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Volumn 181, Issue 3, 1999, Pages 949-956

EmrE, a small Escherichia coli multidrug transporter, protects Saccharomyces cerevisiae from toxins by sequestration in the vacuole

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CARRIER PROTEIN; TOXIN;

EID: 0032891452     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.181.3.949-956.1999     Document Type: Article
Times cited : (15)

References (47)
  • 1
    • 0023392267 scopus 로고
    • A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains
    • Alani, E., L. Cao, and N. Kleckner. 1987. A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains. Genetics 116:541-545.
    • (1987) Genetics , vol.116 , pp. 541-545
    • Alani, E.1    Cao, L.2    Kleckner, N.3
  • 2
    • 0029999396 scopus 로고    scopus 로고
    • Determining the secondary structure and orientation of EmrE, a multi-drug transporter, indicates a transmembrane four helix burdle
    • Arkin, I., W. Russ, M. Lebendiker, and S. Schuldiner. 1996. Determining the secondary structure and orientation of EmrE, a multi-drug transporter, indicates a transmembrane four helix burdle. Biochemistry 35:7233-7238.
    • (1996) Biochemistry , vol.35 , pp. 7233-7238
    • Arkin, I.1    Russ, W.2    Lebendiker, M.3    Schuldiner, S.4
  • 3
    • 0031908241 scopus 로고    scopus 로고
    • Role of the vacuolar H+-ATPase in daunorubicin distribution in etoposide-resistant MCF7 cells overexpressing the multidrug-resistance associated protein
    • Benderra, Z., H. Morjani, A. Trussardi, and M. Manfait. 1998. Role of the vacuolar H+-ATPase in daunorubicin distribution in etoposide-resistant MCF7 cells overexpressing the multidrug-resistance associated protein. Int. J. Oncol. 12:711-715.
    • (1998) Int. J. Oncol. , vol.12 , pp. 711-715
    • Benderra, Z.1    Morjani, H.2    Trussardi, A.3    Manfait, M.4
  • 4
    • 0020024572 scopus 로고
    • Codon selection in yeast
    • Bennetzen, J. L., and B. D. Hall. 1982. Codon selection in yeast. J. Biol. Chem. 257:3026-3031.
    • (1982) J. Biol. Chem. , vol.257 , pp. 3026-3031
    • Bennetzen, J.L.1    Hall, B.D.2
  • 5
    • 0029677414 scopus 로고    scopus 로고
    • Ultrastructural changes related to multidrug resistance in CEM cells: Role of cytoplasmic vesicles in drue exclusion
    • Bobichon, H., M. Colin, C. Depierreux, F. Liautaud-Roger, and J. C. Jardillier. 1996. Ultrastructural changes related to multidrug resistance in CEM cells: role of cytoplasmic vesicles in drue exclusion. J. Exp. Ther. Oncol. 1:49-61.
    • (1996) J. Exp. Ther. Oncol. , vol.1 , pp. 49-61
    • Bobichon, H.1    Colin, M.2    Depierreux, C.3    Liautaud-Roger, F.4    Jardillier, J.C.5
  • 6
    • 0028844581 scopus 로고
    • Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution
    • Breuninger, L. M., S. Paul, K. Gaughan, T. Miki, A. Chan, S. A. Aarnnson, and G. D. Kruh. 1995. Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution. Cancer Res. 55:5342-5347.
    • (1995) Cancer Res. , vol.55 , pp. 5342-5347
    • Breuninger, L.M.1    Paul, S.2    Gaughan, K.3    Miki, T.4    Chan, A.5    Aarnnson, S.A.6    Kruh, G.D.7
  • 7
    • 0030844320 scopus 로고    scopus 로고
    • The multidrugresistant human lung tumour cell line. DLKP-A10. Expresses novel drug accumulation and sequestration systems
    • Cleary, I., G. Doherty, E. Moran, and M, Clynes. 1997. The multidrugresistant human lung tumour cell line. DLKP-A10. expresses novel drug accumulation and sequestration systems. Biochem. Pharmacol. 53:1493-1502.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 1493-1502
    • Cleary, I.1    Doherty, G.2    Moran, E.3    Clynes, M.4
  • 8
    • 0028095510 scopus 로고
    • Interactions between gene products involved in divalent cation transport in Saccharomyces cerevisiae
    • Conklin, D. S., M. R. Culbertson, and C. Kung. 1994. Interactions between gene products involved in divalent cation transport in Saccharomyces cerevisiae. Mol. Gen. Genet. 244:303-311.
