Blockade of CD28/CTLA4-B7 pathway prevented autoantibody-related- diseases but not lung disease in MRL/Ipr mice

Laboratory Investigation

Volumn 79, Issue 3, 1999, Pages 317-326

  Takiguchi, Mitsuyoshi ^a,b   Murakami, Masaaki ^a   Nakagawa, Izumi ^a   Yamada, Akira ^a   Chikuma, Shunsuke ^a   Kawaguchi, Yoshinori ^a   Hashimoto, Akira ^b   Uede, Toshimitsu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; B7 ANTIGEN; CD28 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; ENZYME LINKED IMMUNOSORBENT ASSAY; LUNG DISEASE; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0032893867     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Adachi M, Watanabe-Fukunaga R, and Nagata S (1993). Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc Natl Acad Sci USA 90:1756-1760.
2. Allison JP (1994). CD28-B7 interactions in T-cell activation. Curr Opin Immunol 6:414-419.
3. Andrews BS, Eisenberg RA, Theofilopoulos AN, Izui S, Wilson CB, McConahey PJ, Murphy ED, Roth JB, and Dixon FJ (1978). Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med 148:1198-1215.
4. + lymphocytes delete activated macrophages through the FAS/APO-1 antigen pathway. Proc Natl Acad Sci USA 21:11225-11229.
5. Blossom S, Chu EB, Weigle WO, and Gilbert KM (1997). CD40 ligand expressed on B cells in BXSB mouse model of systemic lupus erythematosus. J Immunol 159:4580-4586.
6. Bolster MB, Ludwicka A, Sutherland SE, Strange C, and Silver RM (1997). Cytokine concentration in bronchoalveolar lavage fluid of patients with systemic sclerosis. Arthritis Rheum 40:743-751.
7. Bullard DC, King PD, Hicks MJ, Dupont B, Beaudet AL, and Elkon KB (1997). Intercellular adhesion molecule-1 deficiency protects MRL/MpJ-Fas(lpr) mice from early lethality. J Immunol 159:2058-2067.
8. Cerny A, Kimoto M, Hugin AW, Merino R, and Izui S (1989). Anti-IgM treatment of C57BL/6-lpr/lpr mice: Depletion of B cells reduces lpr gene-induced lymphoproliferation and mononuclear cell vasculitis. Clin Exp Immunol 77:124-129.
9. + cell subset shifts and autoimmunity in the BXSB mouse by mouse CTLA4lg. J Immunol 156:1262-1268.
10. Chu JL, Drappa J, Parnassa A, and Elkon KB (1993). The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn. J Exp Med 178:723-730.
11. Clynes R, Dumitru C, and Ravetch JV (1998). Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science 279:1052-1054.
12. de Alboran IM, Gonzalo J, Kroemer G, Leonardo E, Marcos M, and Martinez C (1992). Attenuation of autoimmune disease and lymphocyte accumulation in MRL/lpr mice by treatment with anti-V beta 8 antibodies. Eur J Immunol 22:2153-2158.
13. Eisenberg RA, Tan EM, and Dixon FJ (1978). Presence of anti-Sm reactivity in autoimmune mouse strains. J Exp Med 147:582-587.
14. Finck BK, Linsley PS, and Wofsy D (1994). Treatment of murine lupus with CTLA4lg. Science 265:1225-1227.
15. Fisher GH, Rosenberg FJ, Straus SE, Dale JK, Middleton LA, Lin AY, Strober W, Lenardo MJ, and Puck JM (1995). Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 81:935-946.
16. Fukuyama H, Adachi M, Suematsu S, Miwa K, Suda T, Yoshida N, and Nagata S (1998). Transgenic expression of Fas in T cells blocks lymphoproliferation but not autoimmune disease in MRL-lpr mice. J Immunol 160:3805-3811.
17. Henrickson M, Giannini EH, and Hirsch R (1994). Reduction of mortality and lymphadenopathy in MRL-lpr/lpr mice treated with nonmitogenic anti-CD3 monoclonal antibody. Arthritis Rheum 37:587-594.
