Select 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors vary in their ability to reduce egg yolk cholesterol levels in laying hens through alteration of hepatic cholesterol biosynthesis and plasma VLDL composition

Journal of Nutrition

Volumn 129, Issue 5, 1999, Pages 1010-1019

  Elkin, Robert G ^a   Yan, Zhihong ^a   Zhong, Yuan ^a   Donkin, Shawn S ^a   Buhman, Kimberly K ^a   Story, Jon A ^a   Turek, John J ^b   Porter Jr , Robert E ^b   Anderson, Maureen ^c   Homan, Reynold ^c   Newton, Roger S ^c  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c PFIZER INC   (United States)

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A reductase inhibitors; Chickens; Cholesterol; Egg; VLDL

Indexed keywords

ATORVASTATIN; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; SIMVASTATIN; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL TISSUE; ARTICLE; CHOLESTEROL LIVER LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; EGG PRODUCTION; EGG YOLK; ENZYME ACTIVITY; HEN; LIPID COMPOSITION; NONHUMAN; PARTICLE SIZE; VITELLOGENESIS;

EID: 0032930562     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/129.5.1010     Document Type: Article

References (67)

1. Andrews, J. W., Wagstaff, R. K. & Edwards, H. M. (1968) Cholesterol metabolism in the laying fowl. Am. J. Physiol. 214: 1078-1083.
2. Auerbach, B. J., Krause, B. R., Bisgaier, C. L. & Newton, R. S. (1995) Comparative effects of HMG-CoA reductase inhibitors on apo B production in the caseinfad rabbit: Atorvastatin versus lovastatin. Atherosclerosis 115: 173-180.
3. Bakker-Arkema, R. G., Davidson, M. H., Goldstein, R. J., Davignon, J., Isaacsohn, J. L., Weiss, S. R., Keilson, L. M., Brown, V. W., Miller, V. T., Shurzinske, L. J. & Black, D. M. (1996) Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia. JAMA. 275: 128-133.
4. Bisgaier, C. L., Essenburg, A. D., Auerbach, B. J., Pape, M. E., Sekerke, C. S., Gee, A., Wölle, S. & Newton, R. S. (1997) Attenuation of plasma low density lipoprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in mice devoid of low density lipoprotein receptors. J. Lipid Res. 38: 2502-2515.
5. Bocan, T.M.A, Ferguson, E., McNally, W., Uhlendorf, P. D., Mueller, S. B., Dehart, P., Sliskovic, D. R., Roth, B. D., Krause, B. R. & Newton, R. S. (1992) Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: Comparison with selected HMG-CoA reductase inhibitors. Biochim. Biophys. Acta 1123: 133-144.
6. Bujo, H., Hermann, M., Kaderli, M. O., Jacobsen, L., Sugawara, S., Nimpf, J., Yamamoto, T. & Schneider, W. J. (1994) Chicken oocyte growth is mediated by an eight ligand binding repeat member of the LDL receptor family. EMBO J. 13: 5165-5175.
7. Bujo, H., Lindstedt, K. A., Hermann, M., Dalmau, L. M., Nimpf, J. & Schneider, W. J. (1995) Chicken oocytes and somatic cells express different splice variants of a multifunctional receptor. J. Biol. Chem. 270: 23546-23551.
8. Burley, R. W., Evans, A. J. & Pearson, J. A. (1993) Molecular aspects of the synthesis and deposition of hens' egg yolk with special reference to low density lipoprotein. Poultry Sci. 72: 850-855.
9. Burnett, J. R., Wilcox, L. J., Telford, D. E., Kleinstiver, S. J., Hugh, P., Barrett, P., Newton, R. S. & Huff, M. W. (1997) Inhibition of HMG-CoA reductase by atorvastatin decreases both VLDL and LDL apolipoprotein B production in miniature pigs. Arterioscter. Thromb. Vasc. Biol. 17: 2589-2600.
10. Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
11. Conde, K., Vergara-Jimenez, M., Krause, B. R., Newton, R. S. & Fernandez, M. L. (1996) Hypocholesterolemic actions of atorvastatin are associated with alterations on hepatic cholesterol metabolism and lipoprotein composition in the guinea pig. J. Lipid Res. 37: 2372-2382.
12. 14 into egg yolk cholesterol. Proc. Soc. Exp. Biol. Med. 118: 710-713.
13. Dart, A., Jerums, G., Nicholson, G., d'Emden, M., Hamilton-Craig, I., Tallis, G., Best, J., West, M., Sullivan, D., Bracs, P. & Black, D. M. (1997) A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients with hypercholesterolemia. Am. J. Cardiol. 80: 39-44.
14. Davidson, E. H. (1986) Gene Activity in Early Development. Academic Press, London, UK.
15. Davidson, M., McKenney, J., Stein, E., Schrott, H., Bakker-Arkema, R., Fayyad, R. & Black, D. M. (1997) Comparison of one-year efficacy and safety of atorvastatin versus lovastatin in primary hypercholesterolemia. Atorvastatin study group I. Am. J. Cardiol. 79: 1475-1481.
16. Donkin, S. S., McNall, A. D., Swencki, B. S., Peters, J. L. & Etherton, T. D. (1996) The growth hormone-dependent decrease in hepatic fatty acid synthase mRNA is the result of a decrease in gene transcription. J. Mol. Endocrinol. 16: 151-158.
17. Dujovre, C. A. (1997) New lipid lowering drugs and new effects of old drugs. Curr. Opin. Lipidol 8: 362-368.
18. Elkin, R. G. & Rogler, J. C. (1990) Reduction of the cholesterol content of eggs by the oral administration of lovastatin to laying hens. J. Agric. Food Chem. 38: 1635-1641.
19. Elkin, R. G. & Schneider, W. J. (1994) Visualization of the chicken oocyte lipoprotein receptor by ligand blotting with biotinylated plasma and yolk very low density lipoproteins. Poult. Sci. 73: 1127-1136.
20. Elkin, R. G. & Yan, Z. (1999) Association of mevalonate biosynthesis inhibition with reduced fertility in laying hens. J. Repro. Fertil. (in press).
21. Elkin, R. G., Freed, M. B., Danetz, S.A.H & Bidwell, C. A. (1995) Proteolysis of Japanese quail and chicken plasma apolipoprotein B and vitellogenin by cathepsin D: Similarity of the resulting protein fragments with egg yolk polypeptides. Comp. Biochem. Physiol. 112B: 191-196.
22. Elkin, R. G., Freed, M. B., Kieft, K. A. & Newton, R. S. (1993a) Alteration of egg yolk cholesterol content and plasma lipoprotein profiles following administration of a totally synthetic HMG-CoA reductase inhibitor to laying hens. J. Agric. Food Chem. 41: 1094-1101.
23. Elkin, R. G., Freed, M., Watkins, B. A., Srebnik, M., Kieft, K. A. & Newton, R. S. (1993b) Evaluation of two novel biochemicals on plasma and egg yolk lipid composition and laying hen performance. Poult. Sci. 72: 513-520.
24. Endo, A. (1992) The discovery and development of HMG-CoA reductase inhibitors. J. Lipid Res. 33: 1569-1582.
25. Favre, D. (1992) Improved phenol-based method for the isolation of DNA fragments from low melting temperature agarose gels. Biotechniques 13: 22, 25-26.
26. Gordon, D. A. (1997) Recent advances in elucidating the role of the microsomal triglyceride transfer protein in apolipoprotein B lipoprotein assembly. Curr. Opin. Lipidol. 8: 131-137.
27. Griffin, H. D. (1992) Manipulation of egg yolk cholesterol: A physiologist's view. World's Poultry Sci. J. 48: 101-112.
28. Hargis, P. S. (1988) Modifying egg yolk cholesterol in the domestic fowl: A review. World's Poultry Sci. J. 44: 17-29.
