A dense cell culture system for microorganisms using a stirred ceramic membrane reactor incorporating asymmetric porous ceramic filters

Journal of Fermentation and Bioengineering

Volumn 82, Issue 3, 1996, Pages 264-271

  Suzuki, Takahiro ^a,b  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

dense cell culture; filtering culture; Lactococcus lactis; membrane fouling; stirred ceramic membrane reactor

Indexed keywords

ARTICLE; BIOMASS; BIOREACTOR; BIOTRANSFORMATION; CELL CULTURE; CELL VIABILITY; CERAMICS; MEMBRANE REACTOR; NONHUMAN;

LACTOCOCCUS LACTIS;

EID: 0029859398     PISSN: 0922338X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0922-338X(96)88818-0     Document Type: Article

References (33)

1. Chang, H. N., Lee, W. G., and Kim, B. S.: Cell retention culture with an internal filter module: continuous ethanol fermentation. Biotechnol. Bioeng., 41, 677-681 (1993).
2. Suzuki, T., Sato, T., and Kominami, M.: A dense cell retention culture system using a stirred ceramic membrane reactor system. Biotechnol. Bioeng., 44, 1186-1192 (1994).
3. Taniguchi, M., Kotani, N., and Kobayashi, T.: High-concentration cultivation of lactic acid bacteria in fermentor with cross-flow filtration. J. Ferment. Technol., 65, 179-184 (1987).
4. Imasaka, T., Kanekuni, N., So, H., and Yoshino, S.: Cross-flow filtration of methane fermentation broth by ceramic membrane. J. Ferment. Bioeng., 68, 200-206 (1989).
5. Nakano, K., Matsumura, M., and Kataoka, H.: Application of a rotating ceramic membrane to dense cell culture. J. Ferment. Bioeng., 76, 49-54 (1993).
6. Cysewski, G. R. and Wilke, C. R.: Rapid ethanol fermentations using vacuum and cell recycle. Biotechnol. Bioeng., 19, 1125-1143 (1978).
7. Cysewski, G. R. and Wilke, C. R.: Process design and economic studies of alternative fermentation methods for the production of ethanol. Biotechnol. Bioeng., 20, 1421-1444 (1978).
8. Kayawake, E., Narukami, Y., and Yamagata, M.: Anaerobic digestion by a ceramic membrane enclosed reactor. J. Ferment. Bioeng., 71, 122-125 (1991).
9. Suzuki, T., Nishizawa, K., Yokogawa, Y., Kawamoto, Y., Nagata, F., and Kameyama, T.: Time-dependent variation of the surface structure of bioceramics in tissue culture medium and the effect on adhesiveness of cells. J. Ferment. Bioeng., 81, 226-232 (1996).
10. 6 to carriers for immobilization of enzymes. J. Ferment. Bioeng., 72, 384-391 (1991).
11. Al-markhlafi, H., McGuire, J., and Daschel, M.: Influence of preadsorbed milk protein on adhesion of Listeria monocytogenes to hydrophobic and hydrophilic silica surfaces. Appl. Environ. Microbiol., 60, 3560-3565 (1994).
12. Krekeler, C., Ziehr, H., and Klein, J.: Influence of physicochemical bacterial surface properties on adsorption to inorganic porous supports. Appl. Microbiol. Biotechnol., 35, 484-490 (1991).
13. Iwasaki, K., Nakajima, M., and Sasahara, H.: Porous alumina beads for immobilization of lactic acid bacteria and its application for repeated-batch fermentation in soy sauce production. J. Ferment. Bioeng., 73, 375-379 (1992).
14. Cachon, R., Molin, P., and Divies, C.: Modeling of continuous pH-stat stirred tank reactor with Lactococcus lactis ssp. lactis bv. diacetylactis immobilized in calcium alginate gel beads. Biotechnol. Bioeng., 47, 567-574 (1995).
15. Ishizaki, A., Osajima, K., Nakamura, K., Kimura, K., Hara, T., and Ezaki, T.: Biochemical characterization of Lactococcus lactis IO-1 whose optimal temperature is as high as 37°C. J. Gen. Appl. Microbiol., 36, 1-6 (1990).