    • (1994) Mol. Gen. Genet. , vol.244 , pp. 303-311
    • Conklin, D.S.1    Culbertson, M.R.2    Kung, C.3
  • 9
    • 0032517896 scopus 로고    scopus 로고
    • The sge1 protein of Saccharomyces cerevisiae is a membrane-associated multidrug transporter
    • Ehrenhofer-Murray, A. E., M. U. Seitz, and C. Sengstag. 1998. The Sge1 protein of Saccharomyces cerevisiae is a membrane-associated multidrug transporter. Yeast 14:49-65.
    • (1998) Yeast , vol.14 , pp. 49-65
    • Ehrenhofer-Murray, A.E.1    Seitz, M.U.2    Sengstag, C.3
  • 10
    • 0028067604 scopus 로고
    • The Saccharomyces cerevisiae SGE1 gene product: A novel drug-resistance protein within the major facilitator superfamily
    • Ehrenhofer-Murray, A. E., F. E. Wurgler, and C. Sengstag. 1994. The Saccharomyces cerevisiae SGE1 gene product: a novel drug-resistance protein within the major facilitator superfamily. Mol. Gen. Genet. 244:287-294.
    • (1994) Mol. Gen. Genet. , vol.244 , pp. 287-294
    • Ehrenhofer-Murray, A.E.1    Wurgler, F.E.2    Sengstag, C.3
  • 11
    • 0026703547 scopus 로고
    • A simple and efficient procedure for transformation of yeasts
    • Elble, R. 1992. A simple and efficient procedure for transformation of yeasts. BioTechniques 13:18-20.
    • (1992) BioTechniques , vol.13 , pp. 18-20
    • Elble, R.1
  • 12
    • 0020571419 scopus 로고
    • Glucose transport activity in isolated plasma membrane vesicles from Saccharomyces cerevisiae
    • Franzusoff, A. J., and V. P. Cirillo. 1983. Glucose transport activity in isolated plasma membrane vesicles from Saccharomyces cerevisiae. J. Biol. Chem. 258:3608-3614.
    • (1983) J. Biol. Chem. , vol.258 , pp. 3608-3614
    • Franzusoff, A.J.1    Cirillo, V.P.2
  • 13
    • 0031887852 scopus 로고    scopus 로고
    • Evidence for the involvement of vacuolar activity in metal(loid) tolerance: Vacuolar-lacking and -defective mutants of Saccharomyces cerevisiae display higher sensitivity to chromate, tellurite and selenite
    • Gharieb, M. M., and G. M. Gadd. 1998. Evidence for the involvement of vacuolar activity in metal(loid) tolerance: vacuolar-lacking and -defective mutants of Saccharomyces cerevisiae display higher sensitivity to chromate, tellurite and selenite. Biometals 11:101-106.
    • (1998) Biometals , vol.11 , pp. 101-106
    • Gharieb, M.M.1    Gadd, G.M.2
  • 14
    • 0023647666 scopus 로고
    • Effects of growth state and amines on cytoplasmic and vacuolar pH, phosphate and polyphosphate levels in Saccharomyces cerevisiae: A 31P-nuclear magnetic resonance study
    • Greenfield, N. J., M. Hussain, and J. Lenard. 1987. Effects of growth state and amines on cytoplasmic and vacuolar pH, phosphate and polyphosphate levels in Saccharomyces cerevisiae: a 31P-nuclear magnetic resonance study. Biochim. Biophys. Acta 926:205-214.
    • (1987) Biochim. Biophys. Acta , vol.926 , pp. 205-214
    • Greenfield, N.J.1    Hussain, M.2    Lenard, J.3
  • 15
    • 0026553163 scopus 로고
    • A staphylococcal multidrug resistance gene product is a member of a new protein family
    • Grinius, L., G. Dreguniene, E. B. Goldberg, C. H. Liao, and S. J. Projan. 1992. A staphylococcal multidrug resistance gene product is a member of a new protein family. Plasmid 27:119-129.