29. Hayashi, K., Ando, S., Stifani, S. & Schneider, W. J. (1989a) A novel sterol-regulated surface protein on chicken fibroblasts. J. Lipid Res. 30: 1421-1428.
30. Hayashi, K., Nimpf, J. & Schneider, W. J. (1989b) Chicken oocytes and fibroblasts express different apolipoprotein-B-specific receptors. J. Biol. Chem. 264: 3131-3139.
31. Hermier, D., Forgez, P., Williams, J. & Chapman, M. J. (1989) Alterations in plasma lipoproteins and apolipoproteins associated with estrogen-induced hyperlipidemia in the laying hen. Eur. J. Biochem. 184: 109-118.
32. Homan, R. & Anderson, M. K. (1998) Rapid separation and quantitation of combined neutral and polar lipid classes by high-performance liquid chromatography and evaporative light-scattering mass detection. J. Chromatogr. B. 708: 21-26.
33. Huff, M. W. & Burnett, J. R. (1997) 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and hepatic apolipoprotein B secretion. Curr. Opin. Lipidol. 8: 138-145.
34. Junker, L. H. & Story, J. A. (1985) An improved assay for cholesterol 7α-hydroxylase activity using phospholipid liposome solubilized substrate. Lipids 20: 712-718,
35. Kieft, K. A., Bocan, T.M.A. & Krause, B. R. (1991) Rapid on-line determination of cholesterol distribution among plasma lipoproteins after high-performance gel filtration chromatography. J. Lipid Res. 32: 859-866.
36. Kirchgessner, T. G., Heinzmann, C., Svenson, K. L., Gordon, D. A., Nicosia, M., Lebherz, H. G., Lusis, A. J. & Williams, D. L. (1987) Regulation of chicken apolipoprotein B: cloning, tissue distribution, and estrogen induction of mRNA. Gene 59: 241-251.
37. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265-275.
38. Lumei, J. T. (1994) Avian clinical enzymology. Semin. Avian Exotic Pet Med. 3: 14-24.
39. McNamara, D. J., Kolb, R., Parker, T. S., Batwin, H., Samuel, P., Brown, C. D. & Ahrens, E. H. (1987) Heterogeneity of cholesterol homeostasis in man: Response to changes in dietary tat quality and cholesterol quantity. J. Clin. Invest. 79: 1729-1739.
40. MacLachlan, I., Steyrer, E., Hermetter, A., Nimpf, J. & Schneider, W. J. (1996) Molecular characterization of quail apolipoprotein very-low-density lipoprotein II: Disulphide-bond-mediated dimerization is not essential for inhibition of lipoprotein lipase. Biochem. J. 317: 599-604.
41. Merck Sharp & Dohme. (1988) Mevacor™ package insert. Merck Sharp & Dohme, West Point, PA.
42. Naber, E. C. (1976) The cholesterol problem, the egg and lipid metabolism in the laying hen, Poult. Sci. 55: 14-30.
43. Naber, E. C. (1983) Nutrient and drug effects on cholesterol metabolism in the laying hen. Federation Proc. 42: 2486-2493.
44. Ness, G. C., Chambers, C. M. & Lopez, D. (1998) Atorvastatin action involves diminished recovery of hepatic HMG-CoA reductase activity. J. Lipid Res. 39: 75-84.
45. Noble, R. C. & Cocchi, M. (1990) Lipid metabolism and the neonatal chicken. Prog. Lipid Res. 29: 107-140.
46. Oms, P., Assie, N., Bruniquel, F., Degryse, A. D., van Haverbeke, G. & Delhon, A. (1995) Biochemical changes and morphological alterations of liver and kidney in hamsters after administration of the HMG-coenzyme A reductase inhibitor, simvastatin: prevention and reversibility by mevalonate. Pharmacol. Toxicol. 77: 391-396.
47. Parkkonen, T., Kivirikko, K. I. & Pihlajaniemi, T. (1988) Molecular cloning of a multifunctional chicken protein acting as the prolyl 4-hydroxylase β-subunit, protein disulphide-isomerase and a cellular thyroid-hormone-binding protein: Comparison of cDNA-deduced amino acid sequences with those in other species. Biochem. J. 256: 1005-1011.
