Activation of gp130 signaling in vivo by the IL-6 super-agonist K-7/D-6 accelerates repopulation of lymphoid organs after irradiation

European Journal of Immunology

Volumn 29, Issue 1, 1999, Pages 300-310

  Frasca, Daniela ^a   Doria, Gino ^a   Barattini, Paola ^a   Guidi, Francesco ^a   Salvati, AnnaLaura ^b,c   Toniatti, Carlo ^b   Ciliberto, Gennaro ^b  

^a ENEA C R CASACCIA   (Italy)

^b IRBM   (Italy)

^c IDI Farmaceutici   (Italy)

Author keywords

gp130; IL 6; Irradiation; Lymphoid organ

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; GLYCOPROTEIN GP 130; INTERLEUKIN 3; INTERLEUKIN 6; MYELOABLATIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; IRRADIATION; ISOGRAFT; LYMPHOID ORGAN; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SPLEEN; STIMULATION; THYMUS;

ANIMALS; ANTIGENS, CD; B-LYMPHOCYTES; BONE MARROW TRANSPLANTATION; CYTOKINE RECEPTOR GP130; FEMALE; HEMATOPOIESIS; HUMANS; INTERLEUKIN-6; LYMPHOID TISSUE; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; RECEPTORS, INTERLEUKIN-6; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSPLANTATION, ISOGENEIC; VARIATION (GENETICS);

EID: 0032895229     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199901)29:01<300::AID-IMMU300>3.0.CO;2-J     Document Type: Article

References (44)

