T-cell anergy induced by clonotype-specific antibodies: Modulation of an autoreactive human T-cell clone in vitro

Immunology

Volumn 96, Issue 4, 1999, Pages 586-594

  Steenbakkers, P G A ^a   Boots, A M H ^a   Rijnders, A W M ^a  

^a N V Organon ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; INTERLEUKIN 2; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

ANTIBODY SPECIFICITY; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL VIABILITY; CLONAL ANERGY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOSTIMULATION; INTERFERON PRODUCTION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ANTIBODIES, MONOCLONAL; ANTIGEN-PRESENTING CELLS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CLONAL ANERGY; CYCLOHEXIMIDE; CYCLOSPORINE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE II; INTERLEUKIN-2; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 0032923641     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1999.00737.x     Document Type: Article

References (37)

1. 1. Melamed D. & Friedman A. (1994) In vivo tolerization of Th1 lymphocytes following a single feeding with ovalbumin: anergy in the absence of suppression. Eur J Immunol 24, 1974.
2. 2. Schwartz R.H. (1996) Models of T cell anergy: is there a common molecular mechanism. J Exp Med 184, 1.
3. 3. Johnson J.G. & Jenkins M.K. (1994) The role of anergy in peripheral T cell unresponsiveness. Life Sci 55, 1767.
4. 4. Kersh G.J. & Allen P.M. (1996) Essential flexibility in the T-cell recognition of antigen. Nature 380, 495.
5. 5. Oksenberg J.R., Panzara M.A., Begovich A.B. et al. (1993) Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 362, 68.
6. 6. Allegretta M., Albertini R.J., Howell M.D. et al. (1994) Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis. J Clin Invest 94, 105.
7. 7. Jenkins M.K., Chen C., Jung G., Mueller D.L. & Schwartz R.H. (1990) Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J Immunol 144, 16.
8. 8. Andris F., Van Mechelen M., De Mattia F., Baus E., Urbain J. & Leo O. (1996) Induction of T cell unresponsiveness by anti-CD3 antibodies occurs independently of co-stimulatory functions. Eur J Immunol 26, 1187.
9. 9. Ben-Amor A., De Lette Moraes M.C., Lepault F. et al. (1996) In vitro T cell unresponsiveness following low-dose injection of anti-CD3 MoAb. Clin Exp Immunol 103, 491.
10. 10. Fischman A.J., Babich J.W. & Strauss H.W. (1993) A ticket to ride: peptide radiopharmaceuticals. J Nucl Med 34, 2253.
11. 11. Molthoff C.F., Buist M.R., Kenemans P., Pinedo H.M. & Boven E. (1992) Experimental and clinical analysis of the characteristics of a chimeric monoclonal antibody, MOv18, reactive with an ovarian cancer-associated antigen. J Nucl Med 33, 2000.
12. 12. Jolliffe L.K. (1993) Humanized antibodies: Enhancing therapeutic utility though antibody engineering. Int Rev Immunol 10, 241.
13. 13. Knulst A.C., Noort W.A., Tibbe G.J., Benner R. & Savelkoul H.F. (1994) Prevention of lethal graft-versus-host disease in mice by monoclonal antibodies directed to T cells or their subsets. II. Differential effectiveness of IgG2a and IgG2b isotypes of anti-CD3 and anti-CD4 moAb. Bone Marrow Transplant 14, 535.
14. 14. Verheijden G.F., Rijnders A.W.M., Bos E. et al. (1997) Human cartilage glycoprotein-39 is a candidate autoantigen in rheumatoid arthritis. Arhritis Rheum 40, 1115.
15. 15. Steenbakkers P.G.A., Boots A.M.H. & Rijnders A.W.M. (1997) Generation and functional characterization of anti-clonotype antibodies to human T-cell receptors. J Immunol Methods 210, 51.
