Escherichia coli bound to the primate erythrocyte complement receptor via bispecific monoclonal antibodies are transferred to and phagocytosed by human monocytes in an in vitro model

Journal of Immunology

Volumn 160, Issue 10, 1998, Pages 5088-5097

  Kuhn, Susan E ^a   Nardin, Alessandra ^a   Klebba, Philip E ^b   Taylor, Ronald P ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT RECEPTOR; MONOCLONAL ANTIBODY;

ARTICLE; ERYTHROCYTE MEMBRANE; ESCHERICHIA COLI; GRAM NEGATIVE INFECTION; HUMAN; HUMAN CELL; MONOCYTE; OPSONIZATION; PHAGOCYTOSIS; PRIMATE; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; CYTOCHALASIN D; EDETIC ACID; ERYTHROCYTES; ESCHERICHIA COLI; HUMANS; MACACA; MICE; MONOCYTES; PHAGOCYTOSIS; RECEPTORS, COMPLEMENT 3B;

EID: 0032525002     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Nelson, R. A. 1953. The immune adherence phenomenon: an immunologically specific reaction between micro-organisms and erythrocytes leading to enhanced phagocytosis. Science 118:733.
2. Fearon, D. T. 1980. Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte. J. Exp. Med. 152:20.
3. Schifferli, J. A., and R. P. Taylor. 1989. Physiological and pathological aspects of circulating immune complexes. Kidney Int. 35:993.
4. Cornacoff, J. B., L. A. Hebert, W. L. Smead, M. E. Van Aman, D. J. Birmingham, and F. J. Waxman. 1983. Primate erythrocyte-immune complex-clearing mechanism. J. Clin. Invest. 71:236.
5. Hebert, L. A., and G. Cosio. 1987. The erythrocyte-immune complex-glomerulonephritis connection in man. Kidney Int. 31:877.
6. Taylor, R. P., W. M. Sutherland, C. Reist, D. J. Webb, E. L. Wright, and R. H. Labugen. 1991. Use of heteropolymeric monoclonal antibodies to attach antigens to the C3b receptor of human erythrocytes: a potential therapeutic treatment. Proc. Natl. Acad. Sci. USA 88:3305.
7. Powers, J. H., B. L. Buster, C. J. Reist, E. Martin, M. Bridges, W. M. Sutherland, R. P. Taylor, and W. M. Scheld. 1995. Complement-independent binding of microorganisms to primate erythrocytes in vitro by cross-linked monoclonal antibodies via complement receptor 1. Infect. Immun. 63:1329.
8. Reist, C. J., H.-Y. Liang, D. Denny, E. N. Martin, W. M. Scheid, and R. P. Taylor. 1994. Cross-linked bispecific monoclonal antibody heteropolymers facilitate the clearance of human IgM from the circulation of squirrel monkeys. Eur. J. Immunol. 24:2018.
9. Taylor, R. P., and P. J. Ferguson. 1995. Primate erythrocyte complement receptor (CR1) as an anchor site for bispecific-based therapies to clear pathogens or autoantibodies safely from the circulation. J. Hematother. 4:357.
10. Ferguson, P. J., E. N. Martin, K. L. Greene, S. Kuhn, D. S. Cafiso, G. Addona, and R. P. Taylor. 1995. Antigen-based heteropolymers facilitate, via primate erythrocyte complement receptor type1, rapid erythrocyte binding of an autoantibody and its clearance from the circulation in rhesus monkeys. J. Immunol. 155:339.
11. Taylor, R. P., W. M. Sutherland, E. N. Martin, P. J. Ferguson, M. L. Reinagel, E. Gilbert, K. Lopez, N. L. Incardona, and H. D. Ochs. 1997. Bispecific monoclonal antibody complexes bound to primate erythrocyte complement receptor 1 facilitate virus clearance in a monkey model. J. Immunol. 158:842.
12. Murphy, C. K., V. I. Kalve, and P. E. Klebba. 1990. Surface topology of the Escherichia coll K-12 ferric enterobactin receptor. J. Bacteriol. 172:2736.
13. Rutz, J. M., J. Liu, J. A. Lyons, J. Goranson, S. K. Armstrong, M. A. McIntosh, J. B. Feix, and P. E. Klebba. 1992. Formation of a gated channel by a ligand-specific transport protein in the bacterial outer membrane. Science 258:471.
