A prototype pathogen bound ex vivo to human erythrocyte complement receptor 1 via bispecific monoclonal antibody complexes is cleared to the liver in a mouse model

European Journal of Immunology

Volumn 29, Issue 5, 1999, Pages 1581-1586

  Nardin, Alessandra ^a   Schlimgen, Ryan ^a   Holers, V Michael ^b   Taylor, Ronald P ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Animal model; Antibody; Complement; Immunotherapy

Indexed keywords

COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3B RECEPTOR; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BACTERIOPHAGE PHI X 174; CIRCULATION; CROSS LINKING; ERYTHROCYTE; FLOW CYTOMETRY; HUMAN; LIVER; MOUSE; NONHUMAN; OPSONIZATION; PRIMATE; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

ANIMALS; ANTIBODIES, MONOCLONAL; ERYTHROCYTES; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; LIVER; MICE; MICE, INBRED BALB C; RECEPTORS, COMPLEMENT;

EID: 0032923687     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199905)29:05<1581::AID-IMMU1581>3.0.CO;2-V     Document Type: Article

References (21)

1. Cornacoff, J. B., Hebert, L A., Smead, W. L., Van Aman, M. E., Birmingham, D. J. and Waxman, F. J., Primate erythrocyte-immune complex-clearing mechanism. J. Clin. Invest. 1983. 71: 236-247.
2. Schifferli, J. A. and Taylor, R. P., Physiological and pathological aspects of circulating immune complexes. Kidney Int. 1989. 35: 993-1003.
3. Davies, K. A., Complement, immune complexes and systemic lupus erythematosus. Brit. J. Rheum. 1996. 35: 5-23.
4. Ross, G. D., Yount, W. J., Walport, M. J., Winfield, J. B., Parker, C. J., Fuller, C. R., Taylor, R. R, Myones, B. L. and Lachmann, P. J., Disease-associated loss of erythrocyte complement receptors (CR1, C3b receptors) in patients with systemic lupus erythematosus and other diseases involving autoantibodies and/or complement activation. J. Immunol. 1985. 135: 2005-2014.
5. Taylor, R. P., Ferguson, P. J., Martin, E. N., Cooke, J., Greene, K. L., Grinspun, K., Guttman, M. and Kuhn, S., Immune complexes bound to the primate erythrocyte complement receptor (CR1) via anti-CR1 mAbs are cleared simultaneously with loss of CR1 in a concerted reaction in a rhesus monkey model. Clin, Immunol. Immunopathol. 1997. 82: 49-59.
6. Taylor, R. P., Sutherland, W. M., Reist, C. J., Webb, D. J., Wright, E. L. and Labuguen, R. H., Use of heteropolymeric monoclonal antibodies to attach antigens to the C3b receptor of human erythrocytes: A potential therapeutic treatment. Proc. Natl. Acad. Sci. USA 1991. 88: 3305-3309.
7. Reist, C. J., Liang, H. Y., Denny, D., Martin, E. N., Scheld, W. M. and Taylor, R. P., Cross-linked bispecific monoclonal antibody heteropolymers facilitate the clearance of human IgM from the circulation of squirrel monkeys. Eur. J. immunol. 1994. 24:2018-2025.
8. Taylor, R. P., Martin, E. N., Reinagel, M. L, Nardin, A., Craig, M., Choice, Q., Schlimgen, R., Greenbaum, S., Incardona, N. L. and Ochs, H. D., Bispecific monoclonal antibody complexes facilitate erythrocyte binding and liver clearance of a prototype particulate pathogen in a monkey model. J. Immunol. 1997. 159: 4035-4044.
9. Wang, Y., Hu, Q., Madri, J. A., Rollins, S. A., Chodera, A. and Matis, L. A., Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5. Proc. Natl. Acad. Sci. USA 1996. 93: 8563-8568.
10. Quigg, R. J., Kozono, Y., Berthiaume, D., Lim, A., Salant, D. J., Weinfeld, A., Griffin, P., Kremmer, E. and Holers, V. M., Blockade of antibody-induced glomerulonephritis with Crry-lg, a soluble murine complement inhibitor. J. Immunol. 1998. 160: 4553-4560.
11. Kuhn, S. E., Nardin, A., Klebba, P. E. and Taylor, R. P., Escherichia coli bound to the primate erythrocyte complement receptor via bispecific monoclonal antibodies are transferred to and phagocytosed by human monocytes in an in vitro model. J. Immunol. 1998. 160: 5088-5097.
12. Chen, A., Engel, P. and Tedder, T. F., Structural requirements regulate endoproteolytic release of the L-Selectin (CD62L) adhesion receptor fom the cell surface of leukocytes. J. Exp. Med. 1995. 182: 519-530.
13. Fremeaux-Bacchi, V., Bernard, I., Maillet, F., Mani, J., Fontaine, M., Bonnefoy, J., Kazatchkine, M. D. and Fischer, E., Human lymphocytes shed a soluble form of CD21 (the C3dg/Epstein-Barr virus receptor, CR2) that bind iC3b and CD23. Eur. J. Immunol. 1996. 26: 1497-1503.
14. Huser, H.-J. (Eds.) Atlas of comparative primate hematology. Academic Press. New York 1970.
15. Birmingham, D. J., Logar, C. M., Shen, X.-P. and Chen, W., The baboon erythrocyte complement receptor is a glycophosphatidylinositol-linked protein encoded by a homologoue of the human CR1-like genetic element. J. Immunol. 1996. 157: 2586-2592.
16. Nickells, M. W., Subramanian, V. B., Clemenza, L. and Atkinson, J., Identification of complement receptor type 1-related proteins on primate erythrocytes. J. Immunol. 1995. 154: 2829-2837.
17. Unkeless, J. C., Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 1979. 150: 580-596.
18. Taylor, R. P., Sutherland, W. M., Martin, E. N., Ferguson, P. J., Reinagel, M. L., Gilbert, E., Lopez, K., Incardona, N. L. and Ochs, H. D., Bispecific monoclonal antibody complexes bound to primate erythrocyte complement receptor 1 facilitate virus clearance in a monkey model. J. Immunol. 1997. 158: 842-850.
19. Fraker, P. J. and Speck, J. C., Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3α,6α-diphenylglycoluril. Biochem. Biophys. Res. Commun. 1978. 80: 849-857.
20. Lautt, W. W., Hepatic vasculature: a conceptual review. Gastroenterology 1977. 73: 1163-1169.
21. Sluiter, W., Oomens, L. W., Brand, A. and van Furth, R., Determination of blood volume in the mouse with 51 chromium-labelled erythrocytes. J. Immuno. Methods 1984. 73: 221-225.