1. Metcalf, D., Hematopoietic regulators: redundancy or subtlety? Blood 1993. 82: 3515-3523.
2. Kishimoto, T., Taga, T., Akira, S., Cytokine signal transduction. Cell 1994. 76: 253-262.
3. Ogawa, M., Differentiation and proliferation of hematopoietic stem cells. Blood 1993. 81: 2844-2853.
4. Taga, T., Kishimoto, T., Signaling mechanism through cytokine receptors. That share signal transducing receptor components. Curr. Opin. Immunol. 1995. 7: 17-23.
5. Hibi, M., Murakami, M., Sato, M., Hirano, T., Taga, T., Kishimoto, T., Molecular cloning and expression of an IL-6 signal transducer gp130. Cell 1990. 63: 1149-1157.
6. Saito, M., Yoshida, M., Hibi, T., Taga, T., Kishimoto, T., Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J. Immunol. 1992. 148: 4066-4071.
7. Yoshida, K., Taga, T., Saito, M., Suematsu, S., Kumanogoh, A., Tanaka, T., Fujiwara, H., Hirata, M., Yamagami, T., Nakahata, T., Hirabayashi, T., Yoneda, Y., Tanaka, K., Wang, W.-Z., Mori, C., Shiota, K., Yoshida, N., Kishimoto, T., Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc. Natl. Acad. Sci. USA 1996. 93: 407-411.
8. Bernad, A., Kopf, M., Kulbacki, R., Weich, N., Koehler, G., Gutierrez-Ramos, J. C., Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system. Immunity 1994. 1: 725-731.
9. Taga, T., Hibi, M., Hirata, Y., Yamesaki, K., Yasukawa, K., Matsuda, T., Hirano, T., Kishimoto, T., IL-6 triggers the association of its receptor with a possible signal transducer gp130. Cell 1989. 58: 573-581.
10. Murakami, M., Hibi, M., Nakagawa, K., Yasukawa, T., Yamanishi, T., Taga, T., Kishimoto, T., IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 1993. 260: 1808-1810.
11. Paonessa, G., Graziani, R., De Serio, A., Savino, R., Ciapponi, L., Lahm, A., Salvati, A. L., Toniatti, C., Ciliberto, G., Two distinct and independent sites on IL-6 trigger gp130 dimer formation and signalling. EMBO J. 1996. 14: 1942-1951.
12. Mackiewicz, A., Schooltink, H., Heinrich, P. C., Rose-John, S., Complex of soluble human IL-6 receptor/IL-6 up-regulates expression of acute phase proteins. J. Immunol. 1992. 149: 2021-2027.
13. Tamura, T., Udagawa, N., Takahashi, N., Miyaura, C., Tanaka, S., Yamada, Y., Koishihara, Y., Ohsugi, Y., Kumaki, K., Taga, T., Kishimoto, T., Suda, T., Soluble interleukin-6 receptor triggers osteoclast formation by interleukin-6. Proc. Natl. Acad. Sci. USA 1993. 90: 11924-11928.
14. Mihara, M., Moriya, Y., Kishimoto, T., Ohsugi, Y., Interleukin-6 (IL-6) induces the proliferation of synovial fibroblastic cells in the presence of soluble IL-6 receptor. Br. J. Rheumatol. 1995. 34: 321-325.
15. Romano, M., Sironi, M., Toniatti, C., Polentarutti, N., Fruscella, P., Ghezzi, P., Faggioni, R., Luini, W., van Hinsbergh, V., Sozzani, S., Bussolino, F., Poli, V., Ciliberto, G., Mantovani, A., Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 1997. 6: 315-325.
16. Tajima, S., Tsuji, K., Ebihara, Y., Sui, X., Tanaka, R., Muraoka, K., Yoshida, M., Yamada, K., Yasukawa, K., Taga, T., Kishimoto, T., Nakahata, T., Analysis of IL-6 receptor and gp130 expressions and proliferative capability of human CD34+ cells. J. Exp. Med. 1996. 184: 1357-1364.
17. Sui, X., Tsuji, K., Tanaka, R., Tajima, S., Muraoka, K., Ebihara, Y., Ikebuchi, K., Yasukawa, K., Taga, T., Kishimoto, T., Nakahata, T., gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells. Proc. Natl. Acad. Sci. USA 1995. 92: 2859-2863.
18. Peters, M., Schirmacher, P., Goldschnitt, J., Odenthal, M., Peschle, C., Fattori, E., Ciliberto, G., Dienes, H.-P., Buschenfelde, K. H. M., Rose-John, S., Extra-medullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R transgenic mice. J. Exp. Med. 1997. 185: 755-766.
19. Peters, M., Odenthal, M., Schirmacher, P., Blessing, M., Fattori, E., Ciliberto, G., zum Buschenfelde, K. H. M., Rose-John, S., Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice. J. Immunol. 1997. 159: 1474-1481.
20. Cabibbo, A., Sporeno, E., Toniatti, C., Altamura, S., Savino, R., Paonessa, G., Ciliberto, G., Monovalent phage display of human interleukin (hIL)-6: selection of superbinder variants from a complex molecular repertoire in the hIL-6 D-helix. Gene 1995. 167: 41-47.
21. Toniatti, C., Cabibbo, A., Sporeno, E., Salvati, A. L., Cerretani, M., Serafini, S., Lahm, A., Cortese, R., Ciliberto, G., Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity. EMBO J. 1996.. 15: 2726-2737.
22. Farese, A. M., Herodin, H., McKearn, J. P., Baum, C., Burton, E., MacVittie, T. J., Acceleration of hematopoietic reconstitution with a synthetic cytokine (SC-55494) after radiation-induced bone marrow aplasia. Blood 1996. 87: 581-591.
