Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity

EMBO Journal

Volumn 15, Issue 11, 1996, Pages 2726-2737

  Toniatti, Carlo ^a   Cabibbo, Andrea ^b   Sporeno, Elisabetta ^a   Salvati, Anna Laura ^a   Cerretani, Mauro ^a   Serafini, Sergio ^a   Lahm, Armin ^a   Cortese, Riccardo ^a   Ciliberto, Gennaro ^a  

^a IRBM   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

BAF cells; IL 6; IL 6 receptor superagonists; IL 6R; Phage display

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENETIC ENGINEERING; HUMAN; PRIORITY JOURNAL; PROTEIN VARIANT; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

EID: 0029931316     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00633.x     Document Type: Article

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