16. Ishizaki, A., Nomura, Y., and Iwahara, M.: Built-in electrodialysis batch culture, a new approach to release of end product inhibition. J. Ferment. Bioeng., 70, 108-113 (1990).
17. Hayakawa, K., Sansawa, H., Nagamune, T., and Endo, I.: High density culture of Lactobacillus casei by a cross-flow culture method based on kinetic properties of the microorganism. J. Ferment. Bioeng., 70, 404-408 (1990).
18. Ohara, H., Hiyama, K., and Yoshida, T: Lactic acid production by a filter-bed-type reactor. J. Ferment. Bioeng., 76, 73-75 (1993).
19. Ishizaki, A. and Kobayashi, G.: Computer simulation of L-lactate batch culture fermentation applying the enzyme inactivation scheme. J. Ferment. Bioeng., 70, 139-140 (1990).
20. Shi, Z., Shimizu, K., Iijima, S., Izumi, R., Matsumoto, K., and Kobayashi, T.: Development of dual on-line analyzer and its application to fed-batch lactic acid fermentation. J. Fer- ment. Bioeng., 73, 22-25 (1992).
21. Suzuki, T., Yamane, T., and Shimizu, S.: Control of carbon source supply and dissolved oxygen by use of carbon dioxide concentration of exhaust gas in fed-batch culture. J. Ferment. Technol., 64, 317-323 (1986).
22. Ishihara, K., Suzuki, T., Yamane, T., and Shimizu, S.: Effective production of Pseudomonas fluorescence lipase by semi-batch culture with turbidity-dependent automatic feeding of both olive oil and iron ion. Appl. Microbiol. Biotech., 31, 45-48 (1990).
23. Suzuki, T., Yamane, T., and Shimizu, S.: Phenomenological background and some preliminary trials of automated substrate supply in pH-stat fed-batch culture utilizing a set-point of high limit. J. Ferment. Bioeng., 69, 292-297 (1990).
24. Suzuki, T., Yamane, T., and Shimizu, S.: Effect of ammonium feeding on production of thiostrepton by fed-batch culture. Appl. Microbiol. Biotech., 28, 188-192 (1988).
25. Suzuki, T., Yamane, T., and Shimizu, S.: Effect and control of glucose feeding on bacitracin production by fed-batch culture of Bacillus licheniformis. J. Ferment. Technol., 66, 85-91 (1988).
26. Suzuki, T., Yamane, T., and Shimizu, S.: Kinetics and effect of nitrogen source feeding of poly-β-hydroxybutyric acid in fed-batch culture. Appl. Microbiol. Biotech., 24, 366-369 (1986).
27. Suzuki, T., Yamane, T., and Shimizu, S.: Mass production of poly-β-hydroxybutyric acid by fed-batch culture with controlled carbon/nitrogen feedings. Appl. Microbiol. Biotech., 24, 370-374 (1986).
28. Suzuki, T., Yasuda, T., Yamane, T., and Shimizu, S.: Detection and control of ammonium ion concentration in microbial culture with an ammonium ion selective electrode. J. Ferment. Technol., 64, 63-70 (1986).
29. Suzuki, T., Mon, H., Yamane, T., and Shimizu, S: Automatic supplementation of minerals in fed-batch culture to high cell mass concentration. Biotechnol. Bioeng., 27, 192-201 (1985).
30. Suzuki, T., Yamane, T., and Shimizu, S.: Mass production of thiostrepton by fed-batch culture of Streptomyces laurentii with pH-stat modal feeding of multi-substrate. Appl. Microbiol. Biotech., 25, 526-570 (1987).
31. Suzuki, T., Yamane, T., and Shimizu, S.: Mass production of poly-β-hydroxybutyric acid by fully automatic fed-batch culture of methylotroph. Appl. Microbiol. Biotech., 23, 322-329 (1986).
32. Suzuki, T., Mushiga, Y., Yamane, T., and Shimizu, S: Mass production of lipase by fed-batch culture of Pseudomonas fluorescens. Appl. Microbiol. Biotech., 27, 417-422 (1988).
33. Vontktaveesuk, P., Tonokawa, M., and Ishizaki, A.: Stimulation of the rate of L-lactate fermentation using Lactococcus lactis IO-1 by periodic electrodialysis. J. Ferment. Bioeng., 77, 508-512 (1994).