GRB2 and phospholipase C-γ1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation

Molecular and Cellular Biology

Volumn 14, Issue 7, 1994, Pages 4435-4442

  Sieh, Monica ^a   Batzer, Andreas ^b   Schlessinger, Joseph ^b   Weiss, Arthur ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHOSPHOLIPASE C; PHOSPHOTYROSINE; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; TYROSINE;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 0028180585     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.14.7.4435     Document Type: Article

References (61)

1. lck. Nature (London) 350:62-66.
2. Bar-Sagi, D., D. Rotin, A. Batzer, V. Mandiyan, and J. Schlessinger. 1993. SH3 domains direct cellular localization of signaling molecules. Cell 74:83-91.
3. Beitel, G. J., S. G. Clark, and H. R. Horvitz. 1990. Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction. Nature (London) 348:503-509.
4. Buday, L., and J. Downward. 1993. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, GRB2 adaptor protein, and Sos nucleotide exchange factor. Cell 73:611-620.
5. ras in fibroblasts. Mol. Cell. Biol. 13:1903-1910.
6. Buday, L., S. E. Egan, P. R. Yiciana, and D. A. Cantrell. 1994. A complex of GRB2 adaptor protein, SOS exchange factor and a 36 kD membrane-bound tyrosine phosphoprotein is implicated in Ras activation in T cells. J. Biol. Chem. 269:9019-9023.
7. shc in T lymphocytes. J. Biol. Chem. 268:17659-17661.
8. Chan, A. C., B. A. Irving, and A. Weiss. 1992. New insights into T-cell antigen receptor structure and signal transduction. Curr. Opin. Immunol. 4:246-251.
9. Chan, A. C., M. Iwashima, C. W. Turck, and A. Weiss. 1992. ZAP-70: a 70kD protein tyrosine kinase that associates with the TCR ζ chain. Cell 71:649-662.
10. Chardin, P., J. H. Camonis, N. W. Gale, L. V. Aelst, J. Schlessinger, M. H. Wigler, and D. Bar-Sagi. 1993. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260:1338-1343.
11. Chou, M. M., J. E. Fajardo, and H. Hanafusa. 1992. The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels. Mol. Cell. Biol. 12:5834-5842.
12. Clark, S. G., M. J. Stern, and H. R. Horvitz. 1992. C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature (London) 356:340-344.
13. fyn). Cell 65:281-292.
14. ras upon T-cell activation. Nature (London) 346:719-723.
15. Egan, S. E., B. W. Giddings, M. W. Brooks, L. Buday, A. M. Sizeland, and R. A. Weinberg. 1993. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature (London) 363:45-51.
16. Fortini, M. E., M. A. Simon, and G. M. Rubin. 1992. Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature (London) 355:559-561.
17. Gale, N. W., S. Kaplan, E. J. Lowenstein, J. Schlessinger, and D. Bar-Sagi. 1993. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature (London) 363:88-92.
18. Gibbs, J. B., M. S. Marshall, E. M. Scolnick, R. F. Dixon, and U. S. Vogel. 1990. Modulation of guanine nucleotides bound to ras in NIH 3T3 cells by oncogenes, growth factors and the GTPases activating protein (GAP). J. Biol. Chem. 265:20437-20442.
19. Gilliland, L. K., G. L. Schieven, N. A. Norris, S. B. Kanner, A. Aruffo, and J. A. Ledbetter. 1992. Lymphocyte lineage-restricted tyrosine-phosphorylated proteins that bind PLCγ1 SH2 domains. J. Biol. Chem. 267:13610-13616.
20. lck with CD4 in antigen-specific signal transduction in T cells. Cell 64:511-520.
21. Graber, M., C. H. June, L. E. Samelson, and A. Weiss. 1992. The protein tyrosine kinase inhibitor herbimycin A, but not genestein, specifically inhibits signal transduction by the T cell antigen receptor. Int. Immunol. 4:1201-1210.
