Ultrastructural changes related to multidrug resistance in CEM cells: Role of cytoplasmic vesicles in drug exclusion

Journal of Experimental Therapeutics and Oncology

Volumn 1, Issue 1, 1996, Pages 49-61

  Bobichon, H ^a   Colin, M ^a   Depierreux, C ^a   Liautaud Roger, F ^a   Jardillier, J C ^a,b  

^a GIBSA (EA 1238)   (France)

^b INSTITUT JEAN GODINOT   (France)

Author keywords

Multidrug resistance; Nucleus; P glycoprotein; Ultrastructure; Vesicles

Indexed keywords

DRUG; GLYCOPROTEIN P;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL NUCLEUS; CYTOPLASM; DRUG RESISTANCE; ELECTRON MICROSCOPY; ENZYMOLOGY; GENE; GENETICS; GOLGI COMPLEX; HUMAN; IMAGE CYTOMETRY; LYMPHATIC LEUKEMIA; LYSOSOME; METABOLISM; MULTIDRUG RESISTANCE; NUCLEOLUS; PATHOLOGY; PHENOTYPE; SCANNING ELECTRON MICROSCOPY; ULTRASTRUCTURE;

CELL NUCLEOLUS; CELL NUCLEUS; CYTOPLASM; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENES, MDR; GOLGI APPARATUS; HUMANS; IMAGE CYTOMETRY; LEUKEMIA, LYMPHOCYTIC; LYSOSOMES; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, SCANNING; P-GLYCOPROTEIN; PHARMACEUTICAL PREPARATIONS; PHENOTYPE; TUMOR CELLS, CULTURED;

EID: 0029677414     PISSN: 13594117     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Bradley G, Juranka PF, Ling V. Mechanism of multidrug resistance. Biochim Biophys Acta 948: 87-128, 1988.
2. Gottesman MM, Pastan I. Biochemistry of multidrug mediated by the multidrug transporter. Ann Rev Biochem 62: 385-427, 1993.
3. Hegewich-Becker S, Fliegner M, Tsuruo T, Zander T, Zeller W, Hossfeld DK. P-glycoprotein expression in normal and reactive bone marrows. Br J Cancer 67: 430-435, 1993.
4. Hindenburg AA, Gervasoni JE, Krishna S, et al. Intracellular distribution and pharmacokinetics of daunorubicin in anthracycline-sensitive and resistant HL-60 cells. Cancer Res 49: 4607-4614, 1989.
5. Hitchins RN, Harman DH, Davey RA, Bell DR. Identification of a multidrug resistance associated antigen (P-glycoprotein) in normal human tisues. Eur J Cancer Clin Oncol 24: 449-454, 1988.
6. Mattern J, Volm M. Multiple pathway drug resistance. Int J Oncol 2: 557-561, 1993.
7. Coley HM, Amos WB, Twentyman PR, Workman P. Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines. Brit J Cancer 67: 1316-1323, 1993.
8. Beck WT. The cell biology of multiple drug resistance. Biochem Pharmacol 36: 2879-2887, 1987.
9. Boiocchi M, Tumiotto L, Gianini F, Viel A. Biscontin G, Sartor F, Toffoli G. P-glycoprotein but not topoisomerase II and glutahione-S-transferase-p accounts for enhanced intracellular drug-resistance in LoVo MDR human cell lines. Tumori 78: 159-166, 1992.
10. Sugawara I, Katakoa I, Morishita Y, Hamada H, Tsuruo T, Itoyama S, Mori S. Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16. Cancer Res 48: 1926-1929, 1988.
11. Willingham MC, Richert ND, Cornwell MM, Tsuruo T, Hamada H, Gottesman MM, Pastan IH. Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells. J Histochem Cytochem 35: 12, 1451-1456, 1987.
12. Dufer J, Akeli MG, Jeannesson P, Desplaces A, Jardillier JC. Quantitative morphological analysis of adriamycin-resistant human K 562 leukemic cells. Cytometry 10: 37-43, 1989.
13. Bobichon H, Okiemi MG, Broglio C, Ploton D, Dufer J. Adriamycin resistance is characterized by ultrastructural changes in human leukaemic K 562 cells in vitro. Biol Cell 74: 287-297, 1992.
14. Kartner N, Everden-Porelle D, Bradley G, Ling V. Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Nature 316: 820-823, 1985.
15. Warren L, Jardillier JC, Ordentlich P. Secretion of lysosomal enzymes by drug-sensitive and multiple drug-resistant cells. Cancer Res 51: 1996-2001, 1991.
16. Warren L, Malarska A, Jardillier JC. The structure of P-plycoprotein and the secretion of lysososmal enzymes in MDR cells. Cancer Chemother Pharmacol, 35: 267-269, 1995.
17. Jardillier JC, Warren L, Colin M, Madoulet C. Effect of vanadate on multidrug resistance in CEM cells. Proc Am Assoc Cancer Res 33: 474, 1992.
18. Brugal G. Image analysis of microscopic preparations. In: Jasmin G, Proschek L (eds) Methods and achievements in experimental pathology. Karger, Basel, pp. 1-33, 1984.
19. Shands JW. Embedding free-floating cells and microscopic particles: serum albumin coagulum-epoxy resin. Stain Technol 43: 15-19, 1968.
20. Pavelka M, Ellinger A. Cytochemical characteristics of the Golgi apparatus. J Electron Microsc Techniques 17: 35-50, 1991.
21. Quatacker JR. Lectin-gold cytochemistry of the Golgi apparatus in rabbit luteal cells, with special emphasis on the formation of a lysosomal-type membrane. Histochemistry 90: 399-404, 1989.
22. Callaghan R, Stafford A, Epand RM. Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties. Biochim Biophys Acta 1175: 277-282, 1993.
23. 3H) vinblastine transport by isolated vesicles. Biochim Biophys Acta 1061: 106-110, 1991.
24. Smith PJ, Sykes HR, Fox ME, Furlong IJ. Subcellular distribution of the anticancer drug mitoxantrone in human and drug-resistant murine cells analysed by flow cytometry and confocal microscopy and its relationship to the induction of DNA damage. Cancer Res 52: 4000-4008, 1992.
25. Weaver JL, Scott Pine P, Aszalos A, Schoenlein PV, Currier SJ, Padmanabhan R, Gottesman MM. Laser scanning and confocal microscopy of daunorubicin, doxorubicin, and rhodamine 123 in multidrug-resistant cells. Exp Cell Res, 196: 323-329, 1991.
26. Rutherford A, Willingham MC. Ultrastructural localization of daunomycin in multidrug-resistant cells with modulation of the multidrug transporter. J Histochem Cytochem 41: 1573-1577, 1993.
27. Klochs WD, Steinkampf RW. The effect of lysomotropic agents and secretory inhibitors on anthracycline retention and activity in multiple drug-resistant cells. Molecular Pharmacol 34: 180-185, 1989.
28. Barrand MA, Rhodes T, Centre MS, Twentyman PR. Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein. Eur J Cancer 29A: 408-415, 1993.
29. Slater LM, Sweet P, Hsu TC, Chan PK. Novel nucleolar and nuclear morphology in a vincristine-dependent human leukemia cell line (L100). Exp Cell Res 198: 170-174, 1992.