23. Peters, S. O., Kittler, E. L. W., Ramshaw, H. S., Quesenberry, P. J., Ex vivo expansion of murine marrow cells with IL-3, IL-6, IL-11, and Stem Cell Factor leads to impaired engraftment in irradiated hosts. Blood 1996. 87: 30-37.
24. Williams, S. F., Lee, W. J., Bender, J. G., Zimmerman, T., Swinney, P., Blake, M., Carreon, J., Schilling, M., Smith, S., Williams, D. E., Oldham, F., Van Epps, D., Selection and expansion of peripheral blood CD34+ cells in autologous stem cell transplantation for breast cancer. Blood 1996. 87: 1687-1691.
25. Frasca, D., Pioli, C., Guidi, F., Pucci, S., Arbitrio, M., Leter, G., Doria, G., IL-11 synergize with IL-3 on the recovery of the immune system in irradiated mice. Int. Immunol. 1996. 8: 1651-1657.
26. Frasca, D., Guidi, F., Arbitrio, M., Pioli, C., Leter, G., Spanò, M., Doria, G., Use of hematopoietic cytokines to accelerate the recovery of the immune system in irradiated mice. Exp. Hematol. 1997. 25: 1167-1171.
27. Frasca, D., Arbitrio, M., Guidi, F., Leter, G., Poccia, F., Doria, G., Hematopoietic cytokines accelerate the recovery of the immune system after lethal irradiation and bone marrow transplantation. Exp. Hematol., see Note added proof.
28. Siena, S., Bregni, M., Brando, B., Ravagnani, F., Bonadonna, G., Gianni, A. M., Circulation of CD34+ hematopoietic stem cells in the peripheral blood of high-dose cyclophosphamide treated patients: enhancement by intravenous recombinant human GM-CSF. Blood 1989. 74: 1905-1914.
29. Giani, A. M., Siena, S., Bregni, M., Tarella, C., Stern, A. C., Pileri, A., Bonadonna, G., GM-CSF to harvest circulating hematopoietic stem cells for autotransplantation. Lancet 1989. 2: 580-582.
30. Haas, R., Ho, A. D., Bredthauer, U., Cayeux, S., Egerer, G., Knauf, W., Hunstein, W., Successful autologous transplantation of blood stem cells mobilized with recombinant human GM-CSF. Exp. Hematol. 1990. 18: 94-98.
31. Socinski, M. A., Elias, A., Schnipper, L., Cannistra, S. A., Antman, K. H., Griffin, J. D., GM-CSF expands the circulating hematopoietic progenitor cell compartment in man. Lancer 1988. 1: 1194-1198.
32. Lane, T. A., Law, P., Maruyama, M., Young, D., Burgess, J., Mullen, M., Mealiffe, M., Terstappen, L. W. M. M., Hardwick, A., Moubayed, M., Oldham, F., Corringham, R. E. T., Ho, A. D., Harvesting and enrichment of hematopoietic progenitor cells mobilized into the peripheral blood of normal donors by GM-CSF or G-CSF: potential role in allogeneic marrow transplantation. Blood 1995. 85: 275-282.
33. Korbling, M., Dorken, B., Ho, A. D., Pezzutto, A., Hunstein, W., Fliedner, T. M., Autologous transplantation of blood-derived stem cells after myeloablative therapy in a patient with Burkitt's lymphoma. Blood 1986. 67: 529-532.
34. Kessinger, A., Armitage, J. O., Landmark, J. D., Autologous peripheral hematopoietic stem cell transplantation restores hematopoietic function following marrow ablative therapy. Blood 1988. 71: 723-727.
35. Juttner, C. A., Ho, T. O., Ho, J. Q., Bardy, P. G., Dyson, P. G., Haylock, D. N., Kimber, R. J., Early lymphohematopoietic recovery after autografting using peripheral blood stem cells in acute non-lymphoblastic leukemia. Transplant. Proc. 1988. 20: 40-42.
36. Richman, C. M., Weiner, R. S., Yankee, R. A., Increase in circulating stem cells following chemotherapy in man. Blood 1976. 47: 1031-1039.
37. Leary, A. G., Ikebuchi, K., Hirai, Y., Wong, G. G., Yang, Y.-C., Clark, S. C., Ogawa, M., Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: comparison with interleukin-1α. Blood 1988. 71: 1759-1763.
38. Kimura, T., Sakabe, H., Tanumukai, S., Abe, T., Urata, Y., Yasukawa, K., Okano, A., Taga, T., Sugiyama, H., Kishimoto, T., Sonoda, Y., Simultaneous activation of signals through gp130, c-kit and interleukin-3 receptor promotes a trilineage blood cell production in the absence of terminally acting lineage-specific factors. Blood 1997. 90: 4767-4778.
39. Wu, H., Klingmuller, U., Besmer, P., Lodish, H. F., Interaction of the erythropoietin and stem-cell-factor receptors. Nature 1995. 377: 242-246.
40. Kishimoto, T., Akira, S., Narazaki, M., Taga, T., Interleukin-6 family of cytokines and gp130. Blood 1995. 86: 1243-1254.
41. Ihle, J. N., Cytokine receptor signaling. Nature 1995. 377: 591-594.
42. Honda, M., Yamamoto, S., Cheng, M., Yasukawa, K., Suzuki, H., Saito, T., Osugi, Y., Tokunaga, T., Kishimoto, T., Human soluble IL-6 receptor: its detection and enhanced release by HIV infection. J. Immunol. 1992. 148: 2175-2181.
43. Sporeno, E., Paonessa, G., Salvati, A. L., Graziani, R., Delmastro, P., Ciliberto, G., Toniatti, C., Oncostatin M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional Oncostatin M receptors. J. Biol. Chem. 1994. 269: 10991-10995.
44. Scheffé, H., A method for judging all contrasts in the analysis of variance. Biometrika 1953. 40: 87-99.