Lack of association between HLA-DRB1* alleles of the major histocompatibility complex and p-ANCA status or clinical characteristics in patients with ulcerative colitis

Zeitschrift fur Gastroenterologie

Volumn 37, Issue 2, 1999, Pages 133-140

  Folwaczny, C ^a   Zahn, R ^b   Brunnler C ^b   Albert, E ^a   Koenig, A ^a   Noehl, N ^a   Loeschke, K ^a   Fricke, H ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

HLA DRB1*; p ANCA; Ulcerative colitis

Indexed keywords

HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; NEUTROPHIL CYTOPLASMIC ANTIBODY;

ADOLESCENT; ADULT; AGED; ANTIGEN DETECTION; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOT HYBRIDIZATION; ETHNIC GROUP; FEMALE; GENE FREQUENCY; GERMANY; HEREDITY; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; PHENOTYPE; ULCERATIVE COLITIS;

EID: 0032914205     PISSN: 00442771     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. McConnell RB, Vadheim CM. Inflammatory bowel diesease. In: King RA, Rotter JI, Motulsky AO (eds.). The genetic bases of common disease. Oxford. Oxford University press, 1992; 326-48
2. Asakura H, Tsuchiya M, Aiso S et al. Association of the human lymphocyte DR2 antigen with Japanese ulcerative colitis. Gastroenterology 1982; 82: 413-8
3. Farrant JM, Bunce M, Arelett C et al. HLA-DR2 is a susceptibility marker for UC in British patients irrespective of ANCA positivity. Gastroenterology 1994; 106: A679
4. Futami S, Aoyama N, Honsako Y et al. HLA-DRR1* 1502 allele, subtype of DR 15 is associated with susceptibility to ulcerative colitis and its progression. Dig Dis Sci 1995; 40: 814-8
5. Yang H, Rotter JI, Toyoda H, Landers C et al. Ulcerative colitis: A genetically heterogenous disorder defined by genetic (HLA Class II) and subclinical (antineutrophil cytoplasmatic antibodies) markers. J Clin Invest 1993; 92: 1080-4
6. Lee JC, Lennard-Jones JE, Cambridge G. Antineutrophil antibodies in familial inflammatory bowel disease. Gastroenterology 1995; 108: 428-33
7. Masuda H, Nakamura Y, Tanaka T et al. Distinct relationship between HLA-DR genes and intractability of ulcerative colitis. Am J Gastroenterol 1994; 89: 1957-62
8. Duerr RH, Neigut DA. Molecularly defined HLA-DR2 allels in ulcerative colitis and antineutrophil cytoplasmatic antibody positive subgroup. Gastroenterology 1995; 108: 423-7
9. Folwaczny C, Noehl N, Endres SP et al. Pancreatic-and antineutrophil autoantibodies in first-degree of patients with inflammatory bowel disease. Scand J Gastroenterol 1998; 33: 523-8
10. Monteleone G, Doldo P, Marasco R et al. Perinuclear neutrophil autoantibodies (p-ANCA) in unaffected relatives of patients with ulcerative colitis (UC). Suggestions against familial aggregation. Gut 1994; 35 (suppl.) 4: A31
11. Papo M, Quer JC, Pastor MR et al. Antineutrophil cytoplasmatic antibodies in relatives of patients with inflammatory bowel disease. Am J Gastroenterol 1996; 91: 1512-5
12. Reumaux D, Delecourt L, Colombel JF et al. Antineutrophil cytoplasmic autoantibodies in relatives of patients with ulcerative colitis (letter). Gastroenterology 1992; 103: 1706
13. Seibold F, Slametschka D, Gregor M et al. Neutrophil autoantibodies: A genetic marker in primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 1994; 107: 532-6
14. Shanahan F, Duerr RH, Rotter IJ et al. Neutrophil autoantibodies in ulcerative colitis: Familial aggregation and genetic heterogeneity. Gastroenterology 1992; 103: 456-61
15. Nevinny-Stickel C, Hinzpeter M, Andreas A et al. Non-radioactive oligotyping for HLA-DR1-DRw10 using polymerase chain reaction, digoxigenin-labelled oligonucleotides and chemiluminescence detection. Eur J Immunogenetics 1991; 18: 323-32
16. Calkins BM, Mendeloff AI. Epidemiology of inflammatory bowel disease. Epidemiol Rev 1986; 8: 60-91
17. Podolsky DK. Inflammatory bowel disease (2). N Engl J Med 1992; 325: 1008-16
18. Farmer RG. Association of inflammatory bowel disease in families. Front Gastrointest Res 1986; 11: 235-41
19. Tysk C, Lindberg E, Jarnerot G et al. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 1988; 29: 990-6
20. Bennet RA, Rubin PH, Present DH. Frequency of inflammatory bowel disease in offspring of couples both presenting with inflammatory bowel disease. Gastroenterology 1991; 100: 1638-43
21. Fiocchi C, Roche JK, Michener WM. High prevalence of antibodies to intestinal epithelial antigens in patients with inflammatory bowel disease and their relatives. Ann Intern Med 1989; 110: 786-94
