Precocious expression of T cell functional response genes in vivo in primitive thymocytes before T lineage commitment

International Immunology

Volumn 10, Issue 11, 1998, Pages 1623-1635

  Wang, Hua ^a,b   Diamond, Rochelle A ^b   Yang Snyder, Julia A ^c   Rothenberg, Ellen V ^b  

^a STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

IL 2; IL 4; NK cells; Perforin; RT PCR; T cell development; Thymocyte subsets

Indexed keywords

CD69 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA; PERFORIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; IMMUNOGENETICS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR GENE; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE;

EID: 0031756526     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.11.1623     Document Type: Article

References (57)

1. Rothenberg, E. V. and Ward, S. B. 1996. A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin-2 gene regulation Proc. Natl Acad. Sci. USA 93:9358.
2. Wilson, A., Held, W. and MacDonald, H. R. 1994. Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 179:1355.
3. Saint-Ruf, C., Ungewiss, K., Groettrup, M., Bruno, L., Fehling, H. J. and von Boehmer, H. 1994. Analysis and expression of a cloned pre-T cell receptor gene. Science 266:1208.
4. Wilson, A. and MacDonald, H. R. 1995. Expression of genes encoding the pre-TCR and CD3 complex during thymus development. Int. Immunol. 7:1659.
5. Bruno, L., Rocha, B., Rolink, A., von Boehmer, H. and Rodewald, H.-R. 1995. Intra- and extra-thymic expression of the pre-T cell receptor a gene. Eur. J. Immunol. 25:1877.
6. Ismaili, J., Antica, M. and Wu, L. 1996. CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intrathymic precursor cells. Eur. J. Immunol. 26:731.
7. Wang, H., Diamond, R. A. and Rothenberg, E. V. 1998. Crosslineage expression of Ig-β (B29) in thymocytes: positive and negative gene regulation to establish T cell identity. Proc. Natl Acad. Sci. USA 95:6831.
8. Rothenberg, E. V., Diamond, R. A. and Chen, D. 1994. Programming for recognition and programming for response: separate developmental subroutines in the murine thymus. Thymus 22:215.
9. Vanhecke, D., Verhasselt, B., Debacker, V., Leclercq, G., Plum, J. and Vandekerckhove, B. 1995. Differentiation to T helper cells in the thymus - gradual acquisition of T helper cell-function by CD3(+)CD4(+) cells. J. Immunol. 155:4711.
10. Simon, A. K., Auphan, N. and Schmitt-Verhulst, A. M. 1996. Developmental control of antigen-induced thymic transcription factors. Int. Immunol. 8:1421.
11. Rincon, M. and Flavell, R. A. 1996. Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells. Mol. Cell. Biol. 16:1074.
12. + thymocytes in suspension culture. Eur. J. Immunol. 26:2081.
13. Carlyle, J. R., Michie, A. M., Furlonger, C., Nakano, T., Lenardo, M. J., Paige, C. J. and Zúñiga-Pflücker, J. C. 1997. Identification of a novel developmental stage marking lineage commitment of progenitor thymocytes. J. Exp. Med. 186:173
14. -/- and scid thymocytes on two genetic backgrounds: developmental choices and cell death mechanisms before TCR gene rearrangement. J. Immunol. 158:4052.
15. Reya, T., Yang-Snyder, J. A., Rothenberg, E. V. and Carding, S. R. 1996. Regulated expression and function of CD122 (interleukin-2/interleukin-15 R-β) during lymphoid development. Blood 87:190.
16. Zlotnik, A. and Moore, T. A. 1995. Cytokine production and requirements during T cell development. Curr. Opin. Immunol. 7:206.
17. Rothenberg, E. V., Chen, D. and Diamond, R. A. 1993. Functional and phenotypic analysis of thymocytes in SCID mice: evidence for functional response transitions before and after the SCID arrest point. J. Immunol. 151:3530.
18. Deman, J., Humblet, C., Martin, M.-T., Boniver, J. and Defresne, M.-P. 1994. Analysis by in situ hybridization of cytokine mRNA expression in the murine developing thymus. Int. Immunol. 6:1613.
19. Yang-Snyder, J. A. and Rothenberg, E. V. 1993. Developmental and anatomical patterns of IL-2 gene expression in vivo in the murine thymus. Dev. Immunol. 3:85.
20. Carding, S. R., Hayday, A. C. and Bottomly, K. 1991. Cytokines in T cell development, Immunol. Today 12:239.
21. Carding, S. R., Jenkinson, E. R., Kingston, R., Hayday, A. C., Bottomly, K. and Owen, J. J. T. 1989. Developmental control of lymphokine gene expression in fetal thymocytes during T cell ontogeny. Proc. Natl Acad. Sci. USA 86:3342.
22. Yang-Snyder, J. A. and Rothenberg, E. V. 1998. Spontaneous expression of interleukin-2 in vivo in specific tissues of young mice. Dev. Immunol. 5: in press.
23. high human thymocytes are activated and already functionally differentiated into helper and cytotoxic cells. J. Immunol. 152:1738.
24. Rothenberg, E. V. and Diamond, R. A. 1994. Costimulation by interleukin-1 of multiple activation responses in a developmentally restricted subset of immature thymocytes. Eur. J. Immunol. 24:24.
25. Diamond, R. A. 1998. Quality control guidelines for research flow cytometry. In Diamond, R. A. and DiMaggio, S., eds, In Living Color: Protocols in Flow Cytometry and Cell Sorting. Springer, Heidelberg, in press.
