindvall T, Sundin B. Ambient nitrogen dioxide concentrations increase bronchial responsiveness in subjects with mild asthma. Eur Respir J 1988;1(7):606-612.
138. Morrow PE, Utell MJ, Bauer MA, Smeglin AM, Frampton MW, Cox C, et al. Pulmonary performance of elderly normal subjects and subjects with chronic obstructive pulmonary disease exposed to 0.3 ppm nitrogen dioxide Am Rev Respir Dis 1992,145(2 Pt 1):291-300.
139. 2 air space absorption in isolated rat lungs J Appl Physiol 1992;73(5):1939-1945.
140. Kelly FJ, Blomberg A, Frew A, Holgate ST, Sandstrom T. Anti-oxidant kinetics in lung lavage fluid following exposure of humans to nitrogen dioxide. Am J Respir Cru Care Med 1996;154(6 Pt 1):1700-1705.
141. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA, Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87(4):1620-1624.
142. Cassina A, Radi R. Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport. Arch Biochem Biophys 1996;328(2):309-316.
143. Denicola A, Freeman BA, Trujillo M, Radi R Peroxyn ite reaction with carbon dioxide/bicarbonate: kinetics and influence on peroxynitrite-mediated oxidations. Arch Biochem Biophys 1996. 333(1):49-58.
144. Freeman B. Free radical chemistry of nitric oxide: looking at the dark side (review). Chest 1994;105(3 Suppl):79S-84S.
145. Prutz WA, Monig H. Butler J, Land EJ. Reactions of nitrogen dioxide in aqueous model systems: oxidation of tyrosine units in peptides and proteins. Arch Biochem Biophys 1985;243(1):125-134.
146. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite oxidation of sulfhydryls: the cytotoxic potential of Superoxide and nitric oxide. J Biol Chem 1991;266(7):4244-4250.
147. Radi R, Rodriquez M, Castro L, Telleri R. Inhibition of mitrochodrial electron transport by peroxynitrite. Arch Biochem Biophys 1994;308(1):89-95.
148. Stamler JS, Singel DJ, Loscalzo J. Biochemisty of nitric oxide and its redox-activated forms (review). Science 1992;258(5090),1899-1902.
149. Xia Y, Dawson VL, Dawson TM, Snyder SH, Zweier JL. Nitric oxide synthase generates Superoxide and nitric oxide in argininedepleted cells leading to peroxynitrite-mediated cellular injury. Proc Natl Acad Sci USA 1996;93(13):6770-6774.
150. Ischiropoulos H, Zhu L, Beckman JS. Peroxynitirite formation from macrophage-derived nitric oxide. Arch Biochem Biophys 1992;293(2):446-451.
151. Kooy NW, Royall JA. Agonist-induced peroxynitrite production from endothelial cells. Arch Biochem Biophys 1994;310(2) 352-359.
152. Gow AJ, Thorn SR, Ischiropoulos H. Nitric oxide and peroxynitrite-mediated pulmonary cell death. Am J Physiol 1998;274(1 Pt 1):L112-L118.
153. Ischiropoulos H, al-Mehdi AB, Fisher AB. Reactive species in ischemic rat lung injury : contribution of peroxynitrite. Am J Physiol 1995,269(2 Pt 1):L158-L164.
154. Cuthbertson BH, Galley HF, Webster NR. The effects of nitric oxide and peroxynitrite on interleukin-8 and elastase from lipopolysaccharide-stimulated whole blood. Anesth Analg 1998;86(2): 427-431.
155. Kooy NW, Royall JA, YE YZ, Kelly DR, Beckman JS. Evidence for in vivo peroxynitrite production in human acute lung injury. Am J Respir Crit Care Med 1995,151(4):1250-1254.
156. Hallman M, Bry K, Turbow R, Waffarn F, Lappalainen U. Pulmonary toxicity associated with nitric oxide in term infants with severe respiratory failure, J Pediatr 1998;312(5):827-829.
157. Haddad IY, Ischiropoulos H, Holm BA, Beckman JS, Baker JR, Matalon S. Mechanisms of peroxynitrite-induced injury to pulmonary surfactants. Am J Physiol 1993;265(6 Pt 1):L555-L564.
158. Haddad IY, Crow JP, HU P, Beckman J. Matalon S. Concurrent generation of nitric oxide and Superoxide damages surfactant protein A. Am J Physiol 1994,267(3 Pt 1).L242-L249.
159. Haddad IY, Zhu S, Crow J, Barefield E, Gadilhe J, Matalon S. Inhibition of alveolar Type II cell ATP and surfactant synthesis by nitric oxide. Am J Physiol 1996;270(6 Pt 1 ):L898-L906.
160. Hallman M, Bry K, Lappalainen U A mechanism of nitric oxideinduced surfactant dysfunction. J Appl Physiol 1996;80(6):2035-2043
161. Hallman M, Bry K, Nitric oxide and lung surfactant (review). Semin Perinatol 1996;20(3):173-185.
162. Hallman M, Waffarn F, Bry, K, Turbow R, Kleinman MT, Mautz WJ, et al Surfactant dysfunction after inhalation of nitric oxide. J Appl Physiol 1996;80(6),2026-2034.
163. Matalon S, DeMarco V, Haddad IY, Myles C, Skimming JW, Schurch S, et al. Inhaled nitric oxide injures the pulmonary surfactant system of lambs in vivo Am J Physiol 1996;270(2 Pt 1):L273-L280.
164. Robbins CG, Davis JM, Mernitt TA, Amirkhanian JD, Sahgal N, Morin FC 3rd. Horowitz S Combined effects of nitric oxide and hyperoxia on surfactant function and pulmonary inflammation. Am J Physiol 1995;269(4 Pt 1):L545-L550.
165. Ayad O, Wong HR. Nitric oxide decreases surfactant protein A gene expression in H441 cells. Crit Care Med 1998;26(7):1277-1282.