22. Hugot JP, Laurent-Puig P, Gower-Rousseau C et al. Linkage analyses of chromosome 6 loci, including HLA, in familial aggregations of Crohn's disease. Am J Med Genet 1994; 52: 207-14
23. Naom IS, Lee JC, Ford D et al. Genetic predisposition in ulcerative colitis: A detailed study of the HLA region by linkage analysis. Gut 1994; 35: S30
24. Bayless TM, Tokayer AZ, Polito JM et al. Crohn's disease: Concordance for site and clinical type in affected family members-potential hereditary influences. Gastroenterology 1996; 111: 573-9
25. Colombel JF, Grandbastien B, Gower-Russeau C et al. Clinical characteristics of Crohn's disease in 72 families. Gastroenterology 1996; 111: 604-7
26. Peeters M, Nevens H, Baert F et al. Familial aggregation in Crohn's disease. Increased age-adjusted risk and concordance in clinical characteristics. Gastroenterology 1996; 111: 597-603
27. Polito MJ, Rees CR, Childs B et al. Preliminary evidence for genetic anticipation in Crohn's disease. Lancet 1996; 347: 798-800
28. Polito JM, Childs B, Mellits DE et al. Crohn's disease: Influence of age at diagnosis on site and clinical type of disease. Gastroenterology 1996; 111: 580-6
29. Satsangi J, Grootscholten C, Holt H et al. Clinical patterns of familial inflammatory bowel disease. Gut 1996; 38: 738-41
30. Hugot JP, Laurent-Puig P, Gower-Rousseau C et al. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 1996; 379: 821-3
31. Ohmen JD, Yang HY, Yamamoto KK et al. Susceptibility locus for Crohn's disease on chromosome 16 has a role in Crohn's disease, but not in ulcerative colitis. Hum Mol Genet 1996; 5: 1679-83
32. Mansfield JC, Holden H, Tarlow JK et al. Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist. Gastroenterology 1994; 106: 637-42
33. Louis E, Satsangi J, Roussomoustakaki M et al. Cytokine gene polymorphisms in inflammatory bowel disease. Gut 1996; 39: 705-10
34. Hacker UT, Gomolka M, Keller E et al. Lack of association between an interleukin-1 receptor antagonist gene polymorphism and ulcerative colitis. Gut 1997; 40: 623-7
35. Bioque G, Crusius JB, Koutoubakis I et al. Allelic polymorphism in IL-1beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease. Clin Exp Immunol 1995; 102: 379-83
36. Hacker UT, Bidlingmaier C, Gomolka M et al. Inflammatory bowel disease: No association between allelic polymorphisms of interleukin (IL)-1β and IL-1 receptor antagonist gene polymorphisms. Eur J Clin Invest 1998; 28: 234-9
37. Gleeson M, Walker JS, Wentzel J et al. Human leukocyte antigen in Crohn's disease and ulcerative colitis. Gut 1972; 13: 439-40
38. Nahir M, Gideoni O, Eidelman S et al. HLA antigens in ulcerative colitis. Lancet 1976; 2: 573
39. Delpre G, Kadish U, Gazit E et al. HLA antigens in ulcerative colitis and Crohn's disease in Israel. Gastroenterology 1980; 78: 1452-7
40. Toyoda H, Wang SJ, Yang HY et al. Distinct association of HLA class II genes with inflammatory bowel disease. Gastroenterology 1993; 104: 741-8
41. Duerr RH, Chensy LJ, Wong CT et al. Homozygosity for an HLA class II group haplotype is associated with p-ANCA-positive and familial ulcerative colitis. Gastroenterology 1995; 108: A812
42. Satsangi J, Wlesh KI, Bunce M et al. Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease. Lancet 1996; 347: 1212-7
43. Cavanaugh J, Wilson S, Sraml M et al. Affected sibpair analysis of pericentric chromosome 16 markers in inflammatory bowel disease families. Gastroenterology 1997; 112: A946
44. Cho JH, Fu Y, Kirschner BS et al. Confirmation of susceptibility locus IBD-1, for Crohn's disease on chromosome 16. Gastroenterology 1997; 112: A948
45. Brant SR, Fu Y, Fields CT et al. American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 12. Gastroenterology 1998; 115: 1056-61
46. Satsangi J, Parkes M, Louis E et al. Two-stage genome wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet 1996; 14: 199-202
47. Hampe J, Stokkers P. Nürnberg T et al. Linkage to a susceptibility region on chromosome 12 but not 16 in a north central european family sample by multipoint nonparametric linkage analysis. Gastroenterology 1997; 112: A990
48. Duerr RH, Xhang L, Preston S et al. Further evidence for an inflammatory bowel disease susceptibility locus on chromosome 12. Gastroenterology 1997; 112: A963
49. Curran ME, Lau KF, Hampe J et al. Genetic analysis of inflammatory bowel disease in a large european cohort supports linkage to chromosomes 12 and 16. Gastroenterology 1998; 115: 1066-71
50. Rioux JD, Daly MJ, Green T et al. Absence of linkage between inflammatory bowel disease and selected loci on chromosomes 3, 7, 12 and 16. Gastroenterology 1998; 115: 1062-5