16. 16. Sorg R., Enczmann J., Sorg U., Heermeier K., Schneider E.M. & Wernet P. (1991) Rapid and sensitive mRNA phenotyping for interleukins (IL-1 to IL-6) and colony-stimulating factors (G-CSF, M-CSF, and GM-CSF) by reverse transcription and subsequent polymerase chain reaction. Exp Hematol 19, 882.
17. 17. Madrenas J., Schwartz R.H. & Germain R.N. (1996) Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists. Proc Natl Acad Sci USA 93, 9736.
18. 18. Quil H. & Schwartz R.H. (1987) Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness. J Immunol 138, 3704.
19. 19. Essery G., Feldmann M. & Lamb J.R. (1988) Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes. Immunology 64, 413.
20. 20. Vergelli M., Hemmer B., Utz U. et al. (1996) Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87). Eur J Immunol 26, 2624.
21. 21. Sidhu S., Deacock S., Bal V., Batchelor J.R., Lomhardi G. & Lechler R.I. (1992) Human T cells cannot act as autonomous antigen-presenting cells, but induce tolerance in antigen-specific and alloreactive responder cells. J Exp Med 176, 875.
22. c chain of the IL-2 receptor. Science 266, 1039.
23. 23. Van Gool S., De Boer M. & Ceuppens J.L. (1994) The combination of anti-B7 monoclonal antibody and cyclosporin A induces alloantigen-specific anergy during a primary mixed lymphocyte reaction. J Exp Med 179, 715.
24. 24. Sloan-Lancaster J., Evavold B.D. & Allen P.M. (1993) Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363, 156.
25. 25. Williams M.E., Shea C.M., Lichtman A.H. & Abbas A.K. (1992) Antigen receptor-mediated anergy in resting T lymphocytes and T cell clones. J Immunol 149, 1921.
26. 26. Lombardi G., Sidhe S., Batchelor R. & Lechler R. (1994) Anergic T cells as suppressor cells in vitro. Science 264, 1587.
27. 27. Mannie M.D., Rendali S.K., Arnold P.Y., Nardella J.P. & Wihte G.A. (1996) Anergy-associated T cell antigen presentation. A mechanism of infectious tolerance in experimental autoimmune encephalomyelitis. J Immunol 157, 1062.
28. + T cells in vitro. J Virol 70, 7540.
29. 29. Viola A. & Lanzavecchia A. (1996) T cell activation determined by T cell receptor number and tunable thresholds. Science 273, 104.
30. 30. Lobo P.I. & Patel H.C. (1997) Murine monoclonal IgG antibodies: Differences in their IgG isotypes can affect the antibody effector activity when using human cells. Immunol Cell Biol 75, 267.
31. 31. Duits A.J., Aarden L.A., Ernst L.K., Capel P.J.A. & Van de Winkel J.G.J. (1993) Isotype-specific cross-linking of select human FcγR isoforms triggers release of IL-6. Clin Exp Immunol 92, 225.
32. 32. Lombardi G., Hargreaves R., Sidhu S. et al. (1996) Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals. J Immunol 156, 2769.
33. 33. Willems F., Andris F., Arramowicz D. et al. (1995) Induction of T-cell anergy by OKT3 requires cyclosporine-insensitive activation signals. Transplant Proc 27, 1425.
34. 34. Kishimoto H., Kubo R.T., Yorifuji H., Nakayama T., Asano Y. & Tada T. (1995) Physical dissociation of the TCR-CD3 complex accompanies receptor ligation. J Exp Med 182, 1997.
35. 35. Thomson H.S., Harper N., Bevan D.J. & Staines N.A. (1993) Suppression of collagen induced arthritis by oral administration of type II collagen: changes in immune and arthritic responses mediated by active peripheral suppression. Autoimmunity 16, 189.
36. 36. Liblau R.S., Tisch R., Shokat K. et al. (1996) Intravenous injection of soluble antigen induces thymic and peripheral T-cell apoptosis. Proc Natl Acad Sci USA 93, 3031.
37. 37. Friedman A., Al-Sabbagh A., Santos L.M. et al. (1994) Oral tolerance: a biologically relevant pathway to generate peripheral tolerance against external and self antigens. Chem Immunol 58, 259.