    • (1992) Plasmid , vol.27 , pp. 119-129
    • Grinius, L.1    Dreguniene, G.2    Goldberg, E.B.3    Liao, C.H.4    Projan, S.J.5
  • 16
  • 17
    • 0020959710 scopus 로고
    • Studies on transformation of Escherichia coli with plasmids
    • Hanahan, D. 1983. Studies on transformation of Escherichia coli with plasmids. J. Mol. Biol. 166:557-580.
    • (1983) J. Mol. Biol. , vol.166 , pp. 557-580
    • Hanahan, D.1
  • 18
    • 0028921834 scopus 로고
    • Improved green fluorescence
    • Heim, R., A. B. Cubitt, and R. Y. Tsien. 1995. Improved green fluorescence. Nature 373:663-664.
    • (1995) Nature , vol.373 , pp. 663-664
    • Heim, R.1    Cubitt, A.B.2    Tsien, R.Y.3
  • 19
    • 0026619845 scopus 로고
    • The subcellular distribution of nickel in Ni-sensitive and Ni-resistant strains of Saccharomyces cerevisiae
    • Joho, M., Y. Ishikawa, M. Kunikane, M. Inouhe, H. Tohoyama, and T. Murayama. 1992. The subcellular distribution of nickel in Ni-sensitive and Ni-resistant strains of Saccharomyces cerevisiae. Microbios 71:149-159.
    • (1992) Microbios , vol.71 , pp. 149-159
    • Joho, M.1    Ishikawa, Y.2    Kunikane, M.3    Inouhe, M.4    Tohoyama, H.5    Murayama, T.6
  • 20
    • 0026584962 scopus 로고
    • Assembly and targeting of peripheral and integral membrane subunits of the yeast vacuolar H(+)-ATPase
    • Kane, P. M., M. C. Kuehn, I. Howald-Stevenson, and T. H. Stevens. 1992. Assembly and targeting of peripheral and integral membrane subunits of the yeast vacuolar H(+)-ATPase. J. Biol. Chem. 267:447-454.
    • (1992) J. Biol. Chem. , vol.267 , pp. 447-454
    • Kane, P.M.1    Kuehn, M.C.2    Howald-Stevenson, I.3    Stevens, T.H.4
  • 21
    • 0024022640 scopus 로고
    • Dynamic aspects of vacuolar and cytosolic amino acid pools of Saccharomyces cerevisiae
    • Kitamoto, K., K. Yoshizawa, Y. Ohsumi, and Y. Anraku. 1988. Dynamic aspects of vacuolar and cytosolic amino acid pools of Saccharomyces cerevisiae. J. Bacteriol. 170:2683-2686.
    • (1988) J. Bacteriol. , vol.170 , pp. 2683-2686
    • Kitamoto, K.1    Yoshizawa, K.2    Ohsumi, Y.3    Anraku, Y.4
  • 22
    • 0032079372 scopus 로고    scopus 로고
    • Nonclassical protein sorting to the yeast vacuole
    • Klionsky, D. J. 1998. Nonclassical protein sorting to the yeast vacuole. J. Biol. Chem. 273:10807-10810.
    • (1998) J. Biol. Chem. , vol.273 , pp. 10807-10810
    • Klionsky, D.J.1
  • 23
    • 0031013876 scopus 로고    scopus 로고
    • A new pathway for vacuolar cadmium sequestration in saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium
    • Li, Z. S., Y. P. Lu, R. G. Zhen, M. Szczypka, D. J. Thiele, and P. A. Rea. 1997. A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium. Proc. Natl. Acad. Sci. USA 94:42-17.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 42-117
    • Li, Z.S.1    Lu, P.2    Zhen, R.G.3    Szczypka, M.4    Thiele, D.J.5    Rea, P.A.6
  • 24
    • 0030989006 scopus 로고    scopus 로고
    • In vivo drug-selectable genes: A new concept in gene therapy
    • Licht, T., F. Hermann, M. M. Gottesman, and I. Pastan. 1997. In vivo drug-selectable genes: a new concept in gene therapy. Stem Cells 15:104-111.