14. Jiang, X., M. A. Payne, Z. Cao, S. B. Foster, J. B. Feix, S. M. C. Newton, and P. E. Klebba. 1997. Ligand-specific opening of a gated-porin channel in the outer membrane of living bacteria. Science 276:1261.
15. Tausk, F. A., J. A. McCutchan, P. Spechko, R. D. Schreiber, and I. Gigli. 1986. Altered erythrocyte C3b receptor expression, immune complexes, and complement activation in homosexual men in varying risk groups for acquired immune deficiency syndrome. J. Clin. Invest. 78:977.
16. Segal, D. M., and B. Bast. 1995. Production of bispecific antibodies. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, editors. John Wiley and Sons, p. 2.13.1.
17. Oda, T., and H. Maeda. 1986. A new simple fluorometric assay for phagocytosis. J. Immunol. Methods 88:175.
18. Muzykantov, V. R., and R. P. Taylor. 1994. Attachment of biotinylated antibody to red blood cells: antigen-binding capacity of immunoerythrocytes and their susceptibility to lysis by complement. Anal. Biochem. 223:142.
19. Reinegel, M. L., M. Gezen, P. J. Ferguson, S. Kuhn, E. N. Martin, and R. P. Taylor. 1997. The primate erythrocyte complement receptor (CR1) as a privileged site: binding of immunoglobulin G to erythrocyte CR1 does not target erythrocytes for phagocytosis. Blood 89:1068.
20. Edberg, J. C., G. A. Kujala, and R. P. Taylor. 1987. Rapid immune adherence reactivity of nascent, soluble antibody/DNA immune complexes in the circulation. J. Immunol. 139:1240.
21. Taylor, R. P., P. J. Ferguson, E. N. Martin, J. Cooke, K. L. Greene, K. Grinspun, M. Guttman, and S. Kuhn. 1997. Immune complexes bound to the primate erythrocyte complement receptor (CR1) via anti-CR1 mAbs are cleared simultaneously with loss of CR1 in a concerted reaction in a rhesus monkey model. Clin. Immunol. Immunopathol. 82:49.
22. Mok, S. S., G. Evin, Q.-X. Lin, A. I. Smith, K. Beyreuther, C. L. Masters, and D. H. Small. 1997. A novel metalloprotease in rat brain cleaves the amyloid precursor protein of Alzheimer's disease generating amyloidogenic fragments. Biochemistry 36:156.
23. Newman, S. L., L. K. Mikus, and M. A. Tucci. 1991. Differential requirements for cellular cytoskeleton in human macrophage complement receptor- and Fc receptor-mediated phagocytosis. J. Immnunol. 146:967.
24. Wright, S. D., and S. C. Silverstein. 1982. Tumor-producing phorbol esters stimulate C3b and C3b′ receptor-mediated phagocytosis in cultured human monocytes. J. Exp. Med. 156:1149.
25. 2+ accumulation in receptor-mediated phagocytosis of human neutrophils. J. Biochem. 117:1156.
26. Kimberly, R. P., J. C. Edberg, L. T. Merriam, S. B. Clarkson, J. C. Unkeless, and R. P. Taylor. 1989. In vivo handling of soluble complement fixing Ab/dsDNA immune complexes in chimpanzees. J. Clin. Invest. 84:962.
27. Ross, G. D., W. J. Yount, M. J. Walport, J. B. Winfield, C. J. Parker, C. R. Fuller, R. P. Taylor, B. L. Myones, and P. J. Lachmann. 1985. Disease-associated loss of erythrocyte complement receptors (CR1, C3b receptors) in patients with systemic lupus erythematosus and other diseases involving autoantibodies and/or complement activation. J. Immunol. 135:2005.
28. Birmingham, D. J., C. M. Logar, X.-P. Shen, and W. Chen. 1996. The baboon erythrocyte complement receptor is a glycophosphatidylinositol-linked protein encoded by a homologue of the human CR1-like genetic element. J. Immunol. 157:2586.
29. Cooper, J. A. 1987. Effects of cytochalasin and phalloidin on actin. J. Cell Biol. 105:1473.