22. Gulbins, E., K. M. Coggeshall, G. Baier, S. Katzav, P. Burn, and A. Altman. 1993. Tyrosine kinase-stimulated guanine nucleotide activity of Vav in T cell activation. Science 260:822-825.
23. Hall, C. G., J. Sancho, and C. Terhorst. 1993. Reconstitution of T cell receptor ζ-mediated calcium mobilization in non-lymphoid cells. Science 261:915-918.
24. Han, M., and P. W. Sternberg. 1990. let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein. Cell 63:921-931.
25. Harlow, E., and D. Lane. 1988. Antibodies, a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
26. Hsi, E. D., J. N. Siegel, Y. Minami, E. T. Luong, R. D. Klausner, and L. E. Samelson. 1989. T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates. J. Biol. Chem. 264:10836-10842.
27. ras regulatory pathways coexist in T cells. Mol. Cell. Biol. 12:3305-3312.
28. June, C. H., M. C. Fletcher, J. A. Ledbetter, and L. E. Samelson. 1990. Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J. Immunol. 144:1591-1599.
29. June, C. H., M. C. Fletcher, J. A. Ledbetter, G. L. Schieven, J. N. Siegel, A. F. Phillips, and L. E. Samelson. 1990. Inhibition of tyrosine phosphorylation prevents T cell receptor-mediated signal transduction. Proc. Natl. Acad. Sci. USA 87:7722-7726.
30. Kim, H. K., J. W. Kim, A. Zilberstein, B. Margolis, J. G. Kim, J. Schlessinger, and S. G. Rhee. 1991. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254. Cell 65:435-441.
31. Li, B., D. Kaplan, H. Kung, and T. Kamata. 1992. Nerve growth factor stimulation of the Ras-guanine nucleotide exchange factor and GAP activities. Science 256:1456-1459.
32. Li, N., A. Batzer, R. Daly, V. Yajnik, E. Skolnik, P. Chardin, D. Bar-Sagi, B. Margolis, and J. Schlessinger. 1993. Guanine-nucleotide-releasing factor hSos1 binds to GRB2 and links receptor tyrosine kinases to Ras signalling. Nature (London) 363:85-88.
33. Lowenstein, E. J., D. R. J., A. G. Batzer, W. Li, B. Margolis, R. Lammers, A. Ullrich, E. Y. Skolnik, D. Bar-Sagi, and J. Schlessinger. 1992. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70:431-442.
34. Mayer, B. J., M. Hamaguchi, and H. Hanafusa. 1988. A novel viral oncogene with structural similarity to phospholipase C. Nature (London) 332:272-275.
35. McGlade, J., A. Cheng, G. Pelicci, P. G. Pelicci, and T. Pawson. 1992. Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases. Proc. Natl. Acad. Sci. USA 89:8869-8873.
36. ras. Mol. Cell. Biol. 13:155-162.
37. Muroya, K., S. Hattori, and S. Nakamura. 1992. Nerve growth factor induces rapid accumulation of the GTP-bound form of p21ras in rat pheochromocytoma PC12 cells. Oncogene 7:277-281.
38. Mustelin, T., K. M. Coggeshall, N. Isakov, and A. Altman. 1990. T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation. Science 247:1584-1587.
39. Nishibe, S., M. I. Wahl, S. M. Hernandez-Sotomayor, N. K. Tonk, S. G. Rhee, and G. Carpenter. 1990. Increase of the catalytic activity of phospholipase C-γ1 by tyrosine phosphorylation. Science 250:1253-1256.
40. Ohmichi, M., S. J. Decker, and A. R. Saltiel. 1992. Nerve growth factor stimulates the tyrosine phosphorylation of a 38 kDa protein that specifically associates with the src homology domain of phospholipase C-γ1. J. Biol. Chem. 267:21601-21606.
41. Olivier, J. P., T. Raabe, M. Henkemeyer, B. Dickson, G. Mbamalu, B. Margolis, J. Schlessinger, E. Hafen, and T. Pawson. 1993. A drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell 73:179-191.
