Differential development of type 1 and type 2 cytokines and β-chemokines in the ontogeny of healthy newborns

Biology of the Neonate

Volumn 75, Issue 1, 1999, Pages 1-8

  Vigano, Alessandra ^a   Esposito, Susanna ^a   Arienti, Donatella ^a   Zagliani, Arianna ^a   Massironi, Emilia ^a   Principi, Nicola ^a   Clerici, Mario ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

chemokines; Cytokines; Immunity; Infant; Newborn; Ontogeny

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MITOGENIC AGENT; RANTES;

ARTICLE; B LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNITY; IMMUNOPHENOTYPING; LEUKOCYTE COUNT; LYMPHOCYTE; MATURATION; NATURAL KILLER CELL; NEWBORN; NORMAL HUMAN; ONTOGENY; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; UMBILICAL CORD BLOOD;

AGING; CELLS, CULTURED; CHEMOKINES; CROSS-SECTIONAL STUDIES; CYTOKINES; FETAL BLOOD; HUMANS; IMMUNOPHENOTYPING; INFANT; INFANT, NEWBORN; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-4; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; LYMPHOCYTES; MACROPHAGE INFLAMMATORY PROTEIN-1; RANTES;

EID: 0032890320     PISSN: 00063126     EISSN: None     Source Type: Journal    
DOI: 10.1159/000014071     Document Type: Article

References (39)