30. Akiyama, T., J. Ishida, S. Nakagawa, H. Ogawara, S. Watanabe, N. Itoh, M. Shibuya, and Y. Fukamki. 1987. Genistein, a specific inhibitor of tyrosinespecific protein kinases. J. Biol. Chem. 262:5592.
31. 2+ dependent protein kinase. Biochem. Biophys. Res. Commun. 135:397.
32. Wilson, L., J. R. Bamburg, S. B. Mizel, L. M. Grisham, and K. M. Creswell. 1974. Interaction of drugs with microtubule proteins. Fed. Proc. 33:158.
33. Hannun, Y. A., C. R. Loomis, A. H. Merril, and R. M. Bell. 1986. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J. Biol. Chem. 261:12604.
34. Miyakawa, Y., A. Yamada, K. Kosaka, F. Tsuda, E. Kosugi, and M. Mayumi. 1981. Defective immune-adherence (C3b) receptor on erythrocytes from patients with systemic lupus erythematosus. Lancet ii:493.
35. Walport, M. J., and P. J. Lachmann. 1988. Erythrocyte complement receptor type 1, immune complexes, and the rheumatic diseases. Arthritis Rheum. 31:153.
36. Birmingham, D. J., L. A. Hebert, F. G. Cosio, and M. E. van Aman. 1990. Immune complex erythrocyte complement receptor interactions in vivo during induction of glomerulonephritis. J. Lab. Clin. Med. 116:242.
37. Cosio, F. G., S. Xiao-Ping, D. J. Birmingham, M. van Aman, and L. A. Hebert. 1990. Evaluation of the mechanisms responsible for the reduction in erythrocyte complement receptors when immune complexes form in vivo in primates. J. Immunol. 145:4198.
38. Davies, K. A., V. Hird, S. Stewart, G. B. Sivolapenko, P. Jose, A. A. Epenetos, and M. J. Walport. 1990. A study of in vivo immune complex formation and clearance in man. J. Immunol. 144:4613.
39. Davies, K. A., A. M. Peters, H. L. C. Benyon, and M. Walport. 1992. Immune complex processing in patients with systemic lupus erythematosus. J. Clin. Invest. 90:2075.
40. Huizinga, T. W. J., M. de Haas, M. Kleijer, J. H. Nuijens, D. Roos, and A. E. G.Kr. Von dem Borne. 1990. Soluble Fcγ receptor 111 in human plasma originates from release by neutrophils. J. Clin. Invest. 86:416.
41. Mohler, K. M., P. R. Sleath, J. F. Filzner, D. P. Cerretti, M. Alderson, S. S. Kerwar, D. S. Torrance, C. Otto-Evans, T. Greenstreet, K. Weerawarna, S. R. Kronheim, M. Peterson, M. Gerhart, C. J. Kozlosky, C. J. Marsh, and R. A. Black. 1994. Protection against a lethal dose of endotoxin by an inhibitor of tumor necrosis factor processing. Nature 370:218.
42. Mullberg, J., F. H. Durie, C. Otto-Evans, M. Alderson, S. Rose-John, D. Cosman, R. A. Black, and K. M. Mohler 1995. A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor. J. Immunol. 155:5198.
43. Chen, A., P. Engel, and T. F. Tedder. 1995. Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes. J. Exp. Med. 182:519.
44. Fremeaux-Bacchi, V., I. Bernard, F. Maillet, J.-C. Mani, M. Fontaine, J.-V. Bonnefoy, M. D. Kazatchkine, and E. Fischer. 1996. Human lymphocytes shed a soluble form of CD21 (the C3dg/Epstein-Barr virus receptor, CR2) that binds iC3b and CD23. Eur. J. Immunol. 26:1497.
45. Preece, G., G. Murphy, and A. Ager. Metalloproteinase-mediated regulation of L-selectin levels on leucocytes. J. Biol. Chem. 271:11634.
46. Emlen, W., V. Carl, and G. Burdick. 1992. Mechanism of transfer of immune complexes from red blood cell CR1 to monocytes. Clin. Exp. Immunol. 89:8.
47. Allen, L.-A. H., and A. Aderem. 1996. Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages. J. Exp. Med. 184:627.
48. Greenberg, S., P. Chang, and S. C. Silverstein. 1993. Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages. J. Exp. Med. 177:529.
49. Wright, S. D., and M. T. C. Jong. 1986. Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide. J. Exp. Med. 164:1876.