18. Inobe M, Linsley PS, Ledbetter JA, Nagai Y, Tamakoshi M, and Uede T (1994). Identification of an alternatively spliced form of the murine homologue of B7. Biochem Biophys Res Commun 200:443-449.
19. Inobe M, Aoki N, Linsley PS, Ledbetter JA, Abe R, Murakami M, and Uede T (1996). The role of the B7-1a molecule, an alternatively spliced form of murine B7-1 (CD80), on T cell activation. J Immunol 157:582-588.
20. Jabs DA, Lee, B, and Prendergast RA (1997). Role of T cells in the pathogenesis of autoimmune lacrimal gland disease in MRL/Mp-lpr/lpr mice. Curr Eye Res 16:909-916.
21. Jenkins MK and Johnson JG (1993). Molecules involved in T-cell costimulation. Curr Opin Immunol 5:361-367.
22. Jevnikar AM, Grusby MJ, and Glimcher LH (1994). Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. J Exp Med 179:1137-1143.
23. June CH, Bluestone JA, Nadler LM, and Thompson CB (1994). The B7 and CD28 receptor families. Immunol Today 15:321-332.
24. Kapsenberg ML, Hilkens CM, Jansen HM, Bos JD, Snijders A, and Wierenga EA (1996). Production and modulation of T-cell cytokines in atopic allergy. Int Arch Allergy Immunol 110:107-113.
25. + T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J Immunol 155:1032-1036.
26. Klaus SJ, Pinchuk LM, Ochs HD, Law CL, Fanslow WC, Armitage RJ, and Clark EA (1994). Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction. J Immunol 152:5643-5652.
27. Kobayashi S, Hirano T, Kakinuma M, and Uede T (1993). Transcriptional repression and differential splicing of Fas mRNA by early transposon (ETn) insertion in autoimmune lpr mice. Biochem Biophys Res Commun 191:617-624.
28. Koh DR, Ho A, Rahemtulla A, Fung LW, Griesser H, and Mak TW (1995). Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells. Eur J Immunol 25:2558-2562.
29. Krummel MF, Sullivan TJ, and Allison JP (1996). Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. Int Immunol 8:519-523.
30. Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, and Glimcher LH (1995). B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy. Cell 80:707-718.
31. Lafferty KJ and Gill RG (1993). The maintenance of self-tolerance. Immunol Cell Biol 71:209-214.
32. Leach DR, Krummel MF, and Allison JP (1996). Enhancement of antitumor immunity by CTLA-4 blockade. Science 271: 1734-1736.
33. Liu Y, Jones B, Aruffo A, Sullivan KM, Linsley PS, and Janeway CAJ (1992). Heat-stable antigen is a costimulatory molecule for CD4 T cell growth. J Exp Med 175:437-445.
34. Lloyd CM, Gonzalo JA, Salant DJ, Just J, and Gutierrez-Ramos JC (1997). Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus. J Clin Invest 100:963-971.
35. McKenzie WN, Walker SE, Thomas NE, Waggle KS, and Sunderrajan EV (1984). Pulmonary vascular changes in MRL mice in response to treatment with cyclophosphamide(CY) (abstract). Arthritis Rheum 27:579.
36. Morse HCI, Davidson WF. Yetter RA, Murphy ED, Roths JB, and Coffman RL (1982). Abnormalities induced by the mutant gene lpr: Expression of a unique lymphocyte subset. J Immunol 129:2612-2615.
37. Murakami M, Takahashi Y, Isashi Y, Kon S, Jia W, Inobe M, Abe R, and Uede T (1996). Identification and characterization of an alternative cytotoxic T lymphocyte-associated protein 4 binding molecule on B cells. Proc Natl Acad Sci USA 93:7838-7842.
38. Nakagawa I, Murakami M, Ijima K, Chikuma C, Saito I, Kanegae Y, Ishikura H, Yoshiki T, Okamoto H, Kitabatake A, and Uede T (1998). Persistent and secondary adenovirus-mediated hepatic gene expression using adenovirus vector containing CTLA4lgG. Hum Gene Ther 9:1739-1745.
39. Nakajima A, Watanabe N, Yoshino S, Yagita H, Okumura K, and Azuma M (1997). Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells. Int Immunol 9:637-644.