26. Murphy, E., Hieny, S., Sher, A. and O'Garra, A. 1993. Detection of in vivo expression of interleukin-10 using a semi-quantitative polymerase chain reaction method in Schistosoma mansoni infected mice. J. Immunol. Methods 162:211.
27. McClanahan, T., Dalrymple, S., Barkett, M. and Lee. F. 1993. Hematopoietic growth factor receptor genes as markers of lineage commitment during in vitro development of hematopoietic cells. Blood 81:2903.
28. Owen, M. J. and Venkitaraman, A. R. 1996. Signalling in lymphocyte development. Curr. Opin. Immunol. 8:191.
29. Shortman, K. and Wu, L. 1996. Early T lymphocyte progenitors. Annu. Rev. Immunol. 14:29.
30. Zúñiga-Pflücker, J. C. and Lenardo, M. J. 1996. Regulation of thymocyte development from immature progenitors. Curr. Opin. Immunol. 8:215.
31. Moore, T. A. and Zlotnik, A. 1995. T lineage commitment and cytokine responses of thymic progenitors. Blood 86:1850.
32. Wu, L., Li, C.-L. and Shortman, K. 1996. Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny. J. Exp. Med. 184:903.
33. Wu, L., Antica, M., Johnson, G. R., Scollay, R. and Shortman, K. 1991. Developmental potential of the earliest precursor cells from the adult mouse thymus. J. Exp. Med. 174:1617.
34. Kondo, M., Weissman, I. L. and Akashi, K. 1997. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91:661.
35. Taylor-Fishwick, D. A. and Siegel, J. N. 1995. Raf-1 provides a dominant but not exclusive signal for the induction of CD69 expression on T cells. Eur. J. Immunol. 25:3215.
36. + thymocytes. Eur. J. Immunol. 23:739.
37. Lucas, B., Vasseur, F. and Penit, C. 1994. Production, selection, and maturation of thymocytes with high surface density of TCR. J. Immunol. 153:53
38. lck and CD3ζ in early thymic selection. Immunity 3:215.
39. Wilkinson, R. W., Anderson, G., Owen, J. J. T. and Jenkinson, E. J. 1995. Positive selection of thymocytes involves sustained interactions with the thymic microenvironment. J. Immunol. 155:5234.
40. + T cells. Curr. Opin. Immunol. 7:367.
41. + thymocytes in vitro. J. Immunol. 154:3636.
42. Ivanov, V. and Ceredig, R. 1992. Transcription factors in mouse fetal thymus development. Int. Immunol. 4:729.
43. neg thymocytes resembles antigen-activated mature T cells. J. Exp. Med. 178:1139.
44. Zúñiga-Pflücker, J. C., Jiang, D. and Lenardo, M. J. 1995. Requirement for TNF-α and IL-1α in fetal thymocyte commitment and differentiation. Science 268:1906.
45. Manoussaka, M., Georgiou, A., Rossiter, B., Shrestha, S., Toomey, J. A., Sivakumar, P. V., Bennett, M., Kumar, V. and Brooks, C. G. 1997. Phenotypic and functional characterization of long-lived NK cell lines of different maturational status obtained from mouse fetal liver. J. Immunol. 158:112.
46. Rothenberg, E. V. 1998. Gene regulation in T cell lineage commitment. In Monroe, J. and Rothenberg, E. V., eds, Molecular Biology of B-cell and T-cell Development, p. 337. Humana Press, Totowa, NJ.
47. Hu, M., Krause, D., Greaves, M., Sharkis, S., Dexter, M., Heyworth, C. and Enver, T. 1997. Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev. 11:774.
48. Cross, M. A., Heyworth, C. M., Murrell, A. M., Bockamp, E. O., Dexter, T. M. and Green, A. R. 1994. Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line. Oncogene 9:3013.
49. Taira, S., Matsui, M., Hayakawa, K., Yokoyama, T. and Nariuchi, H. 1987. Interleukin 2 secretion by B cell lines and splenic B cells stimulated with calcium ionophore and phorbol ester. J. Immunol. 139:2957.
50. Plaut, M., Pierce, J. H., Watson, C. J., Hanley-Hyde, J., Nordan, R. P. and Paul, W. E. 1989. Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores. Nature 339:64.
51. Bossé, M., Audette, M., Ferland, C., Pelletier, G., Chu, H. W., Dakhama, A., Lavigne, S., Boulet, L.-P. and Laviolette, M. 1996. Gene expression of interleukin-2 in purified human peripheral blood eosinophils. Immunology 87:149.
52. Levi-Schaffer, F., Barkans, J., Newman, T. M., Ying, S., Wakelin, M., Hohenstein, R., Barak, V., Lacy, P., Kay, A. B. and Moqbel, R. 1996. Identification of interleukin-2 in human peripheral blood eosinophils. Immunology 87:155.
53. Reya, T. 1996. The role of interleukin 2 in hematopoiesis. PhD Thesis, University of Pennsylvania, Philadelphia, PA.
54. + precursors. Science 242:1174.
55. Festenstein, R., Tolaini, M., Corbella, P., Mamalaki, C., Parrington, J., Fox, M., Miliou, A., Jones, M. and Kioussis, D. 1996. Locus control region function and heterochromatin-induced position effect variegation. Science 271:1123.
56. Brown, K. E., Guest, S. S., Smale, S. T., Hahm, K., Merkenschlager, M. and Fisher. A. G. 1997. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 91:845.
57. Holländer, G. A., Zuklys, S., Morel, C., Mizoguchi, E., Mobisson, K., Simpson, S., Terhorst, C., Wishart, W., Golan, D. E., Bhan, A. K. and Burakoff, S. J. 1998. Monoallelic expression of the interleukin-2 locus. Science 279:2118.