42. Park, D. J., H. W. Rho, and S. G. Rhee. 1991. CD3 stimulation causes phosphorylation of phospholipase C-γ1 on serine and tyrosine residues in a human T cell line. Proc. Natl. Acad. Sci. USA 88:5453-5456.
43. Pelicci, G., L. Lanfrancone, F. Grignani, J. McGlade, F. Cavallo, G. Forni, I. Nicoletti, F. Grignani, T. Pawson, and P. G. Pelicci. 1992. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70:93-104.
44. Pronk, G. J., J. McGlade, G. Pelicci, T. Pawson, and J. B. Bos. 1993. Insulin-induced phosphorylation of the 46- and 52kDa Shc proteins. J. Biol. Chem. 8:5748-5753.
45. Rayter, S. I., M. Woodrow, S. C. Lucas, D. A. Cantrell, and J. Downward. 1992. p21ras mediates control of IL-2 gene promoter function in T cell activation. EMBO J. 12:4549-4556.
46. Rozakis-Adcock, M., R. Fernley, J. Wade, T. Pawson, and D. Bowtell. 1993. The SH2 and SH3 domains of mammalian Grb2 couple of the EGF receptor to the Ras activator mSos1. Nature (London) 363:83-85.
47. Rozakis-Adcock, M., et al. 1992. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature (London) 360:689-692.
48. Samelson, L. E., A. F. Phillips, E. T. Luong, and R. D. Klausner. 1990. Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc. Natl. Acad. Sci. USA 87:4358-4362.
49. Satoh, T., M. Endo, M. Nakafuku, S. Nakamura, T. Yamamoto, and Y. Kaziro. 1990. Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity. Proc. Natl. Acad. Sci. USA 87:5993-5997.
50. Schlessinger, J. 1993. How receptor tyrosine kinases activate Ras. Trends Biochem. Sci. 18:273-275.
51. Secrist, J. P., L. Karnitz, and R. T. Abraham. 1991. T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-γ1. J. Biol. Chem. 266:12135-12139.
52. Simon, M. A., D. D. L. Bowtell, G. S. Dodson, T. R. Laverty, and G. M. Rubin. 1991. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67:701-716.
53. Simon, M. A., G. S. Dodson, and G. M. Rubin. 1993. An SH3-SH2-SH3 protein is required for p21ras1 activation and binds to sevenless and Sos proteins in vitro. Cell 73:169-177.
54. Skolnik, E. Y., A. Batzer, N. Li, C. H. Lee, E. Lowenstein, M. Mohammadi, B. Margolis, and J. Schlessinger. 1993. The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science 260:1953-1955.
55. Straus, D., and A. Weiss. 1992. Genetic evidence for the involvement of the Lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585-593.
56. Todderud, G., M. J. Wahl, S. G. Rhee, and G. Carpenter. 1990. Stimulation of phospholipase C-γ1 membrane association by epidermal growth factor. Science 249:296-298.
57. fyn following T cell antigen receptor cross-linking. J. Biol. Chem. 267:18259-18262.
58. Wange, R. L., S. N. Malek, S. Desiderio, and L. E. Samelson. 1993. Tandem SH2 domains of ZAP70 bind to T cell antigen receptor ζ and CD3ε from activated Jurkat T cells. J. Biol. Chem. 268:19797-19801.
59. Weber, J. R., G. M. Bell, M. Y. Han, T. Pawson, and J. B. Imboden. 1992. Association of the tyrosine kinase LCK with phospholipase C-γ1 after stimulation of the T cell antigen receptor. J. Exp. Med. 176:373-379.
60. Weiss, A., G. Koretzky, R. Schatzman, and T. Kadlecek. 1991. Stimulation of the T cell antigen receptor induces tyrosine phosphorylation of phospholipase C γ1. Proc. Natl. Acad. Sci. USA 88:5484-5488.
61. Weiss, A., and J. D. Stobo. 1984. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. J. Exp. Med. 160:1284-1299.