40. O'Sullivan FX, Ray CJ, Takeda Y, Sharp GC, and Walker SE (1991). Long-term anti-CD4 treatment of MRL/lpr mice ameliorates immunopathology and lymphoproliferation but fails to suppress rheumatoid factor production. Clin Immunol Immunopathol 61:421-435.
41. Peng SL, Fatenejad S, and Craft J (1996). Induction of nonpathologic, humoral autoimmunity in lupus-prone mice by a class II-restricted, transgenic alpha beta T cell. Separation of autoantigen-specific and -nonspecific help. J Immunol 157:5225-5230.
42. Ravirajan CT, Sarraf CE, Anilkumar TV, Golding MC, Alison MR, and Isenberg DA (1996). An analysis of apoptosis in lymphoid organs and lupus disease in murine systemic lupus erythematosus (SLE). Clin Exp Immunol 105:306-312.
43. Reap EA, Sobel ES, Cohen PL, and Eisenberg RA (1993). Conventional B cells, not B-1 cells, are responsible for producing autoantibodies in lpr mice. J Exp Med 177:69-78.
44. Reininger L, Radaszkiewicz T, Kosco M, Melchers F, and Rolink AG (1992). Development of autoimmune disease in SCID mice populated with long-term "in vitro" proliferating (NZB X NZW) F1 pre-B cells. J Exp Med 176:1343-1353.
45. Renno T, Hahne M, Tschopp J, and MacDonald HR (1996). Pheripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand. J Exp Med 183:431-437.
46. + T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice. J Exp Med 167:1713-1718.
47. Seaman WE, Wofsy D, Greenspan JS, and Ledbetter JA (1983). Treatment of autoimmune MRL/lpr mice with monoclonal antibody to Thy-1.2: A single injection has sustained effects on lymphoproliferation and renal disease. J Immunol 130:1713-1718.
48. Shlomchik MJ, Madaio MP, Ni D, Trounstein M, and Huszar D (1994). The role of B cells in lpr/lpr-induced autoimmunity. J Exp Med 180:1295-1306.
49. Singer GG and Abbas AK (1994). The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1:365-371.
50. Sunderrajan EV, McKenzie WN, Lieske TR, Kavanaugh JL, Braun SR, and Walker SE (1986). Pulmonary inflammation in autoimmune MRL/Mp-lpr/lpr mice. Histopathology and bronchoalveolar lavage evaluation. Am J Pathol 124:353-362.
51. Szechtman H, Sakic B, and Denburg JA (1997). Behaviour of MRL mice: An animal model of disturbed behaviour in systemic autoimmune disease. Lupus 6:223-229.
52. Taniguchi Y, Ito MR, Mori S, Yonehara S, and Nose M (1996). Role of macrophages in the development of arteritis in MRL strains of mice with a deficit in Fas-mediated apoptosis. Clin Exp Immunol 106:26-34.
53. Taub DD and Cox GW (1995). Murine Th1 and Th2 cell clones differentially regulate macrophage nitric oxide production. J Leukoc Biol 58:80-89.
54. Theofilopoulos AN and Dixon FJ (1985). Murine models of systemic lupus erythematosus. Adv Immunol 37:269-390.
55. Van Parijis L, Ibraghimov A, and Abbas AK (1996). The roles of costimulation and fas in T cell apoptosis and peripheral tolerance. Immunity 4:321-328.
56. Warren RW, Caster SA, Roths JB, Murphy ED, and Pisetsky DS (1984). The influence of the lpr gene on B cell activation: Differential antibody expression in lpr congenic mouse strains. Clin Immunol Immunopathol 31:65-77.
57. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, and Nagata S (1992). Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (Lond) 356:314-317.
58. Weinberg JB, Granger DL, Pisetsky DS, Seldin MF, Misukonis MA, Mason SN, Rippen AM, Ruiz P, Wood ER, and Gilkeson GS (1994). The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-arginine. J Exp Med 179:651-660.
59. Wu J, Zhou T, He J, and Mountz JD (1993). Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene. J Exp Med 178:461-468.