48. Retzek, H., Steyrer, E., Sanders, E. J., Nimpf, J. & Schneider, W. J. (1992) Molecular cloning and functional characterization of chicken cathepsin D, a key enzyme for yolk formation. DNA Cell Biol. 11: 661-672.
49. Roth, B. D., Blankley, C. J., Chucholowski, A. W., Ferguson, E., Hoefle, M. L., Ortwine, D. F., Newton, R. S., Sekerke, C. S., Sliskovic, D. R., Stratton, C. D. & Wilson, M. W. (1991) Inhibitors of cholesterol biosynthesis. 3. Tetrahydro4-hydroxy-6-[2-(1H-pyrrol-1 -yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus. J. Med. Chem. 34: 357-366.
50. Rudel, L. L. & Morris, M. D. (1973) Determination of cholesterol using o-phthalaldehyde. J. Lipid Res. 14: 364-366.
51. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory Press, Plainview, NY.
52. SAS Institute (1989) SAS/STAT™ User's Guide, Version 6, 4th ed., vol. 2. SAS Institute, Cary, NC.
53. Schneider, W. J. (1992) Lipoprotein receptors in oocyte growth. Clin. Investig. 70: 385-390.
54. Schneider, W. J. (1996) Removal of lipoproteins from plasma. In: Biochemistry of Lipids, Lipoproteins and Membranes (Vance, D. E. & Vance, J. E., eds.), pp. 517-541. Elsevier Science, New York, NY.
55. Schneider, W. J., Carroll, R., Severson, D. L. & Nimpf, J. (1990) Apoliprotein VLOL-II inhibits lipolysis of triglyceride-rich lipoproteins in the laying hen. J. Lipid Res. 31: 507-513.
56. Shapiro, D. J., Nordstrom, J. L., Mitschelen, J. J., Rodwell, V. R. & Schimke, R. T. (1974) Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. Biochim. Biophys. Acta 370: 369-377.
57. Shen, X., Styrer, E., Retzek, H., Sanders, E. J. & Schneider, W. J. (1993) Chicken oocyte growth: Receptor-mediated yolk deposition. Cell Tissue Res. 272: 459-471.
58. Shiomi, M. & Ito, T. (1994) Pravastatin sodium, a competitive inhibitor of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase, decreases the cholesterol content of newly-secreted very-low density lipoprotein in Watanabe heritable hyperlipidemic rabbits. Metabolism 43: 559-564.
59. Slayback, J.R.B., Cheung, L.W.Y. & Geyer, R. P. (1977) Quantitative extraction of microgram amounts of lipid from cultured human cells. Anal. Biochem. 83: 372-384.
60. Steel, R.G.D. & Torrie, J. H. (1980) Principles and Procedures of Statistics: A Biometrical Approach. 2nd ed. McGraw-Hill, New York, NY.
61. Tarumi, C., Matsunumo, N., Miyakoshi, N., Yamashita, K. & Masuda, H. (1989) Long term oral administration study of pravastatin sodium to beagles for 104 weeks. J. Toxicol. Sci. 14: 85-101.
62. Tsang, S. S., Yin, X., Guzzo-Arkuran, C., Jones, V. S. & Davison, A. J. (1993) Loss of resolution in gel electrophoresis of RNA: A problem associated with the presence of formaldehyde gradients. Biotechniques 14: 380-381.
63. Walsh, K. M., Albassam, M. A. & Clark, D. E. (1996) Subchronic toxicity of atorvastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor, in beagle dogs. Toxicol. Pathol. 24: 468-476.
64. Walzem, R. L. (1996) Lipoproteins and the laying hen: Form follows function. Poult. Avian Biol. Rev. 7: 31-64.
65. 14C into hen liver and ovarian lipids. J. Nutr. 93: 142-152.
66. 14C into egg yolk lipids. J. Nutr. 93: 153-160.
67. Yao, Z. & McLeod, R. S. (1994) Synthesis and secretion of hepatic apolipoprotein B-containing lipoproteins. Biochim. Biophys. Acta 1212: 152-166.