Role of the vacuolar H+-ATPase in daunorubicin distribution in etoposide-resistant MCF7 cells overexpressing the multidrug-resistance associated protein

International Journal of Oncology

Volumn 12, Issue 3, 1998, Pages 711-715

  Benderra, Zineb ^a   Morjani, Hamid ^a   Trussardi, Aurélie ^b   Manfait, Michel ^a  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^b INSTITUT JEAN GODINOT   (France)

Author keywords

Anthracyclines; Microspectrofluorometry; Multidrug resistance associated protein; RT PCR; Vacuolar H+ ATPase

Indexed keywords

4 CHLORO 7 NITROBENZOFURAZAN; ANTHRACYCLINE; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; VERAPAMIL;

ARTICLE; BREAST ADENOCARCINOMA; CELL STRAIN MCF 7; CELL VACUOLE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CYTOPLASM VESICLE; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; MICROFLUOROMETRY; PRIORITY JOURNAL;

EID: 0031908241     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.12.3.711     Document Type: Article

References (28)

1. Gottesman MM and Pastan I: Biochemistry of multidrug resistance mediated by the multidrug transporter. Ann Rev Biochem 62: 385-427, 1993.
2. Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AMV and Deeley RG: Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650-1654, 1992.
3. Barrand MA, Heppell-Parton AC, Wright KA, Rabbitts PH and Twentyman PR: A 190-kilodalton protein overexpressed in non-P-glycoprotein-containing multidrug-resistant cells and its relationship to the MRP gene. J Natl Cancer Inst 86: 110-117, 1994.
4. Cole SPC, Sparks KE, Fraser K, Loe DW, Grant CE, Wilson GM and Deely RG: Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res 54: 5902-5910, 1994.
5. Coly HM, Amos PR, Twentyman PR and Workman P: Examination by confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines. Br J Cancer 67: 1316-1323, 1993.
6. Gervasoni JE, Fields SZ, Krishna S, Baker MA, Rosado M, Thuraisamy K, Hindenburg AA and Taub RN: Subcellular distribution of daunorubicin in P-glycoprotein-positive and - negative drug-resistant cell lines using laser-assisted confocal microscopy. Cancer Res 51: 4955-4963, 1991.
7. Duffy PM, Hayes MC, Gatrell SKE, Cooper A and Smart CJ: Determination and reversal of resistance to epirubicin intravesical chemotherapy. A confocal imaging study. Br J Urol 77: 824-829, 1996.
8. Feller N, Broxterman HJ, Wahrer DCR and Pinedo HM: ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion. FEBS Lett 368: 385-388, 1995.
9. +-adenosine triphosphatase activity in multidrug resistance in HL60 cells. J Natl Cancer Inst 83: 1098-1102, 1991.
10. Tsuruo T, Iida H, Tsukagoshi S and Sakurat Y: Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors. Cancer Res 42: 4730-4733, 1982.
11. Safa AR, Glover CJ, Sewell JL, Meyers MB, Biedler JL and Felsted RL: Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers. J Biol Chem 262: 7884-7888, 1987.
12. Schneider E, Horton JK, Yang C-H, Nakagawa M and Cowan KH: Multidrug resistance-associated protein (MRP) gene over-expression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance. Cancer Res 54: 152-158, 1994.
13. Schneider E, Yamazaki H, Sinha BK and Cowan KH: Buthionine sulphoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation. Br J Cancer 71: 738-743, 1995.
14. Fairchild CR, Ivy SP, Kao-shan C, Whang-Peng J, Rosen N, Israel MA, Melera PW, Cowan KH and Goldsmith ME: Isolation of amplified and over-expressed DNA sequences from adriamycin-resistant human breast cancer cells. Cancer Res 47: 5141-5148, 1987.
15. Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DLA, Mayo JG, Shoemaker RH and Boyd MR: Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 48: 589-601, 1988.
16. Chomczynski P and Sacchi N: Single-step-method of RNA isolation by acid guanidinium-thiocynate-phenolchloroform extration. Anal Biochem 162: 156-159, 1987.
17. Bordow SB, Haber M, Madafiglio J, Cheung B, Marshall GM and Norris MD: Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma. Cancer Res 54: 5036-5040, 1994.
18. Gigli M, Doglia S, Millot JM, Valentini L and Manfait M: Quantitative study of doxorubicin in living cell nuclei by microspectrofluorometry. Biochem Biophys Acta 950: 13-20, 1988.
19. Gigli M, Rasoanaivo TWD, Millot JM, Jeannesson P, Rizzo V, Jardillier JC, Arcamone F and Manfait M: Correlation between growth inhibition and intranuclear doxorubicin and 4'-iododoxorubicin quantitated in living K562 cells by microspectrofluorometry. Cancer Res 49: 560-564, 1989.
20. Millot JM, Rasoanaivo TWD, Morjani H and Manfait M: Role of the aclacinomycin A-doxorubicin associated in reversal of doxorubicin resistance in K562 tumour cells. Br J Cancer 69: 678-684, 1989.
21. Millot JM, Joly P, Benoist H and Manfait M: Doxorubicin nuclear distribution necessary to induce erythroid differentiation of K562 cells. J Cell Pharmacol 2: 1-8, 1991.
22. Barrand MA, Rhodes T, Center MS and Twentyman PR: Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190 K membrane protein distinct from P-glycoprotein. Eur J Cancer 29: 408-415, 1993.
23. Cole SPC, Downes HF and Slovak ML: Effect of calcium antagonists on the chemosensitivity. of two multidrug resistant cell lines which do not overexpress P-glycoprotein. Br J Cancer 59: 42-46, 1989.
24. Zamora JM and Beck WT: Chloroquine enhancement of anticancer drug cytotoxicity in multiple drug resistant human leukemic cells. Biochem Pharmacol 35: 4303-4310, 1986.
25. Shiraishi N, Akiyama SI, Kobayashi M and Kuwano M: Lysosomotropic agents reverse multiple drug resistance in human cancer cells. Cancer Lett 30: 251-259, 1986.
26. Marquardt D and Center MS: Drug transport mechanism in HL60 cells isolated for resistance to adriamycin: evidence for nuclear drug accumulation in resistant cells. Cancer Res 52: 3157-3163, 1992.
27. Schindler M, Grabski S, Hoff E and Simon SM: Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells (MCF-7 adr). Biochemistry 35: 2811-2817, 1996.
28. Thiebault F, Currier SJ, Whitaker J, Haugland RF, Gottesman M, Pastan I and Willingham MC: Activity of the multidrug transporter results in alkalinisation of the cytosol: measurements of cytosolic pH by microinjection of a pH-sensitive dye. J Histochem Cytochem 38: 685-690, 1990.