    • (1997) Stem Cells , vol.15 , pp. 104-111
    • Licht, T.1    Hermann, F.2    Gottesman, M.M.3    Pastan, I.4
  • 26
    • 0026653589 scopus 로고
    • Cloning and characterization of the mvrC gene of Escherichia coli K12 which confers resistance against methyl viologen toxicity
    • Morimyo, M., E. Kongo, H. Hama-Inaba, and I. Machida. 1992. Cloning and characterization of the mvrC gene of Escherichia coli K12 which confers resistance against methyl viologen toxicity. Nucleic Acids Res. 20:3159-3165.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 3159-3165
    • Morimyo, M.1    Kongo, E.2    Hama-Inaba, H.3    Machida, I.4
  • 27
    • 0024022990 scopus 로고
    • Changes induced in the permeability barrier of the yeast plasma membrane by cupric ion
    • Ohsumi, Y., K. Kitamoto, and Y. Anraku. 1988. Changes induced in the permeability barrier of the yeast plasma membrane by cupric ion. J. Bacteriol. 170:2676-2682.
    • (1988) J. Bacteriol. , vol.170 , pp. 2676-2682
    • Ohsumi, Y.1    Kitamoto, K.2    Anraku, Y.3
  • 28
    • 0026578325 scopus 로고
    • Primary structure of the Aequorea victoria green-fluorescent protein
    • Prasher, D. C., V. K. Eckenrode, W. W. Ward, F. G. Prendergast, and M. J. Cormier. 1992. Primary structure of the Aequorea victoria green-fluorescent protein. Gene 111:229-233.
    • (1992) Gene , vol.111 , pp. 229-233
    • Prasher, D.C.1    Eckenrode, V.K.2    Ward, W.W.3    Prendergast, F.G.4    Cormier, M.J.5
  • 29
    • 0025392644 scopus 로고
    • Cloning of the ethidium efflux gene from Escherichia coli
    • Purewal, A. S., I. G. Jones, and M. Midgley. 1990. Cloning of the ethidium efflux gene from Escherichia coli. FEMS Microbiol. Lett. 68:73-76.
    • (1990) FEMS Microbiol. Lett. , vol.68 , pp. 73-76
    • Purewal, A.S.1    Jones, I.G.2    Midgley, M.3
  • 30
    • 0030788474 scopus 로고    scopus 로고
    • Mutants of saccharomyces cerevisiae defective in vacuolar function confirm a role for the vacuole in toxic metal ion detoxification
    • Ramsay, L. M., and G. M. Gadd. 1997. Mutants of Saccharomyces cerevisiae defective in vacuolar function confirm a role for the vacuole in toxic metal ion detoxification. FEMS Microbiol. Lett. 152:293-298.
    • (1997) FEMS Microbiol. Lett. , vol.152 , pp. 293-298
    • Ramsay, L.M.1    Gadd, G.M.2
  • 31
    • 0026034114 scopus 로고
    • Evidence that the inhibition sites of the neurotoxic amine 1-methyl-4-phenylpyridinium (MPP +) and of the respiratory chain inhibitor piericidin A are the same
    • Ramsay, R. R., M. J. Krueger, S. K. Youngster, and T. P. Singer. 1991. Evidence that the inhibition sites of the neurotoxic amine 1-methyl-4-phenylpyridinium (MPP +) and of the respiratory chain inhibitor piericidin A are the same. Biochem. J. 273:481-484.
    • (1991) Biochem. J. , vol.273 , pp. 481-484
    • Ramsay, R.R.1    Krueger, M.J.2    Youngster, S.K.3    Singer, T.P.4
  • 32
    • 0021128729 scopus 로고
    • Substrate specificities of active transport systems for amino acids in vacuolar-membrane vesicles of Saccharomyces cerevisiae. Evidence of seven independent proton/amino acid antiport systems
    • Sato, T., Y. Ohsumi, and Y. Anraku. 1984. Substrate specificities of active transport systems for amino acids in vacuolar-membrane vesicles of Saccharomyces cerevisiae. Evidence of seven independent proton/amino acid antiport systems. J. Biol. Chem. 259:11505-11508.
    • (1984) J. Biol. Chem. , vol.259 , pp. 11505-11508
    • Sato, T.1    Ohsumi, Y.2    Anraku, Y.3
  • 33
    • 0023472472 scopus 로고
    • Tricine-SDS PAGE for the separation of proteins in the range from 1 to 100 kDa
    • Schagger, H., and G. von Jagow. 1987. Tricine-SDS PAGE for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166:368-379.