1. Mosmann TR, Coffman RL: Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173.
2. Stevens DL: Cytokines: An updated compendium. Curr Opin Infect Dis 1995;8:175-180.
3. Clerici M, Shearer GM: A Th1→Th2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993;14:107-11.
4. Clerici M, Shearer GM: The TH1-Th2 hypothesis of HIV infection: New insights. Immunol Today 1994;15:575-581.
5. Heinzel FP: Th1 and Th2 cells in the cure and pathogenesis of infectious diseases. Curr Opin Infect Dis 1995; 8:151-155.
6. Cocchi F, Devico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1α, MIP-1β as the major HIV-suppressive factors produced by CD8 T cells. Science 1995;270:1811-1815.
7. Ad Hoc Working Group for the Development of Standards for Pediatric Immunization Practices: Standards for pediatric immunization practices. JAMA 1993;269:1817-1822.
8. Wakasugi N, Virelizier JL: Defective IFN-γ production in the human neonate. I. Dysregulation rather than intrinsic abnormality. J Immunol 1985;134:167-171.
9. Wilson CB, Westall J, Johnston L, Lewis DB, Dower SK, Alpert AR: Decreased production of interferon-gamma by human neonatal cells. Intrinsic and regulatory deficiencies. J Clin Invest 1986;77:860-867.
10. Tang ML, Kemp AS: Ontogeny of IL-4 production. Pediatr Allergy Immunol 1995;6:11-19.
11. Adkins B, Ghanei A, Hamilton K: Developmental regulation of IL-4, IL-2, and IFN gamma production by murine peripheral T lymphocytes. J Immunol 1993;151:6617-6626.
12. Roser BJ: Cellular mechanisms in neonatal and adult tolerance. Immunol Rev 1989;107:179-202.
13. Ridge JP, Fuchs EJ, Matzinger P: Neonatal tolerance revisited: Turning of newborn T cells with dendritic cells. Science 1996;271:1723-1726.
14. Abramowicz D, Vandervorst P, Bruyns C, Doutrelepont JM, Vandenabeele P, Goldman M: Persistence of anti-donor allohelper T cells after neonatal induction of allotolerance in mice. Eur J Immunol 1990; 20:1647-1653.
15. Sarzotti M, Robbins DS, Hoffman PM: Induction of protective CTL responses in newborn mice by a murine retrovirus. Science 1996;271: 1726-1728.
16. Forsthuber T, Yip HC, Lehmann PV: Induction of Th1 and Th2 immunity in neonatal mice. Science 1996;271:1728-1730.
17. Hosken NA, Shibuya K, Heath AW, Murphy KM, OíGarra A: The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-β-transgenic model. J Exp Med 1995;182:1579-1584.
18. Bona C, Bot A: Neonatal immunoresponsiveness. Immunologist 1997; 5:5-9.
19. Clerici M, Stocks NI, Zajac RA, Boswell N, Lucey DR, Via CS, Shearer GM: Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. J Clin Invest 1989;84: 1892-1899.
20. Petersen J, Church J, Gomperts E, Parkman R: Lymphocyte phenotype does not predict immune function in pediatric patients infected with human immunodeficiency virus type 1. J Pediatr 1989;115:944-948.
21. Clerici M, Hakim FT, Venzon DJ, Blatt S, Hendrix CW, Wynn TA, Shearer GM: Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. J Clin Invest 1993;91:759-765.
22. Abo T, Miller C, Gartland G: Differentiation stages of human natural killer cells in lymphoid tissues from fetal to adult life. J Exp Med 1983; 157:273-284.
23. Erkeller-Yuksel FM, Deneys V, Yuksel B, Hannet I, Hulstaert F, Hamilton C, Mackinnon H, Turner Stokes L, Munhyeshuli V, Vanlangendonck F, De Bruyere M, Bach BA, Lydyard PM: Age-related changes in human blood lymphocyte subpopulations. J Pediatr 1992; 120:216-222.
24. Taylor S, Bryson Y: Impaired production of IFN gamma by newborn cells in vitro is due to a functionally immature macrophage. J Immunol 1985;134:1493-1497.
25. Wilson CB: The ontogeny of T lymphocytes maturation and function. J Pediatr 1991;118:S4-S9.
26. Lewis DB, Yu CC, Meyer J, English BK, Kahn SJ, Wilson CB: Cellular and molecular mechanisms for reduced interleukin 4 and interferon-γ production by neonatal T cells. J Clin Invest 1991;87:194-202.
27. Ehlers S, Smith KA: Differentiation of T cell lymphokine gene expression: The in vitro acquisition of T cell memory. J Exp Med 1991;173: 25-36.
28. Zola H, Flego L, Weedon H: Expression of IL-4 receptor on human T and B lymphocytes. Cell Immunol 1993;150:149-158.
29. Zola H, Fusco M, Macardle PJ, Flego L, Roberton D: Expression of cytokine receptors by human cord blood lymphocytes: Comparison with adult blood lymphocytes. Pediatr Res 1995;38:397-403.
30. Zola H, Fusco M, Weedon H, Macardle PJ, Ridings J, Roberton DM: Reduced expression of the interleukin-2-receptor γ chain on cord blood lymphocytes: Relationship to functional immaturity of the neonatal immune response. Immunology 1996;87:86-91.
31. Yu M, Fredrikson S, Link J, Link H: High numbers of autoantigen-reactive mononuclear cells expressing interferon-gamma (IFN-γ), IL-4 and transforming growth factor-beta (TGF-β) are present in cord blood. Clin Exp Immunol 1995;101:190-196.
32. Kuzu H, Kuzu Y, Zaghuani H, Bona CA: In vivo priming effect during various stages of ontogeny of an influenza A virus nucleoprotein peptide. Eur J Immunol 1993;23:1397-1401.
33. Fiorentino DF, Bond MW, Mosmann TR: Two types of mouse helper T cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989; 170:2081-2095.
34. Powrie F, Coffman R: IL-4 and IL-10 inhibit DTH and IFN-γ production. Eur J Immunol 1993;23:2223-2229.
35. Zou WP, Lackner AA, Simon M, Durand Gasselin I, Galanaud P, Desrosiers RC, Emilie D: Early cytokine and chemokine gene expression in lymph nodes of macaques infected with simian immunodeficiency virus is predictive of disease outcome and vaccine efficacy. J Virol 1997;71:1227-1236.
36. Hayward AR, Lee J, Beverly PCL: Ontogeny of expression of UCHL1 antigen on TcR-1+ (CD4/8) and TcR-8+ T cells. Eur J Immunol 1989;46:771-773.
37. Hulstaert F, Hannet I, Deneys V, Munhyeshuli V, Reichert T, De Bruyere M, Strauss K: Age-related changes in human blood lymphocyte subpopulation. II. Varying kinetics of percentage and absolute count measurements. Clin Immunol Immunopathol 1994;70:152-158.
38. Osugi Y, Hara J, Kurahashi H, Sakata N, Inoue M, Yumura-Yagi K, Kawa-Ha K, Okada S, Tawa A: Age-related changes in surface antigens on peripheral lymphocytes of healthy children. Clin Exp Immunol 1995;100:543-548.
39. Clerici M, DePalma L, Roilides E, Baker R, Shearer GM: Analysis of T helper and antigen-presenting cell functions in cord blood and peripheral blood leukocytes from healthy children of different ages. J Clin Invest 1993;91:2829-2836.