    • (1987) Anal. Biochem. , vol.166 , pp. 368-379
    • Schagger, H.1    Von Jagow, G.2
  • 34
    • 0030939276 scopus 로고    scopus 로고
    • EmrE, the smallest ion coupled transporter, provides a unique paradigm for structure function studies
    • Schuldiner, S., M. Lebendiker, and H. Yerushalmi. 1997. EmrE, the smallest ion coupled transporter, provides a unique paradigm for structure function studies. J. Exp. Biol. 200:335-341.
    • (1997) J. Exp. Biol. , vol.200 , pp. 335-341
    • Schuldiner, S.1    Lebendiker, M.2    Yerushalmi, H.3
  • 36
    • 0030659440 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae mutants altered in vacuole function are defective in copper detoxification and iron-responsive gene transcription
    • Szczypka, M. S., Z. Zhu, P. Silar, and D. J. Thiele. 1997. Saccharomyces cerevisiae mutants altered in vacuole function are defective in copper detoxification and iron-responsive gene transcription. Yeast 13:1423-1435.
    • (1997) Yeast , vol.13 , pp. 1423-1435
    • Szczypka, M.S.1    Zhu, Z.2    Silar, P.3    Thiele, D.J.4
  • 38
    • 0026509543 scopus 로고
    • The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation
    • Tyers, M., G. Tokiwa, R. Nash, and B. Futcher. 1992. The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation. EMBO J. 11:1773-1784.
    • (1992) EMBO J. , vol.11 , pp. 1773-1784
    • Tyers, M.1    Tokiwa, G.2    Nash, R.3    Futcher, B.4
  • 39
    • 0024470598 scopus 로고
    • Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: Similarities between CAN1. HIP1 and PUT4 permeases
    • Vandenbol, M., J. C. Jauniaux, and M. Grenson. 1989. Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1. HIP1 and PUT4 permeases. Gene 83:153-159.
    • (1989) Gene , vol.83 , pp. 153-159
    • Vandenbol, M.1    Jauniaux, J.C.2    Grenson, M.3
  • 40
    • 0028929242 scopus 로고
    • A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast
    • Vida, T. A., and S. D. Emr. 1995. A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast. J. Cell Biol. 128:779-792.
    • (1995) J. Cell Biol. , vol.128 , pp. 779-792
    • Vida, T.A.1    Emr, S.D.2
  • 42
    • 0001227894 scopus 로고
    • The plant vacuole: A multifunctional compartment
    • Wink, M. 1993. The plant vacuole: a multifunctional compartment. J. Exp. Bot. 44:231-246.
    • (1993) J. Exp. Bot. , vol.44 , pp. 231-246
    • Wink, M.1
  • 43
    • 0021943518 scopus 로고
    • Improved M13 phage cloning vectors and host strains: Nucleotide sequences of the M13mp18 and pUC19 vectors
    • Yanisch-Perron, C., J. Vieira, and J. Messing. 1985. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33:103-199.
    • (1985) Gene , vol.33 , pp. 103-199
    • Yanisch-Perron, C.1    Vieira, J.2    Messing, J.3
  • 44
    • 0029583203 scopus 로고
    • The pharmacological profile of the vesicular monoamine transporter resembles that of multidrug transporters
    • Yelin, R., and S. Schuldiner. 1995. The pharmacological profile of the vesicular monoamine transporter resembles that of multidrug transporters. FEBS Lett. 377:201-207.
    • (1995) FEBS Lett. , vol.377 , pp. 201-207
    • Yelin, R.1    Schuldiner, S.2
  • 46
    • 0029856981 scopus 로고    scopus 로고
    • Negative dominance studies demonstrate the oligomeric structure of EmrE, a multidrug antiporter from Escherichia coli
    • Yerushalmi, H., M. Lebendiker, and S. Schuldiner. 1996. Negative dominance studies demonstrate the oligomeric structure of EmrE, a multidrug antiporter from Escherichia coli. J. Biol. Chem. 271:31044-31048.
    • (1996) J. Biol. Chem. , vol.271 , pp. 31044-31048
    • Yerushalmi, H.1    Lebendiker, M.2    Schuldiner, S.3
  • 47
    • 0030574278 scopus 로고    scopus 로고
    • Heavy metal detoxification in higher plants - A review
    • Zenk, M. H. 1996. Heavy metal detoxification in higher plants - a review. Gene 179:21-30.
    • (1996) Gene , vol.179 , pp. 21-30
    • Zenk, M.H.1


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